Department of Pharmacology, School of Medicine
Central regulation of cardiopulmonary system
Blood pressure and heart rate are regulated by CNS on a moment-to-moment bases. Depending on the interaction between the genetic and environmental factors, the CNS regulatory output can result in either a normal or a pathological outcome. My research focuses on central regulation of cardiovascular function and how this regulation is altered in response to environmental factors such as exercise, stress, exposure to air pollution, hypertension, and obesity. I am particularly interested in how the neurons in the autonomic pathways change their intrinsic and/or synaptic properties as well as the neurotransmitter/neuromodulator and the receptors involved in the altered regulatory output. Studies are carried out in two major brainstem nuclei: the first central site that receives and integrates sensory information (Nucleus Tractus Solitarii) and the final output for cardiac parasympathetic motor nerves (Nucleus Ambiguus).
Grad Group Affiliations
- Molecular, Cellular and Integrative Physiology (MCIP)
- Pharmacology and Toxicology (PTX)
Specialties / Focus
- Cardiorespiratory Physiology
- Cellular Physiology
- Systemic Physiology
- MCP 210B Advanced Physiology - Autonomic and cardiovascular physiology, Winter
- MCP 290 Putting physiology to work: Surgical solution to hypertension, Fall
- MCP / PTX 215 Electrophysiology Techniques and Applications , Spring
- Shiyue (June) Pan
- Junqing Sun
- Amber Morris
- Alanna Gerton
- John Park
- Briseis Yue
- Breanna Velasquez
Honors and Awards
- 2003 American Physiological Society NCAR Young Investigator Award
- 2002-3 Postdoctoral Fellowship Award, AHA Western States Affiliate
- 1996 Excellence for Doctoral dissertation, Kent State University
- 1996 David B. Smith Fellowship. Kent State University
- 1995 Excellence in research. Kent State University
- American Physiological Society
- The Society for Neuroscience
- 1996 PhD Physiology NEOUCOM/Kent State University
Wang, Z., L. Wang, S. Tapa, K. E. Pinkerton, C.-Y. Chen, C.M. Ripplinger. Exposure to secondhand smoke and arrhythmogenic cardiac alternans in a mouse model. Environmental Health Perspectives 126(12): 127001, 2018.
Mizuno, GO, Y. Wang, G. Shi, Y. Wang, J. Sun, S. Papadopoulos, GJ Broussard, EK Unger, W. Deng, J. Weick, A. Bhattacharyya, C.-Y. Chen, G. Yu, LL Looger, L. Tian. Aberrant calcium signaling in astrocytes inhibits neuronal excitability in a human Down syndrome stem cell model. Cell Rep. 24(2):355-365, 2018.
Chen, C.-Y., J. Di Lucente, YC Lin, CC Lien, M.A. Rogawski, I. Maezawa, L.W. Jin. Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome. Neurobiology of Disease 109:25-32, 2018.
Chowdhury, D., M Turner, T. Patriarchi, AC Hergarden, D Anderson, Y Zhang, J Sun, C-Y. Chen, Ames JB, JW Hell. Ca2+/calmodulin binding to PSD-95 mediates homeostatic synaptic scaling down. EMBO J. 37:122-138, 2018.
Pinkerton, K.E., M. J. Kleeman, A. S. Wexler, and C.-Y. Chen. Particle dose related to effects of concentrated ambient particles on cardiac autonomic function and arrhythmia burdens at rest and during stress in mice. In: Advances in inhaled aerosol dosimetry research conference proceedings, 2017.
Chen, C-Y. Patch clamp technique and applications. In: Modern tools of biophysics. Springer Nature, 2017
Patriarchi T, Qian H, Di Biase V, Malik ZA, Chowdhury D, Price JL, Hammes EA, Buonarati OR, Westenbroek RE, Catterall WA, Hofmann F, Xiang YK, Murphy GG, Chen CY, Navedo MF, Hell JW. Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the β2 adrenergic receptor. EMBO J. 35(12):1330-45, 2016
Nystoriak, M. A., M. Nieves-Cintron, P. J. Nygren, S. A. Hinke, C. B. Nichols, C-Y. Chen, J. L. Puglisi, L. Izu, D. M. Bers, M. L. Dell’Acqua, J. Scott, L. F. Santana, and M. F. Navedo. AKAP150 Contributes to Enhanced Vascular Tone by Facilitating Large-Conductance Ca2+-Activated K+ Channel Remodeling in Hyperglycemia and Diabetes Mellitus. 114(4):607-615, 2014.
Chen, C.-Y., L. Matt, J. W. Hell and M. A. Rogawski. Perampanel Inhibition of AMPA Receptor Currents in Cultured Hippocampal Neurons. PLoS One 9(9):e108021, 2014.
Chen, C-Y. and S. Tjen-A-Looi. Treating hypertension: multiple approaches to a common multifactorial disease? Austin J. Vas. Med. 1(2): 1008, 2014.
Horwitz, B. A., S. M. Chau, J. S. Hamilton, C. song, J. Gorgone, M. Saenz, J. M. Horowitz, and C-Y. Chen. Temporal relationships of blood pressure, heart rate, baroreflex function, and body temperature change over a hibernation bout in Syrian hamsters. Am. J. Physiol. Regul. Integr. Comp. Physiol. 305(7):R759-68, 2013.
Sekizawa, S., B. A. Horwitz, J. M. Horowitz, and C-Y. Chen. Protection of signal processing at low temperature in baroreceptive neurons in the nucleus solitarius of Syrian hamsters, a hibernating species. Am. J. Physiol. Regul. Integr. Comp. Physiol. 305(10):R1153-62, 2013
Sekizawa, S., J. M. Horowitz, B. A. Horwitz, and C-Y. Chen. Realignment of signal processing within a sensory brainstem nucleus as brain temperature declines in the Syrian hamster, a hibernating species. Journal of Comparative Physiology A 198:267-282, 2012.
Chen C-Y., A. C. Bonham, C. Dean, F. A. Hopp, C. J. Hillard, and J. L. Seagard. Retrograde release of endocannabinoid inhibits presynaptic GABA release in baroreceptive second-order neurons in NTS Autonom. Neurosci. 158:44-50, 2010.
Chen C-Y. and A.C. Bonham. Postexercise hypotension: central mechanisms. Exercise and Sport Sciences Reviews 38:122-127, 2010.
Howell, L.P., C-Y. Chen, J. Joad, R. Green, E. Callahan, A.C. Bonham. Addressing the Issues and Challenges of Non-Tenure Track Research Faculty at the UCDavis School of Medicine. Acad. Med. 85(6): 1041-1047, 2010.
Zhong, C-Y., Y-M. Zhou, K.R. Smith, I.M. Kennedy, C-Y. Chen, A.E. Aust, K.E. Pinkerton. Oxidative injury in the lungs of neonatal rats following short-term exposure to ultrafine iron and soot particles. J. Toxicol. Environ. Health. 73:837-847, 2010.
Pham, H., A. C. Bonham, K. E. Pinkerton, C-Y. Chen. Central neuroplasticity and decreased heart rate variability following particulate matter exposure in mice. Environmental Health Perspective. 117(9): 1448 – 53., 2009
Chen, C-Y., A.G. Bechtold, J.M. Tabor, and A.C. Bonham. Post-exercise hypotension is associated with neurokinin 1 receptor internalization. J. Neurosciences. 29:2754-2761., 2009
C-Y. Chen, J. P. Joad, J. Bric, and A. C. Bonham. Central mechanisms I: plasticity of central pathways. In: Pharmacology and Therapeutics of Cough. Eds: K. F. Chung and J. Widdicombe. Springer-Verlag Berlin Heidelberg, 2009