John Yoon

John Yoon

Position Title
Assistant Professor

Department of Internal Medicine (Endocrinology), School of Medicine

Tupper Hall 2206T

Profile Introduction

Molecular studies of metabolic regulation and human disease

Research Interests

Molecular studies of metabolic regulation and human disease

Dr. Yoon's laboratory is interested in the roles of intercellular signaling pathways in the regulation of cellular metabolism and their impact on physiological and pathological processes, with a particular focus on diabetes mellitus.  In addition to type 2 diabetes, less common types of diabetes due to specific genetic defects are being examined.  Another area of interest is the contribution of mitochondrial defects and inflammatory processes to the development of metabolic disease.  Large-scale genetic screens in muscle cells have been performed to isolate regulators of mitochondrial function and some of the identified genes are being characterized.  Human and mouse cell culture and genetic mouse models are utilized.

Grad Group Affiliations

  • Molecular, Cellular and Integrative Physiology

Specialties / Focus

  • Endocrinology
  • Metabolic Physiology
  • Molecular Physiology

Honors and Awards

  • Leon Reznick Prize for Excellence in Research, Harvard Medical School, 2002
  • Damon Runyon Cancer Research Foundation Fellow, 2007

    Professional Societies

    • American Diabetes Association
    • The Endocrine Society


    • 1990 AB Harvard University
    • 2002 MD PhD Harvard Medical School


    Yoon JC. Evolving mechanistic views and emerging therapeutic strategies for cystic fibrosis-related diabetes. Journal of the Endocrine Society 2017; 1:1386-1400.

    Yoon JC, Ling AL, Isik M, Lee DD, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ. GLTSCR2/PICT-1 links mitochondrial stress and Myc signaling. Proc Natl Acad Sci USA. 2014;111: 3781-3786.

    Davoli T, Xu W, Mengwasser KE, Sack LM, Yoon JC, Park PJ, Elledge SJ. Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell. 2013;155:948-962.

    Yoon JC, Ng A, Kim BH, Bianco A, Xavier RJ, Elledge SJ. Wnt signaling regulates mitochondrial physiology and insulin sensitivity. Genes Dev. 2010;24:1507-1518.

    Puigserver, P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong H, Accili, and Spiegelman BM. Insulin-Regulated Hepatic Gluconeogenesis through FOXO1-PGC-1α Interaction. Nature. 2003;423(6939):550-555.

    Yoon JC, Puigserver P, Chen G, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, and Spiegelman BM. Control of Hepatic Gluconeogenesis through the Transcriptional Coactivator PGC-1. Nature. 2001;413:131-138.