Kent Pinkerton

Kent Pinkerton

Position Title

Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine
Department of Pediatrics, School of Medicine

103 Center for Health and the Environment, Davis, CA 95616

Profile Introduction

Professor of Pediatrics, School of Medicine, Professor of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine

Research Interests

Pathophysiology of the respiratory system. The effects of environmental air pollutants (gases, vapors, and particles) on lung inflammation and disease. The role of cytokines and growth factors in lung maturation and development. The impact of nanotechnology on health and disease. Research techniques include pulmonary function testing of small laboratory animals, telemetry for cardiovascular physiology, morphometric assessment of respiratory structure and function, inhalation chambers and exposure systems.

Grad Group Affiliations

  • Molecular, Cellular and Integrative Physiology

Specialties / Focus

  • Cardiorespiratory Physiology
  • Comparative Physiology


  • Center for Health and the Environment
    • Dale Uyeminami

Professional Societies

  • American Thoracic Society
  • Society of Toxicology
  • American Physiological Society
  • American Association of Immunologists


  • 1974 BS Microbiology Brigham Young University
  • 1978 MS Pathology Duke University
  • 1982 PhD Pathology Duke University


2016 Kuempel ED, Jaurand MC, Møller P, Morimoto Y, Kobayashi N, Pinkerton KE, Sargent LM, Vermeulen RC, Fubini B, Kane AB. Evaluating the mechanistic evidence and key data gaps in assessing the potential carcinogenicity of carbon nanotubes and nanofibers in humans. Crit Rev Toxicol, A47(1): 1-58

2016 Shen, YH, Pham, AK, Davis, B, Smiley-Jewell, S, Wang, L, Kodavanti, UP, Takeuchi, M, Tancredi, DJ, Pinkerton, KE. Sex and strain-based inflammatory response to repeated tobacco smoke exposure in spontaneously hypertensive and Wistar Kyoto rats. Inhalation Toxicology, 28(14): 677-685.

2016 Castandea, AR, Bein, KJ, Smiley-Jewell, S, Pinkerton, KE. Fine Particulate Matter (PM2.5) Enhances Allergic Sensitization in BALB/c Mice. Journal of Toxicology and Environmental Health, Part A, 80(4): 197-207.

2017 Christensen S, Jaffar Z, Cole E, Porter V, Ferrini M, Postma B, Pinkerton KE, Yang M, Kim YJ, Montrose L, Roberts K, Holian A, Cho YH. Prenatal Environmental Tobacco Smoke Exposure Increases Allergic Asthma Risk With Methylation Changes in Mice. Environ Mol Mutagen, 58(6): 423-433

2017 Zhao D, Qiu X, Wang B, Wang Z, Wang W, Ouyang J, Silva RM, Shi X, Kang K, Xu D, Li C, Zhong S, Zhang Y, Pinkerton KE. Epiphyseal Arterial Network and Inferior Retinacular Artery Seem Critical to Femoral Head Perfusion in Adults With Femoral Neck Fractures. Clin Orthop Relat Res., 475(8): 2011-2023
 2017 Sun, A, Wei, H, Young, DE, Bein, KJ, Smiley-Jewell, SM, Zhang, Q, Fulgar, CCB, Castaneda, AR, Pham, AK, Li, W, Pinkerton, KE. Differential pulmonary effects of wintertime California and China particulate matter in healthy young mice. Toxicology Letters, 278: 1-8.

2015 Kent E. Pinkerton, Mary Harbaugh, MeiLan K. Han, Claude Jourdan Le Saux, Laura S. Van Winkle, William J. Martin II, Rose J. Kosgei, E. Jane Carter, Nicole Sitkin, Suzette M. Smiley-Jewell, and Maureen George Women and Lung Disease Sex Differences and Global Health Disparities American Journal of Respiratory and Critical Care Medicine,

2015 Carosino CM, Bein KJ, Plummer LE, Castañeda AR, Zhao Y, Wexler AS, Pinkerton KE Allergic Airway Inflammation is Differentially Exacerbated by Daytime and Nighttime Ultrafine and Submicron Fine Ambient Particles: Heme Oxygenase-1 as an Indicator of PM-Mediated Allergic Inflammation Journal of Toxicology and Environmental Health,

2015 Gary W. Ewart, William N. Rom, Sidney S. Braman, and Kent E. Pinkerton From Closing the Atmospheric Ozone Hole to Reducing Climate Change. Lessons Learned ATS Journals,

2015 Jaime E. Mirowsky, Lan Jin, George Thurston, David Lighthall, Tim Tyner, Lori Horton, Karen Galdanes, Steven Chillrud, James Ross, Kent E. Pinkerton, Lung Chi Chen, Morton Lippmann, Terry Gordon In vitro and in vivo toxicity of urban and rural particulate matter from California Atmospheric Environment,

2015 Davidson, RA, Anderson, DS, Van Winkle, LS, Pinkerton, KE, Guo, T Evolution of Silver Nanoparticles in the Rat Lung Investigated by X-ray Absorption Spectroscopy. The Journal of Physical Chemistry. A,

2015 Anderson, DS, Patchin, ES, Silva, RM, Uyeminami, DL, Sharmah, A, Guo, T, Das, GK, Brown, JM, Shannahan, J, Gordon, T, Chen, LC, Pinkerton, KE, Van Winkle, LS Influence of Particle Size on Persistence and Clearance of Aerosolized Silver Nanoparticles in the Rat Lung. Toxicological Sciences,

2015 Anderson, DS, Silva, RM, Lee, D, Edwards, PC, Sharmah, A, Guo, T, Pinkerton, KE, Van Winkle, LS Persistence of silver nanoparticles in the rat lung: Influence of dose, size, and chemical composition. Nanotoxicology,

2015 Belafsky, PC, Peake, J, Smiley-Jewell, SM, Verma, SP, Dworkin-Valenti, J, Pinkerton, KE Soot and house dust mite allergen cause eosinophilic laryngitis in an animal model. The Laryngoscope,

2015 Carosino, CM, Bein, KJ, Plummer, LE, Castañeda, AR, Zhao, Y, Wexler, AS, Pinkerton, KE Allergic airway inflammation is differentially exacerbated by daytime and nighttime ultrafine and submicron fine ambient particles: heme oxygenase-1 as an indicator of PM-mediated allergic inflammation. Journal of toxicology and environmental health. Part A,

2015 Ewart, GW, Rom, WN, Braman, SS, Pinkerton, KE From closing the atmospheric ozone hole to reducing climate change. Lessons learned. Annals of the American Thoracic Society,