Kaz Shiozaki

Kaz Shiozaki

Position Title
Visiting Professor

Department of Microbiology and Molecular Genetics, College of Biological Sciences


Research Interests

Function of stress MAPK cascade and TOR signaling pathway

My laboratory utilizes fission yeast as a genetically amenable model system to elucidate the regulation and function of the stress MAPK cascade and the TOR (Target Of Rapamycin) signaling pathway.

Grad Group Affiliations

  • Biochemistry, Molecular, Cellular, and Developmental Biology

Specialties / Focus

  • Molecular Medicine


  • BIS 104 Regulation of Cell Function
  • MIC 170 Yeast Molecular Genetics

Honors and Awards

  • Human Frontier Science Program, Long-term Research Fellow
  • American Cancer Society, California Division, Senior Research Fellow
  • National Academies Education Fellow in Life Science

Professional Societies

  • American Society for Cell Biology
  • American Association for the Advancement of Science


  • 1992 Ph.D. Biochemistry/Molecular Biology, Kyoto University
  • 1989 M.S. Biochemistry, Kyoto University
  • 1987 B.S. Biology, Kyoto University


  • Fukuda T and K Shiozaki. 2018. The Rag GTPase-Ragulator complex attenuates TOR complex 1 signaling in fission yeast. Autophagy 14: 1105-1106.

  • Chia KH, T Fukuda, F Sofyantoro, T Matsuda, T Amai and K Shiozaki. 2017. Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases. eLife 6: e30880.

  • Tatebe H and K Shiozaki. 2017. Evolutionary conservation of the components in the TOR signaling pathways. Biomolecules 7: e77.

  • Tatebe H, S Murayama, T Yonekura, T Hatano, D Richter, T Furuya, S Kataoka, K Furuita, C Kojima and K Shiozaki. 2017. Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit. eLife 6: e19594.

  • Hatano T, S Morigasaki, H Tatebe, K Ikeda and K Shiozaki. 2015. Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose. Cell Cycle 14: 848-856.

  • Morigasaki S, A Ikner, H Tatebe and K Shiozaki. 2013. Response regulator-mediated MAPKKK heteromer promotes stress signaling to the Spc1 MAPK in fission yeast. Mol. Biol. Cell 24: 1083-1092. 

  • Tatebe H and K Shiozaki. 2010. Rab small GTPase emerges as a regulator of TOR complex 2. Small GTPases 1: 180-182.

  • Tatebe H, S Morigasaki, S Murayama, CT Zeng and K Shiozaki. 2010. Rab-family GTPase regulates TOR complex 2 signaling in fission yeast. Current Biology 20: 1975-1982.

  • Morigasaki S and K Shiozaki. 2010. Two-component signaling to the stress MAP kinase cascade in fission yeast. Methods in Enzymology 471: 279-289.

  • Shiozaki K. 2009. Nutrition-minded cell cycle. Science Signaling 2: pe74

  • Morigasaki S, K Shimada, A Ikner, M Yanagida and K Shiozaki. 2008. Glycolytic enzyme GAPDH promotes peroxide stress signaling through multistep phosphorelay to a MAPK cascade. Molecular Cell 30: 108-113.

  • Tatebe H, K Nakano, R Maximo and K Shiozaki. 2008. Pom1 DYRK regulates localization of the Rga4 GAP to ensure bipolar activation of Cdc42 in fission yeast. Current Biology 18: 322-330.

  • Ikeda K, S Morigasaki, H Tatebe, F Tamanoi and K Shiozaki. 2008. Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control. Cell Cycle 7: 358-364.

  • Wang L and K Shiozaki. 2006. The fission yeast stress MAPK cascade regulates the pmp3+ gene that encodes a highly conserved plasma membrane protein. FEBS Letter 580: 2409-2413.

  • Tatebe H, K Shimada, S Uzawa, S Morigasaki and K Shiozaki. 2005. Wsh3/Tea4 is a novel cell-end factor essential for bipolar distribution of Tea1 and protects cell polarity under environmental stress in S. pombe. Current Biology 15: 1006-1015.

  • Wang L, K Shimada, M Morishita and K Shiozaki. 2005. Response of fission yeast to toxic cations involves cooperative action of the stress-activated protein kinase, Spc1/Sty1, and the Hal4 protein kinase. Molecular and Cellular Biology 25: 3945-3955.

  • Ikner A and K Shiozaki. 2005. Yeast signaling pathways in the oxidative stress response. Mutation Research 569:13-27.

  • Tatebe H and K Shiozaki. 2003. Identification of Cdc37 as a novel regulator of the stress-responsive mitogen-activated protein kinase. Molecular and Cellular Biology 23:5132-5142.

  • Nguyen AN, AD Ikner , M Shiozaki, SM Warren, and K Shiozaki. 2002. Cytoplasmic localization of Wis1 MAPKK by nuclear export signal is important for nuclear targeting of Spc1/Sty1 MAPK in fission yeast. Molecular Biology of the Cell 13:2651-2663.

  • Santos JL and K Shiozaki. 2001. Fungal histidine kinases. Science's STKE 2001(98): RE1.