Peter Beal

Peter Beal

Position Title
Professor

  • Department of Chemistry, College of Letters and Science
Chemistry Annex, Davis, CA 95616
Bio

Grad Group Affiliations

  • Biochemistry, Molecular, Cellular and Developmental Biology
  • Chemistry (Letters and Science)

Courses

  • CH 128A Organic Chemistry for majors, Fall
  • CH 135A Pharmaceutical Chemistry, Winter
  • MCB 221A Physical Biochemistry, Fall
  • CH 221C Nucleic Acids Chemical Biology, Spring
  • CH 118B Organic Chemistry, Spring

Labs

  • Chemistry Annex, 5th floor

Honors and Awards

  • NIH First Award, 1998
  • Camille Dreyfus Teacher-Scholar Award, 2002
  • Robert A. Parry Teaching Award, 2005
  • NIH Postdoctoral Fellowship, Harvard University, '94-'96

    Professional Societies

    • American Chemical Society (Organic, Biological and Med. Chem. Divisions)
    • RNA Society
    • AAAS Fellow

    Degrees

    • 1989 BS Chemistry University of North Dakota
    • 1994 PhD Chemistry California Institute of Technology

    Publications

    “Rational Design of RNA Editing Guide Strands: Cytidine Analogs at the Orphan Position” Erin E. Doherty, Xander Wilcox, Lenka van Sint Fiet, Cherie Kemmel, Janne J. Turunen, Bart Klein, Dean J. Tantillo, Andrew J. Fisher, and Peter A. Beal J. Am. Chem. Soc. 2021, 143, 6865-6876.

    “Regulation of RNA Editing by Intracellular Acidification” Turnee N. Malik, Erin E. Doherty, Vandana Gaded, Theodore M. Hill, Peter A. Beal and Ronald B. Emeson Nucleic Acids Res. 2021,49, 7, 4020-4036.

    "Ester Modification at the 3' End of Anti-MicroRNA Oligonucleotides Increases Potency of MicroRNA Inhibition" Kevin M. Pham, Scott R. Suter, Shannon S. Lu, and Peter A. Beal Bioorg. Med. Chem. 2021, 29, 115894.

    “High-throughput Mutagenesis Reveals Unique Structural Features of Human ADAR1” SeHee Park, Erin E. Doherty, Yixuan Xie, Anil K. Padyana, Fang Fang, Yue Zhang, Agya Karki, Carlito B. Lebrilla, Justin B. Siegel and Peter A. Beal Nat. Commun. 2020, 11, 1, 5130.

    “Asymmetric Dimerization of Adenosine Deaminase acting on RNA Facilitates Substrate Recognition” Alexander S. Thuy-Boun, Justin M. Thomas, Herra L. Grajo, Cody M. Palumbo, SeHee Park, Luan T. Nguyen, Andrew J. Fisher and Peter A. Beal Nucleic Acids Res. 2020, 48, 14, 7958-7972.

    “DNA capture by a CRISPR-Cas9 guided adenosine base editor” Audrone Lapinaite, Gavin J. Knott, Cody M. Palumbo, Michelle F. Richter, Kevin T. Zhao, Peter A. Beal, David R. Liu and Jennifer A. Doudna Science 2020, 369, 566-571.

    “Chemical Profiling of A-to-I RNA Editing Using a Click-Compatible Phenylacrylamide” Steve D. Knutson, Megan M. Korn, Ryan P. Johnson, Leanna R. Monteleone, Deanna M. Dailey, Colin S. Swenson, Peter A. Beal and Jennifer M. Heemstra Chem. Eur. J. 2020, doi: 10.1002/chem.202001667.

    “Versatile 3’ Functionalization of CRISPR Single Guide RNA” Cody M. Palumbo, Jeton M. Gutierrez-Bujari, Henriette O’Geen, David J. Segal, Peter A. Beal ChemBioChem 2020, 21, 11, 1633-1640.  

     "Off-target Editing by CRISPR-guided DNA base editors" SeHee Park and Peter A. Beal Biochemistry 2019, 58, 36, 3727-3734.

    “RNA Binding Candidates for Human ADAR3 from Substrates of a Gain of Function Mutant Expressed in Neuronal Cells” Yuru Wang, Dong hee Chung, Leanna R. Monteleone, Jie Li, Yao Chiang, Michael D. Toney and Peter A. Beal Nucleic Acids Res. 2019, 47, 20, 10801-10814.

    “A Bump-Hole Approach for Directed RNA Editing” Leanna R. Monteleone, Melissa M. Matthews, Cody M. Palumbo, Justin M. Thomas, Yuxuan Zheng, Yao Chiang, Andrew J. Fisher and Peter A. Beal Cell Chem. Biol. 2019, 26, 269-277.

    “Nucleoside Analogs in the Study of the Epitranscriptome” Cody M. Palumbo and Peter A. Beal Methods 2019, 156, 46-52.

    “Differentiating positional isomers of nucleoside modifications by higher-energy collisional dissociation mass spectrometry (HCD MS)” Manasses Jora, Andrew Burns, Robert Ross, Peter Lobue, Ruoxia Zhao, Cody Palumbo, Peter A. Beal, Balasubrahmanyam Addepalli, and Patrick A. Limbach J. Am. Soc. Mass Spectrom. 2018, 8, 1745-1756.   

    “Structural Basis for Eukaryotic mRNA Modification” Andrew J. Fisher and Peter A. Beal Curr. Opin. Struc. Biol. 2018, 53, 59-68.

    Selective Recognition of RNA Substrates by ADAR Deaminase Domains” Yuru Wang, SeHee Park and Peter A. Beal Biochemistry 2018, 57, 10, 1640-1651.

    “TLR8 activation and inhibition by guanosine analogs in RNA: importance of functional groups and chain length” Tiannan Hu, Scott R. Suter, Madeline M. Mumbleau and Peter A. Beal Bioorg. Med. Chem. 2018, 26, 1, 77-83.

    Identifying biologically important metabolites by mass spectrometry-based cheminformatics” Zijuan Lai, Hiroshi Tsugawa, Gert Wohlgemuth, Yuxuan Zheng, Atsushi Ogiwara, Sajjan Mehta, John Meissen, Kohei Takeuchi, William R. Wikoff, Peter Beal, Masanari Arita and Oliver Fiehn Nat. Methods 2018, 15, 1, 53-56.

    "New Protein-RNA Structures Illuminate Substrate Recognition by the RNA editing ADARs" Justin M. Thomas and Peter A. Beal BioEssays 2017, 39, 4, doi: 10.1002/bies201600187. 

    “Effects of Aicardi-Goutieres Syndrome Mutations Predicted from ADAR-RNA Structures” Andrew J. Fisher and Peter A. Beal RNA Biology 2017, 14, 2, 164-170.

    “DNA Editing in DNA/RNA Hybrids by Adenosine Deaminases that act on RNA” Yuxuan Zheng, Claire Lorenzo and Peter A. Beal Nucleic Acids Res. 2017, 45, 6, 3369-3377.

    Synthesis of native-like cross-linked duplex RNA and study of its properties” Kazumitsu Onizuka, Madoka E. Hazemi, Justin M. Thomas, Leanna R. Monteleone, Ken Yamada, Shuhei Imoto, Peter A. Beal and Fumi Nagatsugi Bioorg. Med. Chem. 2017, 25, 7, 2191-2199.

    “Adenosine Deaminases that Act on RNA (ADARs)” Yuru Wang, Yuxuan Zheng and Peter A. Beal in The Enyzmes, Vol. 41: RNA Modification edited by Guillaume Chantfreau 2017, Elsevier publisher, 215-268.Contributed equally. 

    “Controlling miRNA-like Off-target Effects of an siRNA with Nucleobase Modifications” Scott R. Suter, Alexi Ball-Jones, Madeline M. Mumbleau, Rachel Valenzuela, Jose Ibarra-Soza, Hassan Owens, Andrew J. Fisher and Peter A. Beal Org. Biomol. Chem.  2017, 15, 47, 10029-10036.  

    “Synthesis and evaluation of an alkyne-modified ATP analog for enzymatic incorporation into RNA” Yuxuan Zheng and Peter A. Beal Bioorg. Med. Chem. Lett. 2016, 26, 7, 1799-1802.

    “Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity” Melissa M. Matthews†, Justin M. Thomas†, Yuxuan Zheng, Kiet Tran, Kelly J. Phelps, Anna I. Scott, Jocelyn Havel, Andrew J. Fisher and Peter A. Beal Nat. Struct. Mol. Biol. 2016, 23, 426-433. †Contributed equally. 

    “Structure-Guided Control of siRNA Off Target Effects” Scott R. Suter, Jessica Sheu-Gruttadauria, Nicole T. Schirle, Rachel Valenzuela, Alexi A. Ball-Jones, Kazumitsu Onizuka, Ian J. MacRae and Peter A. Beal J. Am. Chem. Soc. 2016, 138, 8667-8669.

     “Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method” Yuru Wang and Peter A. Beal Nucleic Acids Res. 2016, 44, 20, 9872-9880.

    “Guide Strand 3’-End Modifications Regulate siRNA Specificity” Rachel Valenzuela, Kazumitsu Onizuka, Alexi A. Ball-Jones, Tiannan Hu, Scott Suter and Peter A. Beal ChemBioChem 2016, 17, 24, 2340-2345.

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

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