Glenn Yiu

Glenn Yiu

Position Title
Associate Professor

Unit
Department of Ophthalmology and Vision Science, School of Medicine

Tupper Hall 2403
Bio

Research Interests

Translational Retinal Research employing advanced ocular imaging, optogenetics, nanotechnology, and genome editing to develop therapies for age-related macular degeneration and other diseases of the retina.

Short paragraph with details on research interest

Grad Group Affiliations

  • Biochemistry, Molecular, Cellular, and Developmental Biology 

Specialties / Focus

  • Vision
  • Translational Science
  • Cell Biology
  • Molecular Medicine
  • Neurobiology

Courses

  • OPT442 "Intro to Ophthalmology"
  • OPT465 "Advanced Subspecialty in Ophthalmology"
  • NPB261C "Clinical Vision Science"
  • NSC298 "Neuroscience Group Study"

Honors and Awards

  • Summa Cum Laude, Columbia University
  • Cum Laude, Harvard Medical School
  • Heed Ophthalmic Foundation Fellowship Award
  • Ronald G. Michels Foundation Fellowship Award
  • Retina Society Fellowship Research Award
  • Evangelos S. Gragoudas Award, Macula Society
  • NAEVR Emerging Vision Scientist

    Professional Societies

    • Association for Research in Vision & Ophthalmology (ARVO)
    • American Academy of Ophthalmology (AAO)
    • American Society of Retina Specialists (ASRS)
    • International Society for Eye Research (ISER)
    • Macula Society
    • Retina Society

    Degrees

    • M.D.
    • Ph.D.

    Publications

    Moshiri A, Chen R, Kim S, Harris RA, Li Y, Raveendran M, Davis S, Liang Q, Pomerantz O, Wang J, Garzel L, Cameron A, Yiu G, Stout JT, Huang Y, Murphy CJ, Roberts J, Gopalakrishna KN, Boyd K, Artemyev NO, Rogers J, Thomasy SM. A Non-Human Primate Model of Inherited Retinal Disease. J Clin Invest. 2019 Jan 22. pii: 123980. doi: 10.1172/JCI123980. (PMID: 30667376)

    Smit-McBride Z, Nguyen J, Elliott GW, Wang Z, McBride RA, Nguyen AT, Oltjen SL, Yiu G, Thomasy SM, Pinkerton KE, Lee ES, Cunefare D, Farsiu S, Morse LS. Effects of aging and environmental tobacco smoke exposure on ocular and plasma circulatory microRNAs in the Rhesus macaque. Mol Vis. 2018 Sep 24;24:633-646. (PMID: 30294202)

    Snyder K, Yazdanyar A, Mahajan A, Yiu G. Association Between the Cilioretinal Artery and Choroidal Neovascularization in Age-Related Macular Degeneration: A Secondary Analysis From the Age-Related Eye Disease Study. JAMA Ophthalmol. 2018 Sep 1;136(9):1008-1014. doi: 10.1001/jamaophthalmol.2018.2650. (PMID: 29978186)

    Yiu G, Wang Z, Munevar C, Tieu E, Shibata B, Wong B, Cunefare D, Farsiu S, Roberts J, Thomasy S. Comparison of chorioretinal layers in rhesus macaques using spectral-domain optical coherence tomography and high-resolution histological sections. Exp Eye Res. 2018 Mar;168:69-76. doi: 10.1016/j.exer.2018.01.012. (PMID: 29352993)

    Willoughby AS, Vuong VS, Cunefare D, Farsiu S, Noronha G, Danis RP, Yiu G. Choroidal Changes after Suprachoroidal Injection of Triamcinolone in Eyes with Macular Edema secondary to Retinal Vein Occlusion. Am J Ophthalmol. 2018 Feb;186:144-151. doi: 10.1016/j.ajo.2017.11.020. (PMID: 29199012)
    Yiu G. CRISPR-based Genome Editing in Retinal Diseases. Ophthamol. Retina. 2018 Jan; 2(1): 1-3. doi: 10.1016/j.oret.2017.09.015.

    Wong SS, Vuong VS, Cunefare D, Farsiu S, Moshiri A, Yiu G. Macular fluid reduces reproducibility of choroidal thickness measurements on enhanced depth optical coherence tomography. Am J Ophthalmol. 2017 Dec;184:108-114. doi: 10.1016/j.ajo.2017.10.005. (PMID: 29038011)

    Yiu G, Tieu E, Munevar C, Wong B, Cunefare D, Farsiu S, Garzel L, Roberts J, Thomasy SM. In Vivo Multimodal Imaging of Drusenoid Lesions in Rhesus Macaques. Sci Rep. 2017 Nov 3;7(1):15013. doi: 10.1038/s41598-017-14715-z. (PMID: 29101353)

    Yiu G, Vuong VS, Oltjen S, Cunefare D, Farsiu S, Garzel L, Roberts J, Thomasy SM. Effect of Uveal Melanocytes on Choroidal Morphology in Rhesus Macaques and Humans on Enhanced-Depth Imaging Optical Coherence Tomography. Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5764-5771. doi: 10.1167/iovs.16-20070. (PMID: 27792810)

    Yiu G, Tieu EV, Nguyen AT, Wong B, Smit-McBride Z. Genomic Disruption of VEGF-A Expression in Human Retinal Pigment Epithelial Cells using CRISPR-Cas9 Endonuclease. Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5490-5497. doi: 10.1167/iovs.16-20296. (PMID: 27768202)

    Vuong VS, Moisseiev E, Cunefare D, Farsiu S, Moshiri A, Yiu G. Repeatability of Choroidal Thickness Measurements on Enhanced Depth Imaging OCT using Different Posterior Boundaries. Am J Ophthalmol. 2016 Sep;169:104-12. doi: 10.1016/j.ajo.2016.06.023. (PMID: 27345731)

    Yiu G, Chiu SJ, Petrou PA, Stinnett S, Sarin N, Farsiu S, Chew EY, Wong WT, Toth CA. Relationship of Central Choroidal Thickness with Age-Related Macular Degeneration Status. Am J Ophthalmol. 2015 Apr;159(4):617-26. doi: 10.1016/j.ajo.2014.12.010. (PMID: 25526948)

    Yiu G, Manjunath V, Chiu SJ, Farsiu S, Mahmoud TH. Effect of Anti-Vascular Endothelial Grown Factor Therapy on Choroidal Thickness in Diabetic Macular Edema. Am J Ophthalmol. 2014 Oct;158(4):745-751.e2. doi: 10.1016/j.ajo.2014.06.006. (PMID: 24952275)

    Yiu G, Pecen P, Sarin N, Chiu SJ, Farsiu S, Mruthyunjaya P, Toth CA. Characterization of the Choroid-Scleral Junction and Suprachoroidal Layer in Healthy Individuals on Enhanced-Depth Imaging Optical Coherence Tomography. JAMA Ophthalmol. 2014 Feb;132(2):174-81. doi: 10.1001/jamaophthalmol.2013.7288. (PMID: 24336985)

    Kaneko S, Wang J, Kaneko M, Yiu G, Hurrell JM, Chitnis T, Khoury SJ, He Z. Protecting axonal degeneration by increasing nicotinamide adenine dinucleotide levels in experimental autoimmune encephalomyelitis models. J Neurosci. 2006 Sep 20;26(38):9794-804. (PMID: 16988050)

    Yiu G, He Z. Glial Inhibition of CNS Axon Regeneration. Nat Rev Neurosci. 2006 Aug; 7(8):617-27. (PMID: 16858390)

    Koprivica V, Cho KS, Park JB, Yiu G, Atwal J, Gore B, Kim JA, Lin E, Tessier-Lavigne M, Chen DF, He Z. EGFR Activation Mediates Inhibition of Axon Regeneration by Myelin and Chondroitin Sulfate Proteoglycans. Science. 2005 Oct 7;310(5745):106-10. (PMID: 16210539)

    Park JB*, Yiu G* (*these authors contribute equally), Kaneko S, Wang J, Chang J, He Z. A TNF Receptor Family Member, TROY, is a Coreceptor with Nogo Receptor in Mediating the Inhibitory Activity of Myelin Inhibitors. Neuron. 2005 Feb 3;45(3):345-51. Cover Article. (PMID: 15694321)

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