Paramita M. Ghosh

Paramita Ghosh

Position Title
Professor

Unit
Department of Biochemistry and Molecular Medicine, School of Medicine
Department of Urology, School of Medicine

Rm 1132, Oak Park Research Building, 2700 Stockton Blvd, Sacramento, CA 95817
Bio

Profile Introduction

Paramita Ghosh studies the signal transduction pathways involved in the development and progression of prostate cancer. Advanced prostate cancer is treated by hormonal manipulation using various drugs that affect a steroid nuclear receptor called the androgen receptor. However, patients on this treatment eventually become resistant to this treatment. The overall goal of Dr. Ghosh's lab is to find ways by which resistance to the androgen receptor inhibitors can be overcome. Based on work done in her lab, a clinical trial was recently completed by UC Davis oncologists that demonstrated how a combination of two FDA approved drugs can be used to overcome resistance to each of these drugs. Her lab uses a number of biochemical and molecular biological techniques to achieve these goals. Dr. Ghosh currently has three graduate students and will welcome volunteer undergraduate students who will be working on these projects.

Research Interests

Signal Transduction Pathways in Prostate Cancer

The pathways we study include the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, the Ras/Raf/MEK/MAPK pathway and other signaling pathways both upstream and downstream of these. This includes the mammalian target of rapamycin (mTOR) pathway, and signaling by the epidermal growth factor receptor (EGFR), related receptor tyrosine kinases ErbB2 and ErbB3.

Grad Group Affiliations

  • Biochemistry, Molecular, Cellular and Developmental Biology
  • Comparative Pathology (Vet Med)
  • Integrative Genetics and Genomics
  • Pharmacology and Toxicology (PTX)

Specialties / Focus

  • Cancer Biology
  • Cell Division and the Cytoskeleton
  • Integrated Genetics and Genomics
  • Signal Transduction

Courses

  • PMI 298 Foundations in Research , Fall
  • BCB 298 Cell and Molecular Biology of Cancer , Winter

Labs

  • Postdoctoral Fellows http://www.ucdmc.ucdavis.edu/urology/research/example/example_ghosh.html
    • Salma Siddiqui
  • Graduate Students
    • Maitreyee Jathal (PhD student), GGIP
    • Zsofia Kiss (PhD Student), PTX
    • Elizabeth Messner (MS student); GGIP
  • Research Associate
    • Thomas Steele

Honors and Awards

  • 2000 WICR Young Investigator Scholar Award. American Association for Cancer Research
  • 1997-1999 NIH Postdoctoral Training Award. Department of Pathology, University of Texas Health Science Center at San Antonio, TX.
  • 1989-1994 Tuition Scholarship and Graduate Assistantship. Rensselaer Polytechnic Institute, Troy, NY
  • 1989 Gold Medal for Excellence, Master of Science. Department of Physics, Jadavpur University, Calcutta 700032, India
  • 1989 S.N. Bose Medal for best academic achievement. Department of Physics, Jadavpur University, Calcutta 700032, India.
  • 1983-1989 National Science Scholarship. University Grants Commission, Government of India
  • 2006 UC Davis Academic Federation Travel Award
  • 2006 Best Poster Award. International Symposium on Hormonal Carcinogenesis, Montpellier, France
  • 2010 Travel Award, 6th International Symposium on Hormonal Oncogenesis, Tokyo, Japan.
  • 2007 California Coalition to Cure Prostate Cancer Award, ($26,000) Prostate Cancer Foundation, Santa Monica, CA
  • 2013 Scientist Selected to Join Global Task Force focused on Cancer Causing Potential of Chemicals (Getting to know Cancer)
  • 2016 “Exceptional Women in Endocrine Cancer” profile, Endocrine Related Cancers, 2016.

    Professional Societies

    • American Association for Cancer Research
    • Society of Basic Urological Research
    • American Association for the Advancement of Science
    • American Society for Cell Biology

    Degrees

    • 1994 PhD Chemistry Rensselaer Polytechnic Institute
    • 1988 MS Physics Jadavpur University, Calcutta, INDIA
    • 1986 BS Physics Jadavpur University, Calcutta, INDIA

    Publications

     

    Shi Y, Shu ZJ, Wang H, Barnes JL, Yeh CK, Ghosh PM, Katz MS, Kamat A. Altered Expression of Hepatic β-Adrenergic Receptors in Aging Rats: Implications for Age-Related Metabolic Dysfunction in Liver. Am J Physiol Regul Integr Comp Physiol. 2017 Dec 6:ajpregu.00372.2017. doi: 10.1152/ajpregu.00372.2017. 

     

     

    Kent MS, Zwingenberger A, Westropp JL, Barrett LE, Durbin-Johnson BP, Ghosh P, Vinall RL. MicroRNA profiling of dogs with transitional cell carcinoma of the bladder using blood and urine samples. BMC Vet Res. 2017 Nov 15;13(1):339. doi: 10.1186/s12917-017-1259-1.

     

     

    D'Abronzo LS, Pan CX, Ghosh PM. Evaluation of Protein Levels of the Receptor Tyrosine Kinase ErbB3 in Serum. Methods Mol Biol. 2018;1655:319-334. doi: 10.1007/978-1-4939-7234-0_22.

     

     

    D'Abronzo LS, Bose S, Crapuchettes ME, Beggs RE, Vinall RL, Tepper CG, Siddiqui S, Mudryj M, Melgoza FU, Durbin-Johnson BP, deVere White RW, Ghosh PM. The androgen receptor is a negative regulator of eIF4E phosphorylation at S209: implications for the use of mTOR inhibitors in advanced prostate cancer. Oncogene. 2017 Nov 16;36(46):6359-6373. doi: 10.1038/onc.2017.233. 

     

     

    Shih TC, Liu R, Fung G, Bhardwaj G, Ghosh PM, Lam KS. A Novel Galectin-1 Inhibitor Discovered through One-Bead Two-Compound Library Potentiates the Antitumor Effects of Paclitaxel in vivo. Molecular cancer therapeutics. 2017; 16(7):1212-1223. NIHMSID: NIHMS867388 PMID: 28396365, PMCID: PMC5516795

     

     

    Kiss Z, Ghosh PM. Circadian rhythmicity and the influence of 'clock' genes on prostate cancer.Endocr Relat Cancer. 2016 Sep 22. pii: ERC-16-0366. [Epub ahead of print].

     

     

    Ghosh PM. From physics to cancer biology and everywhere in between. Endocr Relat Cancer. 2016 Sep 7. pii: ERC-16-0382. [Epub ahead of print]

     

     

    Vinall, R.L., Tepper, C.G., Ripoll, A.Z., Gandour- Edwards, R.F., Durbin-Johnson, B.P., Yap, S.A., Ghosh, P.M. and deVere White, R.W. Decreased expression of let-7c is associated with non-response of muscle-invasive bladder cancer patients to neoadjuvant chemotherapy. Genes & Cancer, Vol. 7 (3-4): 86-97, March 2016.

     

     

    Lombard, A. P., Mooso, B. A., Libertini, S. J., Lim, R. M., Nakagawa, R., Vidallo, K., Costanzo, N., Ghosh, P. M., Mudryj, M. miR-148a Dependent Apoptosis of Bladder Cancer Cells is Mediated in Part by the Epigenetic Modifier DNMT1. Molecular Carcinogenesis, 2016 May;55(5):757-67. (PMID: 25865490)

     

     

    Chow, H., Ghosh, PM, deVere White, RW, Evans, CP, Dall’Era, MA, Yap, SA, Li, Y, Beckett, LA, Lara, PN, Pan, CX. A Phase II clinical trial of everolimus plus bicalutamide for castration-resistant prostate cancer. Cancer. 2016 Jun 15;122(12):1897-904. PMID: 27019001.

     

     

    D'Abronzo LS, Ghosh PM. Medical Treatment of Urological Malignancies. Stief CG, Fizazi K, Evans CP, editors. Lisbon: International Consultation on Medical Treatment of Urological Malignancies; 2015. Chapter Section X, The Akt/PI3K/PTEN pathway as a driver and therapeutic target in castration-resistant prostate cancer; p.325-336.

     

     

    Pan, C.-x., Zhang, H., Tepper, C. G., Lin, T.-y., Davis, R. R., Keck, J., Ghosh, P. M., Gill, P., Airhart, S., Bult, C., Gandara, D. R., Liu, E., de Vere White, R. W. Development and characterization of bladder cancer patient-derived xenografts for molecularly guided targeted therapy. PLOS ONE. 2015 Aug 13;10(8):e0134346. PMID: 26270481

     

     

    Narayanan, K.N., Ali, M., Barclay, B., Cheng, Q.S., D'Abronzo, L.S., Dornetshuber-Fleiss, R., Ghosh, P.M., et al, Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death. Carcinogenesis, 2015. ** Jun;36 Suppl 1:S89-S110**. PMID: 26106145

     

     

    Goodson, W.H. III, Lowe, L., ….., Ghosh, P.M., et al. Assessing the Carcinogenic Potential of Low Dose Exposures to Chemical Mixtures in the Environment: The Challenge Ahead. Carcinogenesis, 2015. ** Jun;36 Suppl 1:S254-96**. PMID: 26106142

     

     

    Savoy, R.M., Chen, L., Siddiqui, S., Melgoza, F.U., Durbin-Johnson, B., Drake, C., Jathal, M.K., Bose, S., Steele, T.M., Mooso, B.A., D’Abronzo, L.S., Fry, W.H., Carraway, K.L. III, Mudryj, M. and Ghosh, P.M. Transcription of Nrdp1 by the androgen receptor is regulated by nuclear Filamin A in prostate cancer. Endocrine-related Cancer, 2015. Jun; 22(3):369-86 (PMID: 25759396).

     

     

    Mooso, B.A., Vinall, R.L., Mudryj, M., Yap, S.A., deVere White, R.W., Ghosh, P.M. The Role of EGFR Family Inhibitors in Muscle-Invasive Bladder Cancer. Journal of Urology. 2015. Jan;193(1):19-29.

     

     

    Ghosh P, Qiu Y, Wang LY and Kung HJ: Tyrosine kinome profiling: Oncogenic mutations and therapeutic targeting in cancer, Molecular Oncology – Causes of Cancer ad Targets for Treatment. Eds. Gelmann, E.P., Sawyers, C.L. and Rauscher, F.J. Cambridge University Press. pages 58-75. Feb 2014.

     

     

    Ghosh PM and A.C. Gao. Zoledronic acid at the time of castration prevented castration-induced bone metastasis in mice. Endocrine related Cancers. 2014. Oct;21(5):C11-4

     

     

    Ghosh PM. Editorial Comments on “The impact of histological reclassification during pathology re-review--evidence of a Will Rogers effect in bladder cancer?”. J. Urology. 2013 Nov;190(5):1697

     

     

    Savoy RM, Ghosh PM. The changing roles of steroid nuclear receptors with prostate cancer progression. Endocr Relat Cancer. 2013 Jul 4;20(4):C9-11.

     

     

    Savoy RM, Ghosh PM. Linking inflammation and neuroendocrine differentiation: the role of macrophage migration inhibitory factor-mediated signaling in prostate cancer. Endocr Relat Cancer. 2013 May 21;20(3):C1-4.

     

     

    Savoy RM, Ghosh PM. The dual role of filamin A in cancer: can't live with (too much of) it, can't live without it. Endocr Relat Cancer. 2013 Nov 4;20(6):R341-56.

     

     

    Mooso BA, Vinall RL, Tepper CG, Savoy RM, Cheung JP, Singh S, Siddiqui S, Wang Y, Bedolla RG, Martinez A, Mudryj M, Kung HJ, Devere White RW, Ghosh PM. Enhancing the effectiveness of androgen deprivation in prostate cancer by inducing Filamin A nuclear localization. Endocr Relat Cancer. 2012 Nov 9;19(6):759-77.

     

     

    Ghosh, P.M.,  Shu, Z.J., Zhu, B., Lu, Z., Ikeno, Y., Barnes, J.L., Yeh, C.K., Zhang, B.K., Katz, M.S. and Kamat, A. β-Adrenergic Receptor Signaling Increases Lipid Accumulation In Liver During Aging. Journal of Endocrinology 2012 Jun;213(3):251-61.

     

    Chen L, Mooso BA, Jathal MK, Madhav A, Johnson SD, van Spyk E, Mikhailova M, Zierenberg-Ripoll A, Xue L, Vinall RL, deVere White RW, Ghosh PM. Dual EGFR/HER2 inhibition sensitizes prostate cancer cells to androgen withdrawal by suppressing ErbB3. Clin Cancer Res. 2011 Oct 1; 17 (19):6218-28.

    Vinall RL, Mahaffey CM, Davis RR, Luo Z, Gandour-Edwards R, Ghosh PM, Tepper CG, de Vere White RW. Dual blockade of PKA and NF-B inhibits H2 relaxin-mediated castrate-resistant growth of prostate cancer sublines and induces apoptosis. Horm Cancer. 2011 Aug; 2 (4):224-38. PubMed PMID: 21789713.

    Jathal MK, Chen L, Mudryj M, Ghosh PM. Targeting ErbB3: the New RTK(id) on the Prostate Cancer Block. Immunol Endocr Metab Agents Med Chem. 2011 Jun; 11 (2):131-149. PubMed PMID: 21603064

    Roy M, Kung HJ, Ghosh PM. Statins and prostate cancer: role of cholesterol inhibition vs prevention of small GTP-binding proteins. Am J Cancer Res. 2011; 1 (4):542-61. PubMed PMID: 21984972.

     

    Ghosh PM. What controls PTEN and what it controls (in prostate cancer). Asian J Androl. 2011 Sep 26; 14(1): 130-131. PubMed PMID: 21946231.

     

    Chen H, Libertini SJ, Wang Y, Kung HJ, Ghosh P, Mudryj M. ERK regulates calpain 2-induced androgen receptor proteolysis in CWR22 relapsed prostate tumor cell lines. J Biol Chem. Jan 22;285(4):2368-74. 2010

    Chen, L, Lu, X.-H., Shi, X.-B., R., deVere White, RW, Carraway, K.L. III and Ghosh, PM. Nrdp1-mediated regulation of ErbB3 expression by the androgen receptor in androgen-dependent but not castrate–resistant prostate cancer cells. Cancer Research. 70(14):5994-6003, 2010.

    Mooso, B., Madhav, A. Johnson, S.D., Roy, M., Moore, M.E., Moy, C., Loredo, Mehta, R.G., Vaughan, A.T.M. and Ghosh, P.M. Androgen Receptor regulation of Vitamin D receptor in response of castration-resistant prostate cancer cells to 1α-Hydroxyvitamin D5 – a calcitriol analog. Genes and Cancer, 2010. Nov 16;1(9):927-940.

    Chen, H., Libertini, S.J., George, M., Dandekar, S., Tepper, C.G., Al-Bataina, B., Kung, H.-J., Ghosh, P.M., Mudryj, M. Genome-wide analysis of androgen receptor binding and gene regulation in two CWR22-derived prostate cancer cell lines. Endocrine-related cancers. 2010. Oct 5;17(4):857-73.

    Khan, IH, Zhao, J, Ghosh, PM, Ziman, M, Sweeney, C, Kung, HJ and Luciw, PA. Activation and Dimerization of Receptor Tyrosine Kinases (ErbB Family) in Breast Cancer Cells Analyzed by Multiplex Microbead Suspension Array. ASSAY and Drug Development Technologies. Feb;8(1):27-36. 2010

     

    Ghosh P, Qiu Y, Wang LY and Kung HJ: Tyrosine kinome profiling: Oncogenic mutations and therapeutic targeting in cancer, Molecular Oncology – Causes of Cancer ad Targets for Treatment. Eds. Gelmann, E.P., Sawyers, C.L. and Rauscher, F.J. Cambridge University. 58-75. 2014

     

    Bedolla, RG, Asuncion, A, Chamie, K, Siddiqui, S, Troyer, DA, Mehra, R, Siddiqui, J, Chinnaiyan, AM, deVereWhite, RW, and Ghosh, PM. Nuclear vs Cytoplasmic localization of Filamin A in Prostate Cancer: Immunohistochemical Correlation with Metastases. Clinical Cancer Research, 15(3): 788-796. 2009.

    Chamie, K, Ghosh, PM, Koppie, TM, Romero, V, Troppmann, C,and deVere White, RW. The effect of sirolimus on PSA kinetics in male renal transplant recipients without prostate cancer. American Journal of Transplantation, 8(12): 2668-2673. 2008.

    Wang, Y, Mikhailova, M, deVere White, RW, and Ghosh, PM. Regulation of androgen receptor transcriptional activity by rapamycin. Oncogene, 27(56): 7106-7117. 2008

    Kamat, A., Ghosh, PM, Glover, RL, Zhu, B, Yeh, CK, Choudhury, GG and Katz, MS. Reduced Expression of Epidermal Growth Factor Receptors in. Journal of Gerontology, 63(7): 683-692. 2008

    Mikhailova, M., Wang, Y., Bedolla, R.G., Lu, X.H., Kreisberg, J.I. and Ghosh, P.M.: AKT Regulates Androgen Receptor-dependent Growth and PSA Expression in Prostate Cancer, Adv Exp Med Biol., Vol. 617, pp. 397-405. 2008.

    Wang, Y., Kreisberg, J.I. and Ghosh, P.M. Cross-talk between the Androgen Receptor and the Phosphatidylinositol 3-kinase/Akt pathway in Androgen-Independent Prostate Cancer. Current Cancer Drug Targets. 7: 591-604. 2007

    Shi, X.-B., Xue, L. Tepper, C.G., Gandour-Edwards, R., Ghosh, P., Kung, H.J. and deVere White, R.W. . The oncogenic potential of a prostate cancer-derived androgen receptor mutant. The Prostate, 67(6): 591-602. 2007.

    Bedolla R, Prihoda TJ, Kreisberg JI, Malik SN, Krishnegowda NK, Troyer DA, Ghosh PM. Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation. Clin. Cancer Res., 13(13): 3860-3867. 2007

    Wang, Y., Kreisberg, J.I., Bedolla, R., Mikhailova, M., deVere White, R.W. and Ghosh, P.M. A 90 kDa fragment of filamin A promotes Casodex-induced growth inhibition in Casodex-resistant androgen receptor positive C4-2 prostate cancer cells. Oncogene. 2007.

     

    Mikhailova M, Wang Y, Bedolla RG, Lu XH, Kreisberg JI and Ghosh PM: AKT Regulates Androgen Receptor-dependent Growth and PSA Expression in Prostate Cancer, Adv Exp Med Biol, Vol. 617, pp. 397-405. 2007.

     

    Vinall, R.L., Hwa, K., Ghosh, P., Pan, C-X., Lara, P.N. Jr. and deVere White, R.W. Combination Treatment Of Prostate Cancer Cell Lines With Bioactive Soy Isoflavones (GCP) And Perifosine Causes Increased Growth Arrest And/Or Apoptosis. Clinical Cancer Research. 13: 6204-6216. 2007.

    Wang, Y., Kreisberg, J.I. and Ghosh, P.M. Cross-talk between the Androgen Receptor and the Phosphatidylinositol 3-kinase/Akt pathway in Androgen-Independent Prostate Cancer. Current Cancer Drug Targets. 7: 591-604. 2007

    Vinall, R.L., Hwa, K., Ghosh, P., Pan, C-X., Lara, P.N. Jr. and deVere White, R.W. Combination Treatment Of Prostate Cancer Cell Lines With Bioactive Soy Isoflavones (GCP) And Perifosine Causes Increased Growth Arrest And/Or Apoptosis. Clinical Cancer Res., 13: 6204-6216, 2007

    Ghosh, P.M., Malik, S.N., Prihoda, T.J., Bedolla, R.G., Wang, Y., Troyer, D.A. and Kreisberg, J.I. Akt mediates proliferation via both androgen-dependent and independent pathways in prostate cancer. Endocr Relat Cancer. Mar;12(1):119 34. 2005

    Yeh, C. K.**, Ghosh, P.M.**, Liu, Q., Zhang, B. X., and Katz, M.S. Activation of Mitogen-activated Protein Kinase Mediates Isoproterenol-induced Salivary Cell Growth. Am J Physiol Cell Physiol. 288(6):C1357-C1366. 2005

    Ghosh, P.M., Bedolla, R., Thomas, C.A. and Kreisberg, JI. Role of Protein kinase C in Arginine Vasopressin-stimulated mesangial cell proliferation. J. Cell. Biochem., 2004; 91(6):1109-29.

    Kreisberg, J.I., Malik, S.N., Prihoda, T.J., Bedolla, R.G., Troyer, D.A. Kreisberg, S. and Ghosh, P.M. Expression of phospho-AKT (Ser 473) is an excellent predictor of Poor Clinical Outcome in Prostate Cancer. Cancer Res. Aug 1;64(15):5232-6. 2004

    Ghosh, P.M., Malik, S. N., Bedolla, R. and Kreisberg, J.I. Akt in Prostate Cancer: Possible Role in Androgen-Independence. Current Drug Metabolism, 4(6):487-496. 2003

    Ghosh PM, Bedolla R, Mikhailova M, and Kreisberg JI. RhoA-Dependent Murine Prostate Cancer Cell Proliferation and Apoptosis: Role of PKCzeta. Cancer Res. 62(9):2630-6. 2002

    Malik, S.N., Brattain, M.G., Ghosh, P.M., Troyer, D.A., Prihoda, T., Bedolla, R. and Kreisberg, J.I. Immunohistochemical Demonstration of phospho-Akt in High Gleason Grade Prostate Cancer. Clinical Cancer Res. 8(4):1168-71. 2002

    Sawhney RS, Guo-Hao K, Humphrey LE, Ghosh P, Kreisberg JI, Brattain MG: Differences in sensitivity of biological functions mediated by epidermal growth factor receptor activation with respect to endogenous and exogenous ligands. J Biol Chem 277: 75-86. 2002

    Ghosh, P.M., Mikhailova, M., Bedolla, R. and Kreisberg, J.I. Arginine Vasopressin Stimulates Mesangial Cell Proliferation by Activating the Epidermal Growth Factor Receptor. Am. J. Physiol- Renal Physiology. 280(6):F972-979. 2001

    Ghosh-Choudhury, N., Ghosh-Choudhury, G., Celeste, A., Ghosh, P.M., Moyer, M.L., Abboud, S.L., and Kreisberg, J.I. Bone Morphogenic Protein-2 induces cyclin kinase inhibitor p21 and hypophosphorylation of retinoblastoma protein in estradiol treated MCF- human breast cancer cells. Biochim. Biophys. Acta 1497:186-196. 2000

    Ghosh, P.M., M. Moyer and J.I. Kreisberg. Effect of cyclin E overexpression on lovastatin-induced G1 arrest and RhoA inactivation in NIH3T3 cells. J. Cell. Biochem. 74: 532 543. 1999

    Ghosh, P.M., G.E. Mott, M.L. Stapleton, N. Ghosh-Choudhury and J.I. Kreisberg. Role of RhoA and actin stress fiber formation in the proliferation of a mouse prostate cancer cell line. Oncogene. 18: 4120-4130. 1999

    Ghosh, P., G.E. Mott, N. Ghosh-Choudhury, R.A. Radnik, M.L. Stapleton, J.J. Ghidoni and J.I. Kreisberg. Lovastatin induces apoptosis by inhibiting mitotic and post-mitotic events in cultured mesangial cells. Biochim. Biophys. Acta. 1359: 13-24. 1997

    Klebe, R.J., A. Grant, G. Grant and P. Ghosh. 1995. Cyclic-AMP deficient MDCK cells from tubules. J. Cell Biochem. 59:453-462. 1995

    Klebe, R.J., C.A. Thomas, G.M. Grant, A. Grant and P. Ghosh. Cytoscription: Computer-controlled micropositioning of cell adhesion proteins. J. Tissue Culture Methods. 16:189-192. 1994

    Ghosh, P.M., C.R. Keese and I. Giaever. Morphological response of mammalian cells to pulsed AC fields. Bioelectrochem. Bioenerg. 33:121-133. 1994

    Ghosh, P.M., C.R. Keese and I. Giaever. Monitoring Electropermeabilization in the Plasma Membrane of Adherent Mammalian Cells. Biophys. J. 64: 1602-1609. 1993

    Mitra, P., C.R. Keese and I. Giaever. Electrical Measurements can be used to Monitor the Attachment and Spreading of Cells in Tissue Culture. Biotechniques. 11: 504-510. 1991

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