Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine
My research is in the field of stem cell biology and translational regenerative medicine. Our group is specifically focused on the use of pluripotent stem cells in naturally occurring diseases in companion animals as platforms to conduct high level translational research to facilitate the development of novel regenerative medicine therapeutics for human and veterinary use. Ongoing projects in the lab include the regulatory networks that govern the naive pluripotent state in canine pluripotent stem cells and cellular replacement treatments for canine diabetes mellitus . Our group is always looking for the brightest and most enthusiastic future scientists that are eager to realize the incredible potential and promise of regenerative medicine.
Stem cell biology, Naive pluripotency, Regenerative Medicine, Naturally occurring disease in companion animals
Grad Group Affiliations
- Comparative Pathology (Vet Med
- Molecular, Cellular and Integrative Physiology
- 2002 Bs.C The Hebrew University of Jerusalem
- 2006 DVM The Hebrew University of Jerusalem
- 2015 Ph.D Integrative pathobiology University of California, Davis
Mazaki-Tovi M, Feuermann Y, Segev G, Klement E, Yas-Natan E, Farkas A, Kol A, Shamay A. (2010) Increased serum leptin and insulin concentrations in canine hypothyroidism. Veterinary journal (London, England : 1997) 183(1):109-14.
Kol A, Borjesson DL. (2010) Application of thrombelastography/thromboelastometry to veterinary medicine. Veterinary clinical pathology 39(4):405-16.
Kol A. (2012) The interpretation of thromboelastography tracings: many (more) rivers to cross. Veterinary journal (London, England : 1997) 191(3):275-6.
Kol A, Walker NJ, Galuppo LD, Clark KC, Buerchler S, Bernanke A, Borjesson DL. (2013) Autologous point-of-care cellular therapies variably induce equine mesenchymal stem cell migration, proliferation and cytokine expression. Equine veterinary journal 45(2):193-8.
Kol A, Christopher MM, Skorupski KA, Tokarz D, Vernau W. (2013) B-cell lymphoma with plasmacytoid differentiation, atypical cytoplasmic inclusions, and secondary leukemia in a dog. Veterinary clinical pathology 42(1):40-6.
Kol A, Marks SL, Skorupski KA, Kass PH, Guerrero T, Gosselin RC, Borjesson DL. (2015) Serial haemostatic monitoring of dogs with multicentric lymphoma. Veterinary and comparative oncology 13(3):255-66.
Kol A, Nelson RW, Gosselin RC, Borjesson DL. (2013) Characterization of thrombelastography over time in dogs with hyperadrenocorticism. Veterinary journal (London, England : 1997) 197(3):675-81.
Kol A, Foutouhi S, Walker NJ, Kong NT, Weimer BC, Borjesson DL. (2014) Gastrointestinal microbes interact with canine adipose-derived mesenchymal stem cells in vitro and enhance immunomodulatory functions. Stem cells and development 23(16):1831-43.
Arzi B, Kol A, Murphy B, Walker NJ, Wood JA, Clark K, Verstraete FJ, Borjesson DL. (2015) Feline foamy virus adversely affects feline mesenchymal stem cell culture and expansion: implications for animal model development. Stem cells and development 24(7):814-23.
Mazaki-Tovi M, Abood SK, Kol A, Farkas A, Schenck PA. (2015) Increased serum concentrations of adiponectin in canine hypothyroidism. Veterinary journal (London, England : 1997) 203(2):253-5.
Kol A, Wood JA, Carrade Holt DD, Gillette JA, Bohannon-Worsley LK, Puchalski SM, Walker NJ, Clark KC, Watson JL, Borjesson DL. (2015) Multiple intravenous injections of allogeneic equine mesenchymal stem cells do not induce a systemic inflammatory response but do alter lymphocyte subsets in healthy horses. Stem cell research & therapy 6:73.
Kol A, Arzi B, Athanasiou KA, Farmer DL, Nolta JA, Rebhun RB, Chen X, Griffiths LG, Verstraete FJ, Murphy CJ, Borjesson DL. (2015) Companion animals: Translational scientist's new best friends. Science translational medicine 7(308):308ps21.
Arzi B, Mills-Ko E, Verstraete FJ, Kol A, Walker NJ, Badgley MR, Fazel N, Murphy WJ, Vapniarsky N, Borjesson DL. (2016) Therapeutic Efficacy of Fresh, Autologous Mesenchymal Stem Cells for Severe Refractory Gingivostomatitis in Cats. Stem cells translational medicine 5(1):75-86.
Clark KC, Kol A, Shahbenderian S, Granick JL, Walker NJ, Borjesson DL. (2016) Canine and Equine Mesenchymal Stem Cells Grown in Serum Free Media Have Altered Immunophenotype. Stem cell reviews 12(2):245-56.
Kol A, Walker NJ, Nordstrom M, Borjesson DL. (2016) Th17 Pathway As a Target for Multipotent Stromal Cell Therapy in Dogs: Implications for Translational Research. PloS one 11(2):e0148568.
Monjazeb AM, Kent MS, Grossenbacher SK, Mall C, Zamora AE, Mirsoian A, Chen M, Kol A, Shiao SL, Reddy A, Perks JR, T N Culp W, Sparger EE, Canter RJ, Sckisel GD, Murphy WJ. (2016) Blocking Indolamine-2,3-Dioxygenase Rebound Immune Suppression Boosts Antitumor Effects of Radio-Immunotherapy in Murine Models and Spontaneous Canine Malignancies. Clinical cancer research : an official journal of the American Association for Cancer Research 22(17):4328-40.
Safra N, Hitchens PL, Maverakis E, Mitra A, Korff C, Johnson E, Kol A, Bannasch MJ, Pedersen NC, Bannasch DL. (2016) Serum levels of innate immunity cytokines are elevated in dogs with metaphyseal osteopathy (hypertrophic osteodytrophy) during active disease and remission. Veterinary immunology and immunopathology 179:32-5.
Owens SD, Kol A, Walker NJ, Borjesson DL. (2016) Allogeneic Mesenchymal Stem Cell Treatment Induces Specific Alloantibodies in Horses. Stem cells international 2016:5830103.
Anderson JG, Peralta S, Kol A, Kass PH, Murphy B. (2017) Clinical and Histopathologic Characterization of Canine Chronic Ulcerative Stomatitis. Veterinary pathology 54(3):511-519.
Clark KC, Fierro FA, Ko EM, Walker NJ, Arzi B, Tepper CG, Dahlenburg H, Cicchetto A, Kol A, Marsh L, Murphy WJ, Fazel N, Borjesson DL. (2017) Human and feline adipose-derived mesenchymal stem cells have comparable phenotype, immunomodulatory functions, and transcriptome. Stem cell research & therapy 8(1):69.