Richard W. Michelmore

Richard Michelmore

Position Title
Director, Genome Center; Novozymes Endowed Chair in Genomics; Distinguished Professor

Unit
Genome Center
Department of Molecular and Cellular Biology
Department of Medical Microbiology and Immunology, School of Medicine
Department of Plant Sciences, College of Agricultural and Environmental Sciences

4311 GBSF
Bio

Profile Introduction

Genetics and genomics of plant-pathogen interactions.

Research Interests

Genetics and genomics of disease resistance in plants

Please see website for details

Grad Group Affiliations

  • Agronomy and Horticulture
  • Integrative Genetics and Genomics
  • Plant Biology
  • Plant Pathology

Specialties / Focus

  • Integrated Genetics and Genomics
  • Model Plants
  • Molecular Biology, Biochemistry and Genomics
  • Plant Breeding

Labs

  • The Genome Center http://genomecenter.ucdavis.edu
    • Please see http://michelmorelab.ucdavis.edu

Honors and Awards

  • Fellow, American Association for the Advancement of Science
  • Novozymes Inc. Endowed Chair in Genomics

    Professional Societies

    • American Association for the Advancement of Science
    • American Phytopathological Society
    • American Society of Plant Biologists
    • Genetics Society of America

    Degrees

    • 1976 BA Natural Sciences University of Cambridge, UK
    • 1979 PhD Natural Sciences University of Cambridge, UK

    Publications

    Meyers, B.C., Kozik, A., Griego, A., Kuang, H. and Michelmore, R.W. (2003). Genome-wide analysis of NBS-LRR-encoding genes in Arabidopsis. Plant Cell 15:809-834.

    Kuang, H., Woo, S.-S., Meyers, B., Nevo, E. and Michelmore, R.W. (2004). Multiple genetic processes result in heterogeneous rates of evolution within the major cluster of disease resistance genes in lettuce. Plant Cell 16:2870-2894.

    Bernal, A., Pan, Q., Pollack, J., Rose, L., Willets, N., Kozik, A., Michelmore, R. (2005). Functional dissection of the Pto resistance gene using DNA shuffling. J. Biol. Chem. 280:23073-83.

    McHale, L., Tan, X., Koehl, P., Michelmore, R.W. (2006). Plant NBS-LRR proteins: adaptable guards. Genome Biology 7:212.

    West, M. A.L., van Leeuwen, H., Kozik, A., Kliebenstein, D. J., Doerge, R. W., St.Clair, D. A., Michelmore, R.W. (2006). High-density haplotyping with microarray-based expression and single feature polymorphism markers in Arabidopsis. Genome Research 16: 702-712.

    West, M.A.L., Kim, K., Kliebenstein, D., van Leeuwen, H., Michelmore, R.W., Doerge, R.W., St Clair, D.A. (2007). Global eQTL mapping reveals the complex genetic architecture of transcript-level variation in Arabidopsis. Genetics 175:1441-50.

    Truco, M.J., Antonise, R., Lavelle, D., Ochoa, O., Kozik, A, Witsenboer, H., Fort, S., Jeuken, M.J.W., Kesseli, R. V., Lindhout, P., Michelmore, R.W., Peleman, J. (2007). A high-density, integrated genetic linkage map of lettuce (Lactuca spp.). Theor. Appl. Genet. 115:735-746.

    Wroblewski, T., Piskurewicz, U., Tomczak, A., Ochoa, O., & Michelmore, R.W. (2007). Multiple resistance specificities are lost due to silencing homologs of the RGC2 NBS-LRR-encoding gene family in lettuce. Plant J. 51:803-818.

    Caldwell, K.S. & Michelmore, R.W. (2009). Genes encoding defense signaling proteins in plants are more conserved than those encoding recognition proteins. Genetics 181:671-84.

    Wroblewski, T., Caldwell, K.S., Piskurewicz, U., Cavanaugh, K.A., Xu, H., Kozik, A., Ochoa, O., McHale, L.K., Lahre, K., Jelenska, J., Castillo, J.A., Vinatzer, B.A., Greenberg, J.T., Michelmore, R.W. (2009). Large-scale analysis of interactions between several crop species and the effector repertoires from multiple Pseudomonas and Ralstonia spp. Plant Physiology 150:1733-49.

    Luo, Y., Caldwell, K., T. Wroblewski, Wright, M.E., & Michelmore, R.W. (2009). Cleavage of a negative regulator of plant innate immunity, RIN4, is dependent on resistance genes and affected by multiple bacterial effectors. The Plant Cell 21:2458-2472.

    Cantu, D., Vanzetti, L.S., Sumner, A., Dubcovsky, M., Matvienko, M., Distelfeld, A., Michelmore, R., Dubcovsky, J. (2010). Small RNAs, DNA methylation and transposable elements in wheat. BMC Genomics 11: 408.

    Cantu, D., Govindarajulu, M., Kozik, A., Wang, M., Chen, X., Michelmore, R.W., Dubcovsky, J. (2011). Next-generation sequencing provides rapid access to the genes of wheat stripe rust. Plos One 6:e24230.

    Michelmore, R.W., Christopoulou, M., Caldwell. K. (2013). Impacts of resistance gene genetics, function, and evolution on a durable future. Ann. Rev. Phytopathol. 51: 291–319.

    Matvienko, M., Kozik, A., Froenicke, L., Lavelle, D., Martineau, B., Perroud, B., Michelmore, R. (2013). Consequences of normalizing transcriptomic and genomic libraries of plant genomes using a duplex-specific nuclease and tetramethylammonium chloride. PLoS One. 8:e55913.

    Truco, M.J., Ashrafi, H., Kozik, A., van Leeuwen, H., Bowers, J., Reyes Chin Wo, S., Stoffel, K., Xu, H., Hill, T., van Deynze, A., Michelmore, R.W. (2013). An ultra high-density, transcript-based, genetic map of lettuce. G3, Genes, Genomes, Genetics. 3:617-631

    Wei, Z., Julkowska, M.M., Laloë, J.-O., Hartman, Y.,  de Boer, G.-J., Michelmore, R.W., van Tienderen, P., Testerink, C.S., Schranz, M.E.  (2014).  A mixed model QTL analysis for salt tolerance in crop-wild hybrids of lettuce seedlings.  Mol. Breeding 34:1389-1400.

    Govindarajulu, M., Epstein, L., Wroblewski, T., & Michelmore, R.W. (2014). Host-induced gene silencing inhibits the biotrophic pathogen causing downy mildew of lettuce.  Pl. Biotech. J. DOI: 10.1111/pbi.1230.

    Wroblewski, T., Matvienko, M., Piskurewicz, U., Xu, H., Martineau, B., Wong, J., Kozik, A., Michelmore, R. (2014).  Distinctive profiles of small RNA couple inverted repeat-induced posttranscriptional gene silencing with endogenous RNA silencing pathways in Arabidopsis.  RNA 20:1987 – 1999.

    Derevnina and Michelmore (2015).  Wheat rusts never sleep but neither do sequencers: will pathogenomics transform the way plant diseases are managed?  Genome Biology 16:44-47. DOI 10.1186/s13059-015-0615-3.

    Derevnina, L., Chin-Wo-Reyes, S., Martin, F., Wood, K., Froenicke, L., Spring, O., Michelmore, R. (2015).  Genome sequence and architecture of the tobacco downy mildew pathogen, Peronospora tabacina. Mol. Pl. Microbe Interact. In press.

    Christopoulou, M., McHale, L.K., Kozik, A., Reyes-Chin Wo, S., Wroblewski, T., Michelmore, R.W. (2015).  Dissection of two complex clusters of resistance genes in lettuce (Lactuca sativa).  Molec. Pl.-Micobe Interact.  http://dx.doi.org/10.1094/MPMI-06-14-0175-R.

    Please see website for additional publications.

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