Department of Radiation Oncology, School of Medicine
Target mitochondrial metabolism to treat cancer by radiotherapy
Research interests include the study of the molecular mechanisms causing tumor resistance to radiation and chemotherapy. A tumor resistant signaling network regulated by mitochondrial metabolism and a group of proteins that translocate to the mitochondrion are being investigated in an array of human cancers including breast, lung, prostate and liver.
Additional projects are related to radiation-induced adaptive response in normal tissues and in the radiation-resistant cancer stem cells. The goal of these studies is to find effective therapeutic targets to significantly enhance cancer cure rates by radiotherapy.
Grad Group Affiliations
- Biochemistry, Molecular, Cellular and Developmental Biology
- Radiation and Cancer Biology
- 1994 Ph. D. Radiation Biology Graduate School, University of Iowa
- 1984 M.D. (Mater of Medicine) Radiation Medicine Fourth Military Medical University