Reen Wu

Reen Wu

Position Title
Professor

Unit
Department of Internal Medicine, School of Medicine

GBSF, Room 6523
Bio

Profile Introduction

Gene expression and regulation in airway epithelium

Research Interests

Gene expression and regulation in airway epithelium

Grad Group Affiliations

  • Comparative Pathology Graduate group, Pharmacology and Toxicology Graduate Group
  • Integrative Genetics and Genomics

Specialties / Focus

  • Cardiorespiratory Physiology
  • Cellular Physiology
  • Cellular Responses to Toxins and Stress
  • Human Genetics and Genomics
  • Molecular Medicine

Courses

  • PMI 285 Cellular basis of disease, Winter
  • APC 291 Center for Comparative Respiratory Biology and Medicine seminar series, Fall,Winter,Spring

Labs

  • Center for Comparative Respiratory Biology and Medicine, GBSF
    • Dr. Mary Chang, Dr. Richart Harper, Dr. Philip Thai, Dr. Karen Oslund, Ken Chmiel, Fei Huang, Shinchiro Wachi, Laura Shih, Christy Kim, Li-Yin Hung, Keny Lin, Daphne Wu, Artem Loukoianov, Pimtip Sanvarinda

Honors and Awards

  • 1972-74 American Cancer Society Postdoctoral Fellowship
  • 1974-76 NIH National Research Service Award
  • 1993 Joan Oettinger Memorial Award, School of Medicine
  • 1996 Faculty Research Award, School of Medicine
  • 2000 NIH merit award, R37 HL35635

    Professional Societies

    • American Thoracic Society
    • American Society for Biochemistry and Molecular Biology
    • Oxygen Society
    • American Association for the Advancement of Science
    • The American Association of Immunologist

    Degrees

    • 1972 PhD Biochemistry University of Arkansas Medical Center

    Publications

    Di, Y.P., Zhao, Y.H., Harper, R., and Wu, R. Molecular cloning, and characterization of a human novel gene that is retinoic acid-inducible and encodes a secretory protein specific in upper respiratory tracts, SPURT. J. Biol. Chem. 278:1165-1173, 2003. Kao, C.Y, Chen, Y., Zhao, Y.H., and Wu, R. ORFeome based search of airway epithelial cell-specific novel human b-defensin genes. Am. J. Respir. Cell Mol. Biol. 29: 71-80, 2003. Chen, Y, Thai, P., Zhao, Y.H., Ho, Y.S., DeSouza, M.M., and Wu, R. Stimulation of airway mucin gene expression by IL-17 through IL-6 paracrine/autocrine loop. J. Biol. Chem. 278: 17036-17043, 2003. Chen, Y., Zhao, Y.H., Kalaslavadi, T.J., Hamati, E., Nehrke, K., Le, A.D., Ann, D.K., and Wu, R. Genome-wide search of novel gel-forming mucin genes and identification of MUC19/Muc19 as a new glandular tissue-specific mucin gene. Am. J. Respir. Cell Mol. Biol., in press, 2003. Yoneda, K., Chang, M. M.J., Chmiel, K., Chen, Y., and Wu, R. Application of high density DNA microarray to study smoke- and hydrogen peroxide-induced injury and repair in human bronchial epithelial cells. J. Am. Soc. Nephrology, 14: S284-S289, 2003.

    Chen, Y., Zhao, Y.H., Kalaslavadi, T.J., Hamati, E., Nehrke, K., Le, A.D., Ann, D.K., and Wu, R. Genome-wide search of novel gel-forming mucin genes and identification of MUC19/Muc19 as a new glandular tissue-specific mucin gene. Am. J. Respir. Cell Mol. Biol., 30: 155-165, 2004.

    Chen, Y, Thai, P., Zhao, Y.H., Ho, Y.S., DeSouza, M.M., and Wu, R. Stimulation of airway mucin gene expression by IL-17 through IL-6 paracrine/autocrine loop. J. Biol. Chem. 278: 17036-17043, 2003.

    Kao, C.Y, Chen, Y., Zhao, Y.H., and Wu, R. ORFeome based search of airway epithelial cell-specific novel human b-defensin genes. Am. J. Respir. Cell Mol. Biol. 29: 71-80, 2003.

    Di, Y.P., Zhao, Y.H., Harper, R., and Wu, R. Molecular cloning, and characterization of a human novel gene that is retinoic acid-inducible and encodes a secretory protein specific in upper respiratory tracts, SPURT. J. Biol. Chem. 278:1165-1173, 2003.

    Kao, C.Y, Chen, Y, Thai, P., Wachi, S., Huang, F., Kim, C., Harper, R.W., and Wu, R. Interleukin-17 Markedly Up-Regulates b-Defensin 2 Expression in Human Airway Epithelium via JAK and NF-kB Signaling Pathways. J. Immunol. 173: 3482-3491, 2004.

    Harper, R W, Xu C, Eiserich JP, Kao CY, Thai P, Setiadi H, and Wu, R. Differential regulation of dual NADPH oxidase/peroxidase, Duox 1 and Duox 2, by Th1 and Th2 cytokines in respiratory tract epithelium. FEBS Letter, 579: 4911-4917, 2005.

    Kao CY, Huang F., Chen Y., Thai P, Wachi, S, Kim C, Tam L and Wu R. Up-regulation of CC chemokine ligand 20 expression in human airway epithelium by IL-17 through a JAK-independent but MEK/NF-kappaB-dependent signaling pathway. J. Immunol. 175: 6676-6685, 2005.

    Thai, P., Chen Y, Dolganov G, and Wu, R. Differential regulation of MUC5AC/Muc5ac and hCLCA-1/mGob-5 expression in airway epithelium. American J. Respir. Cell Mol. Biol. 33(6):523-30, 2005.

    Wachi S., Yoneda K, and Wu R. Interactome-transcriptome analysis reveals the high centrality of genes differentially expressed in lung cancer tissues. Bioinformatics, 21(23):4205-8, 2005.

    Chen,Y., Hamati, E., Lee, W.M., Wachi, S., Schnurr, D., Shigeo, Y., Dolganov, G., Boushey, H., and Wu, R. Rhinovirus induces airway epithelial gene expression through double-stranded RNA and IFN-dependent pathways. Am. J. Respir. Cell Mol. Biol. 34: 192-203, 2006.

    Wu, D.Y-C, Wu, R., Reddy, S.P., Lee, Y.C., and Chang, M. M-J. Distinctive EGFR/ERK-Independent and Dependent Signaling Pathways in the Induction of Airway MUC5B and MUC5AC Expression by PMA. J. Am. Pathol. 170(1) 20-32, 2007.

    Wu DPC, Wu R, Chen Y, Tarasova N, and Chang MMJ. PMA stimulates MUC5B gene expression through an SP1-based mechanism in airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 37: 589-597, 2007.

    Thai P, Loukoianov A, Wachi S, and Wu R. Regulation of airway mucin gene expression. Annu. Rev. Physiol. 70: 13.1-13.25, 2008.

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