Robert H Weiss

Robert H Weiss

Position Title
Professor Emeritus

Department of Internal Medicine (Nephrology), School of Medicine

GBSF rm 6311

Profile Introduction

cyclins and cyclin inhibitors, kidney cancer growth control, metabolomics and proteomics, polycystic kidney disease, other kidney diseases

Research Interests

cyclins and cyclin inhibitors, cancer growth control, metabolomics and proteomics, polycystic kidney disease

Grad Group Affiliations

  • Biochemistry, Molecular, Cellular and Developmental Biology
  • Comparative Pathology Graduate
  • ImmunologyComparative Pathology


  • 1976 BA Chemistry University of California, Santa Cruz
  • 1978 MS Physical Chemistry University of California, Los Angeles
  • 1984 MD Medicine University of California, Irvine
  • 1991 Fellowship, Nephrology University of California, San Francisco
  • 1980 MS Medical Physics University of California, Los Angeles


Taylor, S.L., Ganti, S., Bukanov N.O., Chapman, A., Fiehn, O., Osier, M., Kim, K., Weiss, R.H. A metabolomics approach using juvenile cystic mice to identify urinary biomarkers and altered pathways in polycystic kidney disease, American Journal of Physiology: Renal Physiology, 2010, 298:909-922, with Editorial Forum

Chen H, Li C, Huang J, Cung T, Seiss K, Beamon J, Carrington MF, Porter, LC, Burke PS, Yang Y, Ryan BJ, Liu R, Weiss RH, Pereyra F, Cress WD, Brass AL, Rosenberg ES, Walker BD, Yu XG, Lichterfeld M. CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21 (cip-1/waf-1).  Journal of Clinical Investigation. Apr 1;121(4):1549-60, 2011

Weiss R.H, Kim K. Metabolomics in the Study of Kidney Diseases. Nature Reviews Nephrology. Oct 25;8(1):22-33, 2011

Ganti, S., Taylor,S.L., Aboud,O.A., Yang,J., Evans,C., Osier,M.V., Alexander,D.C., Kim,K., Weiss,R.H. Simultaneous multiple matrix metabolomics analysis of a mouse kidney cancer xenograft yields potential tumor biomarkers. Cancer Research, Jul 15;72(14):3471-9, 2012

Abu Aboud, A., Wettersten, H., Weiss, R.H. Inhibition of PPAR<alpha> induces cell cycle arrest and apoptosis, and synergizes with glycolysis inhibition in kidney cancer cells, 2013, PLoS ONE, Aug 7;8(8):e71115

Kim, K.,Mall, C., Taylor, S.L., Hitchcock, S., Zhang, C., Wettersten, H.I., Jones, A.D., Chapman, A., Weiss, R.H., Mealtime, temporal, and daily variability of the human urinary and plasma metabolomes in a tightly controlled environment, 2013, PLoS ONE, Jan 24;9(1):e86223

Gupta, R., Dong, Y., Wettersten, H.I., Chang, C., Min, J., Henson, J.,  Solomon, P. , Dogra,S., Hwang,. S.H., Hammock, B.D., Reddel, R., Zhu, L., Saltzman, W., Weiss, R.H., Chang, S., Green, M., Wajapeyee, N. Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A. Proceedings of the National Academy of Sciences (USA), 2014 Jul 29;111(30):E3062-E3071

Tan, M., Wettersten, H.I., Chu, K., Huso, D.L., Watnick, T., in revision, S., Landesman, Y., Weiss, R.H. Novel inhibitors of nuclear transport cause cell cycle arrest and decrease cyst growth in ADPKD associated with decreased cdk4 levels, American Journal of Physiology: Renal Physiology, 2014 Dec 1;307(11):F1179-86

Wettersten HI, Kauffman M, Shacham S, Landesman Y, Weiss, R.H. Specific Inhibition of the Nuclear Exporter Exportin-1 Attenuates Kidney Cancer Growth, PLoS One, 2014, Dec 2;9(12):e113867

Davis BB, Thompson DA, Howard LL, Morisseau C, Hammock BD and RH Weiss. 2002. Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation. Proceedings of the National Academy of Sciences (USA). 99(4):2222-2227

Lin, P.Y., Fosmire, S.P., Baksh, S., Modiano, J.F., Weiss, R.H. Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance, Molecular Cancer, 6:16, 2007

Park, S.H., Wang, X., Liu, R., Lam, K.S., Weiss, R.H. High throughput screening of a small molecule one-bead-one-compound combinatorial library to identify attenuators of p21 as chemotherapy sensitizers, Cancer Biology & Therapy, 7(12), 2015-22, 2008

Kim, K.M., Aronov, P.A., Zakharkin, S.O., Anderson, D., Perroud, B., Weiss, R.H., Urine metabolomic analysis for kidney cancer detection and biomarker discovery, Molecular and Cellular Proteomics, 8(3):558-70, 2009

Perroud, B., Ishimaru, T., Borowsky, A.D., Weiss, R.H. Grade-dependent proteomic characterization of kidney cancer, Molecular and Cellular Proteomics, May;8(5):971-85, 2009

Liu , J.-Y. Park, S.-H., Morisseau , C., Hwang , S. H., Hammock, B., Weiss, R.H., Sorafenib Has sEH Inhibitory Activity Which Contributes to Its Effect Profile in vivo, Molecular Cancer Therapeutics, 2009 Aug;8(8):2193-203, 2009

Weiss, R.H. p21Waf1/Cip1 as a therapeutic target in breast and other cancers, Cancer Cell, 4: 426-429, 2003