Profile Introduction

Genetics and genomics of plant-pathogen interactions.

Research Interests

Genetics and genomics of disease resistance in plants

Please see website for details

Grad Group Affiliations

• Agronomy and Horticulture
• Integrative Genetics and Genomics
• Plant Biology
• Plant Pathology

Specialties / Focus

• Integrated Genetics and Genomics
• Model Plants
• Molecular Biology, Biochemistry and Genomics
• Plant Breeding

Labs

• The Genome Center http://genomecenter.ucdavis.edu
  • Please see http://michelmorelab.ucdavis.edu

Honors and Awards

• Fellow, American Association for the Advancement of Science
• Novozymes Inc. Endowed Chair in Genomics

Professional Societies

• American Association for the Advancement of Science
• American Phytopathological Society
• American Society of Plant Biologists
• Genetics Society of America

Degrees

• 1976 BA Natural Sciences University of Cambridge, UK
• 1979 PhD Natural Sciences University of Cambridge, UK

Publications

Meyers, B.C., Kozik, A., Griego, A., Kuang, H. and Michelmore, R.W. (2003). Genome-wide analysis of NBS-LRR-encoding genes in Arabidopsis. Plant Cell 15:809-834.

Kuang, H., Woo, S.-S., Meyers, B., Nevo, E. and Michelmore, R.W. (2004). Multiple genetic processes result in heterogeneous rates of evolution within the major cluster of disease resistance genes in lettuce. Plant Cell 16:2870-2894.

Bernal, A., Pan, Q., Pollack, J., Rose, L., Willets, N., Kozik, A., Michelmore, R. (2005). Functional dissection of the Pto resistance gene using DNA shuffling. J. Biol. Chem. 280:23073-83.

McHale, L., Tan, X., Koehl, P., Michelmore, R.W. (2006). Plant NBS-LRR proteins: adaptable guards. Genome Biology 7:212.

West, M. A.L., van Leeuwen, H., Kozik, A., Kliebenstein, D. J., Doerge, R. W., St.Clair, D. A., Michelmore, R.W. (2006). High-density haplotyping with microarray-based expression and single feature polymorphism markers in Arabidopsis. Genome Research 16: 702-712.

West, M.A.L., Kim, K., Kliebenstein, D., van Leeuwen, H., Michelmore, R.W., Doerge, R.W., St Clair, D.A. (2007). Global eQTL mapping reveals the complex genetic architecture of transcript-level variation in Arabidopsis. Genetics 175:1441-50.

Truco, M.J., Antonise, R., Lavelle, D., Ochoa, O., Kozik, A, Witsenboer, H., Fort, S., Jeuken, M.J.W., Kesseli, R. V., Lindhout, P., Michelmore, R.W., Peleman, J. (2007). A high-density, integrated genetic linkage map of lettuce (Lactuca spp.). Theor. Appl. Genet. 115:735-746.

Wroblewski, T., Piskurewicz, U., Tomczak, A., Ochoa, O., & Michelmore, R.W. (2007). Multiple resistance specificities are lost due to silencing homologs of the RGC2 NBS-LRR-encoding gene family in lettuce. Plant J. 51:803-818.

Caldwell, K.S. & Michelmore, R.W. (2009). Genes encoding defense signaling proteins in plants are more conserved than those encoding recognition proteins. Genetics 181:671-84.

Wroblewski, T., Caldwell, K.S., Piskurewicz, U., Cavanaugh, K.A., Xu, H., Kozik, A., Ochoa, O., McHale, L.K., Lahre, K., Jelenska, J., Castillo, J.A., Vinatzer, B.A., Greenberg, J.T., Michelmore, R.W. (2009). Large-scale analysis of interactions between several crop species and the effector repertoires from multiple Pseudomonas and Ralstonia spp. Plant Physiology 150:1733-49.

Luo, Y., Caldwell, K., T. Wroblewski, Wright, M.E., & Michelmore, R.W. (2009). Cleavage of a negative regulator of plant innate immunity, RIN4, is dependent on resistance genes and affected by multiple bacterial effectors. The Plant Cell 21:2458-2472.

Cantu, D., Vanzetti, L.S., Sumner, A., Dubcovsky, M., Matvienko, M., Distelfeld, A., Michelmore, R., Dubcovsky, J. (2010). Small RNAs, DNA methylation and transposable elements in wheat. BMC Genomics 11: 408.

Cantu, D., Govindarajulu, M., Kozik, A., Wang, M., Chen, X., Michelmore, R.W., Dubcovsky, J. (2011). Next-generation sequencing provides rapid access to the genes of wheat stripe rust. Plos One 6:e24230.

Michelmore, R.W., Christopoulou, M., Caldwell. K. (2013). Impacts of resistance gene genetics, function, and evolution on a durable future. Ann. Rev. Phytopathol. 51: 291–319.

Matvienko, M., Kozik, A., Froenicke, L., Lavelle, D., Martineau, B., Perroud, B., Michelmore, R. (2013). Consequences of normalizing transcriptomic and genomic libraries of plant genomes using a duplex-specific nuclease and tetramethylammonium chloride. PLoS One. 8:e55913.

Truco, M.J., Ashrafi, H., Kozik, A., van Leeuwen, H., Bowers, J., Reyes Chin Wo, S., Stoffel, K., Xu, H., Hill, T., van Deynze, A., Michelmore, R.W. (2013). An ultra high-density, transcript-based, genetic map of lettuce. G3, Genes, Genomes, Genetics. 3:617-631

Wei, Z., Julkowska, M.M., Laloë, J.-O., Hartman, Y.,  de Boer, G.-J., Michelmore, R.W., van Tienderen, P., Testerink, C.S., Schranz, M.E.  (2014).  A mixed model QTL analysis for salt tolerance in crop-wild hybrids of lettuce seedlings.  Mol. Breeding 34:1389-1400.

Govindarajulu, M., Epstein, L., Wroblewski, T., & Michelmore, R.W. (2014). Host-induced gene silencing inhibits the biotrophic pathogen causing downy mildew of lettuce.  Pl. Biotech. J. DOI: 10.1111/pbi.1230.

Wroblewski, T., Matvienko, M., Piskurewicz, U., Xu, H., Martineau, B., Wong, J., Kozik, A., Michelmore, R. (2014).  Distinctive profiles of small RNA couple inverted repeat-induced posttranscriptional gene silencing with endogenous RNA silencing pathways in Arabidopsis.  RNA 20:1987 – 1999.

Derevnina and Michelmore (2015).  Wheat rusts never sleep but neither do sequencers: will pathogenomics transform the way plant diseases are managed?  Genome Biology 16:44-47. DOI 10.1186/s13059-015-0615-3.

Derevnina, L., Chin-Wo-Reyes, S., Martin, F., Wood, K., Froenicke, L., Spring, O., Michelmore, R. (2015).  Genome sequence and architecture of the tobacco downy mildew pathogen, Peronospora tabacina. Mol. Pl. Microbe Interact. In press.

Christopoulou, M., McHale, L.K., Kozik, A., Reyes-Chin Wo, S., Wroblewski, T., Michelmore, R.W. (2015).  Dissection of two complex clusters of resistance genes in lettuce (Lactuca sativa).  Molec. Pl.-Micobe Interact.  http://dx.doi.org/10.1094/MPMI-06-14-0175-R.

Please see website for additional publications.