Eamonn Dickson

Eamonn Dickson

Position Title
Assistant Professor

Unit
Department of Physiology and Membrane Biology, School of Medicine


Bio

Research Interests

Lipid-Protein Interactions regulate cellular excitability

Regulation of plasma membrane phosphoinositide-dependent ion channel function, the focus of Dr. Dickson’s hypothesis-driven research program, entails an astonishingly beautiful set of cellular signaling events enchained through time and space. Without the signals these electrically gated ‘pores’ generate, in the peripheral membrane of cells, we would not be able to carry out even the most fundamental of tasks including speaking, listening, or learning. Dr. Dickson’s research group's long-term goals are to understand the molecular mechanisms underlying signaling at diverse membrane surfaces and to explain how these mechanisms are linked to changes in ion channel function, broader cellular programs of gene expression, and signal transduction. The Dickson Laboratory's appraoch to science is multi-disciplinary, involving state-of-the-art biophysical, electrophysiological, imaging, cellular, molecular, and computational approaches. His laboratory uses optical imaging and electrophysiology, together with newly developed mass spectrometry and super resolution approaches to study how signaling nano-domains control the function of plasma membrane ion channels during physiological and pathological conditions.

Neurodegenerative Disorders

Current research projects in the Dickson lab investigate how misregulation of ion channel function, calcium signaling, and lipid metabolism occur in several different neurodegenerative disorders.

Grad Group Affiliations

  • Molecular, Cellular and Integrative Physiology

Specialties / Focus

  • Cellular Physiology
  • Molecular Physiology
  • Neurophysiology

Courses

  • HPH 400
  • MCP 210L

Professional Societies

  • American Society for Cell Biology (ASCB)
  • Biophysical Society

Degrees

  • 2009 PhD Cellular and Molecular Physiology and Pharmacology

Publications

Ground State Depletion Super-resolution Imaging in Mammalian Cells.

Dixon RE, Vivas O, Hannigan KI, Dickson EJ.

J Vis Exp. 2017 Nov 5;(129). doi: 10.3791/56239.

Endoplasmic Reticulum-Plasma Membrane Contacts Regulate Cellular Excitability.

Dickson EJ.

Adv Exp Med Biol. 2017;997:95-109. doi: 10.1007/978-981-10-4567-7_7.

RASSF4: Regulator of plasma membrane PI(4,5)P2.

Dickson EJ.

J Cell Biol. 2017 Jul 3;216(7):1879-1881. doi: 10.1083/jcb.20170604

Dynamic formation of ER-PM junctions presents a lipid phosphatase to regulate phosphoinositides.

Dickson EJ, Jensen JB, Vivas O, Kruse M, Traynor-Kaplan AE, Hille B.

J Cell Biol. 2016 Apr 11;213(1):33-48. doi: 10.1083/jcb.201508106

Fatty-acyl chain profiles of cellular phosphoinositides.

Traynor-Kaplan A, Kruse M, Dickson EJ, Dai G, Vivas O, Yu H, Whittington D, Hille B.

Biochim Biophys Acta. 2017 May;1862(5):513-522. doi: 10.1016/j.bbalip.2017.02.002. Epub 2017 Feb 9.

PMID:28189644

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