Su Hao Lo

Su Hao Lo

Position Title
Professor

Unit
Department of Biochemistry and Molecular Medicine, School of Medicine

Research I/UCDMC
Bio

Research Interests

Molecular and cell biolbogy

Our overall research interests are to understand the molecular mechanisms that underlie the structure and function of focal adhesions. Focal adhesions are integrin-mediated junctions that attach a variety of different cell types to their underlying substratum. They are signal transduction organelles and play a major role in diverse biological processes, including cell growth, attachment, migration, death, polarization, and differentiation. As such, focal adhesion dysfunction is known to have profound repercussions in embryogenesis, tissue development and repair, as well as in many pathological conditions including various forms of cancer.

Grad Group Affiliations

  • Biochemistry, Molecular, Cellular and Developmental Biology
  • PTX, Comparative pathology

Specialties / Focus

  • Molecular Medicine

Labs

  • Irene Shih
    • PhD
  • Peng Sun
    • PhD
  • Shiao Ya Hong
    • PhD
  • Aifeng Wang
    • PhD
  • Gauri Khandekar
    • PhD

Honors and Awards

  • Joan Oettinger Memorial Award (2008)
  • Shriners Hospitals Research Award (2003-2008)

    Professional Societies

    • American Association for the Advancement of Science
    • American Society of Cell Biology
    • European Life Scientist Organization
    • Society for Basic Urologic Research

    Degrees

    • 1993 PhD Cell and Developmental Biology Harvard University
    • 1986 BS National Taiwan University
    • 1997 Postdoctoral fellow U of Chicago, HHMI

    Publications

    Hong, S. Y., Shih, Y.P., Sun, P., Hsieh, W. J., Lin, W. C. and Lo, S. H., Down-regulation of tensin2 enhances tumorigenicity and is associated with a variety of cancers. Oncotarget 2016 in press

    Yang, K., Wu, W. M., Chen, Y. C., Lo, S. H., and Liao Y.C. ΔNp63α Transcriptionally Regulates the Expression of CTEN that Is Associated with Prostate Cell Adhesion. PLoS ONE 2016 11(1):e0147542.

    Shih, Y. P., Sun, P., Wang, A., Lo, S. H. Tensin1 positively regulates RhoA activity through its interaction with DLC1. BBA Molecular Cell Research. 2015, 1853:3258-65

     Dina, C., Bouatia-Naji, N., Tucker, N., Delling, F.N., Toomer, K., Durst, R., Perrocheau, M., Fernandez-Friera, L., Solis, J., Tourneau, T., Chen, M.H., Probst, V., Bosse, Y., Pibarot, P., Zelenika, D., Lathrop, M, Hercberg, S., Rousse, R., Benjamin, E. J., Bonnet, F., Lo, S. H., Dolmatova, E., Simonet, F., Lecointe, S., Kyndt, F., Redon, R, Marec H., Froguel, P., Ellinor, P. T., Vasan, R. S., Bruneval, P., Norris, R. A., Milan, D. J., Slaugenhaupt, S. A., Levine, R. A., Schott, J., Hagege, A. A., Jeunemaitre, X.  Genetic association highlights biological pathways underlying mitral valve prolapse. Nat Genetics 2015 47(10):1206-11

    Lo. S.H. C-terminal tensin-like (CTEN): a promising biomarker and target for cancer. J Biochem Cell Biol. 2014, 51:150-4

    Hung, S.Y., Shih, Y.P., Chen, M., and Lo, S.H. Up-regulated cten by FGF2 contributes to FGF2-mediated cell migration. Mol Carcinog 2014, 53:787-792

    Hong, S. Y., Shih, Y. P., Li, T., Carraway, K., Lo, S.H. CTEN Prolongs Signaling by EGFR through Reducing Its Ligand-Induced Degradation. Cancer Res. 2013 73(16):5266-76.

    Chen, N.T., Kuwabara, Y., Conley, C., Liao, Y. C., Hong, S. Y., Chen, M., Shih, Y. P., Chen, H.W., Hsieh F., Lo, S. H. Phylogenetic analysis, expression patterns, and transcriptional regulation of human CTEN gene. Gene 2013 520(2):90-7.

    Fujita, M., Ieguchi, K., Fong, A., Wilkerson, C., Chen, J.Q, Wu, M., Lo, S.H., Cheung, ATW., Wilson, M.D., Cardiff, R.D. , Borowsky, A.D, Yoko K. Takada, YK, and Takada, Y. An integrin-binding-defective mutant of insulin-like growth factor-1 (R36E/R37E IGF1) acts as a dominant-negative antagonist of IGF1R and suppresses tumorigenesis, while the mutant still binds to IGF1R. J Biol Chem. 2013 288(27):19593-603

    Shih Y.P., Takada, Y., Lo, S.H. Silencing of DLC1 promotes PAI-1 expression and reduces normal cell migration. Mol Cancer Res. 2012, 10:34-39

    Li, J.R., Shi, L., Deng, Z., Lo, S. H., Liu, G.Y. Nanostructures of Designed Geometry and Functionality Enable Regulation of Cellular Signaling Processes. Biochemistry 2012, 51:5876- 5893.

    Shi L, Li, J.R., Shih, Y.P., Lo, S. H., Liu, G. Y., Nanogratings of Fibronectin Provide an Effective Biochemical Cue for Regulating Focal Adhesion and Cellular Structure. Nano Res 2012, 5(8): 565–575

    Zimmer, C.C., Shi, L., Shih, Y.P., Li, J., Jin, LW, Lo, S.H. Liu, G.Y. F-Actin reassembly during focal adhesion impacts single cell mechanics and nanoscale membrane structure. Science China Chemistry, 2012, 55(9):1922-1930

    Albasri, A., Al-Ghamdi, S., Fadhil, W., Aleskandarany, M., Liao, Y.C., Jackson, D., Lobo, D.N., Lo, S. H., Kumari, R., Durrant, L., Watson, S., Kindle, K.B., Ilyas, M. Cten signals through Integrin-linked Kinase (ILK) and may promote metastasis in colorectal cancer. Oncogene 2011, 30(26):2997-3002.

    Wu. Z., Chang, P.C., Yang, Y.C., Chu, C. Y., Wang, L. Y., Chen, N. T., Desai, S. J., Lo, S. H., Evans, C. P., Lam, K. S., Kung, H. J. Autophagy blockade sensitizes prostate cancer cells towards Src family kinase inhibitors. Genes and Cancer 2010, 1:40-49

    Lin, Y., Chen, N. T., Shih, Y. P., Liao, Y. C., Xue, L., and Lo, S. H, DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration. Oncogene 2010, 29:3010-301.

    Shih, Y.P., Liao, Y.C., Lin, Y., Lo, S. H. DLC1 negatively regulates angiogenesis in a paracrine fashion. Cancer Res 2010 70:8270-8275.

    Hsieh S. C., Chen, N. T., Lo, S. H. Conditional loss of PTEN leads to skeletal abnormalities and lipoma formation. Mol Carcinog. 2009, 48:545-552

    Lulevich, V., Shih, I. P., Lo, S. H., and Liu, G. Y. Cell tracing dyes significantly change single cell mechanics. J Phys Chem 2009, 113:6511-6519

    Liao, Y. C., Chen, N. T., Shih Y. P., Dong, Y., Lo, S. H. Up-regulation of C-terminal tensin-like molecule promotes the tumorigenicity of colon cancer cells through beta-catenin. Cancer Res 2009, 69:4563- 4566

    Liao, Y. C., Shih, I. P., and Lo, S. H. Mutations in DLC-1’s focal adhesion targeting region attenuated its expression and function. Cancer Res 2008, 68:7718-7722

    Liao, Y. C. and Lo, S. H. Deleted in Liver Cancer-1 (DLC-1): a tumor suppressor not just for liver. Int J Biochem Cell Biol. 2008, 40:834-847

    Katz, M., Amit, I., Citri, A., Shay, T., Carvalho, S., Lavi, S., Milanezi, F., Lyass, L., Amariglio, N., Jacob-Hirsch, J., Ben-Chetrit, N., Tarcic, G., Lindzen, M., Avraham, R., Liao, Y. C., Trusk, P., Lyass, A., Rechavi, G., Spector, N. L., Lo, S. H., Schmtt, F., Bacus, S. S., Yarden, Y. A reciprocal tensin3-cten switch mediates EGF-driven mammary cell migration. Nat Cell Biol. 2007, 9:961-969.

    Lo, S. H. Reverse interactomics: from peptides to proteins and to function. AC Chem. Biol. 2007, 2:93-95.

    Liao, Y.C., Si, L., deVere White, R., and Lo, S. H. The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1. J Cell Biol. 2007, 176:43-49

    Lo, S. H. Focal adhesions: what's new inside. Dev. Biol. 2006, 294:280-91

    Chen, N. T., and Lo, S. H. The N-terminal half of talin2 is sufficient for mouse development and survive. Biochem Biophys Res Commun. 2005, 337:670-676.

    Lo, S. S., Lo, S. H., and Lo, S. H. Cleavage of cten by caspase 3 during apoptosis. Oncogene. 2005, 24:4311-4314.

    Chiang, M. K., Liao, Y. C., Kuwabara, Y, and Lo, S. H. Targeted disruption of tensin3 in mice results in growth retardation and postnatal lethality. Dev. Biol. 2005, 279:368-377.

    Lo, S. H. Molecules in focus: Tensin. Int J Biochem Cell Biol. 2004, 36:31-34.

    Cui, Y., Liao, Y.C. and Lo, S. H. Epidermal growth factor modulates tyrosine phosphorylation of a novel tensin family member, tensin3. Mol Cancer Res. 2004, 2:225-232.

    Chen, H. and Lo, S. H. Regulation of tensin-promoted cell migration by its focal adhesion-binding and Src Homology 2 domains. Biochem J. 2003, 370:1039-1045.

    Lo, S. H. and Lo, T. B. CTEN, a C-terminal tensin-like protein with prostate restricted expression, is down regulated in prostate cancer. Cancer Res. 2002, 62:4217-4221.

    Chen, H. Duncan, I. C. Bozorgchami, H. and Lo, S. H. Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration. Proc. Natl. Acad. Sci. USA 2002, 99:733-738.

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