Matthew Wood

Matthew Wood

Position Title
Assistant Professor

  • Department of Environmental Toxicology, College of Agricultural and Environmental Sciences
Meyer Hall 4247

Profile Introduction

Biochemical & structural mechanisms of environmental gene regulation

Research Interests

Biochemical & structural mechanisms of environmental gene regulation

Grad Group Affiliations

  • Pharmacology and Toxicology


  • ETX 214 Mechanisms of Toxicity, Spring
  • ETX 220 Analysis of Toxicants, Fall
  • ETX 220L Analysis of Toxicants - Laboratory, Fall


  • Meyer Hall 4330,+Davis,+CA+95616
    • Li-Hua Ma, Postdoctoral Associate;Christina Takanishi, CDB Graduate Student

Honors and Awards

  • NIH Predoctoral Trainee, UC San Diego (1997-2000)
  • National Research Council Fellowship, NIH (2000-2005)
  • American Heart Association, Scientist Development Grant (2006-2010)


    • 2000 PhD Biochemistry University of California, San Diego
    • 1997 MS Biochemistry University of California, San Diego
    • 1996 BS Chemistry University of California, Santa Cruz


    Ma, L., Takanishi, C.L. & Wood, M.J. (2007) Molecular mechanism of oxidative stress perception by the Orp1 protein. Journal of Biological Chemistry, 282, 31429-36.

    Takanishi, C.L., Ma, L. & Wood M.J (2007) A genetically encoded probe for cysteine sulfenic acid protein modification in vivo. Biochemistry, 46, 14725-14732.

    Mason, J.T., Kim, S.K., Knaff, D.B. & Wood, M.J. (2006) Thermodynamic basis for redox regulation of the Yap1 signal transduction pathway. Biochemistry, 45, 13409-13417.

    Wang, X., Mukhopadhyay, P., Wood, M.J., Outten, F.W., Opdyke, J.A., & Storz, G. (2006) Mutational Analysis to Define an Activating Region on the Redox-Sensitive Transcriptional Regulator OxyR. Journal of Bacteriology, 188, 8335-8342.

    Wood, M.J. & Storz, G. (2005) Oxygen, Metabolism and Gene Expression: the T-Rex Connection. Structure, 13, 2-3.

    Wood, M.J., Prieto, J.H. & Komives E.A. (2005) Structural and functional consequences of methionine oxidation in thrombomodulin. Biochimica et Biophysica Acta, 1703, 141-147.

    Wood, M.J., Storz, G. & Tjandra, N. (2004) Structural basis for redox regulation of Yap1 transcription factor localization. Nature, 430, 917-921.

    Wood, M.J., Andrade, E.C. & Storz, G. (2003) The redox domain of the Yap1p transcription factor contains two disulfide bonds. Biochemistry, 42, 11982-11991.

    Carmel-Harel, O., Wood, M.J. & Storz, G. (2003) Regulatory disulfides controlling transcription factor activity in the bacterial and yeast responses to oxidative stress. In Cellular Implications of Redox Signaling. Gitler, C. and Danon, A. (eds). London: Imperial College Press. pp. 287-310.

    Outten, F.W., Wood, M.J., Munoz, F.M. & Storz, G. (2003) The SufE protein and the SufBCD complex enhance SufS cysteine desulfurase activity as part of a sulfur transfer pathway for Fe-S cluster assembly in Escherichia coli. Journal of Biological Chemistry, 278, 45713-9.