Department of Cell Biology and Human Anatomy, School of Medicine
Molecular Mechanisms of Neuron Migrations
The 100 billion neurons that form our central nervous system (CNS) are exquisitely localized and wired, allowing us to perform everyday tasks such as walking, reading or thinking. Neurons find their positions within the brain almost exclusively during embryonic development. A wide variety of guidance cues pilot neurons from the proliferation niches to their final destination, where they stop, mature, and integrate into the existing network. Neurons respond to these guidance cues by regulating signaling pathways that control a myriad of cellular processes (including neuronal speed, direction, and rest phases). The goal of our research is to understand how migrating neurons integrate guidance information by regulating signaling pathways to navigate and successfully reach their final destinations. We are currently investigating 1) molecular mechanisms that control neuronal positioning in the neocortex, 2) the role of the E3 ubiquitin ligase Cullin-5 during Purkinje cell migration, and 3) the evolution of neuronal progenitor competence during CNS development.
Grad Group Affiliations
- Biochemistry, Molecular, Cellular and Developmental Biology
Specialties / Focus
- Cell Biology
- Cellular and Molecular Neurobiology
- Development and Plasticity
- Developmental Biology
- Gene Regulation
- Signal Transduction
- Simo Lab
- Keiko Hino (Lab Manager), Jisoo Han (BMCDB Graduate Student), Raenier Reyes (Junior Specialist)
Fairchild CLA, Cheema SK, Wong J, Hino K, Simó S, La Torre A. Let-7 regulates cell cycle dynamics in the developing cerebral cortex and retina. Sci Rep. 2019 Oct 25;9(1):15336.
Tan R, Lam AJ, Tan T, Han J, Nowakowski DW, Vershinin M, Simó S, Ori-McKenney KM, McKenney RJ. Microtubules gate tau condensation to spatially regulate microtubule functions. Nat Cell Biol. 2019 Sep;21(9):1078-1085.
Prada MP, Syed AU, Buonarati OR, Reddy GR, Nystoriak MA, Ghosh D, Simó S, Sato D, Sasse KC, Ward SM, Santana LF, Xiang YK, Hell JW, Nieves-Cintrón M, Navedo MF. A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia. Elife. 2019 Mar 1;8.
Hino K, Simó S*, Cooper JA*. Comparative Analysis of cul5 and rbx2 Expression in the Developing and Adult Murine Brain and Their Essentiality During Mouse Embryogenesis. Dev Dyn. 2018 Nov;247(11):1227-1236. *, Authors contributed equally.
Fairchild CL, Hino K, Han JS, Miltner AM, Peinado Allina G, Brown CE, Burns ME, La Torre A*, Simó S*. RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion. Development. 2018 Feb 2;145(3). *, Authors contributed equally.
Teckchandani A, Laszlo GS, Simó S, Shah K, Pilling C, Strait AA, Cooper JA. Cullin 5 destabilizes Cas to inhibit Src-dependent cell transformation. J Cell Sci. 2014 Feb 1;127(Pt 3):509-20.
Simó S, Cooper JA. Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors. Dev Cell. 2013 Nov 25;27(4):399-411.
Simó S, Jossin Y, Cooper JA. Cullin 5 regulates cortical layering by modulating the speed and duration of Dab1-dependent neuronal migration. J Neurosci. 2010 Apr 21;30(16):5668-76. doi: 10.1523/JNEUROSCI.0035-10.2010.
Feng L, Allen NS, Simó S, Cooper JA. Cullin 5 regulates Dab1 protein levels and neuron positioning during cortical development. Genes Dev. 2007 Nov 1;21(21):2717-30.
Simó S, Pujadas L, Segura MF, La Torre A, Del Río JA, Ureña JM, Comella JX, Soriano E. Reelin induces the detachment of postnatal subventricular zone cells and the expression of the Egr-1 through Erk1/2 activation. Cereb Cortex. 2007 Feb;17(2):294-303.