Department of Radiation Oncology, School of Medicine
Impact of nuclear structure on the generation of pathogenic rearrangements
My research interests are centered on mechanisms driving DNA aberration formation. These may lead to both neoplastic changes such as leukemia’s and solid tumors as well as lethal changes that kill the cell. Radiation is used in the treament of most solid tumors and the organization and orientation of the whole genome will impact how lethal lesiuons are generated. Such alterations are being studied using both conventional molecular biology tools as well as array technology and massively parallel sequencing.
Grad Group Affiliations
- Biochemistry, Molecular, Cellular and Developmental Biology
Specialties / Focus
- Cancer Biology
- Chromosome Dynamics and Nuclear Function
- Structural Biology
- 1974 BS Biochemistry Portsmouth Poytechnic, UK
- 1975 MS Radiobiology Birmingham University, UK
- 1979 PhD Applied Nuclear Physics Birmingham University, UK
Wright RL, Slemmons KK, Vaughan AT. Estradiol induces gene proximity and MLL-MLLT3 fusion in an AICDA-mediated pathway Leuk Lymphoma. 2015 2015; 56(5):1460-5. PMID 25130479
Wright RL, Vaughan AT. A systematic description of MLL fusion gene formation. Crit Rev Oncol Hematol. 2014 Sep;91(3):283-291 PMID:25130479.
Hess CB, Rash DL, Daly ME, Farwell DG, Bishop J, Vaughan AT, Wilson MD, Chen AM. Competing Causes of Death and Medical Comorbidities Among Patients With Human Papillomavirus-Positive vs Human Papillomavirus-Negative Oropharyngeal Carcinoma and Impact on Adherence to Radiotherapy. JAMA Otolaryngol Head Neck Surg. 2014 Apr 1;140(4):312-6. PMID: 24526276.
Candas D, Fan M, Nantajit D, Vaughan AT, Murley JS, Woloschak GE, Grdina DJ, Li JJ. CyclinB1/Cdk1 phosphorylates mitochondrial antioxidant MnSOD in cell adaptive response to radiation stress. J Mol Cell Biol. 2013 Jun;5(3):166-75 PMC3656610.
Chen AM, Zahra T, Daly ME, Farwell DG, Luu Q, Gandour-Edwards R, Vaughan AT. Definitive radiation therapy without chemotherapy for human papillomavirus-positive head and neck cancer. Head Neck. 2013 Nov;35(11):1652-6 PMID: 23335285.
Chen AM, Li J, Beckett LA, Zhara T, Farwell G, Lau DH, Gandour-Edwards R, Vaughan AT, Purdy JA. Differential response rates to irradiation among patients with human papillomavirus positive and negative oropharyngeal cancer Laryngoscope. 2013 Jan;123(1):152-7. PMID 23008061.
Do TU, Ho B, Shih SJ, Vaughan A. Zinc Finger Nuclease induced DNA double stranded breaks and rearrangements in MLL. Mutat Res. 2012 Dec;740(1-2):34-42. PMC3578303.
Shih S-J, Fass J Buffalo VS, Lin D, Singh S, Diaz MO and Vaughan AT. Multiple clonal MLL fusions in a patient receiving CHOP based chemotherapy Br. J. Haematol. 2012 Oct;159(1):50-7 PMC3444640
Ho B, Baker PM, Singh S, Shih SJ, Vaughan AT. Localized DNA Cleavage Secondary to Genotoxic Exposure Adjacent to an Alu Inverted Repeat Genes Chromosome Cancer 2012 59(1):50-730 PMC3444640.
Klein EA, Guiou M, Farwell DG, Luu Q, Lau DH, Stuart K, Vaughan A, Vijayakumar S, Chen AM Primary Radiation Therapy for Head-and-Neck Cancer in the Setting of Human Immunodeficiency Virus. Int J Radiat Oncol Biol Phys. 2011 Jan 1;79(1):60-4.. PMID: 20385454.
Chen AM, Chen LM, Vaughan AT, Sreeraman R, Farwell DG, Luu Q, Lau DH, Stuart K, Purdy JA, Vijayakumar S. Tobacco Smoking During Radiation Therapy for Head-and-Neck Cancer Is Associated With Unfavorable Outcome. Int J Radiat Oncol Biol Phys, 2011 79(2): 414-419
Chen AM, Chen LM, Vaughan AT, Farwell DG, Luu Q, Purdy JA, Vijayakumar S. Head and Neck Cancer Among Lifelong Never-Smokers and Ever-Smokers: Matched-Pair Analysis of Outcomes After Radiation Therapy. Am J Clin Oncol, 2011 34(3): 270-275
Mooso, B, Madhav, A, Johnson, S, Roy, M, Moore, ME, Moy, C, Loredo, GA, Mehta, RG, Vaughan, AT, Ghosh, PM. Androgen Receptor regulation of Vitamin D receptor in response of castration-resistant prostate cancer cells to 1α-Hydroxyvitamin D5 - a calcitriol analog. Genes & cancer, 2010 1(9): 927-940
Du N, Baker P, Bien C, Bier-Laning C, Singh S, Shih S-J, Diaz M.O and Vaughan AT 11q21-23 is a site of intrinsic genomic instability triggered by irradiation. Genes Chromosomes & Cancer 2010 Sep;49(9):831-43. PMC2921793.
Singh S Le H, Shih S-J, Ho B and Vaughan ATM. SAHA modification of chromatin architecture affects DNA break formation and repair Int J Radiat Oncol Biol Phys In press 2010.
Le H, Singh S, Shih SJ, Du N, Schnyder S, Loredo GA, Bien C, Michaelis L, Toor A, Diaz MO, Vaughan ATM Rearrangements of the MLL gene are influenced by DNA secondary structure, potentially mediated by topoisomerase II binding. Genes Chromosomes Cancer 2009 Sep;48(9):806-15.
Schnyder S, Du S, Le H, Singh S, Loredo GA and Vaughan ATM Estrogen treatment induces MLL aberrations in human lymphoblastoid cells Leukemia Research 2009 Oct;33(10):1400-4.
Yang C, Toor A, Singh S, Betti C, Vaughan ATM Impaired NHEJ function in Multiple Myeloma Mutat Res. 2009 Jan 15;660(1-2):66-73).
Narayan S, Coleman M, Lehmann J, Vijayakumar S, Vaughan ATM, Loredo G and Purdey J. Prospective Evaluation to Establish a Dose Response for Clinical Oral Mucositis in Patients Undergoing Head and Neck Conformal Radiotherapy Int J Radiat Oncol Biol Phys. 2008 Nov 1;72(3):756-62
Chen AM, Vaughan ATM Narayan S, and Vijayakumar S Palliative Radiation Therapy for Head and Neck Cancer: Is There an Optimal Fractionation Scheme? Head & Neck. 2008 Dec;30(12):1586-91.