Charles L. Bevins

Charles Bevins

Position Title
Professor

GBSF, Room 5617
Bio

Research Interests

Innate Immunity, Host-Microbe Interaction, Antimicrobial Peptides/Defensins

 

Grad Group Affiliations

  • Biochemistry, Molecular, Cellular and Developmental Biology
  • Comparative Pathology
  • Immunology
  • Microbiology

Specialties / Focus

  • Molecular Medicine

Courses

  • IMM 201 Basic Immunology (Team Taught), Fall
  • IMM 293 Current Concepts in Immunology (Team Taught), Winter
  • IMM 297 Mucosal Immunology (Team Taught), Spring, Odd Years
  • MMI 210A & B Topics in Animal Models of Infectious Disease (T32 Students, Team Taught), Winter
  • MMI 480A Medical Immunology (Team Taught)
  • IMM 204 Innate Immunology, Spring, Even Years
  • IMM 201L Graduate Laboratory Rotation (Team Taught), Fall, Winter

Labs

  • Bevins Lab/ GBSF 5617
    • Mark Underwood, MD (collaborator), Anchasa Kananurak (PostDoc), Patricia Castillo (PostDoc), Eric Nonnecke (PostDoc), Douglas Akahoshi (Grad Student); Recent Grads and Visiting Scholars: Brian Leonard (DVM/PhD, 2012, Assist Prof, UCD SOVM), Hiutung Chu (PhD, 2011, Assist Prof, UCSD), Joe Russell (PhD, 2011, Research Manager, Janssen Research and Development, Johnson and Johnson), Pak-Lam Yu PhD (sabbatical, Massey Univ), Mats Andersson PhD (sabbatical, Karolinska Inst), Jan Wehkamp MD (Post Doc 2003-6, Prof Tübingen Univ), Marco Schunter MD (Visiting Fellow), Jakob Trimpert (Visiting Vet Student), Jenny Karlsson (Visiting Grad Student), Bjoern Schroeder (Visiting Grad Student)

Professional Societies

  • American Association for the Advancement of Science
  • American Society for Microbiology
  • American Association of Immunology
  • American Gastroenterological Association
  • Fellow, American College of Gastroenterology
  • American Society for Human Genetics
  • Society for Pediatric Research

Degrees

  • 1976 BA Biological Sciences Universty of Maryland, Baltimore County
  • 1983 MD Medicine University of Maryland
  • 1986 PhD Biochemistry University of Maryland

Publications

Clevers, HC and Bevins, CL: Paneth cells: maestros of the small intestinal crypts. Annu Rev Physiol 75: 289-311, 2013.

Chu, H, Pazgier, M, Jung, G, Nuccio, S-P, Castillo, PA, de Jong, MF, Winter, MG, Winter, SE, Wehkamp, J, Shen, B, Salzman NH, Underwood, MA, Tsolis, RM, Young, GM, Lu, W, Lehrer, RI, Bäumler, AJ, and Bevins, CL: Human α-defensin 6 promotes mucosal innate immunity through assembled peptide nanonets. Science 337:477-481, 2012.

Tollner TL, Bevins CL, Cherr GN: Multifunctional glycoprotein DEFB126-a curious story of defensin-clad spermatozoa. Nat Rev Urol. 9:365-375, 2012.

Tollner, TL, Venners, SA, Hollox, EJ, Yudin, AI, Liu, X, Tang, G, Xing, H, Kays, RJ, Lau, T, Overstreet,, JW, Xu, X, Bevins, CL*, Cherr, GN*: A common mutation in DEFB126 causes impaired sperm function and subfertility. Science Transl Med 3: 92ra65, 2011. (equal contributors)

Bevins, CL and Salzman, NH: The potter’s wheel: The host’s role in sculpting its microbiota. Cell Mol Life Sci 68:3675-3685, 2011.

Bevins, CL and Salzmann NH: Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis Nat. Reviews Microbiol. 9: 356-368, 2011.

Winter, SE, Thiennimitr, P, Winter, MG, Butler, BP, Huseby, DL, Crawford, RW, Russell, JM, Bevins, CL, Adams, LG, Tsolis, RM, Roth, JR, and Bäumler, AJ. Gut inflammation provides a respiratory electron acceptor for Salmonella. Nature 467:426-429, 2010

Biswas, A, Liu, Y-J, Hao, L, Mizoguchi, A, Salzman, NH, Bevins, CL, and Kobayashi, KS Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum. Proc. Natl. Acad. Sci. 107:14739-44, 2010

Bevins, CL and Liu, F-T A sweet target for innate immunity. Nat. Medicine 16: 263-264, 2010.

Salzman, NH, Hung, K, Haribhai, D, Chu, H, Karlsson-Sjöberg, J, Amir, E, Teggatz, P, Barman, M, Hayward, M, Eastwood, D, Stoel, M, Zhou, Y, Sodergren, E, Weinstock, GM, Bevins, CL, Williams, C and Bos, NA: Enteric defensins are essential regulators of intestinal microbial ecology. Nat Immunol 11: 76-82, 2010

Raffatellu, M, George, MD, Akiyama, Y, Hornsby, MJ, Nuccio, SP, Paixao, TA, Butler, BP, Chu, H, Santos, RL, Berger, T, Mak, TW, Tsolis, RM, Bevins, CL, Solnick, JV, Dandekar, S, and Baumler, AJ: Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine. Cell Host Microbe 5: 476-86, 2009.

Mukherjee, S, Partch, CL, Lehotzky, RE, Whitham, CV, Chu, H, Bevins, CL, Gardner, KH, and Hooper, LV: Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment. J Biol Chem 284:4881-8, 2009.

Yudin, AI, Tollner, TL, Treece, CA, Kays, RJ, Cherr, GN, Overstreet, JW, Bevins, CL: Beta-defensin 22 is a major component of the mouse sperm glycocalyx. Reproduction 136:753-65, 2008.

Hornsby, MJ, Huff, JL, Kays, RJ, Canfield, DR, Bevins, CL and Solnick, JV Helicobacter pylori induces an antimicrobial host response in rhesus macaques in a Cag Pathogenicity Island-Dependent Manner. Gastroenterology 134:1049-1057, 2008.

Bevins, CL and Liu, F-T Rosacea: Skin innate immunity gone awry? Nat. Medicine 13: 904-905, 2007

Baumgarth, N and Bevins, CL, Skin deep but complex. Nature 449:551-553, 2007.

Wehkamp, J, Wang, G, Kubler, I, Schaeffeler, E, Nuding, S, Gregorieff, A, Schnabel, Kays, RJ, Reinisch, W, Teml,, A, Vermeire, S, Rutgeerts, P, Fellermann, K, Burk, O, Clevers, H, Schwab, M, Bevins, CL and Stange, EF. The Paneth Cell alpha-Defensin Deficiency of Ileal Crohn's Disease is Linked to Wnt/Tcf-4. J. Immunol. 179:3109-3118, 2007.

Wehkamp, J, Chu, H, Shen, B, Feathers, RW, Kays, RJ, Lee, SK, and Bevins, CL, Paneth Cell Antimicrobial Peptides: Topographical Distribution and Quantification in Human Gastrointestinal Tissues. FEBS Lett. 580: 5344-5350, 2006.

McGillivary, G., Ray, W.C., Bevins, C.L., Munson Jr., R.S., Bakaletz, L.O., A member of the cathelicidin family of antimicrobial peptides is produced in the upper airway of the chinchilla and its mRNA expression is altered by common viral and bacterial co-pathogens of otitis media. Molec. Immunol. 44: 2446-2458, 2007.

Salzmann, NH, Underwood, MA, and Bevins CL, Paneth Cells, Defensins, and the Commensal Microbiota: A hypothesis on intimate interplay at the intestinal mucosa. Seminars in Immunology 19: 70-83, 2007.

Wehkamp, J., Salzman, N. H., Porter, E., Weichenthal, M., Petras, R. E., Shen, B., Schaeffeler, E., Schwab, M., Linzmeier, R., Feathers, R. W., Chu, H., Lima, J., H., Fellermann, K., Ganz, T., Stange, E. F. and Bevins, C. L.: Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A 102, 18129-18134, 2005.

Bevins, CL, An important clue: fingerprints point to psoriasin in defense against E. coli. Nat Immunol 6: 12-13, 2005.

Sherman, MP, Bennett, SH, Hwang, FFY, Sherman, J, and Bevins, CL: Paneth Cells and Antibacterial Host Defense in Neonatal Small Intestine. Infect. Immun. 73:6143-6146, 2005.

Salzman, N, Ghosh, D, Huttner, KM, Paterson, Y, and Bevins, CL: Human defensin-5 gene in transgenic mice: Paneth cell specific expression and protection from lethal Salmonella typhimurium infection. Nature 422:522-526, 2003.

Ghosh, D, Porter, EM, Shen, B, Lee, SK, Wilk, DJ, Crabb, JW, Drazba, J, Yadav, SY, Ganz, T and Bevins, CL: Paneth cell trypsin is the processing enzyme for human defensin-5. Nat. Immunol. 3:583-590, 2002.

Diamond, G, Kaiser, V, Rhodes, J, Russell, J, and Bevins, C, Transcriptional regulation of b-defensin gene expression in tracheal epithelial cells. Infect Immun 68: 113-119., 2000.

Tarver AP, Clark DP, Diamond G, Russell, JP, Erdjument-Bromage, H, Tempst P, Cohen K, Jones, DE, Sweeney, RW, Wines M, Huang S and Bevins CL Enteric beta-Defensin: Molecular Cloning and Characterization of a Gene with Inducible Intestinal Epithelial Cell Expression Associated with Cryptosporidium parvum. Infection Infection and Immunity 66: 1045-56, 1998.

Diamond, G, Russell, JP and Bevins, CL: Inducible expression of an endogenous antibiotic in lipopolysaccharide-challenged tracheal epithelial cells. PNAS 93: 5156-5160, 1996.

Mallow, EM, Harris, A, Salzman, N, Russell, JP, DeBerardinis, JP, Ruchelli, E and Bevins, CL: Human enteric defensins: Gene structure and developmental expression. J. Biol. Chem. 271: 4038-4045, 1996.

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