Research Interests

Medical education research

Anatomy education

Grad Group Affiliations

• Integrative Genetics and Genomics
• Biochemistry, Molecular, Cellular and Developmental Biology

Specialties / Focus

• Human genetics
• Medical education research
• Gross Anatomy education

Courses

• GGG 211 Concepts in Human Genetics and Genomics
• GGG 294 Seminar in Human Genetics
• MDS 406 ENRG Genetics
• CHA 400 Developmental, Gross and Radiologic Anatomy

Professional Societies

• American Association of Anatomists

Degrees

• 1984 BS Biology Ochanomizu Women's University
• 1987 MS Genetics Ochanomizu Women's University
• 1995 PhD Molecular Biology University of Tokyo

Publications

Hagiwara, N. (2019) Genome Editing for Cardiovascular Disease-A Brief Review for Cardiologists. Am. J. Cardiol. 123: 1002-1006.

Hagiwara, N. (2017) The application of active learning modalities to achieve medical genetics competencies and their learning outcome assessments. Advances in Medical Education and Practice. Dec 14;8:817-829.

An, C., Ichihashi, Y., Peng, J., Shinha, N.R., and Hagiwara, N. (2016) Transcriptome dynamics and potential roles of Sox6 in the postnatal heart. PLoS ONE 11(11): e0166574.

Kawasaki, K., Kawasaki, M., Watanabe, M., EIdrus, E., Nagai T, Oommen, S., Maeda, T., Hagiwara, N., Que, J., Sharpe, P.T., Ohazama, A. (2015) Expression of Sox genes in tooth development. Int. J. Dev. Biol. 59: 471 – 478.

An, C., Ganio, E., and Hagiwara, N. (2013) Trip12, a HECT domain E3 ubiquitin ligase,  targets Sox6 for proteasome degradation and affects fiber type-specific gene expression in muscle cells. Skeletal Muscle 3: 11.

An, C., Dong, Y., and Hagiwara, N. (2011) Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6. BMC Dev. Biol. 11(1):59.

Hagiwara, N. (2011) Sox6, jack of all trades: A versatile regulatory protein in vertebrate development. Dev. Dyn. 240: 1311-1321

Hagiwara, N., Yeh M, and Liu A. (2007) Sox6 is required for normal fiber type differentiation of fetal skeletal muscle in mice. Dev. Dynamics 236: 2062-2076

Yi, Z., Cohen-Barak, O., Hagiwara, N., Kingsley, P.D., Fuchs, D.A., Erickson, D.T., Epner, E.M., Palis, J., and Brilliant, M.H. (2006) Sox6 directly silences epsilon globin expression in definitive erythropoiesis. PLoS Genetics 2: e14

Hagiwara, N., Ma, B., and Ly, A. (2005) Slow and fast fiber isoform gene expression is systematically altered in skeletal muscle of the Sox6 mutant, p100H. Dev. Dynamics 234:301-311

Hagiwara, N., Katarova, Z., Siracusa, L.D., and Brilliant, M.H. (2003) Non-neuronal expression of the GABAA beta3 subunit gene is required for normal palate development in mice. Dev. Biol. 254:93-101.

Cohen-Barak, O., Yi, Z., Hagiwara, N., Monzen, K., Komuro, I., and Brilliant, M. H. (2003) Sox6 regulation of cardiac myocytes development. Nuc. Acids Res. 31: 5941-5948.

Cohen-Barak, O, N Hagiwara, MF Arlt, JP Horton, and MH Brilliant. (2001) Cloning, characterization and chromosome mapping of the human SOX6 gene. Gene. 265:157-164

Hagiwara, N., SE Klewer, RA Samson, DT Erickson, MF Lyon and MH Brilliant. (2000) SOX6 is a candidate gene for p100H myopathy, heart block and sudden neonatal death. Proc. Natl. Acad. Sci. USA. 97:4180-4185