Jerold Last

Position Title

Department of Internal Medicine (Pulmonary, Critical Care and Sleep Medicine), School of Medicine

6519 GBSF

Research Interests

Lung Biochemistry: Asthma, Air Pollution, and Lung Fibrosis

We study lung biochemistry and inflammation in mouse models of asthma and in mice exposed to particulate air pollutants.  I also have a long-standing interest in changes in lung collagen accompanying fibrotic lung diseases in animal models and human tissue.

Grad Group Affiliations

  • Biochemistry, Molecular, Cellular and Developmental Biology
  • Pharmacology and Toxicology

Specialties / Focus

  • Biochemistry
  • Cellular Responses to Toxins and Stress
  • Genomics, Proteomics and Metabolomics
  • Molecular Medicine


  • 6519 Genomics Building
    • Lisa Franzi, Angela Linderholm

Field Sites

  • National University of Argentina, Salta
  • Universidad de la Republica, Montevideo, Uruguay

Honors and Awards

  • Fulbright Scholar, Uruguay (1982 and 1999), Argentina (1999)
  • Frank R. Blood Award, Society of Toxicology
  • ICI/Zeneca Traveling Scholar Award, Society of Toxicology
  • School of Medicine: Faculty Research Award and Joan Oettinger Memorial Research Award
  • UCD Distinguished Public Service Award, 2003
  • Gaspar de Portola Lectureship, Barcelona, 2000

    Professional Societies

    • ASBMB
    • Society of Toxicology


    • 1959 BS Chemistry University of Wisconsin
    • 1961 MS Biochemistry University of Wisconsin
    • 1965 PhD Ohio State University


    Williams KM, Franzi LM, Last JA. Cell-specific oxidative stress and cytotoxicity after wildfire coarse particulate matter instillation into mouse lung. Toxicol Appl Pharmacol. 2013 Jan 1; 266(1):48-55.

    Morel, N, Lassabe G, Elola S, Herrera S, Mari C, Last JA, Jensen O, Gozalez-Sapienza G.  (2013) A Monoclonal Antibody-Based Copro-ELISA Kit for Canine Echinococcosis to Support the PAHO Effort for Hydatid Disease Control in South America. PLOS Neglected Tropical Diseases, 7(1): e1967. doi:10.1371/journal.pntd.0001967.

    Rossotti M, Carlomagno, M, Gonzalez-Techera A, Hammock B, Last, J, Gonzalez-Sapienza, G. (2010) Phage Anti-Immunocomplex Assay (PHAIA) for clomazone: Two-site recognition increases assay specificity and facilitates adaptation into a rapid on-site format. Analytical Chemistry, 82(21):8838-8843.

    Carlomagno M, Matho C, Cantou, G, Sanborn J, Last J, Hammock B, Roel A, Gonzalez D, Gonzalez-Sapienza, G. (2010) A Clomazone Immunoassay to Study the Environmental Fate of the Herbicide in Rice (Oryza sativa) Agriculture. Journal of Agricultural and Food Chemistry 58:4367-4371. PMID: 20302341

    Zeki AA, Bratt JM, Rabowsky M, Last JA, Kenyon NJ. (2010) Simvastatin Inhibits Goblet Cell Hyperplasia and Lung Arginase in a Mouse Model of Allergic Asthma: A Novel Treatment for Airway Remodeling? Translational Research,156:335-349.

    Bratt JM, Franzi LM, Linderholm AL, O’Roark EM, Kenyon NJ, Last JA. Arginase Inhibition in Airways from Normal and Nitric Oxide Synthase 2-Knockout Mice Exposed to Ovalbumin. Toxicol. Appl. Pharmacol. 2010, 242:1-8. PMID: 19800904

    Zeki AA, Franzi L, Last J, Kenyon NJ. (2009) Simvastatin Inhibits Airway Hyperreactivity: Implications for the Mevalonate Pathway and Beyond. Am J Respir Crit Care Med 180:731-740.

    González-Techera A., Vanrell L., Last J.A., Hammock B.D., and González-Sapienza G. (2007) Phage Anti-Immune Complex Assay: General Strategy for Noncompetitive Immunodetection of Small Molecules. Anal Chem. 79:7799-7806. PMID: 17845007

    Armstrong, L.C. and Last, J.A.. (1995). Rat lysyl hydroxylase: molecular cloning, mRNA distribution, and expression in a baculovirus system. Biochimica et Biophysica Acta. 1264:93-102