Department of Cell Biology and Human Anatomy, School of Medicine
Molecular Mechanisms of Neuron Migrations
The 100 billion neurons that form our central nervous system (CNS) are exquisitely localized and wired, allowing us to perform everyday tasks such as walking, reading or thinking. Neurons find their positions within the brain almost exclusively during embryonic development. A wide variety of guidance cues pilot neurons from the proliferation niches to their final destination, where they stop, mature, and integrate into the existing network. Neurons respond to these guidance cues by regulating signaling pathways that control a myriad of cellular processes (including neuronal speed, direction, and rest phases). The goal of our research is to understand how migrating neurons integrate guidance information by regulating signaling pathways to navigate and successfully reach their final destinations. We are currently investigating 1) molecular mechanisms that control neuronal positioning in the neocortex, 2) the role of the E3 ubiquitin ligase Cullin-5 during Purkinje cell migration, and 3) the evolution of neuronal progenitor competence during CNS development.
Grad Group Affiliations
- Biochemistry, Molecular, Cellular and Developmental Biology
Specialties / Focus
- Cell Biology
- Developmental Biology
- Gene Regulation
- Signal Transduction
- Simo Lab
- Keiko Hino (Junior Specialist), Jisoo Han (BMCDB Graduate Student)
Teckchandani A.*, Laszlo G.*, Simó S., Shah K.G., Pilling C., Strait A.A., and Cooper J.A. 2013. Cullin5 destabilizes Cas to inhibit Src-dependent cell transformation. Journal of Cell Science (In Press).
Simó S., and Cooper J.A. 2013. Rbx2 regulates neuronal migration through different Cullin5-RING ligase adaptors. Developmental Cell. November 6, 2013.
Simo, S., and Cooper, J.A. 2012. Regulation of dendritic branching by Cdc42 GAPs. Genes & Development, 26: 1653-1658.
Simó S., Jossin Y. and Cooper J.A. 2010. Cullin 5 regulates cortical layering by modulating the speed and duration of Dab1-dependent neuronal migration. Journal of Neuroscience. April 21, 2010 • 30(16):5668 –5676.
Feng L.*, Allen N.S.*, Simó S. and Cooper J.A. 2007. Cullin 5 regulates Dab1 protein levels and neuron positioning during cortical development. Genes & Development. 21(21):2717-30.
Borrell V., Pujadas L., Simó S., Durà D., Solé M., Cooper J.A., Del Río J.A. and Soriano E. 2007. Reelin and mDab1 regulate the development of hippocampal connections. Molecular and Cellular Neuroscience. 36(2):158-73.
Simó, S., Pujadas L., Segura M.F., La Torre A., Del Rio J.A., Urena J.M., Comella J. X., and Soriano E. 2007. Reelin induces the detachment of postnatal subventricular zone cells and the expression of the Egr-1 through Erk1/2 activation. Cereb Cortex. 17:294-303.