Department of Pediatrics, School of Medicine
Department of Cell Biology and Human Anatomy, School of Medicine
California National Primate Research Center
Clinical and Translational Science Center
Institute for Regenerative Cures
Primate Center for Gene Therapy
Research focus on congenital and acquired disorders, novel diagnostics and therapies, and preclinical models
Regenerative Medicine, Gene Therapy, Somatic Cell Genome Editing, Stem/Progenitor Cells and Transplantation, Organoids and Tissue Engineering, Fetal:Maternal Microchimerism, In vivo Imaging for Translational Research (ultrasound, optical imaging, PET/CT)
Grad Group Affiliations
- Biochemistry, Molecular, Cellular and Developmental Biology
- Biomedical Engineering
- Integrative Genetics and Genomics
Specialties / Focus
- Cell and Developmental Biology
- Gene Transfer and Genome Editing
- Molecular Medicine
- Reproductive and Developmental Biology
- Stem Cell Biology and Transplantation
- Tissue Engineering
- Translational and Preclinical Models
- In vivo Imaging
- CHA 400 Developmental anatomy lectures in Human Anatomy, Fall
Honors and Awards
- 2004/05 Faculty award, School of Medicine
- American Institute of Ultrasound in Medicine
- American Society of Gene and Cell Therapy
- American Society of Hematology
- American Society of Primatology
- Society for Molecular Imaging
- International Society for Stem Cell Research
- PhD Human Anatomy with a reproductive/developmental emphasis, University of California
Tarantal AF, McDonald RJ, Jimenez DF, Lee CCI, OShea CE, Leapley AC, Won RH, Plopper CG, Lutzko C, and Kohn DB. Intrapulmonary and intramyocardial gene transfer in rhesus monkeys (Macaca mulatta): Safety and efficiency of HIV-1-derived lentiviral vectors for fetal gene delivery. Molecular Therapy 12:87-98, 2005.
Jimenez DF, Leapley AC, Lee CI, Ultsch M-N, and Tarantal AF. Fetal CD34+ cells in the maternal circulation and long-term microchimerism in rhesus macaques (Macaca mulatta). Transplantation 79:142-146, 2005.
Lee CI, Fletcher M, and Tarantal AF. Effects of age on the frequency, cell cycle, and lineage maturation of rhesus monkey (Macaca mulatta) CD34+ and hematopoietic progenitor cells. Pediatric Research 28:315-322, 2005.
Tarantal AF, Lee CC, Jimenez DF, and Cherry SR. Fetal gene transfer using lentiviral vectors: in vivo detection of gene expression by microPET and optical imaging in fetal and infant monkeys. Human Gene Therapy 17:1254-1261, 2006.
Huang J, Lee CCI, Sutcliffe JL, Cherry SR, and Tarantal AF. Radiolabeling rhesus monkey CD34+ hematopoietic and mesenchymal stem cells with 64Cu-PTSM for microPET. Molecular Imaging 7:1-11, 2008.
Tarantal AF, Lee CCI, and Itkin-Ansari P. Real-time bioluminescence imaging of macroencapsulated fibroblasts reveal allograft protection in rhesus monkeys (Macaca mulatta). Transplantation 88:38-41, 2009.
Batchelder CA, Lee CC, Matsell DG, Yoder MC, and Tarantal AF. Renal ontogeny in the rhesus monkey (Macaca mulatta) and directed differentiation of human embryonic stem cells towards kidney precursors. Differentiation 78:45-56, 2009.
Nakayama KH, Batchelder CA, Lee CI, and Tarantal AF. Decellularized rhesus monkey kidney as a three-dimensional scaffold for renal tissue engineering. Tissue Engineering Part A 16:2207-2216, 2010.
Batchelder CA, Lee CCI, Martinez ML, and Tarantal AF. Ontogeny of the kidney and renal development in the rhesus monkey (Macaca mulatta). Anatomical Record 293:1971-1983, 2010.
Tarantal AF and Lee CCI. Long-term luciferase expression monitored by bioluminescence imaging after adeno-associated virus-mediated fetal gene delivery in rhesus monkeys (Macaca mulatta). Human Gene Therapy 21:143-148, 2010.
Nakayama KH, Batchelder CA, Lee CI, and Tarantal AF. Renal tissue engineering with decellularized rhesus monkey kidneys: Age-related differences. Tissue Engineering Part A 17:2891-2901, 2011.
Tarantal AF, Lee CCI, Batchelder CA, Christensen JE, Martinez ML, Prater D, and Cherry SR. Radiolabeling and in vivo imaging of transplanted renal lineages differentiated from human embryonic stem cells in fetal monkeys. Molecular Imaging and Biology 14:197-204, 2012.
Tarantal AF and Skarlatos SI. Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases: an NHLBI resource for the gene therapy community. Human Gene Therapy 23:1130-1135, 2012.
Shelley WC, Huang L, Critser PJ, Leapley AC, Mead LE, Zeng P, Prater D, Ingram DA, Tarantal AF*, and Yoder MC*. Changes in the frequency and in vivo vessel-forming ability of rhesus monkey circulating endothelial colony-forming cells across the lifespan (birth to aged). Pediatric Research 71:156-161, 2012. *Co-senior authors
Tarantal AF, Lee CC, Kukis DL, and Cherry SR. Radiolabeling human peripheral blood stem cells for positron emission tomography (PET) imaging in young rhesus monkeys. PLoS One 8:e77148, 2013.
Batchelder CA, Keyser JL, Lee CC, and Tarantal AF. Characterization of growth, glomerular number, and tubular proteins in the developing rhesus monkey kidney. Anatomical Record (Hoboken) 296:1747-1757, 2013.
Batchelder CA, Duru N, Lee CCI, Baker CAR, Swainson L, McCune JM, and Tarantal AF. Myeloid-lymphoid ontogeny in the rhesus monkey (Macaca mulatta). Anatomical Record (Hoboken) 297:1392-1406, 2014.
Carbonaro Sarracino DA, Tarantal AF, Lee CCI, Martinez M, Jin X, Hardee C, Geiger S, and Kohn DB. Effects of vector backbone and pseudotype on lentiviral vector-mediated gene transfer: Studies in infant ADA-deficient mice and rhesus monkeys. Molecular Therapy 22:1803-1816, 2014.
Batchelder CA, Martinez ML, and Tarantal AF. Natural scaffolds for renal differentiation of human embryonic stem cells for kidney tissue engineering. PLoS One 10:e0143849, 2015.
Corti M, Cleaver B Clément N, Conlon TJ, Faris KJ, Wang G, Benson J, Tarantal AF, Fuller D, Herzog RW, and Byrne BJ. Evaluation of re-administration of a recombinant adeno-associated vector expressing acid alpha-glucosidase (rAAV9-DES-hGAA) in Pompe disease: Preclinical to clinical planning. Human Gene Therapy – Clinical Development 26:185-193, 2015.
Conlon TJ, Mah CS, Pacak CA, Rucker Henninger MB, Eerger KE, Jorgensen ML, Lee CCI, Tarantal AF*, and Byrne BJ*. Transfer of therapeutic genes into fetal rhesus monkeys using recombinant adeno-associated type 1 viral vectors. Human Gene Therapy – Clinical Development 27:152-159, 2016. *Co-senior authors
Tarantal AF, Lee CCI, Martinez ML, Asokan A, and Samulski RJ. Systemic and persistent muscle gene expression in rhesus monkeys with a liver de-targeted adeno-associated virus vector. Human Gene Therapy 28:385-391, 2017.
Berg E, Zhang X, Bec J, Judenhofer MS, Patel B, Peng Q, Kapusta M, Schmand M, Casey ME, Tarantal AF, Qi J, Badawi RD, and Cherry SR. Development and Evaluation of mini-EXPLORER: A Long Axial Field-of-View PET Scanner for Nonhuman Primate Imaging. J Nucl Med 59:993-998, 2018.
Barger N, Keiter J, Kreutz A, Krishnamurthy A, Weidenthaler C, Martínez-Cerdeño V, Tarantal AF, and Noctor SC. Microglia: An intrinsic component of the proliferative zones in the fetal rhesus monkey (Macaca mulatta) cerebral cortex. Cerebral Cortex 29:2782-2796, 2019.
Hordeaux J, Hinderer C, Buza EL, Louboutin JP, Jahan T, Bell P, Chichester JA, Tarantal AF, and Wilson JM. Safe and Sustained Expression of Human Iduronidase After Intrathecal Administration of Adeno-Associated Virus Serotype 9 in Infant Rhesus Monkeys. Hum Gene Ther 30:957-966, 2019.
Berg E, Gill H, Marik J, Ogasawara A, Williams SP, van Dongen GAMS, Vugts DJ, Cherry SR, and Tarantal AF. Total-body PET and highly stable chelators together enable meaningful 89Zr-antibody-PET studies up to 30 days post-injection. J Nucl Med. 2019 Sep 27. pii: jnumed.119.230961. doi: 10.2967/jnumed.119.230961. [Epub ahead of print]