Justin Siegel

Justin Siegel

Position Title

Department of Biochemistry and Molecular Medicine, School of Medicine
Genome Center
Department of Chemistry

GBSF 1402

Research Interests

Computational Enzyme Design

My scientific efforts are focused on combining computational and experimental tools to develop a fundamental knowledge of enzyme catalysis, and applying those principles to design novel proteins of therapeutic or commercial interest. Currently I am working with an international community on the development of Rosetta computational methodology for predicting and designing macromolecular structures, interactions, and functions. Using this methodology I have completed the de novo design of enzymes capable of catalyzing chemical reactions not found in nature, such as the Diels-Alder reaction. This was followed up by working with an online community, Foldit, to further engineer these proteins for enhanced activity. Most recently I have worked on the redesign of naturally occurring enzymes for the degradation of immunogenic gluten proteins, to develop a novel CO2 fixation pathways, and design of a novel anthrax therapeutic. My current focus is on the design of novel biofuel and commodity chemical biosynthetic pathways, the development of novel therapeutics, and the general understanding of the relationship between protein sequence, structure, and function.

Specialties / Focus

  • Biochemistry and Molecular Recognition
  • Computational and Theoretical Biology

Grad Group Affiliations

  • Biochemistry, Molecular, Cellular and Developmental Biology
  • Biophysics
  • Chemistry
  • Integrative Genetics and Genomics


  • 2005 B.S. Biochemistry UC Davis,
  • 2011 Ph.D. Biochemistry University of Washington,