Saul Schaefer

Saul Schaefer

Position Title

Department of Internal Medicine (Cardiology), School of Medicine


Profile Introduction

Mitochondrial calcium regulation in myocytes, oxidative stress, and heart failure

Research Interests

Mitochondrial calcium regulation in myocytes, oxidative stress, and heart failure

Grad Group Affiliations

  • Molecular, Cellular and Integrative Physiology

Specialties / Focus

  • Cardiorespiratory Physiology
  • Cellular Physiology


  • Surge III
    • Phung Thai, PhD, Post-Doctoral Fellow

Honors and Awards

  • UC Davis School of Medicine 2002 Faculty Research Award

    Professional Societies

    • American Heart Association, American College of Cardiology, American Physiology Society


    • B.E. - The Cooper Union, New York - 1968
    • 1981 MD University of California, Davis


    2010  Lu X, Moore PG, Liu H, Schaefer S. Phosphorylation of ARC is a critical element in the anti-apoptotic effect of anesthetic preconditioning. Anesthesia Analgesia 112:525-531

    2012     Inceoglu AB, Clifton HL, Yang J, Hegedus C, Hammock BD, Schaefer S:  Inhibition of epoxide hydrolase prevents niacin-induced flushing in mice. J Cardiovasc Pharmacology 60(1):70-75.

    2014 Ma L, Lee BH, Clifton H; Schaefer S, Zheng J: Nicotinic Acid Activates the Capsaicin Receptor TRPV1: Potential Mechanism for Cutaneous Flushing. Arteriosclerosis, Thrombosis Vasc Biology  34(6):1272-80

    2015 Clifton H, Inceoglu AB, Ma L, Zheng J, Schaefer S: TRPV1 channels Mediate Niacin-Induced Vasodilation. J Cardiovasc Pharmacol 65(2):184-91

    2015    Ma L, Lee BH, Clifton H, Schaefer S, Zheng J: Nicotinic Acid Is A Common Gating Regulator of Heat-Sensing TRPV1-4 Ion Channels.  Sci Rep 5: 8906

    2017     Ortiz J, Saeed R, Little C, Schaefer S: Age-adjusted D-dimer in the prediction of pulmonary embolism: does a normal age-adjusted D-dimer rule out PE? Biomed Res International 1-7

    Wang L, G Cherednichenko, L Hernandez, J Halow, SA Camacho, V Figuredo, S Schaefer. 2001. Preconditioning limits mitochondrial calcium overload during ischemia/reperfusion in rat heart: The role of KATP channels. American Journal of Physiology. 280:H2321-

    Ramasamy R, JA Payne, J Whang, SR Bergmann, S Schaefer. 2001. Protection of ischemic myocardium in diabetics by inhibition of the electroneutral Na+-K+-2Cl- cotransporter. American Journal of Physiology. 281:H515-H522

    Symons JD, S Schaefer. 2001. Na+/H+ exchange subtype 1 inhibition reduces endothelial dysfunction in vessels from stunned myocardium. American Journal of Physiology. 281:H1575-H1582