Stephen P. Cramer

Stephen Cramer

Position Title

Department of Chemistry, College of Letters and Science

3017 Ghausi Hall

Research Interests

Spectroscopy and Biochemistry

The Cramer group uses spectroscopic methods to characterize the molecular and electronic structure of metal sites in bioinorganic systems and environmental samples. Of particular interest are the enzymes nitrogenase (which catalyzes nitrogen fixation to ammonia) and hydrogenases (which catalyze interconversion of protons and electrons to hydrogen molecules).

Grad Group Affiliations

  • Applied Science - Engineering
  • Biophysics
  • Chemistry (Letters and Science)

Specialties / Focus

  •  Spectroscopy and Imaging


  • Chemistry CHE-2B

Honors and Awards

  • 2012 - International X-Ray Absorption Society Edward Stern Outstanding Achievement Award
  • 2012 – Xiamen University – Lu Jiaxi Lectureship
  • 2010 – ACS Division of Analytical Chemistry Award in Spectrochemical Analysis
  • 2008 Chair, Iron-Sulfur Enzyme Gordon Research Conference
  • 2013 - New York Society for Applied Spectroscopy Gold Medal
  • 2013 - AAAS Fellow
  • 2014-2015 - Humboldt Research Award

    Professional Societies

    • ACS
    • APS
    • OSA
    • Biophysical Society
    • Coblentz Society


    • 1978 Ph. D Chemistry Stanford University
    • 1973 B. A. Chemistry Williams College


    "Observation of the Fe-CN and Fe-CO Vibrations in the Active Site of [NiFe] Hydrogenase by Nuclear Resonance Vibrational Spectroscopy", Kamali, S.; Wang, H.; Mitra, D.; Ogata, H.; Lubitz, W.; Manor, B.; Rauchfuss, T.; Byrne, D.; Bonnefoy, V.; Jenney, F.; Adamsn M.; Yoda, Y.; Alp, E.; Zhao, J.; Cramer, S. P. Angew. Chem. Int. Ed., 2013, 52, 724-728.

    "Photolysis of ‘Hi-CO’ Nitrogenase – Observation of a Plethora of Distinct CO Species via Infrared Spectroscopy", Yan, L.; Dapper, C. H.; George, S. J.; Wang, H.-X.; Mitra, D.; Dong, W.-B.; Newton, W. E.; Cramer, S. P. Eur. J. Inorg. Chem., 2011, 2011, 2064-2074.

    "Steric Control of the of Hi-CO MoFe Nitrogenase Complex Revealed by Stopped-Flow Infra-red Spectroscopy", Yang, Z.-Y.; Seefeldt, L. C.; Dean, D. R.; Cramer, S. P.; George, S. J. Angew. Chem., 2011, 123, 286-289.

    "The HydG Enzyme Generates an Fe(CO)2(CN) Synthon in Assembly of the FeFe Hydrogenase H-Cluster", Kuchenreuther, J. M. Myers, W. K., Suess, D. L. M., Stich, T. A., Pelmenschikov, V., Shiigi, S. A., Cramer, S. P., Swartz, J. R., Britt, R. D., George, S. J., Science, 2014, 343, 424-427