Iannis E. Adamopoulos

Iannis Adamopoulos

Position Title
Associate Professor

Department of Internal Medicine, School of Medicine
Department of Internal Medicine (Rheumatology, Allergy and Clinical Immunology), School of Medicine

2425 Stockton Boulevard, Shriners Hospital, Sacramento CA 95817

Research Interests



Osteoimmunology: the interactions of the immune and skeletal systems that lead in the development of autoimmune and musculoskeletal diseases including inflammatory arthritis, rheumatoid arthritis and osteoporosis.


Grad Group Affiliations

  • Biochemistry, Molecular, Cellular and Developmental Biology
  • Graduate Group in Immunology

Specialties / Focus

  • Cell Biology
  • Molecular Medicine


  • 2007 DPhil Wolfson College, Oxford University
  • 2003 MPhil University College London


L Bouchareychas, E Grössinger, M Kang, H Qiu, IE Adamopoulos*. Critical role of LTB4/BLT1 in IL-23 induced synovial inflammation and osteoclastogenesis via NFκB Journal of Immunology 2016 Nov 28. pii: 1601346. [Epub ahead of print]

E Suzuki, E Maverakis, R Sarin, L. Bouchareychas, V Kuchroo, FO Nestle, IE Adamopoulos*. NETosis and selective autophagy-linked FYVE protein Wdfy3 are critical for IL-17A-mediated epidermal hyperplasia Journal of Immunology. 2016 Dec 1;197(11):4403-4412 

DJ Wu, R Gu, R Sarin, R Zavodovskaya, CP Chen, BA Christiansen, IE Adamopoulos*. Autophagy-linked FYVE containing protein WDFY3 interacts with TRAF6 and modulates RANKL-induced osteoclastogenesis. J.Autoimmun. 2016 Sep;73:73-84

*IE Adamopoulos, Suzuki E, Chao CC, Gorman D, Adda S, Maverakis E, Zarbalis K, Geissler R, Asio A, Blumenschein WM, McClanahan T, de Waal Malefyt R, Gershwin ME, EP Bowman. IL-17A induces bone destruction and epidermal hyperplasia associated with psoriatic arthritis. Annals of Rheumatic Diseases 2015 Jun 74(6):1284-92

*IE Adamopoulos and ED Mellins. Arthritis: Alternative Pathways of Osteoclast Differentiation in Inflammatory Arthritis. Nature Rheumatology Reviews 2015 Mar;11(3):189-194 

HS Shin, R Sarin, N Dixit, J Wu, ME Gershwin, EP Bowman and *IE Adamopoulos. Crosstalk among IL-23, MDL-1 and DAP12-dependent pathways promotes bone destruction in inflammatory arthritis.  Journal of Immunology 2015 Jan 1;194(1):316-24

LA Orosco, SL Cates, AP Ross, J Sohn, D Pleasure, SJ Pleasure, IE Adamopoulos, KS Zarbalis. Loss of Wdfy3 in mice results in abnormal cortical neurogenesis reflecting aspects of the autism pathology. Nature Communications 2014 Sep 8;5:4692. doi: 10.1038/ncomms5692.

*IE Adamopoulos, M Tessmer, CC Chao, S Adda, D Gorman, M Petro, CC Chu, RH Pierce, W Yao, NE Lane, D Laface, *EP Bowman. IL-23 is critical for the induction of arthritis, osteoclast formation and maintenance of bone mass. Journal of Immunology 2011 15:187(2):951-9.

B Joyce-Shaikh, M Bigler, CC Chao, E Murphy, IE Adamopoulos, P Heyworth, E Bowman, T McClanahan, J. Phillips and DJ Cua*. Myeloid DAP12- associating lectin (MDL)-1 receptor regulates synovial inflammation and bone erosion associated with autoimmune arthritis. Journal of Experimental Medicine 2010 Mar 15;207(3):579-89.