Department of Microbiology and Molecular Genetics
Function of stress MAPK cascade and TOR signaling pathway
My laboratory utilizes fission yeast as a genetically amenable model system to elucidate the regulation and function of the stress MAPK cascade and the TOR (Target Of Rapamycin) signaling pathway.
Grad Group Affiliations
- Biochemistry, Molecular, Cellular, and Developmental Biology
Specialties / Focus
- Molecular Medicine
- BIS 104 Regulation of Cell Function
- MIC 170 Yeast Molecular Genetics
Honors and Awards
- Human Frontier Science Program, Long-term Research Fellow
- American Cancer Society, California Division, Senior Research Fellow
- National Academies Education Fellow in Life Science
- American Society for Cell Biology
- American Association for the Advancement of Science
- 1992 Ph.D. Biochemistry/Molecular Biology, Kyoto University
- 1989 M.S. Biochemistry, Kyoto University
- 1987 B.S. Biology, Kyoto University
Fukuda T and K Shiozaki. 2018. The Rag GTPase-Ragulator complex attenuates TOR complex 1 signaling in fission yeast. Autophagy 14: 1105-1106.
Chia KH, T Fukuda, F Sofyantoro, T Matsuda, T Amai and K Shiozaki. 2017. Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases. eLife 6: e30880.
Tatebe H and K Shiozaki. 2017. Evolutionary conservation of the components in the TOR signaling pathways. Biomolecules 7: e77.
Tatebe H, S Murayama, T Yonekura, T Hatano, D Richter, T Furuya, S Kataoka, K Furuita, C Kojima and K Shiozaki. 2017. Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit. eLife 6: e19594.
Hatano T, S Morigasaki, H Tatebe, K Ikeda and K Shiozaki. 2015. Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose. Cell Cycle 14: 848-856.
Morigasaki S, A Ikner, H Tatebe and K Shiozaki. 2013. Response regulator-mediated MAPKKK heteromer promotes stress signaling to the Spc1 MAPK in fission yeast. Mol. Biol. Cell 24: 1083-1092.
Tatebe H and K Shiozaki. 2010. Rab small GTPase emerges as a regulator of TOR complex 2. Small GTPases 1: 180-182.
Tatebe H, S Morigasaki, S Murayama, CT Zeng and K Shiozaki. 2010. Rab-family GTPase regulates TOR complex 2 signaling in fission yeast. Current Biology 20: 1975-1982.
Morigasaki S and K Shiozaki. 2010. Two-component signaling to the stress MAP kinase cascade in fission yeast. Methods in Enzymology 471: 279-289.
Shiozaki K. 2009. Nutrition-minded cell cycle. Science Signaling 2: pe74
Morigasaki S, K Shimada, A Ikner, M Yanagida and K Shiozaki. 2008. Glycolytic enzyme GAPDH promotes peroxide stress signaling through multistep phosphorelay to a MAPK cascade. Molecular Cell 30: 108-113.
Tatebe H, K Nakano, R Maximo and K Shiozaki. 2008. Pom1 DYRK regulates localization of the Rga4 GAP to ensure bipolar activation of Cdc42 in fission yeast. Current Biology 18: 322-330.
Ikeda K, S Morigasaki, H Tatebe, F Tamanoi and K Shiozaki. 2008. Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control. Cell Cycle 7: 358-364.
Wang L and K Shiozaki. 2006. The fission yeast stress MAPK cascade regulates the pmp3+ gene that encodes a highly conserved plasma membrane protein. FEBS Letter 580: 2409-2413.
Tatebe H, K Shimada, S Uzawa, S Morigasaki and K Shiozaki. 2005. Wsh3/Tea4 is a novel cell-end factor essential for bipolar distribution of Tea1 and protects cell polarity under environmental stress in S. pombe. Current Biology 15: 1006-1015.
Wang L, K Shimada, M Morishita and K Shiozaki. 2005. Response of fission yeast to toxic cations involves cooperative action of the stress-activated protein kinase, Spc1/Sty1, and the Hal4 protein kinase. Molecular and Cellular Biology 25: 3945-3955.
Ikner A and K Shiozaki. 2005. Yeast signaling pathways in the oxidative stress response. Mutation Research 569:13-27.
Tatebe H and K Shiozaki. 2003. Identification of Cdc37 as a novel regulator of the stress-responsive mitogen-activated protein kinase. Molecular and Cellular Biology 23:5132-5142.
Nguyen AN, AD Ikner , M Shiozaki, SM Warren, and K Shiozaki. 2002. Cytoplasmic localization of Wis1 MAPKK by nuclear export signal is important for nuclear targeting of Spc1/Sty1 MAPK in fission yeast. Molecular Biology of the Cell 13:2651-2663.
Santos JL and K Shiozaki. 2001. Fungal histidine kinases. Science's STKE 2001(98): RE1.