Department of Cell Biology and Human Anatomy, School of Medicine
Brain development is a finely orchestrated process. Transient abnormalities, such as delayed or excessive growth of axons and dendrites in neurons can have a prolonged impact in the formation of functional connections. Early postnatal stages are critical periods, in which both intrinsic genetic programs and sensory experience participate in the formation and refinement of functional circuitry. My lab uses mouse olfactory system as a model to study the molecular mechanisms of neuronal network formation and plasticity. Using a combination of cell biological, genetic and molecular biological approaches, we are focused on studying molecules that regulate olfactory sensory axon growth and guidance, mitral cell dendritic differentiation and olfactory circuitry formation.
Grad Group Affiliations
- Biochemistry, Molecular, Cellular and Developmental Biology
Specialties / Focus
- Developmental Biology
- Genomics, Proteomics and Metabolomics
- Molecular Genetics
- MCB 255 Molecular Mechanisms of Animal Development, Spring
- CHA 400 Developmental, Gross and Radiographic Anatomy, Fall
- NSC 201 Neuroanatomy, Fall
- Association for Chemoreception Sciences
- Society for Neuroscience
- 1986 BS Biology Peking University
- 1994 PhD Cell Biology University of Cincinnati
Gong Q, and MT Shipley. 1995. Evidence that pioneer olfactory axons regulate telencephalon cell cycle kinetics to induce the formation of the olfctory bulb.. Neuron. 14:91-101
Gong Q, Rangarajan R, Seeger M, and U Gaul. 1999. The netrin receptor frazzled is required in the target for establishemnt of retinal projections in the Drosophila visual system.. Development. 126:1451-1456
Rangarajan R, Gong Q, and U Gaul. 1999. Migration and function of glia in the developing Drosophila eye.. Development. 126:3285-3292
Chen H. Dadsetan S. Fomina A.F. and Gong Q. (2008) Expressing exogenous functional odorant receptors in cultured olfactory sensory neurons. Neural Dev 3:22
Chen H. Kohno K. and Gong Q. (2005) Conditional ablation of mature olfactory sensory neurons mediated by diphtheria toxin receptor. J Neurocytology 34: 37-47
Cheng TW, and Gong Q (2009) Secreted TARSH regulates olfactory mitral cell dendritic complexity. Eur J Neurosci 29: 1083-1095.
Lee W. Cheng T.W. and Gong Q. (2008) Olfactory sensory neuron specific and sexually dimorphic expression of protocadherin 20. J Comp Neurol 507(1): 1076-86.
Tran H. Chen H. Walz A. Posthumus J.C. and Gong Q. (2008) Influence of olfactory epithelium on mitral/tufted cell dendritic outgrowth. PLoS One 3(11): e3816 doi:10.1371/journal.pone.0003816.