Department of Physiology and Membrane Biology, School of Medicine
Lipid-Protein Interactions regulate cellular excitability
Regulation of plasma membrane phosphoinositide-dependent ion channel function, the focus of Dr. Dickson’s hypothesis-driven research program, entails an astonishingly beautiful set of cellular signaling events enchained through time and space. Without the signals these electrically gated ‘pores’ generate, in the peripheral membrane of cells, we would not be able to carry out even the most fundamental of tasks including speaking, listening, or learning. Dr. Dickson’s research group's long-term goals are to understand the molecular mechanisms underlying signaling at diverse membrane surfaces and to explain how these mechanisms are linked to changes in ion channel function, broader cellular programs of gene expression, and signal transduction. The Dickson Laboratory's appraoch to science is multi-disciplinary, involving state-of-the-art biophysical, electrophysiological, imaging, cellular, molecular, and computational approaches. His laboratory uses optical imaging and electrophysiology, together with newly developed mass spectrometry and super resolution approaches to study how signaling nano-domains control the function of plasma membrane ion channels during physiological and pathological conditions.
Current research projects in the Dickson lab investigate how misregulation of ion channel function, calcium signaling, and lipid metabolism occur in several different neurodegenerative disorders.
Grad Group Affiliations
- Molecular, Cellular and Integrative Physiology
Specialties / Focus
- Cellular Physiology
- Molecular Physiology
- HPH 400
- MCP 210L
- American Society for Cell Biology (ASCB)
- Biophysical Society
- 2009 PhD Cellular and Molecular Physiology and Pharmacology
Dixon RE, Vivas O, Hannigan KI, Dickson EJ.
J Vis Exp. 2017 Nov 5;(129). doi: 10.3791/56239.
Adv Exp Med Biol. 2017;997:95-109. doi: 10.1007/978-981-10-4567-7_7.
J Cell Biol. 2017 Jul 3;216(7):1879-1881. doi: 10.1083/jcb.20170604
Dickson EJ, Jensen JB, Vivas O, Kruse M, Traynor-Kaplan AE, Hille B.
J Cell Biol. 2016 Apr 11;213(1):33-48. doi: 10.1083/jcb.201508106
Traynor-Kaplan A, Kruse M, Dickson EJ, Dai G, Vivas O, Yu H, Whittington D, Hille B.
Biochim Biophys Acta. 2017 May;1862(5):513-522. doi: 10.1016/j.bbalip.2017.02.002. Epub 2017 Feb 9.