Department of Comprehensive Cancer Center
The laboratory has several major areas. We are interested in control of development by lipid chemical mediators. In mammals we work on enzyme regulation of epoxyeicosanoids that control pain, hypertension and inflammation. In particular we are working to move a small molecule drug to the clinic regulating these lipid mediators and treating diabetes and pain. We also are looking at the effect of diet on these systems. We also work on the development of high throughput systems for metabolite profiling by mass spectrometry (metabolomics) and on immunoassays (biosensors) to monitor human exposure to environmental contaminants. We currently are using recombinant alpaca nanobodies in biosensor formats.
See laboratory publications on web site for current areas.
Technically we are a diverse laboratory applying a variety of tools in biological chemistry to questions in regulatory biology. We attempt to relate our fundamental work to human and environmental health. The technologies include enzymology, physiology, medicinal chemistry, analytical chemistry and others.
Grad Group Affiliations
- Biochemistry, Molecular, Cellular and Developmental Biology
- Pharmacology and Toxicology, , Agricultural and Environmental Chemistry
- ETO 214 Mechanisms of Toxic Action, Spring
- Everson Hall Mass Spectrometry Center
Honors and Awards
- Member National Academy of Sciences
- National Academy of Inventors
- Alexander von Humboldt Award in International Agriculture
- Brodie Award in Xenobiotic Metablism
- See resume on web site
- Gold Country Paddlers
- Sierra Club
- see web site
- 1969 BS Entomology (Chemistry) Louisiana State University
- 1973 PhD Entomology (Toxicology) University of California, Berkeley
646. Ai, D., Y. Fu, D. Guo, H. Tanaka, N. Wang, C. Tang, B.D. Hammock, J.Y-J. Shyy and Y. Zhu. 2007. Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. P. Natl. Acad. Sci. USA. 104:9018-9023.
For current publication see laboratory web site. http://www.biopestlab.ucdavis.edu/