Alan Conley

Alan Conley

Position Title
Professor

Unit
Department of Population Health and Reproduction, School of Veterinary Medicine

3223 VM3B
Bio

Profile Introduction

Biochemical and molecular control of gonadal and adrenal steroidogenesis and its role in the reproductive development and physiology of vertebrates, and the development of endocrine tests for the diagnosis of reproductive disease and fertility

Research Interests

Reproductive Endocrinology

Biochemical and molecular control of gonadal, adrenal and placental steroidogenesis, the role of steroids in reproductive development and the endocrine physiology of male and female reproduction

Grad Group Affiliations

  • Animal Biology
  • Molecular, Cellular and Integrative Physiology

Specialties / Focus

  • Domestic Animal Physiology
  • Endocrinology

Courses

  • MCP 220 General and Comparative Physiology of Reproduction, FALL
  • VET VET410 Veterinary Endocrinology/Reproduction, FALL
  • VMD 446 Veterinary Reproduction, WINTER

Labs

  • Conley Research
    • Jo Corbin (laboratory manager)
  • Clinical Endocrinology Laboratory
    • Rebecca Cotterman
    • Casey Hoffman
    • Erin Legacki

Honors and Awards

  • Chancellor's Fellow 2002-2007
  • Pfizer Award for Research Excellence, School of Veterinary Medicine, University of California-Davis, 2006
  • Favorite Teacher Award 2007, School of Veterinary Medicine (Class of 2009)

    Professional Societies

    • Endocrine Society
    • Society for the Study of Reproduction
    • Royal College of Veterinary Surgeons

    Degrees

    • 1977 BVSc Veterinary Medicine and Surgery University of Melbourne
    • 1986 MS Iowa State University
    • 1988 PhD Iowa State University
    • 2013 Diploma of Fellowship Comparative reproductive physiology Royal College of Veterinary Surgeons

    Publications

    Conley, A. J., E. L. Scholtz, G. A. Dujovne, R. F. Cotterman, E. L. Legacki, R. C. Uliani, M. A. Alvarenga, B. Kalra, G. V. Savjani and A. Kumar.  2018.  Inhibin-A and inhibin-B in cyclic and pregnant mares, and mares with granulosa-theca cell tumors: physiological and diagnostic implications. Theriogenology. (in press)

    Legacki, E. L., C. J. Corbin, B. A. Ball, S. D. Stanley and A. J. Conley 2018.  Steroidogenic enzyme activities in the pre- and parturient equine placenta. (in press)

    Legacki, E. L., B. A. Ball, C. J. Corbin, S. Loux, K. E. Scoggin, S. D. Stanley and A. J. Conley. 2017. Equine fetal adrenal, gonadal and placental steroidogenesis. Reproduction 154(4):445-454.

    Legacki, E. L., C. J. Corbin, B. A. Ball, M. Wynn, S. Loux, S. D. Stanley and A. J. Conley. 2016. Endocrine preparation for equine parturition. Reproduction 152:323-31.

    Legacki, E. L., E. L. Scholtz, B. A. Ball, S. D. Stanley, T. Berger and A. J. Conley.  2016.  The dynamic steroid landscape of equine pregnancy mapped by mass spectrometry. Reproduction 151:421-30.

    Scholtz. E. L., S. Krishnan, B. A. Ball, C. J. Corbin, B. C. Moeller, S. D. Stanley, K. J. McDowell, A. L. Hughes, D. P. McDonnell and A. J. Conley.  2014.  Pregnancy without progesterone in horses defines a second endogenous biopotent progesterone receptor agonist, 5α-dihydroprogesterone. Proc. Natl. Acad. Sci. 111:3365-3370

    Ball, B. A., A. J. Conley, J. Almeida, A. Esteller-Vico, J. Crabtree, C. Munro and I. K. M. Liu.  2014.  A retrospective analysis of 2,253 cases submitted for endocrine diagnosis of possible granulosa cell tumors in mares. J. Equine Vet. Sci. 34:307-313

    Claes, A., B. A. Ball, J. Almeida, C. J. Corbin and A. J. Conley.  2013.  Serum anti-Müllerian hormone concentrations in stallions: Developmental changes, seasonal variation, and differences between intact stallions, cryptorchid stallions and geldings. Theriogenology 79:1229-35

    Conley, A. J., F. Z. Stanczyk, J. H. Morrison, P. Borowicz, K. Benirschke, N. A. Gee and B. L. Lasley.  2013.  Modulation of higher primate adrenal androgen secretion with estradiol or estradiol and progesterone intervention. Menopause 20:322-328

    Brömel, C., R. W. Nelson, E. C. Feldman, C. J. Munro, P. H. Kass, A. E. Vico, P. Labelle and A. J. Conley.  2013.  Serum inhibin concentration in dogs with adrenal gland disease and in healthy dogs. J. Vet. Int. Med. 27:76–82

    Conley, A. J., C. J. Corbin, J. L. Thomas, N. Gee, B. L. Lasley, B. C. Moeller, S. D. Stanley and T. Berger.  2012.  Costs and consequences of cellular compartmentalization and substrate competition among human enzymes involved in androgen and estrogen synthesis. Biol. Reprod. 86:1-8

    Conley, A. J., T. Plant, D. Abbott, B. Moeller and S. Stanley.  2011.  Endocrine evidence for adrenarche in the rhesus macaque. Am. J. Physiol. Endocrinol. Metab. 301:E1229-1235

    Nguyen, A. D., C. J. Corbin, J. C. Pattison, I. M. Bird and A. J. Conley. 2009. The developmental increase in adrenocortical 17,20-lyase activity (biochemical adrenarche) is driven primarily by increasing cytochrome b5 in neonatal rhesus macaques. Endocrinology 150:1748-56

    Corbin, C. J., T. Berger, J. J. Ford, C. E. Roselli, W. Sienkiewicz, B. Trainor, J. F. Roser, J. D. Vidal, N. Harada and A. J. Conley. 2009. Porcine brain aromatase cytochrome P450: isoform characterization, sexually dimorphic and regional expression, and regulation by enzyme inhibition in neonatal boars. Biology of Reproduction 81 388-395

    Praporski, S., S. M. Ng, A. D. Nguyen, C. J. Corbin, A. Mechler, J. Zheng, A. J. Conley and L. L. Martin. 2009. Organization of enzymes involved in sex steroid synthesis: Protein-protein interactions in lipid membranes. Journal of Biological Chemistry 284: 33224-33232

    Nguyen, A. D., S. M. Mapes, C. J. Corbin and A. J. Conley. 2008. Morphological adrenarche in rhesus macaques: Zona reticularis development is concurrent with foetal zone regression in the early neonatal period. Journal of Endocrinology 199:367-78

    Conley, A. J., C. J. Corbin and A. L. Hughes. 2008. Adaptive evolution of mammalian aromatases: Lessons from Suiformes. Journal of Experimental Zoology 309A:1-12

    Corbin, C.J., A. L. Hughes, J. R. Heffelfinger, T. Berger, T. B. Waltzek, J. F. Roser, T. C. Santos, M. A. Miglino, M. F. Oliveira, F. C. Braga, F. V. Meirelles and A. J. Conley. 2007. Evolution of suiform aromatases: ancestral duplication with conservation of tissue-specific expression in the collared peccary (Pecari tayassu). Journal of Molecular Evolution 65:403-12

    Schuler, G., G. R. Oezalp, B. Hoffmann, N. Harada, P. Browne and A. J. Conley. 2006. Reciprocal expression of 17alpha-hydroxylase/C17,20-lyase (P450c17) and aromatase (P450arom) cytochromes P450 during bovine trophoblast differentiation: A two-cell system drives placental estrogen synthesis. Reproduction 131:669-679

    Browne, P., N. J. Place, J. D. Vidal, I. Moore, G. R. Cunha, S. E. Glickman and A. J. Conley. 2006. Endocrine differentiation of fetal ovaries and testes of the spotted hyena (Crocuta crocuta): Timing of androgen-independent versus androgen-driven genital development. Reproduction 132:649-659

    Glickman, S. E., G. R. Cunha, C. M. Drea, A. J. Conley and N. J. Place. 2006. Mammalian sexual differentiation: lessons from the spotted hyena. Trends in Endocrinology and Metabolism 17:349-356

    Johnson, D. L., A. J. Conley and L. L. Martin. 2006. Direct electrochemistry of human, bovine and porcine cytochrome P450c17. Journal of Molecular Endocrinology 36:349-359

    Vidal, J. D., C.A. VandeVoort, C. B. Marcus, N.R. Lazarewicz and A.J. Conley. 2005. 2,3,7,8-tetrachlorodibenzo-p-dioxin induces CYP1B1 expression in human luteinized granulosa cells. Archives of Biochemistry and Biophysics 439:53-60

    Conley, A. J., J. C. Pattison and I. M. Bird. 2004. Variations in adrenal androgen production in (non-human) primates. Seminars in Reproductive Medicine 22:311-326

    Corbin, C. J., S. M. Mapes, J. Marcos, C. H. Shackleton, D. Morrow, S. Safe, T. Wise, J. J. Ford and A. J. Conley. 2004. Porcine paralogues of aromatase cytochome P450: A novel hydroxylase activity is associated with the survival of a duplicated gene. Endocrinology 145:2157-2164

    Mapes, S., A. F. Tarantal, C. R. Parker, F. M. Moran, J. M. Bahr, L. Pyter and A. J. Conley. 2002. Adrenocortical cytochrome b5 expression during fetal development of the rhesus macaque. Endocrinology 143:1451-1458

    Conley, A. J., S. M. Mapes, C. J. Corbin, D. Greger and S. Graham. 2002. Structural determinants of aromatase cytochrome P450 inhibition in substrate recognition site (SRS)-1. Molecular Endocrinology 16:1456-1468

    Conley, A. J. and M. M. Hinshelwood. 2001. Mammalian aromatases. Reproduction. 121:685-695

    Corbin CJ, Trant JM, Walters KW, Conley AJ. 1999. Changes in testosterone metabolism associated with the evolution of placental and gonadal isozymes of porcine aromatase cytochrome P450. Endocrinology. 140:5202-5210

    Mapes S, Corbin CJ, Tarantal A, Conley A. 1999. The primate adrenal zona reticularis is defined by expression of cytochrome b5, P450c17 and reductase but not 3beta-HSD. J Clin Endocrinol Metab 84:3382-3386

    Conley AJ, Elf P, Corbin CJ, Dubowsky S, Fivizzani A, Lang JW. 1997. Yolk steroids decline during sexual differentiation in the alligator. General and Comparative Endocrinology. 107:191-200

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