Aijun Wang

Aijun Wang

Position Title
Associate Professor

Unit
Department of Surgery, School of Medicine
Department of Biomedical Engineering, College of Engineering
Institute for Pediatric Regenerative Medicine


4625 2nd Ave, Research II, Suite 3005, Sacramento CA 95817
Bio

Research Interests

Dr. Wang’s research focuses on developing tools and technologies that combine molecular, cellular, tissue and biomaterial engineering to promote regeneration and restore function. The Wang Group engineers and develops stem cells, stem cell derivatives and extracellular matrix / biomaterial based scaffolds for the treatment of surgical conditions and diseases.  Ongoing projects include: (1) engineering stem cells and stem cell-derived exosomes for tissue regeneration and targeted delivery; (2) developing instructive biomaterial scaffolds for stem cell culture, delivery and recruitment; (3) establishing and using experimental and naturally-occurring disease models to evaluate stem cell and biomaterial products. 

Grad Group Affiliations

  • Biochemistry, Molecular, Cellular and Developmental Biology
  • Graduate Group in Integrative Pathobiology
  • Biomedical Engineering Graduate Group

Specialties / Focus

  • Stem Cell Biology
  • Molecular, Cellular and Tissue Engineering
  • Biomaterials
  • Regenerative Medicine
  • Neovascularization
  • Congenital Anomalies
  • Developmental Biology

Lab Members

  • Christopher Pivetti (Lab Manager)
  • Dr. Priya Kumar (Project Scientist)
  • Dr. Dake Hao (Postdoctoral Scholar)
  • Dr. Laura Galganski (Surgical Resident)
  • Dr. Kaeli Yamashiro (Surgical Resident)
  • Dr. Xinke Zhang (Visiting Professor)
  • Dr. Hongyuan Chen (Visiting Professor)
  • Dr. Chuanchao He (Visiting Professor)
  • Lalitha Ramasubramanian (PhD Student)
  • Kaitlin Clark (PhD Student)
  • Sylvain Barthe (CIRM Bridges Student)
  • Harsha Jyothi (CIRM Bridges Student)
  • Nicole Kreutzberg (Junior Specialist)
  • Chelsey Lee (Junior Specialist)
  • Zachary Paxton (Junior Specialist)
  • Kewa Gao (Visiting Scholar)
  • Siqi He (Visiting Scholar)

Courses

  • FYS: Stem Cell and Genetic Engineering
  • FYS: Surgical Bioengineering - An Interface Between Engineering and Medicine

Honors and Awards

  • Winner, Berkeley Venture Lab Competition

  • Deloitte QB3 Award for Innovation

  • Best of ASH, American Society of Hematology

  • Tony Phillips Research Award, Children’s Miracle Network (CMN)

  • Basil O’Connor Starter Scholar Research Award, March of Dimes Foundation

  • NIH/NHLBI Technology Development Award

  • Deans Fellowship in Entrepreneurship, University of California Davis School of Medicine

Professional Societies

  • Materials Research Society (MRS)

  • American Heart Association (AHA)

  • International Society for Stem Cell Research (ISSCR)

  • Biomedical Engineering Society (BMES)

  • Tissue Engineering and Regenerative Medicine International Society (TERMIS)

  • Founding Member of the International Perinatal Stem Cell Society (IPSCS)

  • Life Member of the World Association for Chinese Biomedical Engineering (WACBE)

Degrees

  • Ph.D., Biology
  • M.S., Biochemical Drugs
  • B.S., Pharmaceutical Chemistry

Publications

  1. Connor Long, Lee Lankford, Aijun WangCell-based In UteroTherapies for Spina Bifida: Implications for Neural RegenerationNeural Regeneration Research2019 Feb; 14(2): 260-261. PMID: 30531007. DOI: 10.4103/1673-5374.244786
  2. Zhengkui Zhang, Jinjin Du, Shuai Wang, Li Shao, Ke Jin, Fang Li, Bajin Wei, Wei Ding, Peifen Fu, Hansvan Dam, Aijun Wang, Jin Jin, Chen Ding, BingYang, Min Zheng, Xin-Hua Feng, Kun-Liang Guan, Long Zhang. OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ. Molecular Cell2019 [Epub ahead of print]. PMID: 30472188. DOI: 10.1016/j.molcel.2018.10.030
  3. Melissa Vanover, Christopher Pivetti, Lee Lankford, Priyadarsini Kumar, Laura Galganski, Sandra Kabagambe, Benjamin Keller, James Becker, Y. Julia Chen, Karen Chung, Chelsey Lee, Zachary Paxton, Bailey Deal, Laura Goodman, Jamie Anderson, Guy Jensen, Aijun Wang, Diana Farmer. High Density Placental Mesenchymal Stromal Cells Provide Neuronal Preservation and Improve Motor Function Following In Utero Treatment of Ovine Myelomeningocele. The Journal of Pediatric Surgery2019 [Epub ahead of print]. PMID: 30529115. DOI: https://doi.org/10.1016/j.jpedsurg.2018.10.032
  4. Yiqian Zhu, Xian Li, Randall Raphael R. Janairo, George Kwong, Anchi D. Tsou, Julia S. Chu, Aijun Wang, Song Li. Matrix Stiffness Modulates the Differentiation of Neural Crest Stem Cells In Vitroand In VivoJournal of Cellular Physiology. 2018. Oct 26. [Epub ahead of print]PMID: 30368818. DOI: 10.1002/jcp.27518
  5. JenniferPhan, PriyadarsiniKumar, Dake Hao, Kewa Gao, Diana Farmer, Aijun WangMesenchymal Stem Cell-Derived Exosomes: Potential Approaches to Improve Efficacy and Yield for Cell-Free TherapyJournal of Extracellular Vesicles. 2018, Sep 26; 7(1): 1522236. PMID: 30275938. PMCID: PMC6161586. DOI: 10.1080/20013078.2018.1522236
  6. Sheng Zhang, Abeer Rasai, Yan Wang, Jie Xu, Peter Bannerman, Daffcar Erol, Danayit Tsegaye, Aijun Wang, Athena Soulika, Xiangjiang Zhan, Fuzheng Guo. The stem cell factor Sox2 is a positive timer of oligodendrocyte development in the postnatal murine spinal cord. Molecular Neurobiology. 2018 Dec; 55(12): 9001-9015. PMID: 29623612. PMCID: PMC6173662. DOI: 10.1007/s12035-018-1035-7
  7. Priyadarsini Kumar, Kewa Gao, Chuwang Wang, Christopher Pivetti, Lee Lankford, Diana Farmer, Aijun WangIn UteroTransplantation of Placenta-derived Mesenchymal Stromal Cells for Potential Application in Hemophilia A TherapyCell Transplantation2018 Jan;27(1):130-139. PMID: 29562772. DOI: 10.1177/0963689717728937
  8. Qi Wang, Jia Chen, Aijun Wang, Lichun Sun, Li Qian, Xiao Zhou, Yu Liu, Shijie Tang, Xiang Chen, Yan Cheng, Ke Cao, Jianda Zhou. Differentially expressed circRNAs in melanocytes and melanoma cells and their effect on cell proliferation and invasion. Oncology Reports2018 Apr; 39(4): 1813-1824. PMID: 29436673. DOI: 10.3892/or.2018.6263
  9. Volodymyr Ryzhuk, Xu-xin Zeng, Xijun Wang, Veniamin Melnychuk, Lee Lankford, Diana Farmer, Aijun Wang. Human amnion extracellular matrix derived bioactive hydrogel for cell delivery and tissue engineering. Materials Science & Engineering C. 2018 Apr 1; 85: 191-202. PMID: 29407148. DOI: 10.1016/j.msec.2017.12.026
  10. Sheng Zhang, Xiaoqing Zhu, Xuehong Gui, Christopher Croteau, Lanying Song, Jie Xu, Aijun Wang, Peter Bannermann, Fuzheng Guo. Sox2 is Essential for Oligodendroglial Proliferation and Differentiation During Postnatal Brain Myelination and CNS Remyelination. The Journal of Neuroscience.2018 Feb 14; 38(7): 1802-1820. PMID: 29335358. PMCID: PMC5815459DOI: 10.1523/JNEUROSCI.1291-17.2018
  11. Dong Wang, LeeAnn K. Li, Tiffany Dai, Aijun Wang, Song Li. Stem Cells in Vascular Remodeling. Theranostics.2018; 8(3):815-829. PMID: 29344309. PMCID: PMC5771096. DOI: 10.7150/thno.19577
  12. Connor Long, Lee Lankford, Priyadarsini Kumar, Robert Grahn, Dori L. Borjesson, Diana Farmer, Aijun WangIsolation and Characterization of Canine Placenta-derived Mesenchymal Stromal Cells for the Treatment of Neurological Disorders in DogsCytometry Part A2018; 93(1): 82-92. PMID: 28715613. DOI: 10.1002/cyto.a.23171
  13. Y. Julia Chen, Karen Chung, Christopher Pivetti, Lee Lankford, Sandra Kabagambe, Melissa Vanover, James Becker, Chelsey Lee, Josephine Tsang, Aijun Wang, Diana Farmer. Fetal Surgical Repair with Placenta-derived Mesenchymal Stromal Cell Engineered Patch in a Rodent Model of Myelomeningocele. The Journal of Pediatric Surgery2018, 53: 183-188.  DOI: https://doi.org/10.1016/j.jpedsurg.2017.10.040
  14. Sandra Kabagambe, Benjamin Keller, James Becker, Laura Goodman, Christopher Pivetti, Lee Lankford, Karen Chung, Chelsey Lee, Y. Julia Chen, Priyadarsini Kumar, Melissa Vanover, Aijun Wang, Diana Farmer. Placental Mesenchymal Stromal Cells Seeded on Clinical Grade Extracellular Matrix Improve Ambulation in Ovine Myelomeningocele. The Journal of Pediatric Surgery2018, 53: 178-182.  DOI: https://doi.org/10.1016/j.jpedsurg.2017.10.032
  15. Ting-Ya Chang, Chen Chen, Ya-Chu Chang, Chi-Huan Lu, Min Lee, Shao-Tzu Lu, De-Yao Wang, Aijun Wang, Chin-Lin Guo, Pei-Lin Cheng. Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery. eLife. 2017; 6: e31101. PMID: 29271742. PMCID: PMC5768420DOI: 10.7554/eLife.31101
  16. Ching-Wen Huang, Wen-Chin Huang, Xuefeng Qiu, Flavia Fernandes Ferreira da Silva, Aijun Wang, Shyam Patel, Leon J. Nesti, Mu-Ming Poo, Song Li. The Differentiation Stage of Transplanted Stem Cells Modulates Nerve Regeneration. Scientific Reports. 2017; 7(1): 17401. PMID: 29234013. PMCID: PMC5727226. DOI: 10.1038/s41598-017-17043-4
  17. Sandra Kabagambe, Lee Lankford, Priyadarsini Kumar, Y. Julia Chen, Kyle Herout, Chelsey Lee, Rebecca Stark, Diana Farmer, Aijun WangIsolation of a Myogenic Progenitor Cell Population from Human Placenta: a pilot study. The Journal of Pediatric Surgery2017; 52(12): 2078-2082. PMID: 28964407. DOI: 10.1016/j.jpedsurg.2017.08.025
  18. Melissa Vanover, Aijun Wang,Diana FarmerPotential clinical applications of placental stem cells for use in fetal therapy of birth defectsPlacenta.2017, 59:107-112. PMID: 28651900. DOI: 10.1016/j.placenta.2017.05.010
  19. Ke Cao, Jingjing Li, Jia Chen, Li Qian, Aijun Wang, Xiang Chen, Wei Xiong, Jingtian Tang, Shijie Tang, Yong Chen, Yao Chen, Yan Cheng, Jianda Zhou. microRNA-33a-5p increases radiosensitivity by modulating glycolysis in melanoma cellsOncotarget2017; 8:83660-83672. DOI: 10.18632/oncotarget.19014
  20. Dong Wang, Fan Wu, Haoyong Yuan, Aijun Wang, Gyeong Jin Kang, Tan Truong, Lu Chen, Andrew S. McCallion, Xiaohua Gong, Song Li. Sox10+ cells contribute to vascular development in multiple organs. Arteriosclerosis, Thrombosis, and Vascular Biology. 2017 Sep; 37(9):1727-1731. PMID: 28751573 PMCID: PMC5572822. DOI: https://doi.org/10.1161/ATVBAHA.117.309774
  21. Junlin Liao, Jia Chen, Bin He, Yong Chen, Jiaqun Xu, Hongju Xie, Feng Hu, Aijun Wang, Chengqun Luo, Qingfeng Li, Jianda Zhou. Viability and Biomechanics of Diced Cartilage Blended with Platelet-Rich Plasma and Wrapped with Poly (Lactic-Co-Glycolic) Acid Membrane. The Journal of Craniofacial Surgery. 2017; 28(6): 1418-1424. PMID: 28692513. DOI: 10.1097/SCS.0000000000003739
  22. Y. Julia Chen, Lee Lankford, Sandra Kabagambe, Zoe Saenz, Priyadarsini Kumar, Diana Farmer, Aijun WangEffect of 2-octylcyanoacrylate on placenta derived mesenchymal stromal cells on extracellular matrixPlacenta2017 Apr 2. pii: S0143-4004 (17 )30222-9. PMID: 28465002. DOI: 10.1016/j.placenta.2017.03.022
  23. Jeffrey Henry, Jian Yu, Aijun Wang, Randall Lee, Jun Fang, Song Li. Engineering the mechanical and biological properties of nanofibrous vascular grafts for in situ vascular tissue engineering. Biofabrication. 2017; 9(3):035007. PMID: 28817384. PMCID: PMC5847368. DOI: 10.1088/1758-5090/aa834b
  24. Lee Lankford, Y. Julia Chen, Zoe Saenz, Priyadarsini Kumar, Connor Long, Diana Farmer, Aijun WangManufacture and preparation of human placenta-derived mesenchymal stromal cells for local tissue deliveryCytotherapy2017 Jun; 19(6): 680-688. PMID: 28438482. DOI: 10.1016/j.jcyt.2017.03.003
  25. Dake Hao, Wenwu Xiao, Ruiwu Liu, Priyadarsini Kumar, Yuanpei Li, Ping Zhou, Fuzheng Guo, Diana L Farmer, Kit S. Lam, Fengshan Wang, Aijun Wang. Discovery and characterization of a potent and specific peptide ligand targeting endothelial progenitor cells and endothelial cells for tissue regeneration. ACS Chem. Biol. 2017, 12 (4), 1075–1086. PMID: 28195700. DOI: 10.1021/acschembio.7b00118
  26. Aja Harding, Elizabeth Cortez-Toledo, Nataly Magner, Julie Beegle, Dane Coleal-Bergum, Dake Hao, Aijun Wang, Jan Nolta, Ping Zhou. Highly Efficient Differentiation of Endothelial Cells from Pluripotent Stem Cells Requires the MAPK and the PI3K Pathways. Stem Cells. 2017 Apr; 35(4):909-919. PMID: 28248004. DOI: 10.1002/stem.2577
  27. Dong Wang/Aijun Wang (Co-first author)Fan Wu, Xuefeng Qiu, Ye Li, Julia Chu, WC Huang, Kang Xu, Xiaohua Gong, Song Li. Sox10+ adult stem cells contribute to biomaterial encapsulation and microvascularization. Scientific Reports. 2017 Jan 10; 7: 40295. PMID: 28071739. PMCID: PMC5223127DOI:  10.1038/srep40295
  28. Erin G. Brown, Benjamin A. Keller, Lee Lankford, Christopher D. Pivetti, Shin Hirose, Diana L. Farmer, Aijun WangAge Does Matter: A Pilot Comparison of Placenta-Derived Stromal Cells for in Utero Repair of Myelomeningocele Using a Lamb ModelFetal Diagnosis and Therapy2016; 39(3):179-85. PMID: 26159889. DOI: 10.1159/000433427
  29. Lee Lankford, Taryn Selby, James Becker, Volodymyr Ryzhuk, Connor Long, Diana Farmer, Aijun Wang. Early Gestation Chorionic Villi-derived Stromal Cells for Fetal Tissue Engineering. World Journal of Stem Cells2015 Jan; 7(1): 195-207. PMCID: PMC4300931. DOI: 10.4252/wjsc.v7.i1.195
  30. Jason A. Meierhenry, Volodymyr Ryzhuk, Maricel G. Miguelino, Lee Lankford, Jerry S. Powell, Diana Farmer, Aijun Wang. Placenta as a Source of Stem Cells for Regenerative Medicine. Current Pathobiology Reports2015, March; 3(1): 9-16. DOI: 10.1007/s40139-015-0070-6
  31. Erin G. Brown, BenjaminA. Keller, Christopher D. Pivetti, Nicole A. Sitkin, Aijun Wang, Diana L. Farmer, Jacqueline C. Bresnahan. Development of a Locomotor Rating Scale for Testing Motor Function in Sheep. The Journal of Pediatric Surgery2015 Apr; 50(4): 617-21.  PMID: 25840074. DOI: 10.1016/j.jpedsurg.2015.01.002
  32. Aijun Wang#, Erin G. Brown, Benjamin A. Keller, Christopher D. Pivetti, Nicole A. Sitkin, Michael S. Beattie, Jacqueline C. Bresnahan, Diana L. Farmer. Placental Mesenchymal Stromal Cells Rescue Ambulation in Ovine Myelomeningocele. Stem Cells Translational Medicine. 2015 Jun; 4(6):659-69. #Corresponding authorPMID: 25911465. PMCID: PMC4449103DOI: 10.5966/sctm.2014-0296
  33. Mei Yu, Zhi-Jun Sun, Lian-Tao Li, Hong-You Ge, Chang-Qin Song, Aijun Wang. The beneficial effects of the herbal medicine Di-huang-yin-zi (DHYZ) on patients with ischemic stroke: A randomized, placebo controlled clinical study. Complementary Therapies in Medicine, 2015; 23(4): 591–597. PMID: 26275652. DOI: 10.1016/j.ctim.2015.06.003
  34. Lin Chen, Qiang Ao, Hari Shanker Sharma, Aijun Wang, Shiqing Feng. Editorial: Neurorestoratologic Strategies and Mechanisms in the Nervous System. BioMed Research International2015: 163170PMID: 26491655. PMCID: PMC4603317DOI: 10.1155/2015/163170
  35. Erin Brown, Payam SaadaiChristopher Pivetti, Michael Beattie, Jacqueline Bresnahan, Aijun Wang, Diana Farmer. In uterorepair of myelomeningocele with autologous amniotic membrane in the fetal lamb model. The Journal of Pediatric Surgery2014 Jan; 49(1):133-7; discussion 137-8. PMID: 24439597. DOI: 10.1016/j.jpedsurg.2013.09.043
  36. Yujun Wei, Kai Gong, Qiang Ao, Aijun Wang, Yandao Gong, Huancong Zuo, Yuqi Zhang, James Wang, Guihuai Wang. Lentiviral vectors enveloped with rabies virus glycoprotein can be used as a novel retrograde tracer to assess nerve recovery in rat sciatic nerve injury models. Cell and Tissue Research. 2014 Feb; 355(2): 255-66. PMID: 24326614. DOI: 10.1007/s00441-013-1756-x
  37. Ping Xiang, Kun-Chao Wu, Ying Zhu, Lue Xiang, Chong Li, Deng-Long Chen, Feng Chen, Guotong Xu, Aijun Wang, Min Li, Zi-Bing Jin. A novel Bruch's membrane-mimetic electrospun substrate scaffold for human retinal pigment epithelium cells. Biomaterials. 2014 Dec; 35(37): 9777-88. PMID: 25220295. DOI: 10.1016/j.biomaterials.2014.08.040
  38. Zhenyu Tang, Aijun Wang, Dong Wang, Song Li. Vascular Smooth Muscle Cells: To Be or Not To Be? Circulation Research. 2013 Jan;112(1):23-6. PMID: 23093574. DOI: 10.1161/CIRCRESAHA.112.281055
  39. Benjamin Lee, Zhenyu Tang, Aijun Wang, Fang Huang, Zhiqiang Yan, Dong Wang, Julia Chu, Li Yang, Song Li. Synovial stem cells and their responses to the porosity of microfibrous scaffold. Acta Biomaterialia. 2013 Jul; 9(7): 7264-75. PMID: 23523935. PMCID: PMC3669641. DOI: 10.1016/j.actbio.2013.03.009
  40. Wei Xu, Yequan Wang, Erfu Liu, Yanjun Sun, Ziwei Luo, Zhiling Xu, Wanqian Liu, Li Zhong, Yonggang Lv, Aijun Wang, Zhenyu Tang, Song Li, Li Yang. Human iPSC-derived Neural Crest Stem Cells Promote Tendon Repair in a Rat Patellar Tendon Window Defect Model. Tissue Eng Part A. 2013 Jul; 19(21-22): 2439-2451. PMID: 23815150. PMCID: PMC3807699. DOI: 10.1089/ten.TEA.2012.0453
  41. Payam SaadaiAijun Wang#, Yvette Nout, Timothy Downing, Michael Beattie, Jacqueline Bresnahan, Song Li, Diana Farmer. Human Induced Pluripotent Stem Cell-derived Neural Crest Stem Cells Integrate into the Injured Spinal Cord in the Fetal Lamb Model of Myelomeningocele. The Journal of Pediatric Surgery2013 Jan; 48(1): 158-63. Corresponding author. PMID: 23331809. DOI: 10.1016/j.jpedsurg.2012.10.034
  42. Aijun Wang, Zhenyu Tang, Xian Li, Yisu Jiang, Danielle A. Tsou, Song Li. Derivation of Smooth Muscle Cells with Neural Crest Origin from Human Induced Pluripotent Stem Cells. Cells Tissues Organs. 2012; 195:5-14. PMID: 22005509. PMCID: PMC3257812. DOI: 10.1159/000331412
  43. Benjamin Lee, Hojeong Jeon, Aijun WangZhiqiang Yan, Jian Yu, Costas Grigoropoulos, Song Li.Femtosecond Laser Ablation Enhances Cell Infiltration into Three-Dimensional Electrospun Scaffolds. Acta Biomaterialia. 2012 Jul; 8(7):2648-58. PMID: 22522128. PMCID: PMC3425609. DOI: 10.1016/j.actbio.2012.04.023
  44. Timothy Downing/Aijun Wang (Co-first author), Zhiqiang Yan, Yvette Nout, Andy Lee, Michael S. Beattie, Jacqueline C. Bresnahan, Diana L. Farmer, Song Li. Drug-eluting microfibrous patches for the local delivery of rolipram in spinal cord repair. Journal of Controlled Release.2012; 161(3):910-917. PMCID22634093. PMCID: PMC3698241DOI: 10.1016/j.jconrel.2012.05.034
  45. Zhenyu Tang/Aijun Wang (Co-first author), Zhiqiang Yan, Bo Liu, Julia Chu, Jill Helms, Song Li. Differentiation of Multipotent Vascular Stem Cells Contributes to Vascular Diseases. Nature Communications. 2012 Jun 6; 3:875. Highlighted in Nature, 486, 9 (07 June 2012) DOI:10.1038/486009d. PMID: 22673902. PMCID: PMC3538044. DOI: 10.1038/ncomms1867Reported by over 100 major news outlets worldwide: NPR’s Science Friday, SF Chronicle (FRONT page on 6/6/2012), Fox News, Medical News Today, US News & World Report, Daily Mail (UK), etc.
  46. Jian Yu/Aijun Wang (Co-first author), Zhenyu Tang, Yiqian Zhu, Jeffrey Henry, Fengping Huang, Song Li. The effect of stromal cell-derived factor-1α/heparin coating of biodegradable vascular grafts on the recruitment of both endothelial and smooth muscle progenitor cells for accelerated regeneration.Biomaterials2012 Nov; 33(32):8062-74. PMID: 22884813. PMCID: PMC3488434. DOI: 10.1016/j.biomaterials.2012.07.042
  47. Yiqian Zhu/Aijun Wang (Co-first author)Shyam Patel, Kyle Kurpinski, Edward Diao, Xuan Bao, George Kwong, William L. Young, Song Li. Engineering Bi-layer Nanofibrous Conduits for Peripheral Nerve Regeneration. Tissue Engineering. 2011, 17(7):705-15. PMID: 21501089. PMCID: PMC3124110. DOI: 10.1089/ten.tec.2010.0565
  48. Jennifer S. Park, Anchi D. Tsou, Rokhaya Diop, Zhenyu Tang, Aijun Wang, Song Li. The Effect of Matrix Stiffness on the Differentiation of Mesenchymal Stem Cells in Response to TGF-β. Biomaterials2011, 32(16): 3921-30. PMID: 21397942. PMCID: PMC3073995. DOI: 10.1016/j.biomaterials.2011.02.019
  49. Aijun Wang, Zhenyu Tang, In-Hyun Park, Yiqian Zhu, Shyam Patel, George Q. Daley, Song Li. Induced Pluripotent Stem Cells for Neural Tissue Engineering. Biomaterials. 2011, 32(22):5023-32. PMID: 21514663. PMCID: PMC3100451. DOI: 10.1016/j.biomaterials.2011.03.070The top 5 most downloaded papers in April-June, 2011. Fig. 1J was selected as one of the 12 best biomaterials-related images published in the Biomaterials 2011 journal catalogue.
  50. Yujun Wei, Kai Gong, Zhenghuan Zheng, Aijun Wang, Qiang Ao, Yandao Gong, Xiufang Zhang. Chitosan/silk Fibroin-based Tissue-engineered Graft Seeded with Adipose-derived Stem Cells Enhances Nerve Regeneration in a Rat Model. Journal of Materials Science: Materials in Medicine. 2011; 22(8): 1947-64. PMID: 21656031. DOI: 10.1007/s10856-011-4370-z
  51. Xian Li, Julia S. Chu, Aijun Wang, Yiqian Zhu, Wai Keung Chu, Li Yang, Song Li. Uniaxial Mechanical Strain Modulates the Differentiation of Neural Crest Stem Cells into Smooth Muscle Lineage on Micropatterned Surfaces. PLoS ONE. 2011; 6(10): e26029. PMID: 22016804. PMCID: PMC3189240. DOI: 10.1371/journal.pone.0026029
  52. Payam SaadaiYvette Nout, Jose Encinas, Aijun Wang, Timothy Downing, Michael S. Beattie, Jacqueline C. Bresnahan, Song Li, Diana L. Farmer. Prenatal Repair of Myelomeningocele with Aligned Nanofibrous Scaffolds - A Pilot Study in Sheep. The Journal of Pediatric Surgery2011; 46:2279-83. PMID: 22152865. DOI: 10.1016/j.jpedsurg.2011.09.014
  53. Steven Hsu, Julia Chu, Fanqing F. Chen, Aijun Wang, Song Li. Effects of Fluid Shear Stress on a Distinct Population of Vascular Smooth Muscle Cells. Cell and Molecular Bioengineering2011; 4:627-36PMID: 22924082. PMCID: PMC3425612. DOI: 10.1007/s12195-011-0205-8
  54. Kyle Kurpinski, Hayley Lam, Julia Chu, Aijun Wang, Ahra Kim, Eric Tsay, Smita Agrawal, David Schaffer, Song Li. TGF-band Notch Signaling Mediate Stem Cell Differentiation into Smooth Muscle Cells. Stem Cells. 2010, 28(4), 734-42PMID: 20146266. DOI: 10.1002/stem.319
  55. Yiqian Zhu/Aijun Wang (Co-first author)Wenqian Shen, Shyam Patel, Rong Zhang, William Young, Song Li. Nanofibrous Patches for Spinal Cord Regeneration. Advanced Functional Materials2010, 20(9), 1433-40. PMID: 23378825. PMCID: PMC3558949. DOI: 10.1002/adfm.200901889
  56. Gan Wang, Qiang Ao, Kai Gong, Aijun Wang, Yandao Gong, Xiufang Zhang. The Effect of Topology of Chitosan Biomaterials on the Differentiation and Proliferation of Neural Stem Cells. Acta Biomaterialia. 2010, 6(9), 3630-9. PMID: 20371303. DOI: 10.1016/j.actbio.2010.03.039
  57. Yujun Wei, Zhenghuan Zheng, Lingling Liu, Aijun Wang, Lihai Zhang, Qiang Ao, Yandao Gong, Xiufang Zhang. Schwann-like Cells Differentiation of Rat Adipose-derived Stem Cells by Indirect Co-culture with Schwann Cells in vitroCell Proliferation. 2010, 43(6):606-16. PMID: 21039999. DOI: 10.1111/j.1365-2184.2010.00710.x
  58. Aijun Wang, Yiqian Zhu, Song Li. Nanofibrous Scaffolds for the Regeneration of Nervous Tissue. Journal of Medical Biomechanics2010, 25, Suppl, 20-21.
  59. Hayley Lam, Shyam Patel, Aijun Wang, Julia Chu, Song Li. Regulation of Neural Differentiation and Axon Growth by Growth Factors and Bioactive Nanofibers. Tissue Engineering. 2010, 16(8): 2641-8. PMID: 20367289. PMCID: PMC2947452. DOI: 10.1089/ten.TEA.2009.0414
  60. Yujun Wei, Jianli Zhou, Zhenghuan Zheng, Aijun Wang, Qiang Ao, Yandao Gong, Xiufang Zhang. An Improved Method for Isolating Schwann Cells from Postnatal Rat Sciatic Nerves. Cell and Tissue Research. 2009, 337(3): 361-9. PMID: 19639342. DOI: 10.1007/s00441-009-0836-4
  61. Zhenhuan Zheng, Ling Zhang, Lijun Kong, Aijun Wang, Yandao Gong, Xiufang Zhang. The Behavior of MC3T3-E1 Cells on Chitosan/poly-L-lysine Composite Films: Effect of Nanotopography, Surface Chemistry, and Wettability. Journal of Biomedical Materials Research Part A. 2009, 89A(2): 453-65. PMID: 18431777. DOI: 10.1002/jbm.a.31979
  62. Zhenhuan Zheng, Yujun Wei, Gan Wang, Aijun Wang, Qiang Ao, Xiufang Zhang. Surface Properties of Chitosan Films Modified with Polycations and Their Effects on the Behavior of PC12 Cells. Journal of Bioactive and Compatible Polymers. 2009, 24(1): 63-82. DOI: 10.1177/0883911508099653
  63. Fangfang Zhou, Long Zhang, Aijun Wang, Bo Song, Kai Gong, Lihai Zhang, Min Hu, Xiufang Zhang, Nanming Zhao, Yandao Gong. The association of GSK3β with E2F1 Facilitates NGF-induced Neural Cell Differentiation. The Journal of Biological Chemistry. 2008, 283(21): 14506-15. PMID: 18367454. DOI: 10.1074/jbc.M706136200
  64. Fangfang Zhou, Long Zhang, Kai Gong, Guangyuan Lu, Baiyang Sheng, Aijun Wang, Nanming Zhao, Xiufang Zhang, Yandao Gong. LEF-1 Activates the Transcription of E2F1. Biochemical and Biophysical Research Communications. 2008, 365(1): 149-53. PMID: 17980157. DOI: 10.1016/j.bbrc.2007.10.138
  65. Qing He, Qiang Ao, Aijun Wang, Yandao Gong, Nanming Zhao, Xiufang Zhang. In VitroCytotoxicity and Protein Drug Release Properties of Chitosan/Heparin Microspheres. Tsinghua Science and Technology. 2007, 12(4): 361-5.  DOI: 10.1016/S1007-0214(07)70054-8http://dx.doi.org/10.1016/S1007-0214(07)70054-8
  66. Aijun Wang, Qiang Ao, Yujun Wei, Kai Gong, Nanming Zhao, Yandao Gong, Xiufang Zhang. Physical Properties and Biocompatibility of a Porous Chitosan-based Fibre-reinforced Conduit for Nerve Regeneration. Biotechnology Letters. 2007, 29(11): 1697-702PMID: 17628751. DOI: 10.1007/s10529-007-9460-0
  67. Qiang Ao/Aijun Wang (Co-first author)Guoqiang Chen, Shijie Wang, Huancong Zuo, Xiufang Zhang. Combined Transplantation of Neural Stem Cells and Olfactory Ensheathing Cells for the Repair of Spinal Cord Injuries. Medical Hypotheses. 2007, 69(6): 1234-7. PMID: 17548168. DOI: 10.1016/j.mehy.2007.04.011
  68. Lijun Kong, Qiang Ao, Aijun Wang, Kai Gong, Xi Wang, Guangyuan Lu, Yandao Gong, Nanming Zhao, Xiufang Zhang. Preparation and Characterization of a Multilayer Biomimetic Scaffold for Bone Tissue Engineering. Journal of Biomaterials Applications. 2007, 22(3): 223-39. PMID: 17255157. DOI: 10.1177/0885328206073706
  69. Aijun Wang, Qiang Ao, Qing He, Xiaoming Gong, Kai Gong, Yandao Gong, Nanming Zhao, Xiufang Zhang. Neural Stem Cell Affinity of Chitosan and Feasibility of Chitosan-based Porous Conduits as Scaffolds for Nerve Tissue Engineering. Tsinghua Science and Technology. 2006, 11(4):415-20.  http://dx.doi.org/10.1016/S1007-0214(06)70210-3
  70. Aijun Wang, Qiang Ao, Wenling Cao, Mingzhi Yu, Qing He, Lijun Kong, Ling Zhang, Yandao Gong, Xiufang Zhang. Porous Chitosan Tubular Scaffolds with Knitted Outer Wall and Controllable Inner Structure for Nerve Tissue Engineering. Journal of Biomedical Materials Research Part A. 2006, 79A(1): 36-46. PMID: 16758450. DOI: 10.1002/jbm.a.30683
  71. Aijun Wang, Wenling Cao, Qiang Ao, Kai Gong, Lijun Kong, Yaodao Gong, Xiufang Zhang. Controlling Morphology and Porosity of 3-D Chitosan Scaffolds Produced by Thermally Induced Phase Separation Technique. Asian Chitin Journal. 2006, 2: 69-78.
  72. Aijun Wang, Wenling Cao, Kai Gong, Qiang Ao, Lijun Kong, Chengzhao He, Yaodao Gong, Xiufang Zhang. Development of Porous Chitosan Tubular Scaffolds for Tissue Engineering Applications. Asian Chitin Journal. 2006, 2: 53-60.
  73. Qiang Ao, Aijun Wang, Wenling Cao, Ling Zhang, Lijun Kong, Qing He, Yandao Gong, Xiufang Zhang. Manufacture of Multi-microtubule Chitosan Nerve Conduits with Novel Molds and Characterization in vitro. Journal of Biomedical Materials Research Part A. 2006, 77A(1): 11-8. PMID: 16345091. DOI: 10.1002/jbm.a.30593
  74. Ling Zhang, Qiang Ao, Aijun Wang, Guangyuan Lu, Lijun Kong, Yandao Gong, Nanming Zhao, Xiufang Zhang. A Sandwich Tubular Scaffold Derived from Chitosan for Blood Vessel Tissue Engineering. Journal of Biomedical Materials Research Part A. 2006, 77A(2): 277-84. PMID: 16400655. DOI: 10.1002/jbm.a.30614
  75. Hongxu Qi, Ping Hu, Jun Xu, Aijun Wang. Encapsulation of Drug Reservoirs in Fibers by Emulsion Electrospinning: Morphology Characterization and Preliminary Release Assessment. Biomacromolecules. 2006, 7(8): 2327-30. PMID: 16903678. DOI: 10.1021/bm060264z
  76. Aijun Wang, Qiang Ao, Kai Gong, Zhenhuan Zheng, Guangyuan Lu, Gan Wang, Qing He, Lijun Kong, Yandao Gong, Nanming Zhao, Xiufang Zhang. Chitosan-based Semi-permeable Nerve Conduits Support Peripheral Nerve Regeneration in Goats and Nonhuman Primates. Molecular and Cellular Biomechanics. 2006, 3 (4): 143-4.
  77. Qiang Ao, Xiuhua Sun, Aijun Wang, Panfeng Fu, Kai Gong, Yandao Gong, Xiufang Zhang. Protective Effects of Extract of Ginkgo Biloba (EGb 761) on Nerve Cells after Spinal Cord Injury in Rats. Spinal Cord. 2006, 44(11): 662-7. PMID: 16415923. DOI: 10.1038/sj.sc.3101900
  78. Qiang Ao, Aijun Wang, Wenling Cao, Chang Zhao, Yandao Gong, Nanming Zhao, Xiufang Zhang. Fabrication and Characterization of Chitosan Nerve Conduits with Microtubular Architecture. Tsinghua Science and Technology. 2005, 10(4):435-8. DOI: 10.1016/S1007-0214(05)70096-1
  79. Wenling Cao, Aijun Wang, Duohui Jing, Yandao Gong, Nanming Zhao, and Xiufang Zhang. Novel Biodegradable Films and Scaffolds of Chitosan Blended with Poly(3-hydroxybutyrate). Journal of Biomaterials Science, Polymer Edition. 2005, 16(11):1379-94. PMID: 16370239. DOI: 10.1163/156856205774472308
  80. Aijun Wang, Qiang Ao, Wenling Cao, Chang Zhao, Yandao Gong, Nanming Zhao, Xiufang Zhang. Fiber-based Chitosan Tubular Scaffolds for Soft Tissue Engineering: Fabrication and in vitroEvaluation. Tsinghua Science and Technology. 2005, 10(4):449-53. DOI: 10.1016/S1007-0214(05)70099-7http://dx.doi.org/10.1016/S1007-0214(05)70099-7
  81. Qiang. Ao, Aijun Wang, Wengling Cao, Chang Zhao, Yandao Gong, Nanming Zhao, Xiufang Zhang. Preparation of Porous Multi-channeled Chitosan Conduits for Nerve Tissue Engineering. Key Engineering Materials. 2005, (288-289): 27-30. DOI: 10.4028/www.scientific.net/KEM.288-289.27http://www.scientific.net/KEM.288-289.27.pdf

 

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