Research Interests

Osteoimmunology

Osteoimmunology: the interactions of the immune and skeletal systems that lead in the development of autoimmune and musculoskeletal diseases including inflammatory arthritis, rheumatoid arthritis and osteoporosis.

Grad Group Affiliations

• Biochemistry, Molecular, Cellular and Developmental Biology
• Graduate Group in Immunology

Specialties / Focus

• Cell Biology
• Molecular Medicine

Degrees

• 2007 DPhil Wolfson College, Oxford University
• 2003 MPhil University College London

Publications

L Bouchareychas, E Grössinger, M Kang, H Qiu, IE Adamopoulos*. Critical role of LTB4/BLT1 in IL-23 induced synovial inflammation and osteoclastogenesis via NFκB Journal of Immunology 2016 Nov 28. pii: 1601346. [Epub ahead of print]

E Suzuki, E Maverakis, R Sarin, L. Bouchareychas, V Kuchroo, FO Nestle, IE Adamopoulos*. NETosis and selective autophagy-linked FYVE protein Wdfy3 are critical for IL-17A-mediated epidermal hyperplasia Journal of Immunology. 2016 Dec 1;197(11):4403-4412 

DJ Wu, R Gu, R Sarin, R Zavodovskaya, CP Chen, BA Christiansen, IE Adamopoulos*. Autophagy-linked FYVE containing protein WDFY3 interacts with TRAF6 and modulates RANKL-induced osteoclastogenesis. J.Autoimmun. 2016 Sep;73:73-84

*IE Adamopoulos, Suzuki E, Chao CC, Gorman D, Adda S, Maverakis E, Zarbalis K, Geissler R, Asio A, Blumenschein WM, McClanahan T, de Waal Malefyt R, Gershwin ME, EP Bowman. IL-17A induces bone destruction and epidermal hyperplasia associated with psoriatic arthritis. Annals of Rheumatic Diseases 2015 Jun 74(6):1284-92

*IE Adamopoulos and ED Mellins. Arthritis: Alternative Pathways of Osteoclast Differentiation in Inflammatory Arthritis. Nature Rheumatology Reviews 2015 Mar;11(3):189-194 

HS Shin, R Sarin, N Dixit, J Wu, ME Gershwin, EP Bowman and *IE Adamopoulos. Crosstalk among IL-23, MDL-1 and DAP12-dependent pathways promotes bone destruction in inflammatory arthritis.  Journal of Immunology 2015 Jan 1;194(1):316-24

LA Orosco, SL Cates, AP Ross, J Sohn, D Pleasure, SJ Pleasure, IE Adamopoulos, KS Zarbalis. Loss of Wdfy3 in mice results in abnormal cortical neurogenesis reflecting aspects of the autism pathology. Nature Communications 2014 Sep 8;5:4692. doi: 10.1038/ncomms5692.

*IE Adamopoulos, M Tessmer, CC Chao, S Adda, D Gorman, M Petro, CC Chu, RH Pierce, W Yao, NE Lane, D Laface, *EP Bowman. IL-23 is critical for the induction of arthritis, osteoclast formation and maintenance of bone mass. Journal of Immunology 2011 15:187(2):951-9.

B Joyce-Shaikh, M Bigler, CC Chao, E Murphy, IE Adamopoulos, P Heyworth, E Bowman, T McClanahan, J. Phillips and DJ Cua*. Myeloid DAP12- associating lectin (MDL)-1 receptor regulates synovial inflammation and bone erosion associated with autoimmune arthritis. Journal of Experimental Medicine 2010 Mar 15;207(3):579-89.