Department of Nutrition, College of Agricultural and Environmental Sciences
Department of Internal Medicine, School of Medicine
Molecular and cellular basis of obesity and diabetes
Molecular and cellular basis of obesity and diabetes
Dr. Haj’s laboratory studies the molecular basis of metabolic diseases with a focus on type 2 diabetes and its complications. The team investigates the role of key signaling molecules, namely protein tyrosine phosphatases and their interacting partners, in metabolic regulation. This is achieved through the combined use of cellular, biochemical, gene knockout and system biology approaches.
Grad Group Affiliations
- Biochemistry, Molecular, Cellular and Developmental Biology
- Molecular, Cellular and Integrative Physiology
- Nutrition Graduate Group
Specialties / Focus
- Cellular Physiology
- Metabolic Physiology
- Molecular Physiology
- Systemic Physiology
- 4306 Meyer Hall
- MingFo Hsu (Assistant Project Scientist), Shinichiro Koike (postdoctoral fellow), Aline Mello (graduate student)
Honors and Awards
- Harvard University, Certificate of Excellence in Research, 2001
- American Diabetes Association Junior Faculty Award, 2006
- University of California Davis, Hellman Fellow, 2008
- American Diabetes Association
- American Society for Cell Biology
- North American Association for the Study of Obesity
- American Diabetes Association (Community Leadership Board Member)
- 1999 D.Phil. Physiology Oxford University
Fawaz Haj, Peter Verveer, Anthony Squire, Benjamin Neel and Philippe Bastiaens (2002). Imaging sites of receptor dephosphorylation by PTP1B on the surface of the endoplasmic reticulum. Science. Mar, 295 (5560): 1708-11.
Janice Zabolotny, Kendra Bence, Alain Stricker-Krongrad, Fawaz Haj, Young-Ping Wang, Yasuhiko Minokoshi, Young-Bum Kim, Joel Elmquist, Luois Tartaglia, Barbara Kahn, Benjamin Neel (2002). PTP1B regulates leptin signal transduction in vivo. Developmental Cell. Apr, 2 (4): 489-95.
Fawaz Haj, Boyka Markova, Lori Klaman, Frank Bohmer and Benjamin Neel (2003). Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B. Journal of Biological Chemistry. Jan 10, 278 (2): 739-44.
Gustavo Sajnani-Perez, John Chilton, Radu Aricescu, Fawaz Haj, Andrew Stoker (2003). Isoform-specific binding of the tyrosine phosphatase PTPs to a ligand in developing muscle. Molecular and Cellular Neuroscience. Jan, 22 (1): 37-48.
Jake Kushner, Fawaz Haj, Lori Klaman, Mathew Dow, Barbara Kahn, Benjamin Neel and Morris White (2004). Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice. Diabetes. Jan, 53 (1): 61-66.
Camilla Persson, Catrine Svenhed, Annie Bourdeau, Michel Tremblay, Boyka Markova, Frank Bhmer, Fawaz Haj, Benjamin Neel, Carl-Henrik Heldin, Lars Rnnstrand, Arne stman and Carina Hellberg (2004). Site-selective regulation of platelet growth factor b receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase. Molecular and Cellular Biology. Mar 1, 24 (5): 2190-2201.
Janice Zabolotny, Fawaz Haj, Jason Kim, Young-Bum Kim, Gerald Shulman, Barbara Kahn and Benjamin Neel (2004). Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action. Journal of Biological Chemistry. Jun 4, 279 (23): 24844-51.
Sandra Galic, Christine Hauser, Barbara Kahn, Fawaz Haj, Benjamin Neel, Nicholas Tonks, and Tony Tiganis (2005). Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP. Molecular and Cellular Biology. Jan, 25 (2): 819-29.
Fawaz Haj, Janice Zabolotny, Young-Bum Kim, Barbara Kahn and Benjamin Neel (2005). Liver-specific re-expression of protein-tyrosine phosphatase 1B reverses insulin sensitivity in PTP1B knockout mice. Journal of Biological Chemistry. Apr 15, 280 (15): 15038-46.
Shrikrishna Dadke, Sophie Cotteret, Shu-Chin Yip, Zahara Jaffer, Fawaz Haj, Alexey Ivanov, Frank Rauscher III, Ke Shuai, Tony Ng, Benjamin Neel, and Jonathan Chernoff (2007). Regulation of protein-tyrosine phosphatase 1B through sumoylation. Nature Cell Biology. Jan, 9(1): 80-85.
Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues. Xue B, Pulinilkunnil T, Murano I, Bence KK, He H, Minokoshi Y, Asakura K, Lee A, Haj F, Furukawa N, Catalano KJ, Delibegovic M, Balschi JA, Cinti S, Neel BG, Kahn BB. Mol Cell Biol. 2009 Aug;29(16):4563-73. Epub 2009 Jun 15.
Altered glucose homeostasis in mice with liver-specific deletion of Src homology phosphatase 2. Matsuo K, Delibegovic M, Matsuo I, Nagata N, Liu S, Bettaieb A, Xi Y, Araki K, Yang W, Kahn BB, Neel BG, Haj FG. J Biol Chem. 2010 Dec 17;285(51):39750-8. Epub 2010 Sep 14.
PTP1B regulates Eph receptor function and trafficking. Nievergall E, Janes PW, Stegmayer C, Vail ME, Haj FG, Teng SW, Neel BG, Bastiaens PI, Lackmann M. J Cell Biol. 2010 Dec 13;191(6):1189-203. Epub 2010 Dec 6.
Differential regulation of endoplasmic reticulum stress by protein tyrosine phosphatase 1B and T cell protein tyrosine phosphatase. Bettaieb A, Liu S, Xi Y, Nagata N, Matsuo K, Matsuo I, Chahed S, Bakke J, Keilhack H, Tiganis T, Haj FG. J Biol Chem. 2011 Jan 7. [Epub ahead of print]
Adipose-specific deletion of Src homology phosphatase 2 does not significantly alter systemic glucose homeostasis. Bettaieb A, Matsuo K, Matsuo I, Nagata N, Chahed S, Liu S, Haj FG. Metabolism. 2011 Feb 24. [Epub ahead of print]
Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance. Luria A, Bettaieb A, Xi Y, Shieh GJ, Liu HC, Inoue H, Tsai HJ, Imig JD, Haj FG, Hammock BD. Proc Natl Acad Sci U S A. 2011 May 31;108(22):9038-43. Epub 2011 May 12.
Regulation of brown fat adipogenesis by protein tyrosine phosphatase 1B. Matsuo K, Bettaieb A, Nagata N, Matsuo I, Keilhack H, Haj FG. PLoS One. 2011 Jan 31;6(1):e16446.
Subcutaneous administration of leptin normalizes fasting plasma glucose in obese type 2 diabetic UCD-T2DM rats. Cummings BP, Bettaieb A, Graham JL, Stanhope KL, Dill R, Morton GJ, Haj FG, Havel PJ. Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14670-5. Epub 2011 Aug 22.