John C. Rutledge

John Rutledge

Position Title
Professor

Unit
Department of Internal Medicine (Cardiology), School of Medicine

Genome and Biomedical Sciences Facility
Bio

Profile Introduction

Vascular biology, vascular inflammation, diabetic vasculopathy, lipoproteins, gender effects on the vascular wall pathology, maternal-fetal imprinting

Research Interests

Vascular biology, vascular inflammation, diabetic vasculopathy, lipoproteins, gender effects on the vascular wall pathology, maternal-fetal imprinting

Grad Group Affiliations

  • Nutritional Sciences

Labs

  • Rutledge Laboratory
    • Robin Altman-MCIP graduate student, Kit Ng-MCIP graduate student, Hnin Hnin Aung-project scientist, Collin Ellis-Nutrition Sciences Graduate student, Al Sarieh-lab technician, Romobia Hutchinson-lab technician

Honors and Awards

  • Richard A. and Nora Eccles Harrison Endowed Chair in Diabetes Research
  • Dean's Award for Excellence in Mentoring

    Professional Societies

    • American Heart Association
    • American Physiology Society
    • American Association for the Advancement of Science

    Degrees

    • 1972 BA Biology University of Texas
    • 1976 MD - Baylor College of Medicine

    Publications

    Mullick AE, Powers AF, Kota RS, Tetali SD, Eiserich JP, Rutledge JC. Apolipoprotein E3- and nitric oxide-dependent modulation of endothelial cell inflammatory responses. Arterioscler Thromb Vasc Biol 2007;27(2):339-345.

    Motton DD, Keim NL, Tenorio FA, Horn WF, Rutledge JC. Postprandial monocyte activation in response to meals with high and low glycemic loads in overweight women. Am J Clin Nutr 2007;85:60-65.

    Eiselein L, Wilson D, Lame M. Rutledge JC. Lipolysis products from triglyceride-rich lipoproteins increase endothelial permeability, perturb zonula occludens-1, F-actin, and induce apoptosis. Am J Physiol Heart Circ Physiol 2007 Jan 26;[Epub ahead of print]

    Wang L, Sapuri-Butti AR, Aung HH, Parikh AN, Rutledge JC. Triglyceride-rich lipoprotein lipolysis increases aggregation of endothelial cell membrane microdomains and produces reactive oxygen species. Am J Physiol Heart Circ Physiol. 2008. 295(1):H237-44.

    Wang L, Gill R, Pedersen TL, Higgins LJ, Newman JW, Rutledge JC. Triglyceride-rich lipoprotein lipolysis releases neutral and oxidized free fatty acids that Induce endothelial cell inflammation. J Lipid Res. 2009; 50, 204-213

    Villablanca AC, Tenwolde A, Lee M, Huck M, Mumenthaler S, Rutledge JC. 17beta-Estradiol Prevents Early-Stage Atherosclerosis in Estrogen Receptor-Alpha Deficient Female Mice. J Cardiovasc Transl Res. 2009;2:289-299

    Barnholt K, Kota R, Aung HH, Rutledge JC. Adenosine blocks interferon-γ-induced phosphorylation of STAT1 on serine 727 to reduce macrophage activation. Journal of Immunology. 2009;183,6767-6777.

    Tags