Amparo Villablanca

Amparo Villablanca

Position Title

Department of Internal Medicine (Cardiology), School of Medicine

TB 172

Profile Introduction

Vascular biology, hormonal regulation of gene expression in tissues and cells, atherosclerosis, mouse biology, women's health.

Research Interests

Vascular biology, hormonal regulation of gene expression in tissues and cells, atherosclerosis, mouse biology, women's health.

Grad Group Affiliations

  • Molecular, Cellular and Integrative Physiology

Specialties / Focus

  • Cardiorespiratory Physiology
  • Cellular Physiology
  • Molecular Physiology

Field Sites

  • Surge III

Honors and Awards

  • 1999 Distinguished Alumna of the Year Award, UC Davis School of Medicine
  • 2000 Woman of Achievement in Medicine Award, Capitol Business and Professional Women Association, Sacramento, CA
  • 2003- Fellow, American Heart Association (FAHA) Council on Atherosclerosis, Thrombosis and Vascular Biology
  • 2007 Recipient, Heart of Gold Award, American Heart Association

    Professional Societies

    • American Heart Association, Council on Atherosclerosis, Thrombosis and Vascular Biology


    • 1979 BS Psychobiology University of California, Los Angeles
    • 1983 MD University of California, Davis
    • 1986 Internal Medicine - Residency University of California, Davis
    • 1990 Cardiovascular Medicine - Fellowship University of California,Davis


    Corbacho, AM, Eiserich, JP, Zuniga, LA, Valacchi, G, Cross, CE, and Villablanca, AC. Compromised Aortic Vasoreactivity in Male Estrogen Receptor-Alpha Deficient Mice During Acute Lipopolyssacharide-Induced Inflammation. (2006, in press, Endocrinology).

    Benton, J., Powers, A., Eiselein, L., Fitch, R., Wilson, D., Villablanca, A.C., and Rutledge, J. Hyperglycemia and loss of ovarian hormones mediate atheroma formation through endothelial layer disruption and increased permeability (2006, in press, American J. Physiology: Regulatory, Integrative and Comparative Physiology, special issue on gender and cardiovascular disease).

    Wang-Polagruto, J.,Villablanca, A.C., Polagruto, J, Lee, L.., Holt, RA., Schrader, H., Ensunsa, J., Steinberg, FM., Schmitz, H., and Keen, CL. Chronic Consumption of Flavanol-rich Cocoa Improves Endothelial Function and Decreases Vascular Cell Adhesion Molecule (VCAM-1) in Hypercholesterolemic Postmenopausal Women (J. Cardiovascular Pharmacology, 47[Suppl 2]:S177-S186, 2006.

    Villablanca, A.C., Lubhan, D, Shelby, L., Lloyd, K, and Barthold, S. Susceptibility to early atherosclerosis in male mice is mediated by estrogen receptor a (ERa). Atherosclerosis, Thrombosis and Vascular Biology, 24:1055-1061, 2004 (with journal editorial). Erratum in: Arterioscler Thromb Vasc Biol. 2004, 24(6):1055-1061.

    Steinberg, F.M., Guthrie, N.G., Villablanca, A.C., Kumar, K., and Murray, M.J. In healthy post-menopausal women soy isoflavones have favorable effects on endothelial function, which are independent of lipid and antioxidant effects. Amer. J. Clinical Nutrition, 78:123-130, 2003.

    Villablanca, A.C., K.A. Lewis and J.C. Rutledge. Differential regulation of gene expression by ovariectomy in mouse aorta. Physiological Genomics 12:175-185, 2003.

    Villablanca AC, Lewis KA and JC Rutledge. 2002. Time- and dose-dependent differential upregulation of three genes by 17 beta-estradiol in endothelial cells. J Appl Physiol. 92(3):1064-1073

    Villablanca AC. 1998. Nicotine stimulates DNA synthesis and proliferation in vascular endothelial cells in vitro. J Appl Physiol. 84(6):2089-2098

    Villablanca AC and MR Hanley. 1997. 17 beta-estradiol stimulates substance P receptor gene expression. Mol Cell Endocrinol. 135(2):109-117