Nipavan Chiamvimonvat

Nipavan Chiamvimonvat

Position Title
Roger Tatarian Endowed Professor of Cardiovascular Medicine

Department of Internal Medicine (Cardiology), School of Medicine
Department of Pharmacology

GBSF 6315

Program Director, National Institutes of Health T32 Training Program in Basic and Translational Cardiovascular Sciences

Co-Director, UC Davis Cardiovascular Research Institute (CVRI)

Profile Introduction

Our research focuses on the molecular and cellular mechanisms of cardiac arrhythmias using combined experimental and computational approaches. One of the long-term goals is to identify novel therapeutic strategies for treatment of cardiac arrhythmias. The laboratory has identified some atrial-specific ion channels and the regulatory mechanisms of these channels in atria and pacemaking cells and has begun to develop novel therapeutics for treatment of atrial arrhythmias.

Research Interests

Our laboratory has focused our research efforts in two major areas in cardiovascular diseases. 1. The study of the functional roles of different isoforms of cardiac calcium and calcium-activated potassium channels using combined techniques of transgenic mouse models, gene silencing and patch-clamp recordings. We utilize multiple approaches to determine the functional significance of the interacting partners of Ca and K channels in atrial myocytes and in so doing, provide new insights into the underlying mechanisms of certain forms of atrial arrhythmias. 2. Roles of soluble epoxide hydrolase (sEH) inhibitors in the prevention of cardiac hypertrophy and failure. Eicosanoids are potent modulators of immune responses and are derived from the 20-carbon atom arachidonic acids (AA). Epoxyeicosatrienoic acids (EETs) are derivatives of arachidonic acid (AA) generated through cytochrome P450 pathway. sEH catalizes the conversion of EETs to form the corresponding dihydroxyeicosatrienoic acids (DHETs). Recently, we have shown that several inhibitors of sEH exert beneficial effects in the prevention of cardiac hypertrophy and failure. Moreover, our study shows a beneficial effect of the compounds in the prevention of cardiac arrhythmias which occur in association with cardiac hypertrophy. Very little is known regarding the roles of this new class of compounds in the treatment of atrial arrhythmias. There is consequently an enormous opportunity to uncover a potentially very powerful class of compounds which may be used effectively in the clinical setting.

Grad Group Affiliations

  • Molecular, Cellular and Integrative Physiology (Academic Advisor)
  • Pharmacology and Toxicology

Specialties / Focus

  • Cardiovascular disease


  • PGG 210B Advanced Physiology, Winter
  • PHA 400C Principles of Pharmacology, Winter


  • Genome and Biomedical Science Facility, 6th floor
    • Lab members: Xiao-Dong Zhang, Valeriy Timofeyev, Padmini Sirish, Phung Thai, Ryan Woltz, James Overton, Lu Ren, Kristina Bischak, Wilson Xu

Honors and Awards

  • 2011                                    Dean’s Excellence in Mentoring Award, UC Davis

    2017                                    Career Achievement Award, Department of Internal Medicine, UC Davis

    Professional Societies

    • Society of General Physiologists, Biophysical Society, Heart Rhythm Society, Council on Basic Cardiovascular Sciences, American Heart Association


    • 1984 MD Medicine University of Toronto
    • 1980 Science Faculty of Arts and Science, University of Toronto


    1.          Chiamvimonvat N, Mitchell LB, Gillis AM, Wyse DG, Sheldon RS and Duff HJ. Use-dependent electrophysiologic effects of amiodarone in coronary artery disease and inducible ventricular tachycardia. Am J Cardiol. 1992;70:598-604.


    1.          Wang L, Chiamvimonvat N and Duff HJ. Interaction between selected sodium and potassium channel blockers in guinea pig papillary muscle. J Pharmacol Exp Ther. 1993;264:1056-6


    1.          Duff HJ, Mitchell LB, Gillis AM, Sheldon RS, Chudleigh L, Cassidy P, Chiamvimonvat N and Wyse DG. Electrocardiographic correlates of spontaneous termination of ventricular tachycardia in patients with coronary artery disease. Circulation. 1993;88:1054-62.


    1.          Wang L, Sheldon RS, Mitchell LB, Wyse DG, Gillis AM, Chiamvimonvat N and Duff HJ. Amiloride-quinidine interaction: adverse outcomes. Clin Pharmacol Ther. 1994;56:659-67.
    2.          Lawrence JH, Johns DC, Chiamvimonvat N, Nuss HB and Marban E. Prospects for genetic manipulation of cardiac excitability. Adv Exp Med Biol. 1995;382:41-8.


    1.          Johns DC, Nuss HB, Chiamvimonvat N, Ramza BM, Marban E and Lawrence JH. Adenovirus-mediated expression of a voltage-gated potassium channel in vitro (rat cardiac myocytes) and in vivo (rat liver). A novel strategy for modifying excitability. J Clin Invest. 1995;96:1152-8.


    1.          Nuss HB, Chiamvimonvat N, Perez-Garcia MT, Tomaselli GF and Marban E. Functional association of the beta 1 subunit with human cardiac (hH1) and rat skeletal muscle (mu 1) sodium channel alpha subunits expressed in Xenopus oocytes. J Gen Physiol. 1995;106:1171-91.


    1.          Chiamvimonvat N, O'Rourke B, Kamp TJ, Kallen RG, Hofmann F, Flockerzi V and Marban E. Functional consequences of sulfhydryl modification in the pore-forming subunits of cardiovascular Ca2+ and Na+ channels. Circ Res. 1995;76:325-34.


    1.          Chiamvimonvat N, Kargacin ME, Clark RB and Duff HJ. Effects of intracellular calcium on sodium current density in cultured neonatal rat cardiac myocytes. J Physiol. 1995;483 ( Pt 2):307-18.


    1.        Tomaselli GF, Chiamvimonvat N, Nuss HB, Balser JR, Perez-Garcia MT, Xu RH, Orias DW, Backx PH and Marban E. A mutation in the pore of the sodium channel alters gating. Biophys J. 1995;68:1814-27.


    1.        Kaab S, Nuss HB, Chiamvimonvat N, O'Rourke B, Pak PH, Kass DA, Marban E and Tomaselli GF. Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. Circ Res. 1996;78:262-73.


    1.        Chiamvimonvat N, Perez-Garcia MT, Tomaselli GF and Marban E. Control of ion flux and selectivity by negatively charged residues in the outer mouth of rat sodium channels. J Physiol. 1996;491 ( Pt 1):51-9.


    1.        Perez-Garcia MT, Chiamvimonvat N, Marban E and Tomaselli GF. Structure of the sodium channel pore revealed by serial cysteine mutagenesis. Proc Natl Acad Sci U S A. 1996;93:300-4.


    1.        Balser JR, Nuss HB, Chiamvimonvat N, Perez-Garcia MT, Marban E and Tomaselli GF. External pore residue mediates slow inactivation in mu 1 rat skeletal muscle sodium channels. J Physiol. 1996;494 ( Pt 2):431-42.


    1.        Chiamvimonvat N, Perez-Garcia MT, Ranjan R, Marban E and Tomaselli GF. Depth asymmetries of the pore-lining segments of the Na+ channel revealed by cysteine mutagenesis. Neuron. 1996;16:1037-47.
    2.        Perez-Garcia MT, Chiamvimonvat N, Ranjan R, Balser JR, Tomaselli GF and Marban E. Mechanisms of sodium/calcium selectivity in sodium channels probed by cysteine mutagenesis and sulfhydryl modification. Biophys J. 1997;72:989-96.


    1.        Hu H, Chiamvimonvat N, Yamagishi T and Marban E. Direct inhibition of expressed cardiac L-type Ca2+ channels by S-nitrosothiol nitric oxide donors. Circ Res. 1997;81:742-52.


    1.        Ranjan R, Chiamvimonvat N, Thakor NV, Tomaselli GF and Marban E. Mechanism of anode break stimulation in the heart. Biophys J. 1998;74:1850-63.


    1.        Ji Y, Lalli MJ, Babu GJ, Xu Y, Kirkpatrick DL, Liu LH, Chiamvimonvat N, Walsh RA, Shull GE and Periasamy M. Disruption of a single copy of the SERCA2 gene results in altered Ca2+ homeostasis and cardiomyocyte function. J Biol Chem. 2000;275:38073-80.


    1.        Li RA, Velez P, Chiamvimonvat N, Tomaselli GF and Marban E. Charged residues between the selectivity filter and S6 segments contribute to the permeation phenotype of the sodium channel. J Gen Physiol. 2000;115:81-92.


    1.        Ahmmed GU, Dong PH, Song G, Ball NA, Xu Y, Walsh RA and Chiamvimonvat N. Changes in Ca2+ cycling proteins underlie cardiac action potential prolongation in a pressure-overloaded guinea pig model with cardiac hypertrophy and failure. Circ Res. 2000;86:558-70.


    1.        Ahmmed GU, Xu Y, Hong Dong P, Zhang Z, Eiserich J and Chiamvimonvat N. Nitric oxide modulates cardiac Na(+) channel via protein kinase A and protein kinase G. Circ Res. 2001;89:1005-13.


    1.        Xu Y, Dong PH, Zhang Z, Ahmmed GU and Chiamvimonvat N. Presence of a calcium-activated chloride current in mouse ventricular myocytes. Am J Physiol Heart Circ Physiol. 2002;283:H302-14.


    1.        Chiamvimonvat N. Diastolic dysfunction and the aging heart. J Mol Cell Cardiol. 2002;34:607-10.


    1.        Zhang Z, Xu Y, Song H, Rodriguez J, Tuteja D, Namkung Y, Shin HS and Chiamvimonvat N. Functional Roles of Cav1.3 (a1D) calcium channel in sinoatrial nodes: insight gained using gene-targeted null mutant mice. Circ Res. 2002;90:981-7.


    1.        Xu Y, Chiamvimonvat N, Vazquez AE, Akunuru S, Ratner N and Yamoah EN. Gene-targeted deletion of neurofibromin enhances the expression of a transient outward K+ current in Schwann cells: a protein kinase A-mediated mechanism. J Neurosci. 2002;22:9194-202.


    1.        Xu Y, Tuteja D, Zhang Z, Xu D, Zhang Y, Rodriguez J, Nie L, Tuxson HR, Young JN, Glatter KA, Vazquez AE, Yamoah EN and Chiamvimonvat N. Molecular identification and functional roles of a Ca2+-activated K+ channel in human and mouse hearts. J Biol Chem. 2003;278:49085-94.
    2.        Glatter KA, Chiamvimonvat N, Whitcomb C and Bloom H. Images in cardiovascular medicine. Malignant vasovagal syncope. Circulation. 2003;107:2987-8.


    1.        Zhang Z, Xu Y, Dong PH, Sharma D and Chiamvimonvat N. A negatively charged residue in the outer mouth of rat sodium channel determines the gating kinetics of the channel. Am J Physiol Cell Physiol. 2003;284:C1247-54.


    1.        Glatter KA and Chiamvimonvat N. Tachy- or bradyarrhythmias: implications for therapeutic intervention in LQT3 families. Circ Res. 2003;92:941-3.


    1.        Nie L, Song H, Chen MF, Chiamvimonvat N, Beisel KW, Yamoah EN and Vazquez AE. Cloning and expression of a small-conductance Ca2+-activated K+ channel from the mouse cochlea: coexpression with alpha9/alpha10 acetylcholine receptors. J Neurophysiol. 2004;91:1536-44.


    1.        Chiamvimonvat N, Cain J and Glatter KA. Retrograde cycle length alternans during supraventricular tachycardia: an unusual tachycardia mechanism. Pacing Clin Electrophysiol. 2004;27:1017-9.


    1.        Sharma D, Glatter KA, Timofeyev V, Tuteja D, Zhang Z, Rodriguez J, Tester DJ, Low R, Scheinman MM, Ackerman MJ and Chiamvimonvat N. Characterization of a KCNQ1/KVLQT1 polymorphism in Asian families with LQT2: implications for genetic testing. J Mol Cell Cardiol. 2004;37:79-89.


    1.        Glatter KA, Wang Q, Keating M, Chen S, Chiamvimonvat N and Scheinman MM. Effectiveness of sotalol treatment in symptomatic Brugada syndrome. Am J Cardiol. 2004;93:1320-2.


    1.        Glatter KA, Chiamvimonvat N, Viitasalo M, Wang Q and Tuteja D. Risk stratification in Brugada syndrome. Lancet. 2005;366:530-1.


    1.        Tuteja D, Xu D, Timofeyev V, Lu L, Sharma D, Zhang Z, Xu Y, Nie L, Vazquez AE, Young JN, Glatter KA and Chiamvimonvat N. Differential expression of small-conductance Ca2+-activated K+ channels SK1, SK2, and SK3 in mouse atrial and ventricular myocytes. Am J Physiol Heart Circ Physiol. 2005;289:H2714-23.


    1.        Xu Y, Zhang Z, Timofeyev V, Sharma D, Xu D, Tuteja D, Dong PH, Ahmmed GU, Ji Y, Shull GE, Periasamy M and Chiamvimonvat N. The effects of intracellular Ca2+ on cardiac K+ channel expression and activity: novel insights from genetically altered mice. J Physiol. 2005;562:745-58.


    1.        Glatter KA, Chiamvimonvat N and Xu D. Evaluation of the critical care patient with Brugada syndrome. Crit Care Med. 2005;33:1666-7.


    1.        Glatter KA, Tuteja D, Chiamvimonvat N, Hamdan M and Park JK. Pregnancy in postural orthostatic tachycardia syndrome. Pacing Clin Electrophysiol. 2005;28:591-3.


    1.        Glatter KA and Chiamvimonvat N. Autonomic nerve innervation and the left atrium: a mechanistic link to focal atrial fibrillation. Heart Rhythm. 2005;2:523-4.


    1.        Zhang Z, He Y, Tuteja D, Xu D, Timofeyev V, Zhang Q, Glatter KA, Xu Y, Shin HS, Low R and Chiamvimonvat N. Functional roles of Cav1.3(a1D) calcium channels in atria: insights gained from gene-targeted null mutant mice. Circulation. 2005;112:1936-44.


    1.        Xu D, Li N, He Y, Timofeyev V, Lu L, Tsai HJ, Kim IH, Tuteja D, Mateo RK, Singapuri A, Davis BB, Low R, Hammock BD and Chiamvimonvat N. Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors. Proc Natl Acad Sci U S A. 2006;103:18733-8.


    1.        Viitasalo M, Oikarinen L, Swan H, Glatter KA, Vaananen H, Fodstad H, Chiamvimonvat N, Kontula K, Toivonen L and Scheinman MM. Ratio of late to early T-wave peak amplitude in 24-h electrocardiographic recordings as indicator of symptom history in patients with long-QT Syndrome types 1 and 2. J Am Coll Cardiol. 2006;47:112-20.


    1.        Timofeyev V, He Y, Tuteja D, Zhang Q, Roth DM, Hammond HK and Chiamvimonvat N. Cardiac-directed expression of adenylyl cyclase reverses electrical remodeling in cardiomyopathy. J Mol Cell Cardiol. 2006;41:170-81.


    1.        Kamp TJ and Chiamvimonvat N. Mission impossible: IGF-1 and PTEN specifically "Akt"ing on cardiac L-type Ca2+ channels. Circ Res. 2006;98:1349-51.


    1.        Lu L, Zhang Q, Timofeyev V, Zhang Z, Young JN, Shin HS, Knowlton AA and Chiamvimonvat N. Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2. Circ Res. 2007;100:112-20.


    1.        Xu Y, Zhang Q and Chiamvimonvat N. IK1 and cardiac hypoxia: after the long and short QT syndromes, what else can go wrong with the inward rectifier K+ currents? J Mol Cell Cardiol. 2007;43:15-7.


    1.        Glatter KA, Hamdan MH, Zhang Q and Chiamvimonvat N. Drug-induced long QT syndrome: a continuing challenge in the field. J Cardiovasc Electrophysiol. 2007;18:696-7.


    1.        Dirksen WP, Lacombe VA, Chi M, Kalyanasundaram A, Viatchenko-Karpinski S, Terentyev D, Zhou Z, Vedamoorthyrao S, Li N, Chiamvimonvat N, Carnes CA, Franzini-Armstrong C, Gyorke S and Periasamy M. A mutation in calsequestrin, CASQ2D307H, impairs Sarcoplasmic Reticulum Ca2+ handling and causes complex ventricular arrhythmias in mice. Cardiovasc Res. 2007;75:69-78.


    1.        Babu GJ, Bhupathy P, Timofeyev V, Petrashevskaya NN, Reiser PJ, Chiamvimonvat N and Periasamy M. Ablation of sarcolipin enhances sarcoplasmic reticulum calcium transport and atrial contractility. Proc Natl Acad Sci U S A. 2007;104:17867-72.


    1.        Chiamvimonvat N, Ho CM, Tsai HJ and Hammock BD. The soluble epoxide hydrolase as a pharmaceutical target for hypertension. J Cardiovasc Pharmacol. 2007;50:225-37.


    1.        Chen CY, Chow D, Chiamvimonvat N, Glatter KA, Li N, He Y, Pinkerton KE and Bonham AC. Short-term secondhand smoke exposure decreases heart rate variability and increases arrhythmia susceptibility in mice. Am J Physiol Heart Circ Physiol. 2008;295:H632-9.


    1.        Zhang Q, Timofeyev V, Lu L, Li N, Singapuri A, Long MK, Bond CT, Adelman JP and Chiamvimonvat N. Functional roles of a Ca2+-activated K+ channel in atrioventricular nodes. Circ Res. 2008;102:465-71.


    1.        Harris TR, Li N, Chiamvimonvat N and Hammock BD. The potential of soluble epoxide hydrolase inhibition in the treatment of cardiac hypertrophy. Congest Heart Fail. 2008;14:219-24.


    1.        Wu J, Hecker JG and Chiamvimonvat N. Antioxidant enzyme gene transfer for ischemic diseases. Adv Drug Deliv Rev. 2009;61:351-63.


    1.        Li N, Liu JY, Timofeyev V, Qiu H, Hwang SH, Tuteja D, Lu L, Yang J, Mochida H, Low R, Hammock BD and Chiamvimonvat N. Beneficial effects of soluble epoxide hydrolase inhibitors in myocardial infarction model: Insight gained using metabolomic approaches. J Mol Cell Cardiol. 2009;47:835-45.


    1.        Ai D, Pang W, Li N, Xu M, Jones PD, Yang J, Zhang Y, Chiamvimonvat N, Shyy JY, Hammock BD and Zhu Y. Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy. Proc Natl Acad Sci U S A. 2009;106:564-9.


    1.        Li N, Timofeyev V, Tuteja D, Xu D, Lu L, Zhang Q, Zhang Z, Singapuri A, Albert TR, Rajagopal AV, Bond CT, Periasamy M, Adelman J and Chiamvimonvat N. Ablation of a Ca2+-activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation. J Physiol. 2009;587:1087-100.


    1.        Lu L, Timofeyev V, Li N, Rafizadeh S, Singapuri A, Harris TR and Chiamvimonvat N. Alpha-actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca2+-activated K+ channel (SK2 channel). Proc Natl Acad Sci U S A. 2009;106:18402-7.


    1.        Fu JD, Jiang P, Rushing S, Liu J, Chiamvimonvat N and Li RA. Na+/Ca2+ exchanger is a determinant of excitation-contraction coupling in human embryonic stem cell-derived ventricular cardiomyocytes. Stem Cells Dev. 2010;19:773-82.


    1.        Liu JY, Yang J, Inceoglu B, Qiu H, Ulu A, Hwang SH, Chiamvimonvat N and Hammock BD. Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model. Biochem Pharmacol. 2010;79:880-7.


    1.        Timofeyev V, Porter CA, Tuteja D, Qiu H, Li N, Tang T, Singapuri A, Han PL, Lopez JE, Hammond HK and Chiamvimonvat N. Disruption of adenylyl cyclase type V does not rescue the phenotype of cardiac-specific overexpression of Gaq protein-induced cardiomyopathy. Am J Physiol Heart Circ Physiol. 2010;299:H1459-67.


    1.        Tuteja D, Rafizadeh S, Timofeyev V, Wang S, Zhang Z, Li N, Mateo RK, Singapuri A, Young JN, Knowlton AA and Chiamvimonvat N. Cardiac small conductance Ca2+-activated K+ channel subunits form heteromultimers via the coiled-coil domains in the C termini of the channels. Circ Res. 2010;107:851-9.


    1.        Liu JY, Li N, Yang J, Li N, Qiu H, Ai D, Chiamvimonvat N, Zhu Y and Hammock BD. Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events. Proc Natl Acad Sci U S A. 2010;107:17017-22.


    1.        Fu JD, Rushing SN, Lieu DK, Chan CW, Kong CW, Geng L, Wilson KD, Chiamvimonvat N, Boheler KR, Wu JC, Keller G, Hajjar RJ and Li RA. Distinct roles of microRNA-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytes. PLoS One. 2011;6:e27417.


    1.        Qiu H, Li N, Liu JY, Harris TR, Hammock BD and Chiamvimonvat N. Soluble epoxide hydrolase inhibitors and heart failure. Cardiovasc Ther. 2011;29:99-111.


    1.        Srivatsa U, Cvt MC, Krishnamurthy S, Zhongmin LI, Qiu H and Chiamvimonvat N. Stretch and Inflammation- Their Relation to Fractionation of Electrograms in Atrial Fibrillation. J Atr Fibrillation. 2011;4:406.


    1.        Puglisi JL, Yuan W, Timofeyev V, Myers RE, Chiamvimonvat N, Samarel AM and Bers DM. Phorbol ester and endothelin-1 alter functional expression of Na+/Ca2+ exchange, K+, and Ca2+ currents in cultured neonatal rat myocytes. Am J Physiol Heart Circ Physiol. 2011;300:H617-26.


    1.        Zhang Q, Timofeyev V, Qiu H, Lu L, Li N, Singapuri A, Torado CL, Shin HS and Chiamvimonvat N. Expression and roles of Cav1.3 (a1D) L-type Ca2+ channel in atrioventricular node automaticity. J Mol Cell Cardiol. 2011;50:194-202.


    1.        Li N, Liu JY, Qiu H, Harris TR, Sirish P, Hammock BD and Chiamvimonvat N. Use of metabolomic profiling in the study of arachidonic acid metabolism in cardiovascular disease. Congest Heart Fail. 2011;17:42-6.


    1.        Liu JY, Qiu H, Morisseau C, Hwang SH, Tsai HJ, Ulu A, Chiamvimonvat N and Hammock BD. Inhibition of soluble epoxide hydrolase contributes to the anti-inflammatory effect of antimicrobial triclocarban in a murine model. Toxicol Appl Pharmacol. 2011;255:200-6.


    1.        Qiu H, Liu JY, Wei D, Li N, Yamoah EN, Hammock BD and Chiamvimonvat N. Cardiac-generated prostanoids mediate cardiac myocyte apoptosis after myocardial ischaemia. Cardiovasc Res. 2012;95:336-45.


    1.        Cherednichenko G, Zhang R, Bannister RA, Timofeyev V, Li N, Fritsch EB, Feng W, Barrientos GC, Schebb NH, Hammock BD, Beam KG, Chiamvimonvat N and Pessah IN. Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Proc Natl Acad Sci U S A. 2012;109:14158-63.


    1.        Lim W, Chiamvimonvat N and Amsterdam EA. Electrocardiogram with a twist. Crit Pathw Cardiol. 2012;11:218-9.


    1.        Dolga AM, Letsche T, Gold M, Doti N, Bacher M, Chiamvimonvat N, Dodel R and Culmsee C. Activation of KCNN3/SK3/KCa2.3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia. Glia. 2012;60:2050-64.


    1.        Awasthi S, Matthews DL, Li RA, Chiamvimonvat N, Lieu DK and Chan JW. Label-free identification and characterization of human pluripotent stem cell-derived cardiomyocytes using second harmonic generation (SHG) microscopy. J Biophotonics. 2012;5:57-66.


    1.        Sirish P, Lopez JE, Li N, Wong A, Timofeyev V, Young JN, Majdi M, Li RA, Chen HS and Chiamvimonvat N. MicroRNA profiling predicts a variance in the proliferative potential of cardiac progenitor cells derived from neonatal and adult murine hearts. J Mol Cell Cardiol. 2012;52:264-72.


    1.        Chen L, Liu T, Tran A, Lu X, Tomilov AA, Davies V, Cortopassi G, Chiamvimonvat N, Bers DM, Votruba M and Knowlton AA. OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability. J Am Heart Assoc. 2012;1:e003012.


    1.        Glatter KA, Myers R and Chiamvimonvat N. Recommendations regarding dietary intake and caffeine and alcohol consumption in patients with cardiac arrhythmias: what do you tell your patients to do or not to do? Curr Treat Options Cardiovasc Med. 2012;14:529-35.


    1.        Guglielmino K, Jackson K, Harris TR, Vu V, Dong H, Dutrow G, Evans JE, Graham J, Cummings BP, Havel PJ, Chiamvimonvat N, Despa S, Hammock BD and Despa F. Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats. Am J Physiol Heart Circ Physiol. 2012;303:H853-62.


    1.        Zhang H, Li N, Sirish P, Mahakian L, Ingham E, Curry FR, Yamada S, Chiamvimonvat N and Ferrara KW. The cargo of CRPPR-conjugated liposomes crosses the intact murine cardiac endothelium. J Control Release. 2012;163:10-7.


    1.        Sirish P, Li N, Liu JY, Lee KS, Hwang SH, Qiu H, Zhao C, Ma SM, Lopez JE, Hammock BD and Chiamvimonvat N. Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis. Proc Natl Acad Sci U S A. 2013;110:5618-23.


    1.        Xu DY, Davis BB, Wang ZH, Zhao SP, Wasti B, Liu ZL, Li N, Morisseau C, Chiamvimonvat N and Hammock BD. A potent soluble epoxide hydrolase inhibitor, t-AUCB, acts through PPARgamma to modulate the function of endothelial progenitor cells from patients with acute myocardial infarction. Int J Cardiol. 2013;167:1298-304.


    1.        Lieu DK, Fu JD, Chiamvimonvat N, Tung KC, McNerney GP, Huser T, Keller G, Kong CW and Li RA. Mechanism-based facilitated maturation of human pluripotent stem cell-derived cardiomyocytes. Circ Arrhythm Electrophysiol. 2013;6:191-201.


    1.        Shen MJ, Hao-Che C, Park HW, George Akingba A, Chang PC, Zheng Z, Lin SF, Shen C, Chen LS, Chen Z, Fishbein MC, Chiamvimonvat N and Chen PS. Low-level vagus nerve stimulation upregulates small conductance calcium-activated potassium channels in the stellate ganglion. Heart Rhythm. 2013;10:910-5.


    1.        Timofeyev V, Myers RE, Kim HJ, Woltz RL, Sirish P, Heiserman JP, Li N, Singapuri A, Tang T, Yarov-Yarovoy V, Yamoah EN, Hammond HK and Chiamvimonvat N. Adenylyl cyclase subtype-specific compartmentalization: differential regulation of L-type Ca2+ current in ventricular myocytes. Circ Res. 2013;112:1567-76.


    1.        Liu JY, Lin YP, Qiu H, Morisseau C, Rose TE, Hwang SH, Chiamvimonvat N and Hammock BD. Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models. Eur J Pharm Sci. 2013;48:619-27.


    1.        Knowlton AA, Rainwater JA, Chiamvimonvat N, Bonham AC, Robbins JA, Henderson S and Meyers FJ. Training the translational research teams of the future: UC Davis-HHMI Integrating Medicine into Basic Science program. Clin Transl Sci. 2013;6:339-46.


    1.        Ulu A, Harris TR, Morisseau C, Miyabe C, Inoue H, Schuster G, Dong H, Iosif AM, Liu JY, Weiss RH, Chiamvimonvat N, Imig JD and Hammock BD. Anti-inflammatory effects of omega-3 polyunsaturated fatty acids and soluble epoxide hydrolase inhibitors in angiotensin-II-dependent hypertension. J Cardiovasc Pharmacol. 2013;62:285-97.


    1.        Despa S, Sharma S, Harris TR, Dong H, Li N, Chiamvimonvat N, Taegtmeyer H, Margulies KB, Hammock BD and Despa F. Cardioprotection by controlling hyperamylinemia in a "humanized" diabetic rat model. J Am Heart Assoc. 2014;3.


    1.        Zhang XD, Timofeyev V, Li N, Myers RE, Zhang DM, Singapuri A, Lau VC, Bond CT, Adelman J, Lieu DK and Chiamvimonvat N. Critical roles of a small conductance Ca2+-activated K+ channel (SK3) in the repolarization process of atrial myocytes. Cardiovasc Res. 2014;101:317-25.


    1.        Rafizadeh S, Zhang Z, Woltz RL, Kim HJ, Myers RE, Lu L, Tuteja D, Singapuri A, Bigdeli AA, Harchache SB, Knowlton AA, Yarov-Yarovoy V, Yamoah EN and Chiamvimonvat N. Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channel. Proc Natl Acad Sci U S A. 2014;111:9989-94.


    1.        Jian Z, Han H, Zhang T, Puglisi J, Izu LT, Shaw JA, Onofiok E, Erickson JR, Chen YJ, Horvath B, Shimkunas R, Xiao W, Li Y, Pan T, Chan J, Banyasz T, Tardiff JC, Chiamvimonvat N, Bers DM, Lam KS and Chen-Izu Y. Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling. Sci Signal. 2014;7:ra27.


    1.        Lv P, Kim HJ, Lee JH, Sihn CR, Fathabad Gharaie S, Mousavi-Nik A, Wang W, Wang HG, Gratton MA, Doyle KJ, Zhang XD, Chiamvimonvat N and Yamoah EN. Genetic, cellular, and functional evidence for Ca2+ inflow through Cav1.2 and Cav1.3 channels in murine spiral ganglion neurons. J Neurosci. 2014;34:7383-93.


    1.        Shen L, Peng H, Peng R, Fan Q, Zhao S, Xu D, Morisseau C, Chiamvimonvat N and Hammock BD. Inhibition of soluble epoxide hydrolase in mice promotes reverse cholesterol transport and regression of atherosclerosis. Atherosclerosis. 2015;239:557-65.


    1.        Myers R, Timofeyev V, Li N, Kim C, Ledford HA, Sirish P, Lau V, Zhang Y, Fayyaz K, Singapuri A, Lopez JE, Knowlton AA, Zhang XD and Chiamvimonvat N. Feedback mechanisms for cardiac-specific microRNAs and cAMP signaling in electrical remodeling. Circ Arrhythm Electrophysiol. 2015;8:942-50.


    1.        Zhang XD, Lieu DK and Chiamvimonvat N. Small-conductance Ca2+-activated K+ channels and cardiac arrhythmias. Heart Rhythm. 2015;12:1845-51.


    1.        Deng LM, Li XP, Xu DY, Morisseau C, Chiamvimonvat N and Hammock BD. Aerobic exercise-based rehabilitation affects the activities of progenitor endothelial cells through EETs pathway. Med Hypotheses. 2015;85:1037-8.


    1.        Lu L, Sirish P, Zhang Z, Woltz RL, Li N, Timofeyev V, Knowlton AA, Zhang XD, Yamoah EN and Chiamvimonvat N. Regulation of gene transcription by voltage-gated L-type calcium channel, Cav1.3. J Biol Chem. 2015;290:4663-76.


    1.      Zhang XD, Lee JH, Lv P, Chen WC, Kim HJ, Wei D, Wang W, Sihn CR, Doyle KJ, Rock JR, Chiamvimonvat N and Yamoah EN. Etiology of distinct membrane excitability in pre- and posthearing auditory neurons relies on activity of Cl- channel TMEM16A. Proc Natl Acad Sci U S A. 2015;112:2575-80.


    1.      Van Wagoner DR, Piccini JP, Albert CM, Anderson ME, Benjamin EJ, Brundel B, Califf RM, Calkins H, Chen PS, Chiamvimonvat N, Darbar D, Eckhardt LL, Ellinor PT, Exner DV, Fogel RI, Gillis AM, Healey J, Hohnloser SH, Kamel H, Lathrop DA, Lip GY, Mehra R, Narayan SM, Olgin J, Packer D, Peters NS, Roden DM, Ross HM, Sheldon R and Wehrens XH. Progress toward the prevention and treatment of atrial fibrillation: A summary of the Heart Rhythm Society Research Forum on the Treatment and Prevention of Atrial Fibrillation, Washington, DC, December 9-10, 2013. Heart Rhythm. 2015;12:e5-e29.


    1.      Harris TR, Bettaieb A, Kodani S, Dong H, Myers R, Chiamvimonvat N, Haj FG and Hammock BD. Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice. Toxicol Appl Pharmacol. 2015;286:102-11.


    1.      Wang W, Flores MC, Sihn CR, Kim HJ, Zhang Y, Doyle KJ, Chiamvimonvat N, Zhang XD and Yamoah EN. Identification of a key residue in Kv7.1 potassium channel essential for sensing external potassium ions. J Gen Physiol. 2015;145:201-12.


    1.      Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE and Bers DM. Na+ channel function, regulation, structure, trafficking and sequestration. J Physiol. 2015;593:1347-60.


    1.      Jian Z, Chen YJ, Shimkunas R, Jian Y, Jaradeh M, Chavez K, Chiamvimonvat N, Tardiff JC, Izu LT, Ross RS and Chen-Izu Y. In Vivo Cannulation Methods for Cardiomyocytes Isolation from Heart Disease Models. PLoS One. 2016;11:e0160605.


    1.      Awasthi S, Izu LT, Mao Z, Jian Z, Landas T, Lerner A, Shimkunas R, Woldeyesus R, Bossuyt J, Wood B, Chen YJ, Matthews DL, Lieu DK, Chiamvimonvat N, Lam KS, Chen-Izu Y and Chan JW. Multimodal SHG-2PF Imaging of Microdomain Ca2+-Contraction Coupling in Live Cardiac Myocytes. Circ Res. 2016;118:e19-28.


    1.      Sihn CR, Kim HJ, Woltz RL, Yarov-Yarovoy V, Yang PC, Xu J, Clancy CE, Zhang XD, Chiamvimonvat N and Yamoah EN. Mechanisms of Calmodulin Regulation of Different Isoforms of Kv7.4 K+ Channels. J Biol Chem. 2016;291:2499-509.


    1.      Sirish P, Li N, Timofeyev V, Zhang XD, Wang L, Yang J, Lee KS, Bettaieb A, Ma SM, Lee JH, Su D, Lau VC, Myers RE, Lieu DK, Lopez JE, Young JN, Yamoah EN, Haj F, Ripplinger CM, Hammock BD and Chiamvimonvat N. Molecular Mechanisms and New Treatment Paradigm for Atrial Fibrillation. Circ Arrhythm Electrophysiol. 2016;9:e003721.


    1.      Sun C, Simon SI, Foster GA, Radecke CE, Hwang HV, Zhang X, Hammock BD, Chiamvimonvat N and Knowlton AA. 11,12-Epoxyecosatrienoic acids mitigate endothelial dysfunction associated with estrogen loss and aging: Role of membrane depolarization. J Mol Cell Cardiol. 2016;94:180-8.


    1.      Yechikov S, Copaciu R, Gluck JM, Deng W, Chiamvimonvat N, Chan JW and Lieu DK. Same-Single-Cell Analysis of Pacemaker-Specific Markers in Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Subtypes Classified by Electrophysiology. Stem Cells. 2016;34:2670-2680.


    1.      Kennedy M, Bers DM, Chiamvimonvat N and Sato D. Dynamical effects of calcium-sensitive potassium currents on voltage and calcium alternans. J Physiol. 2017;595:2285-2297.


    1.      Grandi E, Sanguinetti MC, Bartos DC, Bers DM, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo MF, Noskov S, Proenza C, Vandenberg JI and Yarov-Yarovoy V. Potassium channels in the heart: structure, function and regulation. J Physiol. 2017;595:2209-2228.


    1.      Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM and Nerbonne JM. Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics. J Physiol. 2017;595:2229-2252.


    1.      Zhang Z, Ledford HA, Park S, Wang W, Rafizadeh S, Kim HJ, Xu W, Lu L, Lau VC, Knowlton AA, Zhang XD, Yamoah EN and Chiamvimonvat N. Distinct subcellular mechanisms for the enhancement of the surface membrane expression of SK2 channel by its interacting proteins, a-actinin2 and filamin A. J Physiol. 2017;595:2271-2284.


    1.      Frederich BJ, Timofeyev V, Thai PN, Haddad MJ, Poe A, Lau VC, Moshref M, Knowlton AA, Sirish P and Chiamvimonvat N. Electrotaxis of Cardiac Progenitor Cells, Cardiac Fibroblasts, and Induced Pluripotent Stem cell-derived Cardiac Progenitor Cells requires serum and is directed via PI3'K pathways. Heart Rhythm. 2017;5271(17)30840-8.


    1.      Fu Q, Hu Y, Wang Q, Liu Y, Li N, Xu B, Kim S, Chiamvimonvat N and Xiang YK. High-fat diet induces protein kinase A and G-protein receptor kinase phosphorylation of beta2 -adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts. J Physiol. 2017;595:1973-1986.


    1.      Sirish P, Ledford HA, Timofeyev V, Thai PN, Ren L, Park S, Lee JH, Dai G, Moshref M, Sihn C-R, Chen WC, Timofeyeva MV, Jian Z, Shimkunas R, Izu LT, Chiamvimonvat N, Chen-Izu Y, Yamoah EN, Zhang XD. Action potential shortening and impairment of cardiac function by ablation of Slc26a6. Circ Arrhythm Electrophysiol. 2017;10:e005267.


    1.      López JE, Sharma J, Avila J, Wood TS, VanDyke J, Mclaughlin B, Abbey C, Wong A, Myagmar B-E, Swigart PM, Simpson PC, Chiamvimonvat N. Novel large-particle FACS purification of adult ventricular myocytes reveals accumulation of myosin and action disproportionate to cell size and proteome in normal post-weaning development. J Mol Cell Cardiol. 2017;111:114-122.


    1.      Gluck JM, Herren AW, Yechikov S, Kao HKJ, Khan A, Phinney BS, Chiamvimonvat N, Chan JW, Lieu DK. Biochemical and biomechanical properties of the pacemaking sinoatrial node extracellular matrix are distinct from contractile left ventricular matrix. PLoS One. 2017;12(9):e0185125.


    1. Chiamvimonvat N, Song LS. LRRC10 (Leucine-Rich Repeat Containing Protein 10) and REEP5 (Receptor Accessory Protein 5) as Novel Regulators of Cardiac Excitation-Contraction Coupling Structure and Function. J Am Heart Assoc. 2018;7(3). pii: e008260. doi: 10.1161/JAHA.117.008260.


    1.      Srivatsa UN, Danielsen B, Amsterdam EA, Pezeshkian N, Yang Y, Nordsieck E, Fan D, Chiamvimonvat N, White RH. CAABL-AF (California Study of Ablation for Atrial Fibrillation): Mortality and Stroke, 2005 to 2013. Circ Arrhythm Electrophysiol. 2018;11:e005739


    1.      Yeo KK, Armstrong EJ, Lopez JE, Chen DC, Westin GG, Li CS, Anderson D, Hua A, Singapuri A, Amsterdam EA, Chiamvimonvat N, Laird JR. Aspirin and clopidogrel high on-treatment platelet reactivity and genetic predictors in peripheral arterial disease. Catheter Cardiovasc Interv. 2018;91:1308-1317


    1.      Zhang XD, Coulibaly ZA, Chen WC, Ledford HA, Lee JH, Sirish P, Dai G, Jian Z, Chuang F, Brust-Mascher I, Yamoah EN, Chen-Izu Y, Izu LT, Chiamvimonvat N. Coupling of SK channels, L-type Ca2+ channels, and ryanodine receptors in cardiomyocytes. Sci Rep. 2018;8:4670. doi: 10.1038/s41598-018-22843-3


    1.      Hegyi B, Bossuyt J, Griffiths LG, Shimkunas R, Coulibaly Z, Jian Z, Grimsrud KN, Sondergaard CS, Ginsburg KS, Chiamvimonvat N, Belardinelli L, Varro A, Papp JG, Pollesello P, Levijoki J, Izu LT, Boyd WD, Banyasz T, Bers DM, Chen-Izu Y. Complex electrophysiological remodeling in postinfarction ischemic heart failure. Proc Natl Acad Sci U S A. 2018;115:E3036-E3044