Min Zhao

Min Zhao

Position Title
Professor

Unit
Department of Dermatology, School of Medicine
Department of Ophthalmology, School of Medicine

Rm 1134, Tupper Hall, Davis. Rm 1617, Suite 1600, 2921 Stockton Blvd, Sacramento
Bio

Research Interests

To guide cells to heal wounds and to repair diseased tissues

Our goals are 1) To understand electrical signals in regulating cell behavior in wound healing and regeneration, and 2) To develop technology to guide and stimulate cells to heal and repair damaged and diseased tissues.

Grad Group Affiliations

  • Biochemistry, Molecular, Cellular and Developmental Biology
  • Comparative Pathology
  • Neuroscience

Professional Societies

  • Associate Editor, Bioelectricity. 2018-
  • Member of Advisory Panel, Biochemical Journal. 2007-2012
  • Guest Editor, Advances in Wound Care. 2016
  • Member of Editorial Board, Chinese Journal of Trauma. 2003-
  • Member of Editorial Board, International Journal of Lower Extremity Wounds. 2012-2015

Publications

Selected from over 100 publications.

Zhu K, Takada Y, Nakajima K, Sun Y, Jiang J, Zhang Y, Zeng Q, Takada Y, Zhao M. Expression of integrins to control migration direction of electrotaxis. FABSEB J. 2019 Accepted.

Sun Y, Reid B, Ferreira F, Luxardi G, Ma L, Lokken KL, Zhu K, Xu G, Sun Y, Ryzhuk V, Guo BP, Lebrilla CB, Maverakis EM, Mogilner A, Zhao M. Infection-generated electric field in gut epithelium drives bidirectional migration of macrophages. Plos Biology. Apr 9;17(4):e3000044. doi: 10.1371/journal.pbio.3000044. eCollection 2019 Apr. PMID: 30964858

Li A, Cho JH, Reid B, Tseng CC, He L, Tan P, Yeh CY, Wu P, Li Y, Widelitz RB, Zhou Y, Zhao M, Chow RH, Chuong CM. Calcium oscillations coordinate feather mesenchymal cell movement by SHH dependent modulation of gap junction networks. Nature Communications. 2018 Dec 18;9(1):5377. doi: 10.1038/s41467-018-07661-5. PMID: 30560870 PMCID: PMC6299091 DOI: 10.1038/s41467-018-07661-5

Ferreira F, Raghunathan V, Luxardi G, Zhu K & Zhao M. Early redox activities modulate Xenopus tail regeneration. Nature Communications. 2018 Oct 16;9(1):4296. PMID: 30327466 PMCID: PMC6191437 DOI: 10.1038/s41467-018-06614-2

Baidya S, Hassan A, Zhao M. Computational Modeling of Transepithelial Endogenous Electric Signals. Chapter 3 In Handbook of Biological Effects of Electromagnetic Fields (Vol. 1, 4th Edition). Ed. Greenebaum B, Barnes F. CRC Press/Taylor & Francis Group. 2018

Zhao M. Bioelectrics – an underappreciated and fertile field in biology. In Ahead of the Curve: Hidden breakthroughs in the biosciences: Volume 2. Ed. by Michael Levin & Dany Adams. ISBN-13:  978-0750313278 ISBN-10:  0750313277 Publisher: Institute of Physics Publishing (2018)

Sun X, Qi H, Zhang X, Li L, Zhang J, Zeng Q, Laszlo GS, Wei B, Li T,Jiang J, Mogilner A, Zhao M. Src Activation Decouples Cell Division Orientation from Cell Geometry in Mammalian Cells. Biomaterials, 2018. 170: 82-94.

Kim S, Thomasy SM, Ramsey D, Zhao M, Mannis MJ, Murphy CJ. Whorl Pattern Keratopathies in Veterinary and Human Patients. Veterinary Ophthalmology. Vet Ophthalmol. 2018;21(6):661-667. doi: 10.1111/vop.12552. PMID: 29411482.

Sun YH, Sun Y, Zhu K, Reid B, Gao X, Draper BW, Zhao M, Mogilner A. Electric fields accelerate cell polarization and bypass myosin action in motility initiation. J Cell Physiol. 2018;233(3):2378-2385. doi: 10.1002/jcp.26109. Epub 2017 Aug 25. PMID: 28749047 PMCID: PMC5705333

Zhang Y, Xu G, Lee RM, Zhu Z, Wu J, Liao S, Zhang G, Sun Y, Mogilner A, Losert W, Pan T, Lin F, Xu Z, Zhao M. Collective cell migration has distinct directionality and speed dynamics. Cell Mol Life Sci. 2017 Oct;74(20):3841-3850. doi: 10.1007/s00018-017-2553-6. PMID: 28612218. PMCID: PMC5709186

Feng JF, Liu J, Zhang L, Jiang J, Russell M, Lyeth BG, Nolta J, Zhao M. Electrical guidance of human stem cells in the rat brain. Stem Cell Reports. 2017. (9): 177–189. PMID: 28669601 PMCID: PMC5511115

Nakajima K-i, Zhu K, Sun Y-H, Hegyi B, Zeng Q, Murphy CJ, Small JV, Chen-Izu Y, Izumiya Y, Penninger JM et al: KCNJ15/Kir4.2 Couples With Polyamines to Sense Weak Extracellular Electric Fields in Galvanotaxis. Nat Commun 2015.

Gao J, Raghunathan VK, Reid B, Wei D, Diaz RC, Russell P, Murphy CJ, Zhao M: Biomimetic stochastic topography and electric fields synergistically enhance directional migration of corneal epithelial cells in a MMP-3-dependent manner. Acta biomaterialia 2015, 12:102-112.

Gao R, Zhao S, Jiang X, Sun Y, Zhao S, Gao J, Borleis J, Willard S, Tang M, Cai H et al: A large-scale screen reveals genes that mediate electrotaxis in Dictyostelium discoideum. Sci Signal 2015, 8(378):ra50.

A large-scale screen reveals genes that mediate electrotaxis in Dictyostelium discoideum. Gao R, Zhao S, Jiang X, Sun Y, Zhao S, Gao J, Borleis J, Willard S, Tang M, Cai H, Kamimura Y, Huang Y, Jiang J, Huang Z, Mogilner A, Pan T, Devreotes PN, Zhao M.Sci Signal. 2015 May 26;8(378):ra50. 

Li L, Hartley R, Reiss B, Sun Y, Pu J, Wu D, Lin F, Hoang T, Yamada S, Jiang J, Zhao M. E-cadherin plays an essential role in collective directional migration of large epithelial sheets. Cell Mol Life Sci. 2012; 69(16):2779-89.

Cao L, Wei D, Reid R, Zhao S, Pu J, Pan T, Yamoah EN, Zhao M. Endogenous Electric Currents May Guide Rostral Migration of Neuroblasts. EMBO Reports. Accepted. 2013

Zhao M, Chalmers L, Cao L, Vieira AC, Mannis M, Reid B. Electrical signaling in control of ocular cell behaviors. Prog Retin Eye Res. 2012; 31(1):65-88.

Feng JF, Liu J, Zhang XZ, Zhang L, Jiang JY, Nolta J, Zhao M. Guided Migration of Neural Stem Cells Derived from Human Embryonic Stem Cells by an Electric Field. Stem Cells. 2012; 30(2):349-55.

Cao L, Pu J, Zhao M. GSK-3β is essential for physiological electric field-directed Golgi polarization and optimal electrotaxis. Cell Mol Life Sci. 2011;68(18):3081-93.

Guo A, Song B, Reid B, Gu Y, Forrester JV, Jahoda CA, Zhao M. Effects of Physiological Electric Fields on Migration of Human Dermal Fibroblasts. J Invest Dermatol. 2010. 2010 Sep;130(9):2320-7.

Zhao M. Electrical fields in wound healing – an overriding signal that directs cell migration. Semin Cell Dev Biol. 2009, 20(6):674-82.

Zhao M. PTEN: a promising pharmacological target to enhance epithelial wound healing. Br J Pharmacol. 2007;152:1141-4.

Song B, Gu Y, Pu J, Reid B, Zhao Z, Zhao M. Application of direct current electric fields to cells and tissues in vitro and modulation of wound electric field in vivo. Nature Protoc. 2007;2:1479-89.

Reid B, Nuccitelli R, Zhao M. Non-invasive measurement of bioelectric currents with a vibrating probe. Nature Protoc. 2007;2 (3):661-9.

Zhao M, Song B, Pu J, Wada T, Reid B, Tai G, Wang F, Guo A, Walczysko P, Gu Y, Sasaki T, Suzuki A, Forrester JV, Bourne HR, Devreotes PN, McCaig CD, Penninger JM. Electrical signals control wound healing via PI3K and PTEN signalling. Nature, 2006. 442, 457-460.

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