Dr. Stuart A. Meyers

Stuart Meyers

Position Title
Professor

Unit
Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine

3219 VM3B
Bio

Profile Introduction

Cryopreservation and cryobiology of mammalian sperm. Mechanisms of spermatozoal cryoinjury. In vitro embryo production in horses using intracytoplasmic sperm microinjection.

Research Interests

Cryopreservation and cryobiology of mammalian sperm. Mechanisms of spermatozoal cryoinjury.

Grad Group Affiliations

  • Animal Biology Graduate Group
  • Integrative Pathobiology
  • Molecular, Cellular and Integrative Physiology
  • Designated Emphasis in Reproductive Biology (Chair)

Specialties / Focus

  • Cellular Physiology
  • Developmental Physiology
  • Domestic Animal Physiology
  • Reproductive Physiology

Courses

  • VET 403 Musculoskeletal System, Spring Semester
  • VET 410 Reproduction System, Fall Semester
  • VET 401 Foundations, Fall Semester
  • PGG 220 General and Comparative Physiology of Reproduction, Spring
  • APC100/NPB123 Comparative Organology, Fall

Labs

  • Meyers Laboratory www.vetmed.ucdavis.edu/apc/MeyersLab/Labsite%2003/index.html
    • Victoria Burruel, PhD/ Staff Research, Evelyn Bulkeley DVM, PhD candidate, Tawny Scanlan PhD candidate, Azarene Foutouhi PhD candidate, Alejandro de la Fuente-Lara DVM PhD Candidate, Momoe Kato PhD candidate

Professional Societies

  • Society for the Study of Reproduction
  • Society for Theriogenology
  • Amercan College of Theriogenologists
  • Association for Applied Animal Andrology
  • American Association for the Advancement of Science
  • American Society of Andrology

Degrees

  • 1985 DVM Veterinary Medicine Michigan State University
  • 1995 PhD Comparative Pathology University of California, Davis
  • 1980 MS Physiology Oregon State University
  • 1977 BS Zoology Michigan State University
  • 1990 Diplomate American College of Theriogenologists

Publications

Darr CR, Moraes LE, Scanlan TN, Skaife J, Loomis PR, Cortopassi GA, Meyers SA.

Sperm mitochondrial function is affected by stallion age and predicts post-thaw motility. Journal of Equine Veterinary Science 50 52–56, 2017.

Darr CR, Moraes LE, Connon RE, Love CC, Teague S, Varner DD, Meyers SA. The relationship between mitochondrial DNA copy number and stallion sperm function. Theriogenology 94; Pages 94–99, 2017. DOI: http://dx.doi.org/10.1016/j.theriogenology.2017.02.015

Chitwood J, Burruel V,  Meyers S, Ross P. Transcriptome profiling of individual rhesus macaque oocytes and preimplantation embryos. Biology of Reproduction, 2017, 0(0), 1–12 doi:10.1093/biolre/iox114

Andrea Hesser, Christa Darr, Kris Gonzales, Heather Power, Tawny Scanlan, James Thompson, Charles Love, Bruce Christensen, Stuart Meyers. Semen Evaluation and Fertility Assessment in a Purebred Dog Breeding Facility. Theriogenology (2016), doi: 10.1016/j.theriogenology.2016.08.012

Christa R. Darr, Dickson D. Varner, Sheila Teague, Gino A. Cortopassi, Sandipan Datta, Stuart A. Meyers. Lactate and Pyruvate Are Major Sources of Energy for Stallion Sperm with Dose Effects on Mitochondrial Function, Motility, and ROS Production Biol Reprod August 2016 95 (2) 34, 1-11; published ahead of print June 22, 2016, doi:10.1095/biolreprod.116.140707

Christa R. Darr , Gino A. Cortopassi , Sandipan Datta , Dickson D. Varner , Stuart A. Meyers.

Mitochondrial oxygen consumption is a unique indicator of stallion spermatozoal health and varies with cryopreservation media. Theriogenology, Vol. 86, Issue 5, p1382–1392.

Won-Hee Song, Young-Joo Yi, Miriam Sutovsky, Stuart Meyers, Peter Sutovsky. Autophagy and Ubiquitin-Proteasome System Contribute to Sperm Mitophagy after Mammalian Fertilization. Proceedings of the National Academy of Sciences PNAS 2016 ; published ahead of print August 22, 2016, doi:10.1073/pnas.1605844113.

Miller MR, Kenny SJ, Mansell SA, Mannowetz N, Wojcik M, Meyers S, Xu K, Lishko PV. Asymmetrically Positioned Flagellar Control Units Define Sperm Motility. eLife 2016

Won-Hee Song, Young-Joo Yi, Miriam Sutovsky, Stuart Meyers, Peter Sutovsky. Autophagic Punctum: The ART and Science of Sperm Mitophagy. Autophagy, 2016 http://dx.doi.org/10.1080/15548627.2016.1239004.

Shiho Sumigama, Steven Mansell, Melissa Miller, Polina Lishko, Stuart A. Meyers and Theodore L. Tollner. Progesterone Accelerates the Completion of Sperm Capacitation

and activates CatSper Channel in Spermatozoa from the Rhesus Macaque. Biology of  Reproduction December 2015 93 (6) 130, 1-11; published ahead of print October 21, 2015, doi:10.1095/biolreprod.115.129783

Burruel V, Klooster KL, Chitwood J, Ross PJ, Meyers SA. Oxidative Damage to Rhesus Macaque Spermatozoa Results in Mitotic Arrest and Transcript Abundance Changes in Early Embryos. Biol Reprod. 2013 DOI: 10.1095/biolreprod.113.110981 Article Number: 72.

Burruel, V., Klooster, K., Barker, C.M., Pera, R.R. & Meyers, S. Abnormal Early Cleavage Events Predict Early Embryo Demise: Sperm Oxidative Stress and Early Abnormal Cleavage. Scientific Reports 4, 6598; DOI:10.1038/srep06598 (2014).

Melissa Miller, Steven A. Mansell, Stuart Meyers, and Polina Lishko. Flagellar Ion Channels of Sperm: Similarities and Differences Between Species. Cell Calcium. 2014 Oct 29. pii: S0143-4160(14)00164-X. doi: 10.1016/j.ceca.2014.10.009. [Epub ahead of print]

Hagedorn M, McCarthy M, Carter VL, Meyers SA. Oxidative Stress in Zebrafish (Danio rerio) Sperm.  PLoS ONE, June 2012 | Volume 7 | Issue 6 | e39397

Hagedorn M, Carter V, Martorana K, Paresa M, Acker J, Baums I, Borneman E, Brittsan M, Henley M, Laterveer M, Leong J, McCarthy M, Meyers S, Nelson B, Petersen D, Tiersch T, Uribe R, Woods E, Wildt D. Preserving and Using Germplasm and Dissociated Embryonic Cells for Conserving Caribbean and Pacific Coral. PLoS ONE  Volume: 7   Issue: 3   Article Number: e33354   Published: MAR 8 2012

Cole J, Meyers S. Osmotic Stress Stimulates Phosphorylation and Cellular Expression of Heat Shock Proteins in Rhesus Macaque Sperm Journal of Andrology 32 (4): 402-410, 2011

Klooster K, Burruel V, Meyers S. Loss of Fertilization Potential of Desiccated Rhesus Macaque Spermatozoa Following Prolonged Storage. Cryobiology 62 (3): 161-166, 2011

McCarthy M, Meyers S. Antioxidant Treatment in the Absence of Exogenous Lipids and Proteins Protects Rhesus Macaque Spermatozoa from Cryopreservation-Induced Cell Membrane Damage. Theriogenology 76 (1): 168-176, 2011

McCarthy M, Baumber J, Kass P, Meyers S. Osmotic Stress Induces Oxidative Cell Damage to Rhesus Macaque Spermatozoa. Biol Reprod 82 (3) 644-651, 2010

Burnaugh L, Ball BA, Sabeur K, Thomas AD, Meyers SA. Osmotic stress stimulates generation of superoxide anion by spermatozoa in horses. Anim Reprod Sci. 2010 Feb;117(3-4):249-60. 2009.

Meyers S, Wen-Li M, Enders AC, Overstreet JW. Rhesus Macaque Blastocysts Resulting from Intracytoplasmic Sperm Injection of Vacuum-Dried Spermatozoa. Journal of Medical Primatology 38(5): 310-317, 2009.

Correa LM, Thomas A, Meyers SA. Reorganization of the Macaque Sperm Actin Cytoskeleton in Response to Osmotic Stress Contributes to Changes in Motility and Morphology. Biology of Reproduction, 2007. Papers in Press, published online ahead of print September 5, 2007. Biol Reprod 2007, 10.1095/biolreprod.107.060533.

Li MW, Meyers S, Tollner TL, Overstreet JW. Damage to Chromosomes and DNA of Rhesus Monkey Sperm Following Cryopreservation. Journal of Andrology 28: 493-501, 2007.

Baumber J, Meyers S. Changes in Membrane Lipid Order with Capacitation in Rhesus Macaque (Macaca mulatta) Spermatozoa. Journal of Andrology 27(4):578-87, 2006.

Ricker JV, Linfor JJ, Delfino WJ, Kysar P, Scholtz EL, Tablin F, Crowe JH, Ball BA, SA Meyers. Equine Sperm Membrane Phase Behavior: The Effects of Lipid-Based Cryoprotectants. Biology of Reproduction 74, 359-365 (2006)

Enders AC, Douglas GC, Meyers SA, VandeVoort CA. Interactions Of Macaque Blastocysts With Epithelial Cells In Vitro. Human Reproduction 20(11):3026-3032, 2005

Ali Honaramooz, Ming-Wen Li, M. Cecilia T. Penedo, Stuart Meyers, and Ina Dobrinski. Accelerated Maturation of Primate Testis by Xenografting into Mice. Biol Reprod 70: 1500-1503, 2004 .

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