Robert Brosnan, DVM, PhD, DACVAA

Robert Brosnan

Position Title
Professor

Unit
Department of Surgical and Radiological Sciences, School of Veterinary Medicine

1306 Tupper Hall
Bio

Research Interests

Anesthetic Mechanisms of Action
Cardiorespiratory Effects of Anesthetics

Grad Group Affiliations

  • Comparative Pathology
  • Molecular, Cellular and Integrative Physiology
  • Pharmacology and Toxicology

Specialties / Focus

  • Cardiorespiratory Physiology
  • Comparative Physiology
  • Domestic Animal Physiology
  • Systemic Physiology

Courses

  • VET 404 Neuroscience / Senses / Behavior, Spring
  • VET 415 Clinical Foundations, Spring
  • VET 431 Anesthesia/Surgery Stream, Fall, Spring
  • VET 434A Large Animal Stream I, Fall
  • VET 435A Large Animal Stream -- Equine Emphasis, Spring
  • VET 435B Large Animal Stream -- Livestock Emphasis, Spring
  • VSR 491R Anesthesia/Critical Care Basic Science Management Conference, Fall, Spring
  • VSR 493R Anesthesia/Critical Care Clinical Case Management Conference, Fall, Spring
  • VSR 494R Anesthesia/Critical Patient Care Journal Discussion, Fall, Spring

Labs

  • 1110 Tupper Hall
  • 163 Veterinary Medicine II

Professional Societies

  • American College of Veterinary Anesthesiologists
  • American Physiological Society
  • American Veterinary Medical Association
  • International Anesthesia Research Society

Degrees

  • 1994 BS Biology University of California, Los Angeles
  • 1999 DVM Veterinary Medicine University of California, Davis
  • 2002 PhD Physiology University of California, Davis
  • 2004 Diploma American College of Veterinary Anesthesia and Analgesia

Publications

Brosnan RJ, Fukushima FB, Pham TL. Anesthetic synergy between two n-alkanes. Vet Anaesth Analg. 2017 May;44(3):577-588.

Espinosa P, Le Jeune SS, Cenani A, Kass PH, Brosnan RJ.  Investigation of perioperative and anesthetic variables affecting short-term survival of horses with small intestinal strangulating lesions.  Vet Surg. 2017 Apr;46(3):345-353.

Cenani A, Brosnan RJ, Madigan S, Knych HK.  Pharmacokinetics and pharmacodynamics of intravenous romifidine and propranolol administered alone or in combination for equine sedation. Vet Anaesth Analg. 2017 Jan;44(1):86-97.

Brosnan RJ, Pham TL. GABAA Receptor Modulation by Phenyl Ring Compounds Is Associated with a Water Solubility Cut-Off Value.  Pharmacology. 2016;98(1-2):13-9.

Williams DC, Brosnan RJ, Fletcher DJ, Aleman M, Holliday TA, Tharp B, Kass PH, LeCouteur RA, Steffey EP.  Qualitative and Quantitative Characteristics of the Electroencephalogram in Normal Horses during Administration of Inhaled Anesthesia.  J Vet Intern Med. 2016 Jan;30(1):289-303.

Esteller-Vico A, Liu IK, Vaughan B, Steffey EP, Brosnan RJ.  Effects of estradiol on uterine perfusion in anesthetized cyclic mares affected with uterine vascular elastosis.  Anim Reprod Sci. 2016 Jan;164:57-63.

Williams DC, Aleman MR, Brosnan RJ, Fletcher DJ, Holliday TA, Tharp B, Kass PH, Steffey EP, LeCouteur RA.  Electroencephalogram of Healthy Horses During Inhaled Anesthesia.  J Vet Intern Med. 2016 Jan;30(1):304-8.

Tearney CC, Guedes AG, Brosnan RJ.  Equivalence between invasive and oscillometric blood pressures at different anatomic locations in healthy normotensive anaesthetised horses.  Equine Vet J. 2015 Mar 18.

Valente AC, Brosnan RJ, Guedes AG.  Desflurane and sevoflurane elimination kinetics and recovery quality in horses.  Am J Vet Res. 2015 Mar;76(3):201-7.

Esteller-Vico A, Liu IK, Vaughan B, Steffey EP, Brosnan RJ.  Effects of vascular elastosis on uterine blood flow and perfusion in anesthetized mares.  Theriogenology. 2015 Apr 1;83(6):988-94.

Brosnan RJ, Pham TL.  Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation.  BMC Pharmacol Toxicol. 2014 Nov 19;15:62.

Smith AL, Mayhew PD, Soares JH, Kass PH, Brosnan RJ.  Hilar closure using staplers or Hem-o-lok clips in a rabbit model.  J Surg Res. 2014 Dec;192(2):616-20.

Soares JH, Brosnan RJ, Smith A, Mayhew PD.  Rabbit model of chest wall rigidity induced by fentanyl and the effects of apomorphine.  Respir Physiol Neurobiol. 2014 Oct 1;202:50-2.

Wiese AJ, Brosnan RJ, Barter LS.  Effects of acetylcholinesterase inhibition on quality of recovery from isoflurane-induced anesthesia in horses. Am J Vet Res. 2014 Mar;75(3):223-30.

Wiese AJ, Brosnan RJ, Barter LS. Effects of acetylcholinesterase inhibition on quality of recovery from isoflurane-induced anesthesia in horses. Am J Vet Res. 2014 Mar;75(3):223-30.

Guedes AG, Knych HK, Soares JH, Brosnan RJ. Pharmacokinetics and physiological effects of repeated oral administrations of tramadol in horses. J Vet Pharmacol Ther. 2013 Nov 4.

Aleman M, Williams DC, Brosnan RJ, Nieto JE, Pickles KJ, Berger J, Lecouteur RA, Holliday TA, Madigan JE. Sensory nerve conduction and somatosensory evoked potentials of the trigeminal nerve in horses with idiopathic headshaking. J Vet Intern Med. 2013 Nov;27(6):1571-80.

Pypendop BH, Brosnan RJ, Majewski-Tiedeken CR, Stanley SD, Ilkiw JE. Pharmacokinetics of fentanyl, alfentanil, and sufentanil in isoflurane-anesthetized cats. J Vet Pharmacol Ther. 2014 Feb;37(1):13-7.

Ferreira TH, Brosnan RJ, Shilo-Benjamini Y, Moore SB, Hollingsworth SR. Effects of ketamine, propofol, or thiopental administration on intraocular pressure and qualities of induction of and recovery from anesthesia in horses. Am J Vet Res. 2013 Aug;74(8):1070-7.

Brosnan RJ. Inhaled anesthetics in horses. Vet Clin North Am Equine Pract. 2013 Apr;29(1):69-87.

Woodhouse KJ, Brosnan RJ, Nguyen KQ, Moniz GW, Galuppo LD. Effects of postanesthetic sedation with romifidine or xylazine on quality of recovery from isoflurane anesthesia in horses. J Am Vet Med Assoc. 2013 Feb 15;242(4):533-9.

Brosnan RJ, Pypendop BH, Majewski-Tiedeken CR, Shilo-Benjamini Y, Ilkiw JE. Naltrexone does not affect isoflurane minimum alveolar concentration in cats. Vet Anaesth Analg. 2013 Mar;40(2):225-8.

Kelleher ME, Brosnan RJ, Kass PH, le Jeune SS. Use of physiologic and arterial blood gas variables to predict short-term survival in horses with large colon volvulus. Vet Surg. 2013 Jan;42(1):107-13.

Toth B, Aleman M, Brosnan RJ, Dickinson PJ, Conley AJ, Stanley SD, Nogradi N, Williams CD, Madigan JE. Evaluation of squeeze-induced somnolence in neonatal foals. Am J Vet Res. 2012 Dec;73(12):1881-9.

Brosnan RJ, Thiesen R. Increased NMDA receptor inhibition at an increased Sevoflurane MAC. BMC Anesthesiol. 2012 Jun 6;12:9.

Brosnan RJ, Steffey EP, Escobar A. Effects of hypercapnic hyperpnea on recovery from isoflurane or sevoflurane anesthesia in horses. Vet Anaesth Analg. 2012 Jul;39(4):335-44.

Soares JH, Brosnan RJ, Fukushima FB, Hodges J, Liu H. Solubility of haloether anesthetics in human and animal blood. Anesthesiology. 2012 Jul;117(1):48-55.

Escobar A, Valadão CA, Brosnan RJ, Denicol AC, Flôres FN, Thiesen R, Coelho CM. Effects of butorphanol on the minimum anesthetic concentration for sevoflurane in guineafowl (Numida meleagris). Am J Vet Res. 2012 Feb;73(2):183-8.

Sole A, Spriet M, Galuppo LD, Padgett KA, Borjesson DL, Wisner ER, Brosnan RJ, Vidal MA. Scintigraphic evaluation of intra-arterial and intravenous regional limb perfusion of allogeneic bone marrow-derived mesenchymal stem cells in the normal equine distal limb using (99m) Tc-HMPAO. Equine Vet J. 2012 Sep;44(5):594-9.

Brosnan RJ, Steffey EP, Escobar A, Palazoglu M, Fiehn O. Anesthetic induction with guaifenesin and propofol in adult horses. Am J Vet Res. 2011 Dec;72(12):1569-75.

Pypendop BH, Brosnan RJ, Ilkiw JE. Use of naltrexone to antagonize high doses of remifentanil in cats: a dose-finding study. Vet Anaesth Analg. 2011 Nov;38(6):594-7.

Brosnan RJ. GABA(A) receptor antagonism increases NMDA receptor inhibition by isoflurane at a minimum alveolar concentration. Vet Anaesth Analg. 2011 May;38(3):231-9.

Inceoglu B, Wagner K, Schebb NH, Morisseau C, Jinks SL, Ulu A, Hegedus C, Rose T, Brosnan R, Hammock BD. Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5093-7.

Aleman M, Williams DC, Jorge NE, Magdesian KG, Brosnan RJ, Feary DJ, Hilton HG, Kozikowski TA, Higgins JK, Madigan JE, Lecouteur RA. Repetitive stimulation of the common peroneal nerve as a diagnostic aid for botulism in foals. J Vet Intern Med. 2011 Mar;25(2):365-72.

Brosnan RJ, Pham TL. Does anesthetic additivity imply a similar molecular mechanism of anesthetic action at N-methyl-d-aspartate receptors? Anesth Analg. 2011 Mar;112(3):568-73.

Brosnan RJ, Steffey EP, LeCouteur RA, Esteller-Vico A, Vaughan B, Liu IK. Effects of isoflurane anesthesia on cerebrovascular autoregulation in horses. Am J Vet Res. 2011 Jan;72(1):18-24.

Brosnan RJ, Steffey EP, Esteller-Vico A, Vaughan B, Liu IK. The relationship between digital perfusion pressure and hoof lamellar blood flow in isoflurane-anesthetized horses. Res Vet Sci. 2011 Feb;90(1):138-45.

Steffey EP, Brosnan RJ, Galuppo LD, Mama KR, Imai A, Maxwell LK, Cole CA, Stanley SD. Use of propofol-xylazine and the Anderson Sling Suspension System for recovery of horses from desflurane anesthesia. Vet Surg. 2009 Dec;38(8):927-33.

Brosnan RJ, Pypendop BH, Siao KT, Stanley SD. Effects of remifentanil on measures of anesthetic immobility and analgesia in cats. Am J Vet Res. 2009 Sep;70(9):1065-71.

Brosnan RJ, Steffey EP. Sedative effects of propofol in horses. Vet Anaesth Analg. 2009 Sep;36(5):421-5.

Steffey EP, Mama KR, Brosnan RJ, Imai A, Maxwell LK, Cole CA, Stanley SD. Effect of administration of propofol and xylazine hydrochloride on recovery of horses after four hours of anesthesia with desflurane. Am J Vet Res. 2009 Aug;70(8):956-63.

McKune CM, Brosnan RJ, Dark MJ, Haldorson GJ. Safety and efficacy of intramuscular propofol administration in rats. Vet Anaesth Analg. 2008 Nov;35(6):495-500.

Brosnan RJ, Pham TL. Carbon dioxide negatively modulates N-methyl-D-aspartate receptors. Br J Anaesth. 2008 Nov;101(5):673-9.

Brosnan RJ, Esteller-Vico A, Steffey EP, LeCouteur RA, Liu IK, Vaughan B. Effects of head-down positioning on regional central nervous system perfusion in isoflurane-anesthetized horses. Am J Vet Res. 2008 Jun;69(6):737-43.

Pypendop BH, Brosnan RJ, Siao KT, Stanley SD. Pharmacokinetics of remifentanil in conscious cats and cats anesthetized with isoflurane. Am J Vet Res. 2008 Apr;69(4):531-6.

Yang L, Zhao J, Milutinovic PS, Brosnan RJ, Eger EI 2nd, Sonner JM. Anesthetic properties of the ketone bodies beta-hydroxybutyric acid and acetone. Anesth Analg. 2007 Sep;105(3):673-9.

Yang L, Milutinovic PS, Brosnan RJ, Eger EI 2nd, Sonner JM. The plasticizer di(2-ethylhexyl) phthalate modulates gamma-aminobutyric acid type A and glycine receptor function. Anesth Analg. 2007 Aug;105(2):393-6.

Brosnan RJ, Eger EI 2nd, Laster MJ, Sonner JM. Anesthetic properties of carbon dioxide in the rat. Anesth Analg. 2007 Jul;105(1):103-6.

Brosnan RJ, Yang L, Milutinovic PS, Zhao J, Laster MJ, Eger EI 2nd, Sonner JM. Ammonia has anesthetic properties. Anesth Analg. 2007 Jun;104(6):1430-3.

Brosnan RJ, Pypendop BH, Barter LS, Hawkins MG. Pharmacokinetics of inhaled anesthetics in green iguanas (Iguana iguana). Am J Vet Res. 2006 Oct;67(10):1670-4.

Brosnan RJ, Pypendop BH. A technique to depress desflurane vapor pressure. Vet Anaesth Analg. 2006 Sep;33(5):275-80.

Won A, Oh I, Brosnan R, Eger EI 2nd, Sonner JM. Hypothermia decreases ethanol MAC in rats. J Anesth. 2006; 20(3): 247-50.

Brosnan R, Gong D, Cotten J, Keshavaprasad B, Yost CS, Eger EI 2nd, Sonner JM. Chirality in anesthesia II: stereoselective modulation of ion channel function by secondary alcohol enantiomers. Anesth Analg. 2006 Jul;103(1):86-91

Won A, Oh I, Liao M, Sonner JM, Harris RA, Laster MJ, Brosnan R, Trudell JR, Eger EI 2nd. The minimum alveolar anesthetic concentration of 2-, 3-, and 4-alcohols and ketones in rats: relevance to anesthetic mechanisms. Anesth Analg. 2006 May;102(5):1419-26.

Barter LS, Hawkins MG, Brosnan RJ, Antognini JF, Pypendop BH. Median effective dose of isoflurane, sevoflurane, and desflurane in green iguanas. Am J Vet Res. 2006 Mar;67(3):392-7.

Solano AM, Brosnan RJ, Steffey EP. Rate of change of oxygen concentration for a large animal circle anesthetic system. Am J Vet Res. 2005 Oct;66(10):1675-8.

Aleman M, Brosnan RJ, Williams DC, LeCouteur RA, Imai A, Tharp BR, Steffey EP. Malignant hyperthermia in a horse anesthetized with halothane. J Vet Intern Med. 2005 May-Jun;19(3):363-6.

Brosnan RJ, LeCouteur RA, Steffey EP, Imai A, Farver TB. Intracranial elastance in isoflurane-anesthetized horses. Am J Vet Res. 2004 Aug;65(8):1042-6.

Brosnan RJ, Steffey EP, LeCouteur RA, Farver TB, Imai A. Effects of duration of isoflurane anesthesia and mode of ventilation on intracranial and cerebral perfusion pressures in horses. Am J Vet Res. 2003 Nov;64(11):1444-8.

Steffey MA, Brosnan RJ, Steffey EP. Assessment of halothane and sevoflurane anesthesia in spontaneously breathing rats. Am J Vet Res. 2003 Apr;64(4):470-4.

Brosnan RJ, Steffey EP, LeCouteur RA, Imai A, Farver TB, Kortz GD. Effects of ventilation and isoflurane end-tidal concentration on intracranial and cerebral perfusion pressures in horses. Am J Vet Res. 2003 Jan;64(1):21-5.

Brosnan RJ, LeCouteur RA, Steffey EP, Imai A, Kortz GD. Direct measurement of intracranial pressure in adult horses. Am J Vet Res. 2002 Sep;63(9):1252-6.

Brosnan RJ, Steffey EP, LeCouteur RA, Imai A, Farver TB, Kortz GD. Effects of body position on intracranial and cerebral perfusion pressures in isoflurane-anesthetized horses. J Appl Physiol. 2002 Jun;92(6):2542-6.

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