Peter M. Cala

Peter Cala

Position Title
Professor and Chair, Arline Miller Rolkin Chair in Physiology and Membrane Biology

Department of Physiology and Membrane Biology, School of Medicine

4136 Tupper Hall

Profile Introduction

Sodium-Proton exchange (NHE1), Structure-Function, cell volume and pH regulation, Ion transport

Research Interests

Sodium-Proton exchange (NHE1), Structure-Function, cell volume and pH regulation, Ion transport

Specialties / Focus

  • Cell Biology


  • Med HP400 Medical Physiology, Fall
  • PGG 210A General/Membrane Physiology, Fall

Honors and Awards

  • 1994-2004 NIH MERIT award
  • 1999 Research Mentor Award: UCDMC
  • 2000 Leader of the Membrane Biology Initiative, UCDSOM
  • 2003-2005 Association of Chairs of Physiology Departments: President

    Professional Societies

    • Americam Physiological Society
    • Association of Chairs of Physiology Departments (ACDP: past president)


    • 1970 BA Biology/Chemistry Case Western Reserve University
    • 1974 PhD Physiology Case Western Reserve University


    2003 Stine F. Pedersen, Scott A. King, Robert R. Rigor, Zhenpeng Zhuang, Jaimie M. Warren, and Peter M. Cala. Molecular cloning of NHE1 from winter flounder RBCs: activation by osmotic shrinkage, cAMP, and calyculin A. Am J Physiol Cell Physiol 284: C1561-C1576.

    2004 Pedersen, S.F., Cala, P.M. Comparative biology of the ubiquitous Na+/H+ exchanger, NHE1; lessons from erythrocytes. J. Exp. Zoolog. Part A Comp. Exp. Biol. 2004 Jul 1; 301(7):569-78.

    2006 Pedersen, S.F., M.E. O’Donnell, S.E. Anderson and P.M. Cala. Physiology and pathophysiology of Na+/H+ exchange and Na+-K+-2Cl- cotransport in the heart, brain and blood. Am. J. Physiol. Regul. Integr. Comp. Physiol. 291: R1-R25.

    2006 Holt, M.E., S.A. King, P.M. Cala and S.E. Pedersen. Regulation of the Pleuronectes americanus Na+/H+ exchanger by osmotic shrinkage, beta-adrenergic stimuli, and inhibition of the Ser/Thre protein phosphatases. Cell. Biochem. Biophys. 45: 1-18.

    2007 King, S. A., E.B. Nygaard , R.R. Rigor R.R, S. F. Pedersen, and P. M. Cala. NHE1 inhibition by amiloride- and benzoyl guanidine-type compounds: inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity. J Biol Chem. 282(27): 19716-27. Epub 2007 May 10.

    2008 Ortiz-Acevedo A, Rigor III RR, Maldonado HM, Cala PM. Activation of Na+/H+ and K+/H+ Exchange by Calyculin A in Amphiuma tridactylum Red Blood Cells; implications for the control of volume-induced ion flux activity. Am J Physiol Cell Physiol, 284: C-1123-32.

    2010 Ortiz-Acevedo A, Rigor III RR, Maldonado HM, Cala PM. Coordinated control of volume regulatory Na+/H+ and K+/H+ exchange pathways in Amphiuma red blood cells. Am J Physiol Cell Physiol, 298: C510-20. PMCID 2838575

    2011 Nygaard, EB, Lagerstedt, JO, Bjerre, G, Shi, B, Budamagunta, M, Poulsen, KA, Meinild, S, Rigor, RR, Voss, JC, Cala, PM, Pedersen, SF. Structural modeling and electron paramagnetic resonance spectroscopy of the human Na+/H+ exchanger isoform 1, NHE1. J Biol Chem 286: 634-48. PMCID 3013023