Edward Schelegle

Edward Schelegle

Position Title

Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine

2023 VM3B

Profile Introduction

Directs a translational program that examines how environmental factors affect human lung health. This translational program includes both animal and human studies. My primary research interest is pulmonary neurophysiology with a focus on the role that lung vagal afferents play in the control of breathing, epithelial injury, inflammation and repair in models of acute and chronic lung injury and/or disease. Publications in this area examine the contribution of pulmonary afferents to the altered breathing pattern, epithelial injury, inflammation and repair in animal models of acute airway injury. Specifically these studies address how the release of the neuropeptides, substance P and calcitonin gene related peptide (CGRP), from sensory lung afferents during and following acute lung injury orchestrate non-apoptotic programmed cell death in distal conducting airways and are required for the normal proliferation of epithelial cells in both proximal and distal airways. Human studies have focused on the mechanism of response to acute oxidant stress and markers of diseases involving the airway and pulmonary vasculature. As a Core Scientist Exposure Core at the California National Primate Research Center I have utilized primates to examine questions that are informed by observations made in rodent and human clinical studies. As a result of this effort I played a key role in developing models of adult and childhood asthma, and COPD using Rhesus macaques. The majority of my effort using nonhuman primates has been contributing to the design and execution of studies that examined the effect of early-life exposure to ozone on asthma severity.

Research Interests

Integrated lung defense mechanisms. Lung vagal afferents in airway and pulmonary injury, repair and immunologic responses. Respiratory and cardiovascular physiology.

Grad Group Affiliations

  • Immunology, Comparative Pathology
  • Molecular, Cellular and Integrative Physiology
  • Pharmacology and Toxicology (PTX)

Specialties / Focus

  • Cardiorespiratory Physiology
  • Comparative Physiology
  • Exercise Physiology
  • Integrative Physiology
  • Neurophysiology
  • Renal Physiology
  • Systemic Physiology


  • VET 409 Urinary Tract Structure, Function and Pathophysiology, Fall
  • VET 408 Cardiorespiratory Structure, Function and Pathophysiology, Fall
  • NPB 123 Comparative Organology, Fall
  • APC 100 Comparative Organology, Fall


  • Human Performance Laboratory
  • California National Primate Research Center Inhalation Exposure Facility

Field Sites

  • Antafagasta, Chile

Professional Societies

  • American Physiologic Society
  • American Thoracic Society
  • Society of Toxicology


  • 1988 Ph.D. Cardiorespiratory Physiology and Environmental Toxicology University of California, Davis


Complete List of 108 Published Peer-Reviewed Manuscripts in MyBibliography: