Sheila David

Sheila David

Position Title

Department of Chemistry

Chemistry Annex, Rm. 2471 Davis, CA 95616

Profile Introduction

DNA Repair, Chemical Biology

Grad Group Affiliations

  • Biochemistry, Molecular, Cellular and Developmental Biology
  • Chemistry


  • Che 130A Pharmaceutical Chemistry I
  • Che 135 Advanced Bioorganic Chemistry Laboratory, Spring
  • Che 221D Special Topics: Chemical Biology of DNA Damage, Repair and Cancer


  • 370 Chemistry
  • Cindy Khuu, Liz Lotsof, Merve Demir, Robert Van Ostrand, Carlos Trasvina-Arenas, Steven Merrill, Savannah Conlon, Nhu Tran, Jonathan Lin
  • Honors and Awards
  • Beckman Young Investigator
  • AP Sloan Foundation
  • AAAS Fellow
  • American Chemical Society Fellow
  • ADVANCE Scholar Award

Professional Societies

  • American Chemical Society
  • Environmental Mutagen Society


  • 1984 BA Chemistry Saint Olaf College
  • 1989 PhD Chemistry University of Minnesota


When you’re strange: Unusual features of the MUTYH glycosylase and implications in Cancer, Raetz, A.G. , David, S. S., DNA Repair, 2019, 8, 16-25

The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH:  Identifying the Zn2+ ligands and Roles in Damage Recognition and Repair, Nunez, N. N.; Khuu, C.; Babu, C.S.; Bertolani, S. J.; Rajavel, A. N.; Spear, J.E.; Armas, J. A.; Wright, J. D.; Siegel, J. B.; Lim, C.; David, S. S., J. Am. Chem. Soc., 2018, 140, 13260-13271.

Structure Activity Relationships Reveal Key Features of 8-Oxoguanine:A Mismatch Detection and Base Excision by the MutY DNA Glycosylase, Manlove, A. H., McKibbin, P. L. Doyle, E. M., Majumdar, C., Hamm, M.L. David, S. S., ACS, Chem Biol, 2017, 12,

Targeting Base Excision Repair Glycosylase with DNA containing Transition State Mimics Prepared by Click Chemistry, Yuen, P.K., Green, S.A., Ashby, J., Lay, K.T., Santra, A, Chen, X., Horvath, M.P., David, S.S., ACS Chemical Biology 2019, 14, 27-36

Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases, Woods, R.D., O'Shea, V. L., Chu, A. M., Cao, S. Richards, J. L., Horvath, M. P., David, S. S., Nucleic Acids Research, 2016, 44, 801-810  

"Base-excision repair of oxidative DNA damage, " David, S. S., O'Shea, V.L., Kundu, S., Nature, 2007, 447, 941-950.