Profile Introduction

Transgenic and knockout mice, homologous recombination in ES cells, embryo/germplasm cryopreservation, mouse genetics, CRISPR/Cas9, mouse model phenotyping, metabolic phenotyping

Research Interests

mouse translational genetics, transgenic and knockout mice, homologous recombination in ES cells, embryo/germplasm cryopreservation, precision medicine

Grad Group Affiliations

• Comparative Pathology, Immunology
• Molecular, Cellular and Integrative Physiology

Specialties / Focus

• Domestic Animal Physiology
• Molecular Physiology
• Systemic Physiology

Courses

• IMM 293 Immunological Concepts, Winter
• MCP 210C Integrative and Comparative Physiology, Spring
• CLH 203 Methods in Clinical Research, Summer
• MMI 210 Animal Models of Infectious Diseases, Winter
• VMB 253 Drug Metabolism and Disposition, Winter

Honors and Awards

• American Association for the Advancement of Science, 2013

Professional Societies

• American Veterinary Medical Association
• California Veterinary Medical Association
• American Gastroenterological Association
• American Society of Physiology
• American Association for the Advancement of Science, 2013

Degrees

• 1978 BA Biology University of California, San Diego
• 1983 DVM Veterinary Medicine University of California, Davis
• 1993 PhD Physiology University of California, Los Angeles

Publications

Arap1 Deficiency Causes Photoreceptor Degeneration in Mice. Moshiri A, Humpal D, Leonard BC, Imai DM, Tham A, Bower L, Clary D, Glaser TM, Lloyd KC, Murphy CJ. Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1709-1718. doi: 10.1167/iovs.16-20062. PMID: 28324111 PMCID: PMC5361582

Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium. Meehan TF, Conte N, West DB, Jacobsen JO, Mason J, Warren J, Chen CK, Tudose I, Relac M, Matthews P, Karp N, Santos L, Fiegel T, Ring N, Westerberg H, Greenaway S, Sneddon D, Morgan H, Codner GF, Stewart ME, Brown J, Horner N; et al. Nat Genet. 2017 Aug;49(8):1231-1238. doi: 10.1038/ng.3901. Epub 2017 Jun 26. PMID:28650483   PMCID: PMC5546242

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction. Bowl MR, Simon MM, Ingham NJ, Greenaway S, Santos L, Cater H, Taylor S, Mason J, Kurbatova N, Pearson S, Bower LR, Clary DA, Meziane H, Reilly P, Minowa O, Kelsey L; International Mouse Phenotyping Consortium., Tocchini-Valentini GP, Gao X, Bradley A, Skarnes WC, Moore M, et al. Nat Commun. 2017 Oct 12;8(1):886. doi: 10.1038/s41467-017-00595-4. PMID: 29026089  PMCID: PMC5638796

Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. West DB, Engelhard EK, Adkisson M, Nava AJ, Kirov JV, Cipollone A, Willis B, Rapp J, de Jong PJ, Lloyd KC. PLoS Genet. 2016 Feb 3;12(2):e1005691. doi: 10.1371/journal.pgen.1005691. eCollection 2016 Feb. PMID: 26839965  PMCID: PMC4739719

Cryorecovery of Mouse Sperm by Different IVF Methods Using MBCD and GSH. Li MW, Glass OC, Zarrabi J, Baker LN, Lloyd KC. J Fertili In Vitro. 2016 May;4(2). pii: 175. Epub 2016 Mar 18.  PMID: 27413624  PMCID: PMC4940049

High-throughput discovery of novel developmental phenotypes. Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, et al. Nature. 2016 Sep 22;537(7621):508-514. doi: 10.1038/nature19356. Epub 2016 Sep 14. Erratum in: Nature. 2017 Nov 16;551(7680):398. PMID: 27626380  PMCID: PMC5295821

Efficient gene targeting in mouse zygotes mediated by CRISPR/Cas9-protein. Jung CJ, Zhang J, Trenchard E, Lloyd KC, West DB, Rosen B, de Jong PJ.Transgenic Res. 2017 Apr;26(2):263-277. doi: 10.1007/s11248-016-9998-5. Epub 2016 Nov 30. PMID:27905063  PMCID: PMC5350237]

Deficiency of microRNA miR-34a expands cell fate potential in pluripotent stem cells. Choi YJ, Lin CP, Risso D, Chen S, Kim TA, Tan MH, Li JB, Wu Y, Chen C, Xuan Z, Macfarlan T, Peng W, Lloyd KC, Kim SY, Speed TP, He L. Science. 2017 Feb 10;355(6325). pii: eaag1927. doi: 10.1126/science.aag1927. Epub 2017 Jan 12. PMID: 28082412