David P. Richman

David Richman

Position Title
Distinguished Professor

Unit
Department of Neurology, School of Medicine
Center for Neuroscience

510 1515 Newton Court
Bio

Profile Introduction

I am a clinical neuroimmunologist interested in autoimmune and congenital diseases of the neuromuscular junction. Most of my experimental work involves animal models of these diseases.

Research Interests

Development and study of animal models of disorders of the neuromuscular junction

I am presently developing and studying immune-based animal models of seronegative myasthenia gravis with the goal of developing new treatments of these diseases.

Grad Group Affiliations

  • Molecular, Cellular and Integrative Physiology
  • Neuroscience

Specialties / Focus

  • Neurophysiology

Labs

  • Richman Lab
    • Lucia Borges, PhD, Assistant Project Scientist
    • Armineh Stoner, Graduate Student

Professional Societies

  • American Neurologic Association
  • American Association of Immunologists

Degrees

  • 1969 MD Johns Hopkins School of Medicine
  • 1965 BA Mathematics Princeton University

Publications

Fairclough, R.H., Twaddle, G.M., Gudipati, E., Richman, D.P., Burkwall, D.A., and Josephs R. Mapping the mAb 383C epitope to alpha(187-199) of the Torpedo acetylcholine receptor on the three dimensional model. J. Mol. Biol. 282:301-315, 1998.

Fairclough, R.H., Twaddle, G.M., Gudipati, E., Lin, M.Y. and Richman, D.P. Differential surface accessibility of alpha(187-199) in the Torpedo acetylcholine receptor alpha subunits. J. Mol. Biol. 282:317-330, 1998.

Maselli, R.A., Kong, D., Bowe, C., McDonald, C., Ellis, W., Agius, M.A., Gomez, C.M., Richman, D.P., and Wollmann, R.L. Presynaptic congenital myasthenic syndrome due to quantal release deficiency. Neurology 57: 279-289, 2001. 

Richman, D.P. and Agius, M.A.  Treatment of autoimmune myasthenia gravis.  Neurology 61: 1652-1661, 2003.

Kim S.S., Richman, D.P., Zamvil S.S. and Agius. M.A.  Accelerated central nervous system autoimmunity in BAFF-receptor-deficient mice. J Neurol Sci. 306: 9–15, 2011

Richman D.P., Yu Y., Lee T-T, Tseng P-Y, Yu W-P, Maselli R.A., Tang C-Y, and Chen T-Y. Dominantly-Inherited Myotonia Congenita Resulting from Increased Open Probability of the Fast Gate of the Muscle Chloride Channel CLC-1.  NeuroMolecular Medicine 14: 328-337, 2012.

Richman D.P., Nishi K., Morell S., Chang J.M., Ferns, M.J., Wollmann R.M., Maselli R.A., Schnier J. and Agius. M.A.  Acute Severe Animal Model of Anti-MuSK Myasthenia: Combined Postsynaptic and Presynaptic Changes at the Neuromuscular Junction. Arch Neurol 69(4):453-60, 2012

Richman, DP. The future of research in myasthenia. JAMA Neurology 72:812-814.  PMID: 26011044.

Richman DP.  Lrp4 antibodies in myasthenia gravis: Pathogenic or protective.  European J Neurol 23(11):1593-1594, 2016. PMID: 27753233

SEE:  http://www.ncbi.nlm.nih.gov/sites/myncbi/david.richman.1/bibliography/40975700/public/?sort=date&direction=ascending

 

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