Min Zhao

Min Zhao

Position Title

Department of Dermatology, School of Medicine
Department of Eye Center, School of Medicine


Research Interests

To guide cells to heal wounds and regenerate

Our lab's goals are1) To understand electrical signals in regulating cell behavior in wound healing and regeneration, and 2) To develop novel technology to guide and stimulate cells to heal and regenerate damaged and diseased tissues.

Grad Group Affiliations

  • Biochemistry, Molecular, Cellular and Developmental Biology
  • Comparative Pathology
  • Neuroscience

Professional Societies

  • Member of Advisory Panel, Biochemical Journal. 2007-2012
  • Member of Editorial Board, Advances in Wound Care. 2010-
  • Member of Editorial Board, Chinese Journal of Trauma. 2003-
  • Member of Editorial Board, International Journal of Lower Extremity Wounds. 2012-


Selected from ~80 publications.

Nakajima K-i, Zhu K, Sun Y-H, Hegyi B, Zeng Q, Murphy CJ, Small JV, Chen-Izu Y, Izumiya Y, Penninger JM et al: KCNJ15/Kir4.2 Couples With Polyamines to Sense Weak Extracellular Electric Fields in Galvanotaxis. Nat Commun 2015.

Gao J, Raghunathan VK, Reid B, Wei D, Diaz RC, Russell P, Murphy CJ, Zhao M: Biomimetic stochastic topography and electric fields synergistically enhance directional migration of corneal epithelial cells in a MMP-3-dependent manner. Acta biomaterialia 2015, 12:102-112.

Gao R, Zhao S, Jiang X, Sun Y, Zhao S, Gao J, Borleis J, Willard S, Tang M, Cai H et al: A large-scale screen reveals genes that mediate electrotaxis in Dictyostelium discoideum. Sci Signal 2015, 8(378):ra50.

A large-scale screen reveals genes that mediate electrotaxis in Dictyostelium discoideum. Gao R, Zhao S, Jiang X, Sun Y, Zhao S, Gao J, Borleis J, Willard S, Tang M, Cai H, Kamimura Y, Huang Y, Jiang J, Huang Z, Mogilner A, Pan T, Devreotes PN, Zhao M.Sci Signal. 2015 May 26;8(378):ra50. 

Li L, Hartley R, Reiss B, Sun Y, Pu J, Wu D, Lin F, Hoang T, Yamada S, Jiang J, Zhao M. E-cadherin plays an essential role in collective directional migration of large epithelial sheets. Cell Mol Life Sci. 2012; 69(16):2779-89.

Cao L, Wei D, Reid R, Zhao S, Pu J, Pan T, Yamoah EN, Zhao M. Endogenous Electric Currents May Guide Rostral Migration of Neuroblasts. EMBO Reports. Accepted. 2013

Zhao M, Chalmers L, Cao L, Vieira AC, Mannis M, Reid B. Electrical signaling in control of ocular cell behaviors. Prog Retin Eye Res. 2012; 31(1):65-88.

Feng JF, Liu J, Zhang XZ, Zhang L, Jiang JY, Nolta J, Zhao M. Guided Migration of Neural Stem Cells Derived from Human Embryonic Stem Cells by an Electric Field. Stem Cells. 2012; 30(2):349-55.

Cao L, Pu J, Zhao M. GSK-3β is essential for physiological electric field-directed Golgi polarization and optimal electrotaxis. Cell Mol Life Sci. 2011;68(18):3081-93.

Guo A, Song B, Reid B, Gu Y, Forrester JV, Jahoda CA, Zhao M. Effects of Physiological Electric Fields on Migration of Human Dermal Fibroblasts. J Invest Dermatol. 2010. 2010 Sep;130(9):2320-7.

Zhao M. Electrical fields in wound healing – an overriding signal that directs cell migration. Semin Cell Dev Biol. 2009, 20(6):674-82.

Zhao M. PTEN: a promising pharmacological target to enhance epithelial wound healing. Br J Pharmacol. 2007;152:1141-4.

Song B, Gu Y, Pu J, Reid B, Zhao Z, Zhao M. Application of direct current electric fields to cells and tissues in vitro and modulation of wound electric field in vivo. Nature Protoc. 2007;2:1479-89.

Reid B, Nuccitelli R, Zhao M. Non-invasive measurement of bioelectric currents with a vibrating probe. Nature Protoc. 2007;2 (3):661-9.

Zhao M, Song B, Pu J, Wada T, Reid B, Tai G, Wang F, Guo A, Walczysko P, Gu Y, Sasaki T, Suzuki A, Forrester JV, Bourne HR, Devreotes PN, McCaig CD, Penninger JM. Electrical signals control wound healing via PI3K and PTEN signalling. Nature, 2006. 442, 457-460.