Profile Introduction

Vascular biology, vascular inflammation, diabetic vasculopathy, lipoproteins, gender effects on the vascular wall pathology, maternal-fetal imprinting

Research Interests

Vascular biology, vascular inflammation, diabetic vasculopathy, lipoproteins, gender effects on the vascular wall pathology, maternal-fetal imprinting

Grad Group Affiliations

• Nutritional Sciences

Labs

• Rutledge Laboratory
  • Robin Altman-MCIP graduate student, Kit Ng-MCIP graduate student, Hnin Hnin Aung-project scientist, Collin Ellis-Nutrition Sciences Graduate student, Al Sarieh-lab technician, Romobia Hutchinson-lab technician

Honors and Awards

• Richard A. and Nora Eccles Harrison Endowed Chair in Diabetes Research
• Dean's Award for Excellence in Mentoring

Professional Societies

• American Heart Association
• American Physiology Society
• American Association for the Advancement of Science

Degrees

• 1972 BA Biology University of Texas
• 1976 MD - Baylor College of Medicine

Publications

Mullick AE, Powers AF, Kota RS, Tetali SD, Eiserich JP, Rutledge JC. Apolipoprotein E3- and nitric oxide-dependent modulation of endothelial cell inflammatory responses. Arterioscler Thromb Vasc Biol 2007;27(2):339-345.

Motton DD, Keim NL, Tenorio FA, Horn WF, Rutledge JC. Postprandial monocyte activation in response to meals with high and low glycemic loads in overweight women. Am J Clin Nutr 2007;85:60-65.

Eiselein L, Wilson D, Lame M. Rutledge JC. Lipolysis products from triglyceride-rich lipoproteins increase endothelial permeability, perturb zonula occludens-1, F-actin, and induce apoptosis. Am J Physiol Heart Circ Physiol 2007 Jan 26;[Epub ahead of print]

Wang L, Sapuri-Butti AR, Aung HH, Parikh AN, Rutledge JC. Triglyceride-rich lipoprotein lipolysis increases aggregation of endothelial cell membrane microdomains and produces reactive oxygen species. Am J Physiol Heart Circ Physiol. 2008. 295(1):H237-44.

Wang L, Gill R, Pedersen TL, Higgins LJ, Newman JW, Rutledge JC. Triglyceride-rich lipoprotein lipolysis releases neutral and oxidized free fatty acids that Induce endothelial cell inflammation. J Lipid Res. 2009; 50, 204-213

Villablanca AC, Tenwolde A, Lee M, Huck M, Mumenthaler S, Rutledge JC. 17beta-Estradiol Prevents Early-Stage Atherosclerosis in Estrogen Receptor-Alpha Deficient Female Mice. J Cardiovasc Transl Res. 2009;2:289-299

Barnholt K, Kota R, Aung HH, Rutledge JC. Adenosine blocks interferon-γ-induced phosphorylation of STAT1 on serine 727 to reduce macrophage activation. Journal of Immunology. 2009;183,6767-6777.