Thomas Jue

Thomas Jue

Position Title

Department of Biochemistry and Molecular Medicine, School of Medicine

4323 Tupper Hall

Profile Introduction

Nuclear magnetic resonance spectroscopic/imaging techniques to observe the regulation of intermediary metabolism

Research Interests

Nuclear magnetic resonance spectroscopy/imaging, molecular diffusion in the cell, structure-function of protein in the cell, apolipoprotein function/regulation, intermediary metabolism, theory of respiratory control, signal transduction and metabolism linkage in cancer, tumor biomarkers, physiological adaptation in diving mammals, comparative physiology.

Handbook of Modern Biophysics

Book series in modern biophysics

Grad Group Affiliations

  • Biomedical Engineering Graduate Group
  • Biophysics
  • Graduate Group in Nutrition

Specialties / Focus

  • Biochemistry and Molecular Recognition
  • Exercise Physiology
  • Spectroscopy and Imaging


  • 1983 PhD Chemistry University of California, Davis


Bendahan, D., Chatel, B, and Jue, T.  Comparative NMR and NIRS analysis of oxygen dependent metabolism in exercising finger flexor muscles, 2017  Am. J. Physiology  DOI: 10.1152/ajpregu.00203.2017

Jue, T., Shih, L., Chung, Y., Differential interaction of myoglobin with select fatty acids of carbon chain lengths C8 to C16, Lipids, 2017. DOI 10.1007/s11745-017-4272-z

Jue, T., Simond, G., Wright, T. J., Shih, L., Chung, Y., Sriram, R., Kreutzer, U., and Davis, R., Effect of fatty acid interaction on Mb oxygen affinity and triglyceride metabolism, J. Physiol. & Biochem, 2017.  doi:10.1007/s13105-017-0559-z

Masuda, K., Jue, T., Hamidie, R.D.R., Mitochondrial biogenesis induced by exercises and nutrients:  Implication for performance and health benefits, Indonesian J of Sci & Tech, 2, 99-107, 2017.  DOI:

Takakura, H., Ojino, M., Jue, T., Yamada, T., Furuichi, Y., Hashimoto, T., Iwase, S., Masuda, K., Intracellular oxygen tension limits muscle contraction-induced change in muscle oxygen consumption under hypoxic conditions during Hb-free perfusion, 2016. Physiological Reports, doi: 10.14814/phy2.13112

Yamada, T., Takakura, H., Jue, T. Hashimoto, T. Ishizawa, R. Furuichi, Y. Kato, Y., Iwanaka, N. Masuda, K.  Myoglobin and the regulation of mitochondrial respiratory chain complex IV.  J. Physiol., 594, 483-495, 2016.  doi: 10.1113/JP270824.

Shih, L., Chung, Y., Sriram, R., and Jue, T. Interaction of myoglobin with oleic acid. Chem & Physics of Lipids, Chem Phys Lipids, 191, 115-122, 2015. doi: 10.1016/j.chemphyslip.2015.07.010.

Park, J.M., Josan, S., Mayer, D., Hurd, R. E., Chung, Y.,  Bendahan, D.,  Spielman, D. M., and Jue, T., Hyperpolarized 13C NMR Observation of Lactate Kinetics in Skeletal Muscle, J Exp Biol, 18,3308-3318,2015. DOI: 10.1113/JP270824.

Jue, T., Measuring Intracellular Oxygenation with the Myoglobin Signals, Encyclopedia of Magnetic Resonance, ed by John Griffiths and Paul Bottomley, John Wiley & Sons,  4, 635-642,  2015. DOI: 10.1002/9780470034590.emrstm1452.

Takakura, H., Furuichi,Y.Yamada, T., Jue, T., Ojino, M., Hashimoto, T., Iwase, S., Hojo, T., Izawa, T.,  Masuda, K., Endurance training facilitates myoglobin desaturation during muscle contraction in rat skeletal muscle, Scientific Report, 5, 9403, 1-6, 2014. doi:10.1038/srep09403.

Shih, L., Chung, Y., Sriram, R., and Jue, T., Palmitate Interaction with Physiological States of Myoglobin. Bioch BiophyActa, 1840, 656-666, 2014.  DOI: 10.1016/j.bbagen.2013.10.028.

Masuda, K., Yamada, T., and Jue, T. Reply to Pancheva, Pancheva, Pancheva, J. Appl. Physiol., 115, 1, 151, 2013.  doi: 10.1152/japplphysiol.00449.2013.

Lagerstedt, J.O., Petrlova, J., Hilt, S., Marek, A., Chung, Y., Sriram, Budamagunta, M.S.,  Desreux, J. F., Thonon, D., Jue, T., Smirnov, A.I., Voss, J. C.,  EPR assessment of protein sites for incorporation of Gd(III) MRI contrast labels, Contrast Media & Molecular Imaging, 8, 252-264, 2013.  doi: 10.1002/cmmi.1518.

Yamada, T. Yasuro, F., Hisashi, T., Hashimoto, T. Hanai, Y., Jue, T, and Masuda, K.,   Interaction between myoglobin and mitochondria in rat skeletal muscle, J. Appl. Physiol., 114(4):490-7, 2013.  doi: 10.1152/japplphysiol.00789.2012.

Sriram, R. Lagerstedt, J.O., Petrolova, J., Samardzic, H. Kreutzer, U., Xie, Hongtao, Kaysen, G. A., Desreux, J.F., Thonon, D. F., Jacques, V., Van Loan, M., Rutledge, J. C., Oda, M. N., Voss, J. C., and Jue, T. Imaging apolipoprotein AI in vivo. NMR in Biomedicine, 24, 926-024,2011. DOI: 10.1002/nbm.1650.

Tomita, A., Kreutzer, U., Adachi, S., Koshihara, SY, and Jue, T. "It’s Hollow“: the function of pores within myoglobin. J. Exp. Biol. 213: 2748-2754, 2010.

Gros, G., Wittenberg, BA, and Jue, T. Myoglobin’s old and new clothes: form molecular structure to function in living cells. J. Exp. Biol. 213: 2713-2725, 2010.

Takakura, H., Masuda, K., Hashimoto, T., Iwase, S., and Jue, T. Quantification of Myoglobin Deoxygenation and Intracellular PO2 during Muscle Contraction under Hb-free Medium Perfusion, Exp Physiology, 95, 630-640, 2010.

Xie, H., Kreutzer, U., and Jue, T., Oximetry with the NMR Signal of Hemoglobin Val E11, Eur. J. Appl. Physiol., 107,325-333, 2009

Masuda, K., Takakura, H, Furuichi , H., Iwase, S., and Jue, T. NIRS Measurement of O2 Dynamics in Contracting Blood and Buffer Perfused Hindlimb Muscle, Adv. Experimental Med., 662: 323-328, 2009

Sriram, R., Kreutzer, U., Shih, L-F., and Jue, T. Interaction of Fatty Acid with Myoglobin, FEBS Letter, 582, 3643-3549, 2008.

Ponganis, P.J., Kreutzer, U., Stockard, T., Lin, P.C., Sailasuta, N., Tran, T.K., Hurd,R., and Jue, T. Blood Flow and Metabolic Regulation in Seal Muscle During Apnea, J. Exp. Biol., 211, 3323-3332, 2008

Masuda, K., Truscott, K., Lin, P-Chang, Kreutzer, U., Chung, Y., Sriram, R., and Jue, T. Determination of Myoglobin Concentration in Blood Perfused Mouse Myocardium, Eur. J. Appl. Physiol., 104, 41-48, 2008.

Lin, P.C., Kreutzer, U., and Jue, T. Mb Translational Diffusion in Myocardium and Its Implication on Intracellular Oxygen Transport, J. Physiol, 578, 595-603, 2007.

Lin, P.C., Kreutzer, U., and Jue, T. Anisotropy and Temperature Dependence of Mb Translational Diffusion in Myocardium: Implication on Oxygen Transport and Cellular Architecture, Biophysical J. 92: 2608-2620,2007.

Jue, T. A voice over the smoke for academic freedom. Science, 315(5814): 937, 2007.

Kreutzer, U. and Jue, T. Investigation of Bioactive NO Scavenging Role of Mb in Myocardium, Eur. J. Physiol. 452, 36-42, 2006.

Chung, Y., Huang, S.-J., Glabe, A., and Jue, T. Implication of CO inactivation on myoglobin function, Am. J. Physiol., 290, C1616-C1624, 2006.

Chung, Y. Mole, P.A., Sailasuta, N., Tran, T. K., Hurd, R. Control of respiration and bioenergetics during a muscle contraction. Am. J. Physiol. 288, C730-738, 2005.