Bruce Lyeth

Bruce Lyeth

Position Title

Department of Neurological Surgery, School of Medicine

502A 1515 Newton Court

Grad Group Affiliations

  • Neuroscience
  • Pharmacology Toxicology; Comparative Pathology

Specialties / Focus

  • Cellular and Molecular Neurobiology
  • Development and Plasticity
  • Medical Neuroscience


  • 1515 Newton Court
    • Eric West, Ken Van, Justin Beller, Gene Gurkoff, Wang Yu, Chris Cox, Johnathan Ly, Damoon Rejaei, Zhang Bin

Professional Societies

  • Society for Neuroscience
  • National Neurotrauma Society
  • International Neurotrauma Society


  • 1986 PhD Bio-Psychology Virginia Commonwealth University


Zhong C, Zhao X, Van KC, Bzdega T, Smyth A, Zhou J. Kozikowski AP, Jiang J, OConnor WT, Berman RF, Neale JH, Lyeth BG. NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat. J Neurochemistry 97:1015-1025, 2006.

Zhong C, Zhao X, Sarva, J, Kozikowski A, Neale JH, Lyeth BG. NAAG Peptidase Inhibitor Reduces Acute Neuronal Degeneration and Astrocyte Damage Following Lateral Fluid Percussion TBI in Rats. J Neurotrauma 22(2): 266-276, 2005.

Floyd, CL, Gorin FA, Lyeth BG. Mechanical strain injury to cultured astrocytes increases intracellular sodium and reverses Na+/Ca++ exchange. GLIA 51(1):35-46, 2005.

Hallam TM, Floyd CL, Folkerts MM, Lee LL, Gong Q-Z, Lyeth BG, Muizelaar JP, Berman RF. Comparison of Behavioral Deficits and Acute Neuronal Degeneration in Rat Lateral Fluid Percussion and Weight Drop Brain Injury Models. J Neurotrauma 21(5):521-539, 2004.

Zhao X, Ahram A, Muizelaar JP, Berman RF, Lyeth BG. Early Loss Of Astrocytes After Experimental Traumatic Brain Injury. GLIA 44:140-152, 2003.

Rafiq A, Gong QZ, Lyeth BG, DeLorenzo RJ, Coulter DA. Induction of prolonged electrographic seizures in vitro has a defined threshold and is all or none: implications for diagnosis of status epilepticus. Epilepsia 44:1034-1041, 2003

Hu G., Lyeth BG, Zhao X, Mitchell JB, Watson JC. Robust neuroprotection by the stable nitroxide 3-CP during reperfusion in a rat model of transient focal ischemia. J Neurosurgery 98:393-396, 2003.

Floyd CL, Golden KM, Black RT, Hamm RJ, Lyeth BG. Craniectomy Position Affects Morris Water Maze Performance and Hippocampal Cell Loss Following Parasagittal Fluid Percussion. J Neurotrauma 19(3):303- 316, 2002.

Zwienenberg M, Gong Q-Z, Berman RF, Muizelaar JP, Lyeth BG, The effect of group II and III metabotropic glutamate receptor activation on neuronal injury in a rodent model of traumatic brain injury. Neurosurgery 48(5):1119-1126, 2001.

Jiang Z-W, Gong Q-Z, Di, X, Zhu J, Lyeth BG, Dicyclomine, an m1 muscarinic antagonist, reduces infarct volume in a rat subdural hematoma model. Brain Research 852:37-44, 2000.