Specialties / Focus

Dr. Isseroff focuses on healing wounds, both in patients with chronic wounds, and in the laboratory, investigating new approaches to improve healing. In her Wound Clinic (within the affiliated Veterans Association Health Care Systems of Northern California), she treats patients with chronic wounds of any cause, including diabetes, venous disease, pressure ulcers, collagen vascular disease. She directs the multi-specialty Wound clinic, and directs the VA Dermatology Clinical Research Unit, that carries out clinical trials.

As an investigator she studies what mechanisms can modulate cell migration, improve tissue regeneration and mitigate wound infection. She also engineers tissues using scaffolds and mesenchymal stem cells to speed tissue regeneration. The roles of catecholamine stress hormomens in regulating growith of mammalian cells and bacterial pathogens are studied in relation to wound healing. The lab uses multiple approaches including in vitro, ex vivo (human skin) and in vivo (mouse, pig) wound models. Her bench work on catecholamine stress and healing has been translated to patient therapies, where inhibitors are now being tested in clinical trials to improve healing. She has ongoing research funding from the California Institute of Regenerative Medicine, the NIH, the VA and industry.

Degrees

• M.D.- Albert Einstein College of Medicine

Publications 

Selected from >150

2019. Chuong Minh Nguyen, Danielle Marie Tartar, Michelle So, Michelle Dawn Bagood, Andrew Adams, Alan Nguyen, Jaime Joel Fuentes, Benjamin Harouni, Robert William Crawford, Athena M. Soulika and Roslyn Rivkah Isseroff. Topical Fluoxetine Enhances Cutaneous Wound Healing in Diabetic Wounds. Diabetes, In press.

2019. Catherine N. Tchanque-Fossuo,  Sara E. Dahle,  Hadar Lev-Tov, Kaitlyn IM. West, Chin-Shang Li, David Rocke,  R. Rivkah Isseroff. Cellular versus Acellular Matrix Devices in the Treatment of Diabetic Foot Ulcers: Interim Results of a Comparative Efficacy Randomized Controlled Trial. Journal of Tissue Engineering and Regenerative Medicine, In press 

2019. Amir Hossein Siadat,  R. Rivkah Isseroff. Prolotherapy: Potential for the Treatment of Chronic Wounds? Advances in Wound Repair, In press

2019 Yoon DJ, Fregoso DR, Nguyen D, Chen V, Strbo N, Fuentes JJ, Tomic-Canic M, Crawford R, Pastar I, Isseroff RR. A tractable, simplified ex vivo human skin model of wound infection. Wound Repair Regen.  PubMed PMID: 30825247

2018. Albrecht H, Yang HY, Kiuru M, Maksaereekul S, Durbin-Johnson B, Wong MS, Stevenson TR, Rocke DM, Isseroff RR. The Beta 2 Adrenergic Receptor Antagonist Timolol Improves Healing of Combined Burn and Radiation Wounds. Radiat Res.  PubMed PMID: 29373090

2018. Larsen L, Tchanque-Fossuo CN, Gorouhi F, Boudreault D, Nguyen C, Fuentes JJ, Crawford RW, Dahle SE, Whetzel T, Isseroff RR. Combination therapy of autologous adipose mesenchymal stem cell-enriched, high-density lipoaspirate and topical timolol for healing chronic wounds. J Tissue Eng Regen Med.  PubMed PMID: 27943665.

2015. Park SA, Covert J, Teixeira L, Motta MJ, DeRemer SL, Abbott NL, Dubielzig R, Schurr M, Isseroff RR, McAnulty JF, Murphy CJ. Importance of defining experimental conditions in a mouse excisional wound model. Wound Repair Regen. PubMed PMID: 25703258.

2015. Beegle J, Lakatos K, Kalomoiris S, Stewart H, Isseroff RR, Nolta JA, Fierro FA. Hypoxic preconditioning of mesenchymal stromal cells induces metabolic changes, enhances survival, and promotes cell retention in vivo. Stem Cells.  PubMed PMID: 25702874.

2014 Pastar I, Stojadinovic O, Yin NC, Ramirez H, Nusbaum AG, Sawaya A, Patel SB, Khalid L, Isseroff RR, Tomic-Canic M. Epithelialization in Wound Healing: A Comprehensive Review. Adv Wound Care  PubMed PMID: 25032064

2014.  Braun LR, Fisk WA, Lev-Tov H, Kirsner RS, Isseroff RR. Diabetic foot ulcer: an evidence-based treatment update. Am J Clin Dermatol.  PMID: 24902659.

2014. Park SA, Teixeira LB, Raghunathan VK, Covert J, Dubielzig RR, Isseroff RR, Schurr M, Abbott NL, McAnulty J, Murphy CJ. Full-thickness splinted skin wound healing models in db/db and heterozygous mice: implications for wound healing impairment. Wound Repair Regen. PubMed PMID: 24844336

2014. Dasu MR, Ramirez SR, La TD, Gorouhi F, Nguyen C, Lin BR, Mashburn C, Stewart H, Peavy TR, Nolta JA, Isseroff RR. Crosstalk between adrenergic and toll-like receptors in human mesenchymal stem cells and keratinocytes: a recipe for impaired wound healing. Stem Cells Transl Med. PubMed PMID: 24760207

2014.  Gorouhi F, Shah NM, Krishna Raghunathan V, Mohabbati Y, Abbott NL, Isseroff RR, Murphy CJ. Epidermal growth factor-functionalized polymeric multilayer films: interplay between spatial location and bioavailability of EGF. J Invest Dermatol. PubMed PMID: 24390131.

2014. Lev-Tov H, Dahle S, Moss J, Isseroff RR. Successful treatment of a chronic venous leg ulcer using a topical beta-blocker. J Am Acad Dermatol. 2013 Oct;69(4):e204-5. doi: 10.1016/j.jaad.2013.06.003. PubMed PMID: 24034405. 49: Yang HY, Charles RP, Hummler E, Baines DL, Isseroff RR. The epithelial sodium channel mediates the directionality of galvanotaxis in human keratinocytes. J Cell Sci. 2013 May 1;126(Pt 9):1942-51. doi: 10.1242/jcs.113225. Epub 2013 Feb 27. PubMed PMID: 23447677

2014. Kim MH, Gorouhi F, Ramirez S, Granick JL, Byrne BA, Soulika AM, Simon SI, Rivkah Isseroff R. Catecholamine stress alters neutrophil trafficking and impairs wound healing by β2-adrenergic receptor-mediated upregulation of IL-6. J Invest Dermatol.  PubMed PMID: 24121404

2012. Liu W, Hsu DK, Chen HY, Yang RY, Carraway KL 3rd, Isseroff RR, Liu FT. Galectin-3 regulates intracellular trafficking of EGFR through Alix and promotes keratinocyte migration. J Invest Dermatol.  PubMed PMID: 22785133

2012. PPullar CE, Le Provost GS, O'Leary AP, Evans SE, Baier BS, Isseroff RR. β2AR antagonists and β2AR gene deletion both promote skin wound repair processes. J Invest Dermatol. PubMed PMID: 22495178

2011.  Sivamani RK, Schwartz MP, Anseth KS, Isseroff RR. Keratinocyte proximity and contact can play a significant role in determining mesenchymal stem cell fate in human tissue. FASEB J. PubMed PMID: 20847231

2009. Sivamani RK, Pullar CE, Manabat-Hidalgo CG, Rocke DM, Carlsen RC, Greenhalgh DG, Isseroff RR. Stress-mediated increases in systemic and local epinephrine impair skin wound healing: potential new indication for beta blockers. PLoS Med. PubMed PMID: 19143471

2008. Kim MH, Liu W, Borjesson DL, Curry FR, Miller LS, Cheung AL, Liu FT, Isseroff RR, Simon SI. Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging. J Invest Dermatol. PubMed PMID: 18185533

2007. Pullar CE, Zhao M, Song B, Pu J, Reid B, Ghoghawala S, McCaig C, Isseroff RR. Beta-adrenergic receptor agonists delay while antagonists accelerate epithelial wound healing: evidence of an endogenous adrenergic network within the corneal epithelium. J Cell Physiol. PubMed PMID: 17226783.

2006.  Pullar CE, Baier BS, Kariya Y, Russell AJ, Horst BA, Marinkovich MP, Isseroff RR. beta4 integrin and epidermal growth factor coordinately regulate electric field-mediated directional migration via Rac1. Mol Biol Cell. PubMed PMID: 16914518

2005. Pullar CE, Isseroff RR. Cyclic AMP mediates keratinocyte directional migration in an electric field. J Cell Sci.  PubMed PMID: 15840650

2002. Chen J, Hoffman BB, Isseroff RR. Beta-adrenergic receptor activation inhibits keratinocyte migration via a cyclic adenosine monophosphate-independent mechanism. J Invest Dermatol.  PubMed PMID: 12485426

2002.  Trollinger DR, Isseroff RR, Nuccitelli R. Calcium channel blockers inhibit galvanotaxis in human keratinocytes. J Cell Physiol. PubMed PMID: 12209874

2000.  Schwab IR, Isseroff RR. Bioengineered corneas--the promise and the challenge. N Engl J Med. 2000 JPubMed PMID: 10891524

1999.  Fang KS, Ionides E, Oster G, Nuccitelli R, Isseroff RR. Epidermal growth factor receptor relocalization and kinase activity are necessary for directional migration of keratinocytes in DC electric fields. J Cell Sci.  PubMed PMID: 10341215.