Department of Anesthesiology and Pain Medicine, School of Medicine
Dr. Jinks' research interests include sites and mechanisms of general anesthetics, pain mechanisms and treatments, and basic spinal cord/brainstem neurophysiology relating to nociceptive and locomotor function. His laboratory investigates these processes using in vivo electrophysiology in rodents as well as in vitro neonatal rodent and lamprey spinal cord preparations.
- Surge III
- Milo Bravo, B.S., SRA, Lab ManagerJason Andrada, M.S., Junior Specialist
- International Association for the Study of Pain (IASP)
- Association of American Anesthesiologists (ASA)
- American Association for the Advancement of Science (AAAS)
- Society for Neuroscience (SFN)
- Association of University Anesthesiologists (AUA)
- 1994 BS Zoology University of Rhode Island
- 1998 MS Physiology University of California, Davis
- 2001 PhD Physiology University of California, Davis
Jinks SL, Andrada, J. Validation and insights of anesthetic action in an early vertebrate network: the isolated lamprey spinal cord. Anesth Analg. 113: 1033-42, 2011.
Jinks SL, Andrada J, Satter O. Anesthetic effects on fictive locomotion in the rat isolated spinal cord. NeuroReport 22: 655-9, 2011.
Inceoglu B, Wagner K, Schebb NH, Morisseau C, Jinks SL, Ulu A, Hegedus C, Rose T, Brosnan R, Hammock BD. Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP.. Proc Natl Acad Sci 108: 5093-7 (2011)
Jinks SL, Bravo M, Satter O, Chan Y-M. Brainstem Regions Affecting Minimum Alveolar Concentration and Movement Pattern during Isoflurane Anesthesia. Anesthesiology 112: 316-24, 2010
Morisseau C, Inceoglu B, Schmelzer K, Tsai HJ, Jinks SL, Hegedus CM, Hammock BD. Naturally occurring mono epoxides of EPA and DHA are bioactive antihyperalgesic lipids. J Lipid Res. 51: 3481-90, 2010.
Inceoglu, B., Jinks, S.L., Ulu, A., Hegedus, C.M., Georgi, K., Schmelzer, K.R., Wagner, K., Jones, P.D., Morisseau, C., Hammock, B.D. Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways. Proc Natl Acad Sci 105: 18901-6, 2008.
Jinks SL, Bravo M, Hayes SG. Volatile anesthetic Effects on Midbrain-Elicited Locomotion Suggest that the Locomotor Network in the Ventral Spinal Cord is the Primary Site for Immobility. Anesthesiology 108:1016-24. [See comment in: Anesthesiology. 108: 975-6, 2008.]
Jinks SL, Carstens EE, Antongnini JF. Glutamate receptor blockade in the rostral ventromedial medulla reduces the force of multisegmental motor responses to supramaximal noxious stimuli. Neurosci Lett. 426:175-80, 2007.
Schmelzer KR, Inceoglu B, Kubala L, Kim IH, Jinks SL, Eiserich JP, Hammock BD. Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors. Proc Natl Acad Sci 103:13646-51, 2006.
Jinks, S.L., Atherly, R.J., Dominguez, C.L., Sigvardt, K.A., Antognini, J.F. Isoflurane Disrupts Central Pattern Generator Activity and Coordination in the Lamprey Isolated Spinal Cord. Anesthesiology, 103: 567-75, 2005.
Jinks, S.L., Dominguez, C.L., Antognini, J.F. Drastic Decrease in Isoflurane Minimum Alveolar Concentration and Limb Movement Forces after Thoracic Spinal Cooling and Chronic Spinal Transection in Rats. Anesthesiology 102: 624-32, 2005.
Jinks, S.L., Carstens, E., Antognini, J.F. Isoflurane differentially modulates medullary ON- and OFF-neurons while suppressing hindlimb motor withdrawals. Anesthesiol 100:1224-34, 2004.
Jinks, S.L., Martin, J.T, Carstens, E., Jung S-W, Antognini, J.F. Peri-MAC Depression of a nociceptive withdrawal reflex is accompanied by reduced dorsal horn activity with halothane but not isoflurane. Anesthesiol. 98: 1128-38, 2003.
Jinks, S.L., Simons, C.T., Dessirier, J-M., Iodi-Carstens, M., Antognini, J.F., Carstens, E. c-fos induction in rat superficial dorsal horn following cutaneous application of noxious chemical or mechanical stimuli. Journal of Experimental Brain Research 145: 261-269, 2002.
Jinks, S.L., Carstens, E. Responses of superficial dorsal horn neurons to intradermal serotonin and other irritants: comparison with scratching behavior. Journal of Neurophysiology 87: 1280-1289, 2002.
Jinks, S.L., Carstens, E. Superficial dorsal horn neurons identified using intracutaneous histamine as a search stimulus: chemonociceptive responses and modulation by morphine. Journal of Neurophysiology 84: 616-627, 2000
Tabo, E., Jinks, S.L., Eisele, J.H. Jr., Carstens, E. Behavioral manifestations of neuropathic pain and mechanical allodynia, and changes in spinal dorsal horn neurons, following L4-L6 dorsal root constriction. Pain 80:503-520, 1999.
Jinks, S.L., Antognini, J.F., Carstens, E, Buzin, V., Simons, C.T. Isoflurane can indirectly depress lumbar dorsal horn activity via action within the brain. British Journal of Anaesthesia 82:244-249, 1999.
Jinks, S.L., Carstens, E. Spinal NMDA receptor involvement in the expansion of mechanosensitive receptive field area of dorsal horn neurons produced by intracutaneous microinjection of histamine. Journal of Neurophysiology 79:1613-1618, 1998