Scott I. Simon

Scott Simon

Position Title
Professor

Unit
Department of Biomedical Engineering, College of Engineering

Academic Surge Room 1025
Bio

Research Interests

Inflammation, innate immunity, adhesion biomechanics, cardiovascular disease, lab-on-a-chip microfluidics

Grad Group Affiliations

  • Biophysics

Specialties / Focus

  • Dynamics and Biophysical Engineering

Labs

  • simon lab http://www.bme.ucdavis.edu/simonlab/author/simon/

Honors and Awards

  • Established Investigator Award, American Heart Association

    Degrees

    • 1983 BS Applied Mechanics Engineering Sciences University of California, San Diego
    • 1988 PhD Biomedical Engineering University of California, San Diego
    • 1990 Post-Doctoral Fellowship - Scripps Clinic and Research Foundation - Inflammation Biology - 1988-

    Publications

    Morikis VA, Chase S, Wun T, Chaikof EL, Magnani JL, Simon SI.  Selectin catch-bonds mechanotransduce integrin activation and neutrophil arrest on inflamed endothelium under shear flow. 2017. Blood. Aug 15. doi: 10.1182

    Bailey KA, Haj FG, Simon SI, Passerini AG. Atherosusceptible Shear Stress Activates Endoplasmic Reticulum Stress to Promote Endothelial Inflammation. 2017. Sci Rep. Aug 15;7(1):8196.

    Granick, JL, Falahee, P, Dahmubed, D, Borjesson, Miller, LS, Simon, SI. 2013. Staphylococcus aureus recognition by hematopoietic stem and progenitor cells via TLR2/MyD88/PGE2 stimulates granulopoiesis in wounds. Blood 122(10): 1770-1778.

    Falahee PC, Anderson LS, Reynolds MB, Pirir M, McLaughlin BE, Dillen CA, Cheung AL, Miller LS, Simon SI. 2017. α-Toxin Regulates Local Granulocyte Expansion from Hematopoietic Stem and Progenitor Cells in Staphylococcus aureus-Infected Wounds. J Immunol. doi: 10.4049/jimmunol.1700649. [Epub ahead of print]

    Lum, A., Green, C., Staunton, D. and S.I. Simon. (2002) Dynamic regulation of LFA-1 activation and neutrophil arrest on ICAM-1 in shear flow. J. Biol. Chem. 277:20660-20670.

    Evans E., Leung A., Hammer D., and S.I. Simon. Chemically-distinct transition states govern rapid rupture of single L-selectin bonds under force. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3784-

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