Charles L. Bevins

Charles Bevins - photo in lab

Position Title
Professor

Unit
Dept of Microbiology and Immunology

GBSF, Room 5617
Bio

Research Interests

Innate Immunity, Host-Microbe Interaction, Antimicrobial Peptides/Defensins

 

Grad Group Affiliations

  • Biochemistry, Molecular, Cellular and Developmental Biology
  • Comparative Pathology
  • Immunology
  • Microbiology
  • Designated Emphasis in Host-Microbe Interaction

Specialties / Focus

  • Molecular Medicine

Courses

  • IMM 201 Basic Immunology (Team Taught), Fall
  • IMM 293 Current Concepts in Immunology (Team Taught), Winter
  • IMM 297 Mucosal Immunology (Team Taught), Spring, Odd Years
  • MMI 210A & B Topics in Animal Models of Infectious Disease (T32 Students, Team Taught), Winter
  • MMI 480A Medical Immunology (Team Taught)
  • IMM 204 Innate Immunology, Spring, Even Years
  • IMM 201L Graduate Laboratory Rotation (Team Taught), Fall, Winter

Labs

  • Bevins Lab/ GBSF 5617
    • Mark Underwood, MD (collaborator), Anchasa Kananurak (PostDoc), Patricia Castillo (PostDoc), Eric Nonnecke (PostDoc), Douglas Akahoshi (Grad Student); Recent Grads and Visiting Scholars: Brian Leonard (DVM/PhD, 2012, Assist Prof, UCD SOVM), Hiutung Chu (PhD, 2011, Assist Prof, UCSD), Joe Russell (PhD, 2011, Research Manager, Janssen Research and Development, Johnson and Johnson), Pak-Lam Yu PhD (sabbatical, Massey Univ), Mats Andersson PhD (sabbatical, Karolinska Inst), Jan Wehkamp MD (Post Doc 2003-6, Prof Tübingen Univ), Marco Schunter MD (Visiting Fellow), Jakob Trimpert (Visiting Vet Student), Jenny Karlsson (Visiting Grad Student), Bjoern Schroeder (Visiting Grad Student)

Professional Societies

  • American Association for the Advancement of Science
  • American Society for Microbiology
  • American Association of Immunology
  • American Gastroenterological Association
  • Fellow, American College of Gastroenterology
  • American Society for Human Genetics
  • Society for Pediatric Research

Degrees

  • 1976 BA Biological Sciences Universty of Maryland, Baltimore County
  • 1983 MD Medicine University of Maryland
  • 1986 PhD Biochemistry University of Maryland

Publications

Clevers, HC and Bevins, CL: Paneth cells: maestros of the small intestinal crypts. Annu Rev Physiol 75: 289-311, 2013.

Chu, H, Pazgier, M, Jung, G, Nuccio, S-P, Castillo, PA, de Jong, MF, Winter, MG, Winter, SE, Wehkamp, J, Shen, B, Salzman NH, Underwood, MA, Tsolis, RM, Young, GM, Lu, W, Lehrer, RI, Bäumler, AJ, and Bevins, CL: Human α-defensin 6 promotes mucosal innate immunity through assembled peptide nanonets. Science 337:477-481, 2012.

Tollner TL, Bevins CL, Cherr GN: Multifunctional glycoprotein DEFB126-a curious story of defensin-clad spermatozoa. Nat Rev Urol. 9:365-375, 2012.

Tollner, TL, Venners, SA, Hollox, EJ, Yudin, AI, Liu, X, Tang, G, Xing, H, Kays, RJ, Lau, T, Overstreet,, JW, Xu, X, Bevins, CL*, Cherr, GN*: A common mutation in DEFB126 causes impaired sperm function and subfertility. Science Transl Med 3: 92ra65, 2011. (equal contributors)

Bevins, CL and Salzman, NH: The potter’s wheel: The host’s role in sculpting its microbiota. Cell Mol Life Sci 68:3675-3685, 2011.

Bevins, CL and Salzmann NH: Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis Nat. Reviews Microbiol. 9: 356-368, 2011.

Bevins, CL and Liu, F-T A sweet target for innate immunity. Nat. Medicine 16: 263-264, 2010.

Bevins, CL and Liu, F-T Rosacea: Skin innate immunity gone awry? Nat. Medicine 13: 904-905, 2007

Baumgarth, N and Bevins, CL, Skin deep but complex. Nature 449:551-553, 2007.

Salzmann, NH, Underwood, MA, and Bevins CL, Paneth Cells, Defensins, and the Commensal Microbiota: A hypothesis on intimate interplay at the intestinal mucosa. Seminars in Immunology 19: 70-83, 2007.

Wehkamp, J., Salzman, N. H., Porter, E., Weichenthal, M., Petras, R. E., Shen, B., Schaeffeler, E., Schwab, M., Linzmeier, R., Feathers, R. W., Chu, H., Lima, J., H., Fellermann, K., Ganz, T., Stange, E. F. and Bevins, C. L.: Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A 102, 18129-18134, 2005.

Bevins, CL, An important clue: fingerprints point to psoriasin in defense against E. coli. Nat Immunol 6: 12-13, 2005.

Salzman, N, Ghosh, D, Huttner, KM, Paterson, Y, and Bevins, CL: Human defensin-5 gene in transgenic mice: Paneth cell specific expression and protection from lethal Salmonella typhimurium infection. Nature 422:522-526, 2003.

Ghosh, D, Porter, EM, Shen, B, Lee, SK, Wilk, DJ, Crabb, JW, Drazba, J, Yadav, SY, Ganz, T and Bevins, CL: Paneth cell trypsin is the processing enzyme for human defensin-5. Nat. Immunol. 3:583-590, 2002.

Diamond, G, Russell, JP and Bevins, CL: Inducible expression of an endogenous antibiotic in lipopolysaccharide-challenged tracheal epithelial cells. PNAS 93: 5156-5160, 1996.

Mallow, EM, Harris, A, Salzman, N, Russell, JP, DeBerardinis, JP, Ruchelli, E and Bevins, CL: Human enteric defensins: Gene structure and developmental expression. J. Biol. Chem. 271: 4038-4045, 1996.

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