Research Cores

EM Imaging Facility

At the Biological Electron Microscopy Facility, researcher Fei Guo calibrates an electron microscope which is capable of resolution below 3.5 Å at 40,000x magnification. David Slipher/UC Davis.

We are home to many facilities which collaborate across campus to enhance the aim and support for institutional research. Here is a list of research cores which are affiliated with the College of Biological Sciences.

Department of Evolution and Ecology

  • The UCDNA Sequencing Facility can sequence double-stranded and single-stranded templates from purified plasmids, BACs, cosmids, and PCR products. This facility's instruments are capable of processing approximately twelve 96-well plates in a 24-hour period.

Department of Molecular and Cellular Biology

  • The LM Imaging Facility utilizes advanced fluorescence microscopy resources which specialize in live cell imaging and super-resolution methods. 
  • The Biological Electron Microscopy Facility encompasses expertise and imaging systems across the spatial resolution scale, from imaging macromolecular assemblies, subcellular organelles and whole-preserved multicellular tissues.

Department of Plant Biology

  • The Research Greenhouses include the Core Greenhouse Complex and the Orchard Park Facility, which support 24 total greenhouses. 

Genome Center

  • The Bioinformatics Core provides expertise and infrastructure for the acquisition, curation, analysis and distribution of large complex biological datasets, with an emphasis on sequence data.
  • The DNA Technologies Core provides Illumina high-throughput sequencing, PacBio long read sequencing, as well as Fludigm EP1 and Illumina BeadArray high throughput SNP genotyping. The DNA Technologies Core further offers many sequencing-associated services such as library preparation and QC, as well as consultations on project design.
  • The Expression Analysis Core offers many RNA sequencing options such as ribosomal RNA-depletion, polyA enrichment, strand-specific sequencing and ultra-low input libraries. 
  • The Metabolomics Core provides untargeted and metabolite target analyses for a wide range of biochemical pathways, covering over 1,200 identified metabolites with validated analytical methods and known mass spectra and retention times. 
  • The Proteomics Core provides state-of-the-art analytical proteomic services with particular emphasis on label-free quantitative proteomic profiling, the analysis of macromolecular complexes, the post-translational modification of their constituents and standard protein identification from complex protein mixtures.
  • The TILLING Core provides mutants for rice, Arabidopsis thaliana, and tomato as well as other species on request. TILLING (Targeting Induced Local Lesions IN Genomes) is a reverse genetic technique that uses chemical mutagenesis to create libraries of mutagenized individuals that are subjected to high-throughput sequencing for discovery of mutations.

The Office of Research Core Facilities Program promotes a world-class research infrastructure at UC Davis that enables scientific excellence, technology development and outstanding innovations for researchers on campus and the scientific community.