Helen Raybould

Helen Raybould

Position Title
Professor

Unit
Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine

2021 Vet Med 3B
Bio

Profile Introduction

Neural innervation of the gastrointestinal tract, in particular, the primary afferent innervation. Gut microbiota.

Research Interests

Neural innervation of the gastrointestinal tract

Vagal afferent neurons, including their role in GI physiology and food intake.  Research is also looking at how the phenotype of these neurons change in obesity and metabolic disease.

Gut Microbiota

Influence of gut microbiota on GI physiology, including gut epithelium and intestinal barrier function and on plasticity in vagal afferent neurons

Grad Group Affiliations

  • Molecular, Cellular and Integrative Physiology
  • Nutrition

Specialties / Focus

  • Endocrinology
  • Metabolic Physiology
  • Systemic Physiology

Honors and Awards

  • The Physiological Society - Bayliss and Starling Prize Lectureship
  • Zoetis Excellence in Research Award

    Professional Societies

    • American Physiological Society
    • Society for the Study of Ingestive Behavior
    • American Gastroenterological Association

    Degrees

    • 1977 BS Biological Sciences University of Birmingham, United Kingdom
    • 1986 PhD Physiology University of Liverpool, United Kingdom

    Publications

    de Lartigue G, Ronveaux CC, Raybould HE. Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity. Mol Metab. 2014; 3: 595-607. PubMed Central PMCID: PMC4142400.

    Hamilton MK, Boudry G, Lemay DG, Raybould HE. Changes in intestinal barrier function and gumicrobiota in high-fat diet fed rats are dynamic and region-dependent. Am J Physiol Gastrointest Liver Physiol. 2015; 308: G840-51. PubMed PMID: 25747351.

    Boudry G, Hamilton MK, Maciej Chichlowski M, Wickramasinghe S, Barile D, Kalanetra KM, Mills DA and Raybould HE. Bovine milk oligosaccharides decrease gut permeability and improve inflammation and microbial dysbiosis in diet-induced obese mice. J. Diary Science (2016).

    Moran-Ramos S, He X, Chin EL, Tovar AR, Torres N, Slupsky CM, Raybould HE. Nopal feeding reduces adiposity, intestinal inflammation and shifts the cecal microbiota and metabolism in high-fat fed rats. PLoS One 2017; 12(2): e0171672. PMID: 28196086.

    Hamilton MK, Ronveaux CC, Rust BM, Newman JW, Hawley M, Barile D, Mills DA, Raybould HE. Prebiotic milk oligosaccharides prevent development of obese phenotype, impairment of gut permeability and microbial dysbiosis in high-fat fed mice. Am J Physiol Gastrointest Liver Physiol. 2017 Mar 9:ajpgi.00427.2016. [Epub ahead of print] PMID: 28280143.

    Raybould HE. Gut microbiota, epithelial function and derangements in obesity. J Physiol. 2012; 590(Pt 3):441-6. PMID:22183718

    Chichlowski M, De Lartigue G, German JB, Raybould HE, Mills DA. Bifidobacteria isolated from infants and cultured on human milk oligosaccharides affect intestinal epithelial function.J Pediatr Gastroenterol Nutr. 2012 Sep;55(3):321-7. PMID: 22383026

    de Lartigue G, Barbier de la Serre C, Espero E, Lee J, Raybould HE. Leptin resistance in vagal afferent neurons inhibits cholecystokinin signaling and satiation in diet induced obese rats. PLoS One. 2012;7(3):e32967. PMID: 22412960

    Ronveaux CC, de Lartigue G, Raybould HE. Ability of GLP-1 to decrease food intake is dependent on nutritional status. Physiol Behav. 2014 135:222-9. PMID: 24955496

    de Lartigue G, Ronveaux CC, Raybould HE. Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity. Mol Metab. 2014 3(6):595-607. PMID: 25161883

    de La Serre CB, de Lartigue G, Raybould HE. Chronic exposure to Low dose bacterial lipopolysaccharide inhibits leptin signaling in vagal afferent neurons. Physiol Behav. 2015 139:188-94.  PMID:  25446227

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