Danika Bannasch

Danika Bannasch

Position Title
Professor

Unit
Department of Population Health and Reproduction, School of Veterinary Medicine

Room 260 CCAH
Bio

Research Interests

Our current and future research plans are directed towards elucidating the molecular basis of inherited diseases in companion animals. We are interested in developing tests to help breeders eliminate inherited diseases in dogs and horses. A large number of the diseases seen in veterinary practice that affect purebred animals have a heritable basis. Characterizing inherited diseases in dogs has the added benefit of providing an animal model for human diseases. Presently we have projects in both the horse and the dog.

Grad Group Affiliations

  • Animal Biology Graduate Group
  • Comparative Pathology (Vet Med)
  • Integrative Genetics and Genomics

Specialties / Focus

  • Animal Genomics

Courses

  • VET VET401 Veterinary Foundations, Fall Semester
  • IGG 201A Genetic Analysis, Fall Quarter
  • PHR 241 Advanced Dog Genetics, Spring

Honors and Awards

  • Maxine Adler Endowed Chair in Genetics

    Degrees

    • 1994 PhD Princeton University
    • 1998 DVM University of California, Davis

    Publications

    FGF4 retrogene on CFA12 is responsible for chondrodystrophy and intervertebral disc disease in dogs.

    Brown EA, Dickinson PJ, Mansour T, Sturges BK, Aguilar M, Young AE, Korff C, Lind J, Ettinger CL, Varon S, Pollard R, Brown CT, Raudsepp T, Bannasch DL.

    Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11476-11481. doi: 10.1073/pnas.1709082114. Epub 2017 Oct 11.

    Genome-wide association analysis identifies a mutation in the thiamine transporter 2 (SLC19A3) gene associated with Alaskan Husky encephalopathy.

    Vernau KM, Runstadler JA, Brown EA, Cameron JM, Huson HJ, Higgins RJ, Ackerley C, Sturges BK, Dickinson PJ, Puschner B, Giulivi C, Shelton GD, Robinson BH, DiMauro S, Bollen AW, Bannasch DL.

    PLoS One. 2013;8(3):e57195. doi: 10.1371/journal.pone.0057195. Epub 2013 Mar 4.

    Clinical manifestations, response to treatment, and clinical outcome for Weimaraners with hypertrophic osteodystrophy: 53 cases (2009-2011).

    Safra N, Johnson EG, Lit L, Foreman O, Wolf ZT, Aguilar M, Karmi N, Finno CJ, Bannasch DL.

    J Am Vet Med Assoc. 2013 May 1;242(9):1260-6. doi: 10.2460/javma.242.9.1260.

    Genome-wide association mapping in dogs enables identification of the homeobox gene, NKX2-8, as a genetic component of neural tube defects in humans.

    Safra N, Bassuk AG, Ferguson PJ, Aguilar M, Coulson RL, Thomas N, Hitchens PL, Dickinson PJ, Vernau KM, Wolf ZT, Bannasch DL.

    PLoS Genet. 2013;9(7):e1003646. doi: 10.1371/journal.pgen.1003646. Epub 2013 Jul 18.

    A mutation in the canine gene encoding folliculin-interacting protein 2 (FNIP2) associated with a unique disruption in spinal cord myelination.

    Pemberton TJ, Choi S, Mayer JA, Li FY, Gokey N, Svaren J, Safra N, Bannasch DL, Sullivan K, Breuhaus B, Patel PI, Duncan ID.

    Glia. 2014 Jan;62(1):39-51. doi: 10.1002/glia.22582.

    A LINE-1 insertion in DLX6 is responsible for cleft palate and mandibular abnormalities in a canine model of Pierre Robin sequence.

    Wolf ZT, Leslie EJ, Arzi B, Jayashankar K, Karmi N, Jia Z, Rowland DJ, Young A, Safra N, Sliskovic S, Murray JC, Wade CM, Bannasch DL.

    PLoS Genet. 2014 Apr 3;10(4):e1004257. doi: 10.1371/journal.pgen.1004257. eCollection 2014 Apr.

    Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate.

    Wolf ZT, Brand HA, Shaffer JR, Leslie EJ, Arzi B, Willet CE, Cox TC, McHenry T, Narayan N, Feingold E, Wang X, Sliskovic S, Karmi N, Safra N, Sanchez C, Deleyiannis FW, Murray JC, Wade CM, Marazita ML, Bannasch DL.

    PLoS Genet. 2015 Mar 23;11(3):e1005059. doi: 10.1371/journal.pgen.1005059. eCollection 2015 Mar.

    PMID:25798845

    Free PMC Article

    SERPINB11 frameshift variant associated with novel hoof specific phenotype in Connemara ponies.

    Finno CJ, Stevens C, Young A, Affolter V, Joshi NA, Ramsay S, Bannasch DL.

    PLoS Genet. 2015 Apr 13;11(4):e1005122. doi: 10.1371/journal.pgen.1005122. eCollection 2015 Apr.

    Utilizing the Dog Genome in the Search for Novel Candidate Genes Involved in Glioma Development-Genome Wide Association Mapping followed by Targeted Massive Parallel Sequencing Identifies a Strongly Associated Locus.

    Truvé K, Dickinson P, Xiong A, York D, Jayashankar K, Pielberg G, Koltookian M, Murén E, Fuxelius HH, Weishaupt H, Swartling FJ, Andersson G, Hedhammar Å, Bongcam-Rudloff E, Forsberg-Nilsson K, Bannasch D, Lindblad-Toh K.

    PLoS Genet. 2016 May 12;12(5):e1006000. doi: 10.1371/journal.pgen.1006000. eCollection 2016 May.

    Chromosomal Aberrations in Canine Gliomas Define Candidate Genes and Common Pathways in Dogs and Humans.

    Dickinson PJ, York D, Higgins RJ, LeCouteur RA, Joshi N, Bannasch D.

    J Neuropathol Exp Neurol. 2016 Jul;75(7):700-10. doi: 10.1093/jnen/nlw042. Epub 2016 May 31.

    Serum levels of innate immunity cytokines are elevated in dogs with metaphyseal osteopathy (hypertrophic osteodytrophy) during active disease and remission.

    Safra N, Hitchens PL, Maverakis E, Mitra A, Korff C, Johnson E, Kol A, Bannasch MJ, Pedersen NC, Bannasch DL.

    Vet Immunol Immunopathol. 2016 Oct 15;179:32-5. doi: 10.1016/j.vetimm.2016.08.003. Epub 2016 Aug 3.

    PMID: 27590423

    Evaluation of dogs with genetic hyperuricosuria and urate urolithiasis consuming a purine restricted diet: a pilot study.

    Westropp JL, Larsen JA, Johnson EG, Bannasch D, Fascetti AJ, Biourge V, Queau Y.

    BMC Vet Res. 2017 Feb 8;13(1):45. doi: 10.1186/s12917-017-0958-y.

    Association of early onset myasthenia gravis in Newfoundland dogs with the canine major histocompatibility complex class I.

    Wolf Z, Vernau K, Safra N, Shelton GD, King J, Owen J, Weich K, Bannasch D.

    Neuromuscul Disord. 2017 May;27(5):409-416. doi: 10.1016/j.nmd.2017.01.020. Epub 2017 Jan 30.

    Genetic analysis of optic nerve head coloboma in the Nova Scotia Duck Tolling Retriever identifies discordance with the NHEJ1 intronic deletion (collie eye anomaly mutation).

    Brown EA, Thomasy SM, Murphy CJ, Bannasch DL.

    Vet Ophthalmol. 2017 Jul 12. doi: 10.1111/vop.12488. [Epub ahead of print]

    Developing a 670k genotyping array to tag ~2M SNPs across 24 horse breeds.

    Schaefer RJ, Schubert M, Bailey E, Bannasch DL, Barrey E, Bar-Gal GK, Brem G, Brooks SA, Distl O, Fries R, Finno CJ, Gerber V, Haase B, Jagannathan V, Kalbfleisch T, Leeb T, Lindgren G, Lopes MS, Mach N, da Câmara Machado A, MacLeod JN, McCoy A, Metzger J, Penedo C, Polani S, Rieder S, Tammen I, Tetens J, Thaller G, Verini-Supplizi A, Wade CM, Wallner B, Orlando L, Mickelson JR, McCue ME.

    BMC Genomics. 2017 Jul 27;18(1):565. doi: 10.1186/s12864-017-3943-8.

    Identification of a candidate mutation in the COL1A2 gene of a Chow Chow with osteogenesis imperfecta.

    Quist EM, Doan R, Pool RR, Porter BF, Bannasch DL, Dindot SV.

    J Hered. 2017 Sep 19. doi: 10.1093/jhered/esx074. [Epub ahead of print]

    PMID: 29036614

    1994 Metallinos, D.L., A.J. Oppenheimer, E.M. Rinchik, L.B. Russell, W. Dietrich and S.M. Tilghman Fine structure mapping and deletion analysis of the murine piebald locus. Genetics 136(1): 217-223.

    1996 OBrien, T.P., D.L. Metallinos, H. Chen, M.K. Shin and S.M. Tilghman Complementation mapping of skeletal and central nervous system abnormalities in mice of the piebald deletion complex. Genetics 143(1): 447-461.

    1998 Metallinos, D.L., A.T. Bowling and J. Rine A missense mutation in the endothelin-B receptor gene is associated with Lethal White Foal Syndrome: An equine version of Hirschsprung disease. Mammalian Genome 9: 426-431.

    2000 Newton, J.M., A.L. Wilkie, L.He, S.A. Jordan, D.L. Metallinos , N.G. Holmes, I.J. Jackson and G.S. Barsh Melanocortin 1 receptor variation in the domestic dog. Mammalian Genome 11: 24-30.

    2000 Metallinos, D. and J. Rine Exclusion of EDNRB and KIT as the basis for white spotting in border collies. Genome Biology 1(2): research0004.1-0004.4.

    2001 Metallinos, D.L. Canine molecular genetic testing. Veterinary Clinics of North America: Small Animal Practice 31(2): 421-429.

    2004 Davidson, A.P., Pollard, R.E., Bannasch, D.L., Marks, S.L., Hornof, W.J. and T.R. Famula. Cricopharyngeal dysfunction in Golden Retrievers: A heritable disease. Am J Vet Res. 2004 Mar;65(3):344-9.

    2004 White, S. D., Affolter, V.K., Bannasch, D.L., Schultheiss, P.C., Hamar, D.W., Chapman,P.L., Naydan, D., Spier, S.J., Rosychuk, R.A.W., Rees,C, Veneklasen, G.O., Martin, A., Bevier, D., Jackson, H.J., Bettenay,S., Matousek, J., Campbell, K.L. and P.J. Ihrke. Hereditary equine regional dermal asthenia (hyperelastosis cutis) in 50 horses: clinical, histologic, immunohistologic and ultrastructural findings. Veterinary Dermatology;15 207-215

    2004 Bannasch, D.L., Ling, G.V., Bea, J. and T.R. Famula. Inheritance of urinary calculi in the Dalmatian. J Vet Intern Med;18(4):482-487.

    2004 Bannasch, D. L. Ryun JR, Bannasch MJ, Schaible RH, Breen M, Ling G. Exclusion of galectin 9 as a candidate gene for hyperuricosuria in the Dalmatian dog. Anim Genet. 2004 Aug;35(4):326-8

    2005 Tryon, R.C., White, S.D., Famula, T.R., Schultheiss, P.C., Hamar, D.W., Bannasch, D.L. Inheritance of hereditary equine regional dermal asthenia in Quarter Horses. Am J Vet Res. 2005 Mar; 66(3):437-42.

    2005 Bannasch, D.L., Bannasch, M.J., Ryun, J.R., Famula, T.R., Pedersen, N.C. Y chromosome haplotype analysis in purebred dogs. Mamm Genome. 2005 Apr;16(4):273-80.

    2005 Safra, N., Ling, G.V., Schaible, R.H., Bannasch, D.L. Exclusion of urate oxidase as a candidate gene for hyperuricosuria in the Dalmatian dog using an interbreed backcross. J Hered. 2005 Jun; 96(7):750-4.

    2005 Wiersma, A.C., Millon, L.V., van Dongen, A.M., van Oost, B.A., Bannasch, D.L. Evaluation of canine COL4A3 and COL4A4 as candidates for familial renal disease in the Norwegian elkhound. J Hered. 2005 Jul; 96(7):739-44.

    2005 Wiersma, A.C., Millon, L.V., Hestand, M.S., Van Oost, B.A., Bannasch, D.L. Canine COL4A3 and COL4A4: sequencing, mapping and genomic organization. DNA Seq. 2005 Aug; 16(4):241-51.

    2006 Bannasch, D., Rinaldo, C., Millon, L., Latson, K., Spangler, T., Hubberty, S., Galuppo, L., Lowenstine, L. SRY negative 64, XX intersex phenotype in an American saddlebred horse. Vet J., in press, e-pub Dec 2005.

    2006 Young, A.E., Bannasch, D.L. Morphological Variation in the Dog. In: Ostrander, E., Giger, U., Lindblad-Toh, K. (Eds), The Dog and Its Genome. Cold Spring Harbor Laboratory Press, Woodbury, NY, USA.

    2006 Safra, N., Schaible, R.H., Bannasch, D.L. Linkage analysis with an interbreed backcross maps Dalmatian hyperuricosuria to CFA3. Mamm Genome. 2006 April; 17(4):340-345.

    2006 Bannasch, D.L., Hughes, A.H. Recent Advances in Small Animal Genetics. Vet Clin Small Anim. 2006 May; 36(3):461-474.

    2006 Young, A.E., Ryun, J.R., Bannasch, D.L. Deletions in the COL10A1 gene are not associated with skeletal changes in dogs. Mamm Genome. 2006 Jul;17(7):761-8.

    2006 Young, A.E., Bower, L.P., Affolter, V.K., DeCock, H.E.V., Ferraro, G.L., Bannasch, D.L. Evaluation of FOXC2 as a Candidate Gene for Chronic Progressive Lymphedema in Draft Horses. The Veterinary Journal. Vet J. 2006 Jul 31.

    2006 B. Séguin, T. Zwerdling, J. L. McCallan, H. E. V. DeCock, L. L. Dewe, D. K. Naydan, A. E. Young, D. L. Bannasch, O. Foreman, M. S. Kent. Development of a new canine osteosarcoma cell line Veterinary and Comparative Oncology 2006 4:4 232

    2007 Gonzalo Rincón , Amy E. Young , Danika L. Bannasch , Juan F. Medrano. Characterization of variation in the canine suppressor of cytokine signaling-2 (SOCS2) gene. Genetics and Molecular Research Genet. Mol. Res. (1):144-151.

    2007 White SD, Affolter VK, Schultheiss PC, Ball BA, Wessel MT, Kass P, Molinaro AM, Bannasch DL, Ihrke PJ. Clinical and pathological findings in a HERDA-affected foal for 1.5 years of life.Vet Dermatol. 2007 Feb;18(1):36-40.

    2007 Angela Hughes, Thomas Famula, Richard Nelson and Danika Bannasch. Clinical features and heritability of hypoadrenocorticism in Nova Scotia Duck Tolling Retrievers: 25 cases (1994-2006). J Am Vet Med Assoc. 2007 Aug 1;231(3):407-12

    2007 Robert Tryon, Stephen White and Danika Bannasch. Homozygosity mapping approach identifies a missense mutation in equine cyclophilin B (PPIB) associated with HERDA in the American Quarter Horse. Genomics Jul;90(1):93-102.

    2007 Amy Young and Danika Bannasch. SNPs in the promoter regions of the canine RMRP and SHOX genes are not associated with canine chondrodysplasia. Animal Biotech In Press 8/07

    2008 Smith, LB, Bannasch, DL, Young, AE, Grossman, DI, Belanger, JM and Oberbauer, AM. Canine fibroblast growth factor receptor 3 sequence is conserved across dogs of divergent skeletal size. BMC Genetics 2008, 9:67, Epub 2008 Oct 21

    2008 Bannasch, D, Safra, N, Young, A, Karmi, N, Schaible, RS, Ling, GV. Mutations in the SLC2A9 Gene Cause Hyperuricosuria and Hyperuricemia in the Dog. PLoS Genetics 2008, Nov;4(11):e1000246. Epub 2008 Nov 7.

    2009 Tryon, RC, Penedo, MC, McCue, ME, Valberg, SJ, Mickelson, JR, Famula, TR, Wagner, ML, Jackson, M, Hamilton, MJ, Nooteboom, S, Bannasch, DL. Evaluation of allele frequencies of inherited disease genes in subgroups of American Quarter Horses. J Am Vet Med Assoc, 2009 Jan 1;234(1):120-5.

    2009 Bannasch, D, Henthorn, PS. Changing paradigms in diagnosis of inherited defects associated with urolithiasis. Vet Clin North Am Small Anim Pract., 2009 Jan;39(1):111-25.

    Hughes AM, Bannasch DL, Kellett K, Oberbauer AM. Examination of candidate genes for hypoadrenocorticism in Nova Scotia Duck Tolling Retrievers. Vet J. 2009 Nov 18.

    Wilbe M, Jokinen P, Truvé K, Seppala EH, Karlsson EK, Biagi T, Hughes A, Bannasch D, Andersson G, Hansson-Hamlin H, Lohi H, Lindblad-Toh K. Genome-wide association mapping identifies multiple loci for a canine SLE-related disease complex. Nat Genet. 2010 Mar;42(3):250-4. Epub 2010 Jan 31.

    Hughes AM, Jokinen P, Bannasch DL, Lohi H, Oberbauer AM. Association of a dog leukocyte antigen class II haplotype with hypoadrenocorticism in Nova Scotia Duck Tolling Retrievers. Tissue Antigens. 2010 Jun;75(6):684-90. Epub 2010 Jan 28.

    Bannasch D, Young A, Myers J, Truvé K, Dickinson P, Gregg J, Davis R, Bongcam-Rudloff E, Webster MT, Lindblad-Toh K, Pedersen N. Localization of canine brachycephaly using an across breed mapping approach. PLoS One. 2010 Mar 10;5(3):e9632. PubMed PMID: 20224736;

    Vonholdt BM, Pollinger JP, Lohmueller KE, Han E, Parker HG, Quignon P, Degenhardt JD, Boyko AR, Earl DA, Auton A, Reynolds A, Bryc K, Brisbin A, Knowles JC, Mosher DS, Spady TC, Elkahloun A, Geffen E, Pilot M, Jedrzejewski W, Greco C, Randi E, Bannasch D, Wilton A, Shearman J, Musiani M, Cargill M, Jones PG, Qian Z, Huang W, Ding ZL, Zhang YP, Bustamante CD, Ostrander EA, Novembre J, Wayne RK. Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication. Nature. 2010 Apr 8;464(7290):898-902. Epub 2010 Mar 17.

    Karmi N, Safra N, Young A, Bannasch DL. Validation of a urine test and characterization of the putative genetic mutation for hyperuricosuria in Bulldogs and Black Russian Terriers. Am J Vet Res. 2010 Aug;71(8):909-14.

    Karmi N, Brown EA, Hughes SS, McLaughlin B, Mellersh CS, Biourge V, Bannasch DL. Estimated frequency of the canine hyperuricosuria mutation in different dog breeds. J Vet Intern Med. 2010 Nov-Dec;24(6):1337-42.

    Safra N, Pedersen NC, Wolf Z, Johnson EG, Liu HW, Hughes AM, Young A, Bannasch DL. Expanded dog leukocyte antigen (DLA) single nucleotide polymorphism (SNP) genotyping reveals spurious class II associations. Vet J, 2011, 189(2): 220-6.

    Finno CJ, Higgins RJ, Aleman M, Ofri R, Hollingsworth SR, Bannasch DL, Reilly CM, Madigan JE. Equine Degenerative Myeloencephalopathy in Lusitano horses. J Vet Intern Med, 2011, 25(6): 1439-1446.

    Brown SK, Pedersen NC, Jafarishorijeh S, Bannasch DL, Ahrens KD, Wu J-T, Okon M, Sacks BN. Phylogenetic Distinctiveness of Middle Eastern and Southeast Asian Village Dog Y Chromosomes Illuminates Dog Origins. PLoS ONE, 2011, 6(12): e28496.

    Finno, CJ, Higgins, RJ, Aleman, M, Ofri, R, Hollingsworth, SR, Bannasch, DL, Reilly, CM, Madigan, JE. Equine degenerative myeloencephalopathy in Lusitano horses. Journal of veterinary internal medicine, 2011,25(6): 1439-46.

    Leonard, BC, Marks, SL, Outerbridge, CA, Affolter, VK, Kananurak, A, Young, A, Moore, PF, Bannasch, DL, Bevins, CL. Activity, expression and genetic variation of canine b-defensin 103: a multifunctional antimicrobial peptide in the skin of domestic dogs. Journal of innate immunity, 2012, 4(3): 248-59.

    McCue, ME, Bannasch, DL, Petersen, JL, Gurr, J, Bailey, E, Binns, MM, Distl, O, Guérin, G, Hasegawa, T, Hill, EW, Leeb, T, Lindgren, G, Penedo, MC, Røed, KH, Ryder, OA, Swinburne, JE, Tozaki, T, Valberg, SJ, Vaudin, M, Lindblad-Toh, K, Wade, CM, Mickelson, JR. A high density SNP array for the domestic horse and extant Perissodactyla: utility for association mapping, genetic diversity, and phylogeny studies. PLoS genetics, 2012, 8(1): e1002451.

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