Research Interests

Development and disease of skeletal muscle and the heart

Medical education research

Grad Group Affiliations

• Biochemistry, Molecular, Cellular and Developmental Biology
• Integrative Genetics and Genomics

Specialties / Focus

• Human Genetics and Genomics

Courses

• GGG 211 Concepts in Human Genetics and Genomics
• GGG 294 Seminar in Human Genetics
• Genetics MDS 406 ENRG, Block 2

Professional Societies

• American Association of Anatomists

Degrees

• 1984 BS Biology Ochanomizu Women's University
• 1987 MS Genetics Ochanomizu Women's University
• 1995 PhD Molecular Biology University of Tokyo

Publications

Hagiwara, N. (2017) The application of active learning modalities to achieve medical genetics competencies and their learning outcome assessments. Advances in Medical Education and Practice. Dec 14;8:817-829.

An, C., Ichihashi, Y., Peng, J., Shinha, N.R., and Hagiwara, N. (2016) Transcriptome dynamics and potential roles of Sox6 in the postnatal heart. PLoS ONE 11(11): e0166574.

Kawasaki, K., Kawasaki, M., Watanabe, M., EIdrus, E., Nagai T, Oommen, S., Maeda, T., Hagiwara, N., Que, J., Sharpe, P.T., Ohazama, A. (2015) Expression of Sox genes in tooth development. Int. J. Dev. Biol. 59: 471 – 478.

An, C., Ganio, E., and Hagiwara, N. (2013) Trip12, a HECT domain E3 ubiquitin ligase,  targets Sox6 for proteasome degradation and affects fiber type-specific gene expression in muscle cells. Skeletal Muscle 3: 11.

An, C., Dong, Y., and Hagiwara, N. (2011) Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6. BMC Dev. Biol. 11(1):59.

Hagiwara, N. (2011) Sox6, jack of all trades: A versatile regulatory protein in vertebrate development. Dev. Dyn. 240: 1311-1321

Hagiwara, N., Yeh M, and Liu A. (2007) Sox6 is required for normal fiber type differentiation of fetal skeletal muscle in mice. Dev. Dynamics 236: 2062-2076

Yi, Z., Cohen-Barak, O., Hagiwara, N., Kingsley, P.D., Fuchs, D.A., Erickson, D.T., Epner, E.M., Palis, J., and Brilliant, M.H. (2006) Sox6 directly silences epsilon globin expression in definitive erythropoiesis. PLoS Genetics 2: e14

Hagiwara, N., Ma, B., and Ly, A. (2005) Slow and fast fiber isoform gene expression is systematically altered in skeletal muscle of the Sox6 mutant, p100H. Dev. Dynamics 234:301-311

Hagiwara, N., Katarova, Z., Siracusa, L.D., and Brilliant, M.H. (2003) Non-neuronal expression of the GABAA beta3 subunit gene is required for normal palate development in mice. Dev. Biol. 254:93-101.

Cohen-Barak, O., Yi, Z., Hagiwara, N., Monzen, K., Komuro, I., and Brilliant, M. H. (2003) Sox6 regulation of cardiac myocytes development. Nuc. Acids Res. 31: 5941-5948.

Cohen-Barak, O, N Hagiwara, MF Arlt, JP Horton, and MH Brilliant. (2001) Cloning, characterization and chromosome mapping of the human SOX6 gene. Gene. 265:157-164

Hagiwara, N., SE Klewer, RA Samson, DT Erickson, MF Lyon and MH Brilliant. (2000) SOX6 is a candidate gene for p100H myopathy, heart block and sudden neonatal death. Proc. Natl. Acad. Sci. USA. 97:4180-4185