David Pleasure

David Pleasure

Position Title
Distinguished Professor

Unit
Department of Neurology, School of Medicine
Director, Institute for Pediatric Regenerative Medicine

Room 602A, Shriners Hospital
Bio

Profile Introduction

Our laboratory uses cell and molecular biological techniques to study the development and regeneration of the nervous system. Our current focus is on mechanisms of death and regeneration of oligodendroglia, the myelin-forming cells of the central nervous system, that take place during experimental autoimmune encephalomyelitis and in leukodystrophies.

Research Interests

Pathogenesis of multiple sclerosis, leukodystrophies, and cerebral palsy

Genetic and epigenetic regulation of neural stem cell lineages

Grad Group Affiliations

  • Biochemistry, Molecular, Cellular and Developmental Biology
  • Comparative Pathology
  • Comparative Pathology, Clinical Research
  • Immunology
  • Neuroscience

Specialties / Focus

  • Cellular Responses to Toxins and Stress
  • Molecular Medicine

Labs

  • Institute for Pediatric Regenerative Medicine - 6th floor Shriners Hospital
    • Currently, 3 postdoctoral fellows, 4 graduate students (2 from Immunology, 1 from Comparative Pathology, and 1 from BMCDB), and 2 research technicians

Honors and Awards

  • Phi Beta Kappa Yale, Alpha Omega Alpha P&S Columbia
  • Jacob Javits Neuroscience Award, NINDS, NIH 1992-1999
  • Fellow, American Association for the Advancement of Science, 2005
  • Listed in "Best Doctors in America" 1993-2015
  • Phi Beta Kappa Yale, Alpha Omega Alpha P&S Columbia, NIH RO1 NS025044 funded through 6/2012 (year 27); 2011, Elected Honorary Member, American Neurological Association; 2011 Distinguished Professor UC Davis

    Professional Societies

    • Fellow, American Academy of Neurology
    • Honorary Member, American Neurological Association
    • Member, Society for Neuroscience

    Degrees

    • 59 BA History Yale
    • 63 MD Medicine PandS, Columbia

    Publications

    Guo, Lang, Sohn, Hammond, Chang, Pleasure (2015) Canonical Wnt signaling in the oligodendroglial lineage—puzzles remain.  Glia 63:1671-1693, 2015 (PMID: 25782433).

    Guo, Bannerman, Mills Ko, Miers, Xu, Burns, Li, Freeman, McDonough, Pleasure (2015) Ablation of N-acetyl-L-aspartate synthesis prevents leukodystrophy in a murine model of Canavan disease.  Ann Neurol 77:884-888 (PMID: 25712859).

     Hammond, Lang, Maeda, Pleasure, Angus-Hill, Xu, Deng, Guo (2015)  The Wnt effector TCF7l2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/beta-catenin signaling. J Neurosci 35:5007-5022 (PMID: 25810530).

    Sohn, Orosco, Guo, Chung, Bannerman, Mills Ko, Zarbalis, Deng, Pleasure (2015) The subventricular zone continues to generate corpus callosum and rostral migratory stream astroglia in normal adult mice.  J Neurosci 35:3756-3763 (PMID: 25740506).

    Itoh, Horiuchi, Ikeda, Xu, Bannerman, Pleasure, Penninger, Tournier, Itoh (2014) ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates.  J Neurosci 34:10729-10742 (PMID: 25100604).

    Moreno, Bannerman, Ma, Guo, Miers, Soulika, Pleasure (2014) Conditional ablation of astroglial CCL2 suppresses CNS accumulation of M1 macrophages and preserves axons in mice with MOG peptide EAE.  J Neurosci 34:8175-8185 (PMID: 24920622).

    Chetty, Friedman, Kirby, Mirescu, Taravosh-Lahn, Guo, Krupik, Nicholas, Geraghty, Krishnamurthy, Tsai, Covarrubias, Wong, Francis, Sapolsky, Palmer, Pleasure, Kaufer (2014) Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus.  Mol Psychiatry 19:1275-1283 (PMID: 24514565).

    Orosco, Ross, Cates, Scott, Wu, Sohn, Pleasure (D), Pleasure (S), Adamopoulos, Zarbalis (2014) Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology.  Nature Commun 5:4692 (PMID: 25198012).

    Chen, Jiang, Xue, Peterson, Tran, McCann, Parast, Li, Pleasure, Laurent, Loring, Liu, Deng (2014) Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells.  Nature Commun 5:4430 (PMID: 25034944).

    Lang, Maeda, Bannerman, Jie, Xu, Horiuchi, Pleasure*, Guo* (2013) Adenomatous polyposis coli regulates oligodendroglial differentiation.  J Neurosci 33:3113-3130 (PMID: 23407966).  *co-senior authors.

    Jiang, Chen, Wang, Chechneva, Chung, Rao, Pleasure, Liu, Zhang, Deng (2013) hESC-derived Olig2+ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury.  Nature Commun 4:2196 (PMID: 23880652).

    Sohn, Selvaraj, Wakayama, Orosco, Lee, Crawford, Guo, Lang, Horiuchi, Zarbalis, Itoh, Deng, Pleasure (2012) PEDF is a novel oligodendrogenic morphogen acting on the adult SVZ and corpus callosum.  J Neurosci 32:12152-12164 (PMID: 22933798).

    Guo, Maeda, Ma, Delgado, Sohn, Miers, Mills Ko, Bannerman, Xu, Wang, Zhou, Takebayashi, Pleasure (2011) Macroglial plasticity and the origins of reactive astroglia in experimental autoimmune encephalomyelitis. J Neurosci 31:11914-11928 (PMID: 21849552).

    Itoh, Horiuchi, Wakayama, Xu, Bannerman, Pleasure, Itoh  (2011) ZPK/DLK, a mitogen-activated protein kinase kinase kinase, is a critical mediator of programmed cell death of motoneurons. J Neurosci 31:7223-7228 (PMID:  21593306).

    Guo, Maeda, Ma, Xu, Horiuchi, Miers, Vaccarino, Pleasure (2010) Pyramidal neurons are generated from oligodendroglial progenitor cells in adult piriform cortex. J Neurosci 30:12036-12049 (PMID: 20826667).

    Soulika, Lee, McCauley, Miers, Bannerman, Pleasure (2009) Initiation and progression of axonopathy in experimental autoimmune encephalomyelitis. J Neurosci 29:14965-14979 (PMID: 19940192).

    Guo, Ma, McCauley, Bannerman, Pleasure (2009) Early postnatal proteolipid promoter-expressing progenitors produce multilineage cells in vivo. J Neurosci 29:7256-7270 (PMID: 19494148).

    Feldman, Horiuchi, Keachie, McCauley, Bannerman, Itoh, Itoh, Pleasure (2008) Characterization of acid-sensing ion channel expression in oligodendrocyte-lineage cells. Glia 56:1238-1249 (PMID: 18452213).

    Bannerman, Hahn, Gallo, Pleasure (2007) Astrogliosis in EAE: derivation from radial glia, and relationships to oligodendroglia. Glia 55:57-64 (PMID: 17009237).

    Bannerman, Hahn, Ramirez, Morley, Bonnemann, Yu, Zhang, Rostami, Pleasure (2005) Motor neuron pathology in experimental autoimmune encephalomyelitis: studies in THY1-YFP transgenic mice. Brain 128:1877-1886 (PMID: 15901645).

    Tags